Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended hildebrand solubility approach

The Extended Hildebrand Solubility Approach(EHSA) was applied in the presentwork to evaluate the solubility of theanalgesic drug acetaminophen (paracetamol)in polyethylene glycol 400 + watermixtures at 298.15 K. An acceptablecorrelative capacity of EHSA was foundusing a regular polynomial model in o...

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Autores:
Ahumada, Edgar
Delgado, Daniel
Martínez, Fleming
Tipo de recurso:
Article of journal
Fecha de publicación:
2012
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/74504
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/74504
http://bdigital.unal.edu.co/38981/
Palabra clave:
acetaminophen
binary mixtures
extended Hildebrand solubility approach
solubility parameter.
Rights
openAccess
License
Atribución-NoComercial 4.0 Internacional
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spelling Atribución-NoComercial 4.0 InternacionalDerechos reservados - Universidad Nacional de Colombiahttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Ahumada, Edgar851c1c08-8f19-460d-80cf-306e264044f5300Delgado, Daniel2ca85626-d407-4635-a3ee-4e43e795d8da300Martínez, Flemingbe007cbd-0d6f-4f71-bc0c-9a77ef95fca23002019-07-03T17:58:30Z2019-07-03T17:58:30Z2012https://repositorio.unal.edu.co/handle/unal/74504http://bdigital.unal.edu.co/38981/The Extended Hildebrand Solubility Approach(EHSA) was applied in the presentwork to evaluate the solubility of theanalgesic drug acetaminophen (paracetamol)in polyethylene glycol 400 + watermixtures at 298.15 K. An acceptablecorrelative capacity of EHSA was foundusing a regular polynomial model in orderfour (overall deviation below 0.7%),when the W interaction parameter is relatedto the solubility parameter of themixtures. Thus, the deviations obtainedin the estimated solubility with respect toexperimental solubility were lower thanthose obtained directly by means of anempiric regression of the experimentalsolubility as a function of the mixtures’solubility parameters (close to 1.5%).application/pdfspaUniversidad Nacional de Colombiahttp://revistas.unal.edu.co/index.php/rcolquim/article/view/42917Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de QuímicaRevista Colombiana de QuímicaRevista Colombiana de Química; Vol. 41, núm. 3 (2012); 433-448 0120-2804Ahumada, Edgar and Delgado, Daniel and Martínez, Fleming (2012) Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended hildebrand solubility approach. Revista Colombiana de Química; Vol. 41, núm. 3 (2012); 433-448 0120-2804 .Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended hildebrand solubility approachArtículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/ARTacetaminophenbinary mixturesextended Hildebrand solubility approachsolubility parameter.ORIGINAL42917-198675-1-PB.pdfapplication/pdf876970https://repositorio.unal.edu.co/bitstream/unal/74504/1/42917-198675-1-PB.pdf3faef0a8b2f5bac4838cf7f8555d7d0bMD51THUMBNAIL42917-198675-1-PB.pdf.jpg42917-198675-1-PB.pdf.jpgGenerated Thumbnailimage/jpeg6341https://repositorio.unal.edu.co/bitstream/unal/74504/2/42917-198675-1-PB.pdf.jpg51b32b702c2e7b9bb7d5465eb9140a88MD52unal/74504oai:repositorio.unal.edu.co:unal/745042023-07-03 23:03:50.031Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.co
dc.title.spa.fl_str_mv Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended hildebrand solubility approach
title Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended hildebrand solubility approach
spellingShingle Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended hildebrand solubility approach
acetaminophen
binary mixtures
extended Hildebrand solubility approach
solubility parameter.
title_short Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended hildebrand solubility approach
title_full Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended hildebrand solubility approach
title_fullStr Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended hildebrand solubility approach
title_full_unstemmed Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended hildebrand solubility approach
title_sort Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended hildebrand solubility approach
dc.creator.fl_str_mv Ahumada, Edgar
Delgado, Daniel
Martínez, Fleming
dc.contributor.author.spa.fl_str_mv Ahumada, Edgar
Delgado, Daniel
Martínez, Fleming
dc.subject.proposal.spa.fl_str_mv acetaminophen
binary mixtures
extended Hildebrand solubility approach
solubility parameter.
topic acetaminophen
binary mixtures
extended Hildebrand solubility approach
solubility parameter.
description The Extended Hildebrand Solubility Approach(EHSA) was applied in the presentwork to evaluate the solubility of theanalgesic drug acetaminophen (paracetamol)in polyethylene glycol 400 + watermixtures at 298.15 K. An acceptablecorrelative capacity of EHSA was foundusing a regular polynomial model in orderfour (overall deviation below 0.7%),when the W interaction parameter is relatedto the solubility parameter of themixtures. Thus, the deviations obtainedin the estimated solubility with respect toexperimental solubility were lower thanthose obtained directly by means of anempiric regression of the experimentalsolubility as a function of the mixtures’solubility parameters (close to 1.5%).
publishDate 2012
dc.date.issued.spa.fl_str_mv 2012
dc.date.accessioned.spa.fl_str_mv 2019-07-03T17:58:30Z
dc.date.available.spa.fl_str_mv 2019-07-03T17:58:30Z
dc.type.spa.fl_str_mv Artículo de revista
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dc.type.content.spa.fl_str_mv Text
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format http://purl.org/coar/resource_type/c_6501
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dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/74504
dc.identifier.eprints.spa.fl_str_mv http://bdigital.unal.edu.co/38981/
url https://repositorio.unal.edu.co/handle/unal/74504
http://bdigital.unal.edu.co/38981/
dc.language.iso.spa.fl_str_mv spa
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dc.relation.spa.fl_str_mv http://revistas.unal.edu.co/index.php/rcolquim/article/view/42917
dc.relation.ispartof.spa.fl_str_mv Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de Química
Revista Colombiana de Química
dc.relation.ispartofseries.none.fl_str_mv Revista Colombiana de Química; Vol. 41, núm. 3 (2012); 433-448 0120-2804
dc.relation.references.spa.fl_str_mv Ahumada, Edgar and Delgado, Daniel and Martínez, Fleming (2012) Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended hildebrand solubility approach. Revista Colombiana de Química; Vol. 41, núm. 3 (2012); 433-448 0120-2804 .
dc.rights.spa.fl_str_mv Derechos reservados - Universidad Nacional de Colombia
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.license.spa.fl_str_mv Atribución-NoComercial 4.0 Internacional
dc.rights.uri.spa.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv Atribución-NoComercial 4.0 Internacional
Derechos reservados - Universidad Nacional de Colombia
http://creativecommons.org/licenses/by-nc/4.0/
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Universidad Nacional de Colombia
institution Universidad Nacional de Colombia
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