Novel gel-like microemulsion for topical delivery of Amphotericin B

The aim of the present work was to develop a ME for topical delivery of Amphotericin B (AmB). Microemulsions (MEs) are versatile systems to solubilize drugs due to the presence of both a hydrophobic and a hydrophilic region, as well as a distinctive interface composed of surfactant and cosurfactant....

Full description

Autores:
Salerno, Claudia
Gorzalczany, Susana
Arechavala, Alicia
Scioscia, Silvia L.
Carlucci, Adriana M.
Bregni, Carlos
Tipo de recurso:
Article of journal
Fecha de publicación:
2015
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/66627
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/66627
http://bdigital.unal.edu.co/67655/
Palabra clave:
66 Ingeniería química y Tecnologías relacionadas/ Chemical engineering
61 Ciencias médicas; Medicina / Medicine and health
Rights
openAccess
License
Atribución-NoComercial 4.0 Internacional
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spelling Atribución-NoComercial 4.0 InternacionalDerechos reservados - Universidad Nacional de Colombiahttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Salerno, Claudia87e4374d-7652-43af-80dd-bdd4c7c49109300Gorzalczany, Susana54b52d1d-6ddb-4bd0-9152-59a5d4d90dec300Arechavala, Aliciac06c1f52-2a7d-47b6-88aa-e51f4cf35285300Scioscia, Silvia L.0b2055c6-7314-4f79-b73d-7f5722b64337300Carlucci, Adriana M.63e31ddc-c939-448f-bd42-3b1d36495d54300Bregni, Carlos7abe553d-9ca7-425e-adcd-75bc037326f73002019-07-03T02:30:51Z2019-07-03T02:30:51Z2015-09-01ISSN: 1909-6356https://repositorio.unal.edu.co/handle/unal/66627http://bdigital.unal.edu.co/67655/The aim of the present work was to develop a ME for topical delivery of Amphotericin B (AmB). Microemulsions (MEs) are versatile systems to solubilize drugs due to the presence of both a hydrophobic and a hydrophilic region, as well as a distinctive interface composed of surfactant and cosurfactant. MEs have been reported for many advantages for topical application of drugs. Considering that AmB has very low water solubility a screening of surfactants and oils was performed. A gel-like ME system, that can be applied topically without the need for thickeners agents, was selected. AmB was incorporated up to 1 mg/g and remained stable for at least 90 days both at 4 ºC and room temperature, so this formulation would be appropriate as a compounding medication. An in vitro skin penetration test was performed, the applied dose penetrated (10.16 ± 0.01 μg/cm2/h as estimated flux) and remained completely within the skin during the assay; AmB was not detected in the receptorcompartment. In vitro antifungal and antileishmanial activity was tested and drug showed proper activity. AmB is a second line drug for the treatment of cutaneous leishmaniasis, but topical dosage forms are still lacking. This system is potentially useful for the treatment of skin infections avoiding drug toxic systemic effects.application/pdfspaUniversidad Nacional de Colombia - Sede Bogotá - Facultad de Ciencias - Departamento de Farmaciahttps://revistas.unal.edu.co/index.php/rccquifa/article/view/56285Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de Ciencias Químico FarmacéuticasRevista Colombiana de Ciencias Químico FarmacéuticasSalerno, Claudia and Gorzalczany, Susana and Arechavala, Alicia and Scioscia, Silvia L. and Carlucci, Adriana M. and Bregni, Carlos (2015) Novel gel-like microemulsion for topical delivery of Amphotericin B. Revista Colombiana de Ciencias Químico-Farmacéuticas, 44 (3). pp. 359-381. ISSN 1909-635666 Ingeniería química y Tecnologías relacionadas/ Chemical engineering61 Ciencias médicas; Medicina / Medicine and healthNovel gel-like microemulsion for topical delivery of Amphotericin BArtículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/ARTORIGINAL56285-286474-1-SM.pdfapplication/pdf477637https://repositorio.unal.edu.co/bitstream/unal/66627/1/56285-286474-1-SM.pdf92d8c676ba9a0e9e339f3b4aeec4fe33MD51THUMBNAIL56285-286474-1-SM.pdf.jpg56285-286474-1-SM.pdf.jpgGenerated Thumbnailimage/jpeg6560https://repositorio.unal.edu.co/bitstream/unal/66627/2/56285-286474-1-SM.pdf.jpg767453cb7fc0b115ae97c6955b7ba248MD52unal/66627oai:repositorio.unal.edu.co:unal/666272023-05-26 23:02:45.465Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.co
dc.title.spa.fl_str_mv Novel gel-like microemulsion for topical delivery of Amphotericin B
title Novel gel-like microemulsion for topical delivery of Amphotericin B
