Molecular and metabolic insights of creatine supplementation on resistance training

In recent years the research problem in the field of sports supplementation has changed to explain the metabolic mechanisms by which creatine (Cr) administration enhances the performance of certain sports or simply benefits the muscular adaptation. In this review for first time the biochemical mecha...

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Autores:
Bonilla, Diego A.
Moreno, Yurany
Tipo de recurso:
Article of journal
Fecha de publicación:
2015
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/66308
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/66308
http://bdigital.unal.edu.co/67332/
Palabra clave:
54 Química y ciencias afines / Chemistry
Cr/PCr/CK System
creatine monohydrate
muscle energy metabolism
MAPK
IGF-I
resistance training
highintensity exercise
sistema Cr/PCr/CK
monohidrato de creatina
metabolismo energético muscular
MAPK
IGF-I
entrenamiento de fuerza
ejercicio de alta intensidad
Rights
openAccess
License
Atribución-NoComercial 4.0 Internacional
id UNACIONAL2_2d2e2d0ccc6fc3dd7cb4a1aebf4ce0a2
oai_identifier_str oai:repositorio.unal.edu.co:unal/66308
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Molecular and metabolic insights of creatine supplementation on resistance training
title Molecular and metabolic insights of creatine supplementation on resistance training
spellingShingle Molecular and metabolic insights of creatine supplementation on resistance training
54 Química y ciencias afines / Chemistry
Cr/PCr/CK System
creatine monohydrate
muscle energy metabolism
MAPK
IGF-I
resistance training
highintensity exercise
sistema Cr/PCr/CK
monohidrato de creatina
metabolismo energético muscular
MAPK
IGF-I
entrenamiento de fuerza
ejercicio de alta intensidad
title_short Molecular and metabolic insights of creatine supplementation on resistance training
title_full Molecular and metabolic insights of creatine supplementation on resistance training
title_fullStr Molecular and metabolic insights of creatine supplementation on resistance training
title_full_unstemmed Molecular and metabolic insights of creatine supplementation on resistance training
title_sort Molecular and metabolic insights of creatine supplementation on resistance training
dc.creator.fl_str_mv Bonilla, Diego A.
Moreno, Yurany
dc.contributor.author.spa.fl_str_mv Bonilla, Diego A.
Moreno, Yurany
dc.subject.ddc.spa.fl_str_mv 54 Química y ciencias afines / Chemistry
topic 54 Química y ciencias afines / Chemistry
Cr/PCr/CK System
creatine monohydrate
muscle energy metabolism
MAPK
IGF-I
resistance training
highintensity exercise
sistema Cr/PCr/CK
monohidrato de creatina
metabolismo energético muscular
MAPK
IGF-I
entrenamiento de fuerza
ejercicio de alta intensidad
dc.subject.proposal.spa.fl_str_mv Cr/PCr/CK System
creatine monohydrate
muscle energy metabolism
MAPK
IGF-I
resistance training
highintensity exercise
sistema Cr/PCr/CK
monohidrato de creatina
metabolismo energético muscular
MAPK
IGF-I
entrenamiento de fuerza
ejercicio de alta intensidad
description In recent years the research problem in the field of sports supplementation has changed to explain the metabolic mechanisms by which creatine (Cr) administration enhances the performance of certain sports or simply benefits the muscular adaptation. In this review for first time the biochemical mechanisms of Cr ingestion in a cell signaling insight were analyzed, focusing on energetic bioavailability enhancement and optimization of the temporal and spatial buffering of Cr/PCr/CK system. Moreover, intensification in proliferation and differentiation processes of muscle cells (IGF-I/PI3K/Akt-PKB, SPHK1/MAPK/p38/MRFs, mTOR, cellular swelling, mitotic activity of satellite cells, actin polymerization, and myoblast fusion) and inactivation and/or reduction in the expression of ergolitic metabolites (GSK3β, myostatin and AMPK regulation) were examined. In this way, we explained from a metabolic point of view the increase in muscle mass, strength, fatigue resistance, and performance of high intensity sports after Cr monohydrate supplementation.
publishDate 2015
dc.date.issued.spa.fl_str_mv 2015-01-01
dc.date.accessioned.spa.fl_str_mv 2019-07-03T01:52:51Z
dc.date.available.spa.fl_str_mv 2019-07-03T01:52:51Z
dc.type.spa.fl_str_mv Artículo de revista
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dc.identifier.issn.spa.fl_str_mv ISSN: 2357-3791
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identifier_str_mv ISSN: 2357-3791
url https://repositorio.unal.edu.co/handle/unal/66308
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dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.spa.fl_str_mv https://revistas.unal.edu.co/index.php/rcolquim/article/view/53978
dc.relation.ispartof.spa.fl_str_mv Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de Química
Revista Colombiana de Química