spellingShingle Novel gel-like microemulsion for topical delivery of Amphotericin B
66 Ingeniería química y Tecnologías relacionadas/ Chemical engineering
61 Ciencias médicas; Medicina / Medicine and health
title_short Novel gel-like microemulsion for topical delivery of Amphotericin B
title_full Novel gel-like microemulsion for topical delivery of Amphotericin B
title_fullStr Novel gel-like microemulsion for topical delivery of Amphotericin B
title_full_unstemmed Novel gel-like microemulsion for topical delivery of Amphotericin B
title_sort Novel gel-like microemulsion for topical delivery of Amphotericin B
dc.creator.fl_str_mv Salerno, Claudia
Gorzalczany, Susana
Arechavala, Alicia
Scioscia, Silvia L.
Carlucci, Adriana M.
Bregni, Carlos
dc.contributor.author.spa.fl_str_mv Salerno, Claudia
Gorzalczany, Susana
Arechavala, Alicia
Scioscia, Silvia L.
Carlucci, Adriana M.
Bregni, Carlos
dc.subject.ddc.spa.fl_str_mv 66 Ingeniería química y Tecnologías relacionadas/ Chemical engineering
61 Ciencias médicas; Medicina / Medicine and health
topic 66 Ingeniería química y Tecnologías relacionadas/ Chemical engineering
61 Ciencias médicas; Medicina / Medicine and health
description The aim of the present work was to develop a ME for topical delivery of Amphotericin B (AmB). Microemulsions (MEs) are versatile systems to solubilize drugs due to the presence of both a hydrophobic and a hydrophilic region, as well as a distinctive interface composed of surfactant and cosurfactant. MEs have been reported for many advantages for topical application of drugs. Considering that AmB has very low water solubility a screening of surfactants and oils was performed. A gel-like ME system, that can be applied topically without the need for thickeners agents, was selected. AmB was incorporated up to 1 mg/g and remained stable for at least 90 days both at 4 ºC and room temperature, so this formulation would be appropriate as a compounding medication. An in vitro skin penetration test was performed, the applied dose penetrated (10.16 ± 0.01 μg/cm2/h as estimated flux) and remained completely within the skin during the assay; AmB was not detected in the receptorcompartment. In vitro antifungal and antileishmanial activity was tested and drug showed proper activity. AmB is a second line drug for the treatment of cutaneous leishmaniasis, but topical dosage forms are still lacking. This system is potentially useful for the treatment of skin infections avoiding drug toxic systemic effects.
publishDate 2015
dc.date.issued.spa.fl_str_mv 2015-09-01
dc.date.accessioned.spa.fl_str_mv 2019-07-03T02:30:51Z
dc.date.available.spa.fl_str_mv 2019-07-03T02:30:51Z
dc.type.spa.fl_str_mv Artículo de revista
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dc.identifier.issn.spa.fl_str_mv ISSN: 1909-6356
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/66627
dc.identifier.eprints.spa.fl_str_mv http://bdigital.unal.edu.co/67655/
identifier_str_mv ISSN: 1909-6356
url https://repositorio.unal.edu.co/handle/unal/66627
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dc.language.iso.spa.fl_str_mv spa
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dc.relation.spa.fl_str_mv https://revistas.unal.edu.co/index.php/rccquifa/article/view/56285
dc.relation.ispartof.spa.fl_str_mv Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de Ciencias Químico Farmacéuticas
Revista Colombiana de Ciencias Químico Farmacéuticas
dc.relation.references.spa.fl_str_mv Salerno, Claudia and Gorzalczany, Susana and Arechavala, Alicia and Scioscia, Silvia L. and Carlucci, Adriana M. and Bregni, Carlos (2015) Novel gel-like microemulsion for topical delivery of Amphotericin B. Revista Colombiana de Ciencias Químico-Farmacéuticas, 44 (3). pp. 359-381. ISSN 1909-6356
dc.rights.spa.fl_str_mv Derechos reservados - Universidad Nacional de Colombia
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.license.spa.fl_str_mv Atribución-NoComercial 4.0 Internacional
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dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv Atribución-NoComercial 4.0 Internacional
Derechos reservados - Universidad Nacional de Colombia
http://creativecommons.org/licenses/by-nc/4.0/
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eu_rights_str_mv openAccess
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Universidad Nacional de Colombia - Sede Bogotá - Facultad de Ciencias - Departamento de Farmacia
institution Universidad Nacional de Colombia
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