dc.relation.references.spa.fl_str_mv Bonilla, Diego A. and Moreno, Yurany (2015) Molecular and metabolic insights of creatine supplementation on resistance training. Revista Colombiana de Química, 44 (1). pp. 11-18. ISSN 2357-3791
dc.rights.spa.fl_str_mv Derechos reservados - Universidad Nacional de Colombia
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.license.spa.fl_str_mv Atribución-NoComercial 4.0 Internacional
dc.rights.uri.spa.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv Atribución-NoComercial 4.0 Internacional
Derechos reservados - Universidad Nacional de Colombia
http://creativecommons.org/licenses/by-nc/4.0/
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Universidad Nacional de Colombia - Sede Bogotá - Facultad de Ciencias - Departamento de Química
institution Universidad Nacional de Colombia
bitstream.url.fl_str_mv https://repositorio.unal.edu.co/bitstream/unal/66308/1/53978-282710-1-PB.pdf
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spelling Atribución-NoComercial 4.0 InternacionalDerechos reservados - Universidad Nacional de Colombiahttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Bonilla, Diego A.e0ee77f3-64cd-4f43-a3b9-e0376b246b6e300Moreno, Yurany7f4020b6-70e2-4549-959e-4c3209193ae83002019-07-03T01:52:51Z2019-07-03T01:52:51Z2015-01-01ISSN: 2357-3791https://repositorio.unal.edu.co/handle/unal/66308http://bdigital.unal.edu.co/67332/In recent years the research problem in the field of sports supplementation has changed to explain the metabolic mechanisms by which creatine (Cr) administration enhances the performance of certain sports or simply benefits the muscular adaptation. In this review for first time the biochemical mechanisms of Cr ingestion in a cell signaling insight were analyzed, focusing on energetic bioavailability enhancement and optimization of the temporal and spatial buffering of Cr/PCr/CK system. Moreover, intensification in proliferation and differentiation processes of muscle cells (IGF-I/PI3K/Akt-PKB, SPHK1/MAPK/p38/MRFs, mTOR, cellular swelling, mitotic activity of satellite cells, actin polymerization, and myoblast fusion) and inactivation and/or reduction in the expression of ergolitic metabolites (GSK3β, myostatin and AMPK regulation) were examined. In this way, we explained from a metabolic point of view the increase in muscle mass, strength, fatigue resistance, and performance of high intensity sports after Cr monohydrate supplementation.En los últimos años el problema de investigación en el campo de la suplementación deportiva ha cambiado al punto de explicar los mecanismos metabólicos por los cuales la administración de creatina (Cr) incrementa el rendimiento en ciertos deportes o simplemente beneficia la adaptación muscular. Esta revisión analiza por primera vez los mecanismos bioquímicos de la ingesta de Cr desde la perspectiva de señalización celular, enfocándose en la mayor biodisponibilidad energética de Cr y optimización de la acción buffer espacial/ temporal que ofrece el sistema Cr/PCr/CK. Además, se examinan aspectos relacionados con el incremento en los procesos de proliferación y diferenciación de células musculares (IGF-I/PI3K/Akt-PKB, SPHK1/ MAPK/p38/MRFs, mTOR, hinchamiento celular, actividad mitótica de células satélite, polimerización de actina y fusión de mioblastos) y la inactivación y/o reducción en la expresión de proteínas con funciones ergolíticas (GSK3β, miostatina y regulación de AMPK). De esta manera, se explican el aumento de la masa muscular, la fuerza, la resistencia a la fatiga y el rendimiento en ejercicios de alta intensidad, producidos por la suplementación con monohidrato de Cr, desde un punto de vista metabólico.application/pdfspaUniversidad Nacional de Colombia - Sede Bogotá - Facultad de Ciencias - Departamento de Químicahttps://revistas.unal.edu.co/index.php/rcolquim/article/view/53978Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de QuímicaRevista Colombiana de QuímicaBonilla, Diego A. and Moreno, Yurany (2015) Molecular and metabolic insights of creatine supplementation on resistance training. Revista Colombiana de Química, 44 (1). pp. 11-18. ISSN 2357-379154 Química y ciencias afines / ChemistryCr/PCr/CK Systemcreatine monohydratemuscle energy metabolismMAPKIGF-Iresistance traininghighintensity exercisesistema Cr/PCr/CKmonohidrato de creatinametabolismo energético muscularMAPKIGF-Ientrenamiento de fuerzaejercicio de alta intensidadMolecular and metabolic insights of creatine supplementation on resistance trainingArtículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/ARTORIGINAL53978-282710-1-PB.pdfapplication/pdf1646901https://repositorio.unal.edu.co/bitstream/unal/66308/1/53978-282710-1-PB.pdfb3704d425956c543b0e4f08907242111MD51THUMBNAIL53978-282710-1-PB.pdf.jpg53978-282710-1-PB.pdf.jpgGenerated Thumbnailimage/jpeg8643https://repositorio.unal.edu.co/bitstream/unal/66308/2/53978-282710-1-PB.pdf.jpg76b12ae4907033eab74ee5d8a87a8e04MD52unal/66308oai:repositorio.unal.edu.co:unal/663082023-05-24 23:03:04.486Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.co

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