Manejo médico de la contractura capsular en mamoplastia de aumento, una revisión sistemática de la literatura

ilustraciones, diagramas, tablas,

Autores:: Montoya González, David Octavio
Gómez Díaz, Oswaldo

Tipo de recurso:

Fecha de publicación:: 2021

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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repository_id_str
dc.title.spa.fl_str_mv	Manejo médico de la contractura capsular en mamoplastia de aumento, una revisión sistemática de la literatura
dc.title.translated.eng.fl_str_mv	Medical treatment of capsular contracture in breast augmentation, a systematic review of the literature
title	Manejo médico de la contractura capsular en mamoplastia de aumento, una revisión sistemática de la literatura
spellingShingle	Manejo médico de la contractura capsular en mamoplastia de aumento, una revisión sistemática de la literatura 610 - Medicina y salud Contractura capsular Mamoplastia de aumento Ultrasonido Antagonistas leucotrienos Pirfenidona Breast augmentation Capsular contracture Ultrasound Leucotriene antagonist Pirfenidone Cirugía
title_short	Manejo médico de la contractura capsular en mamoplastia de aumento, una revisión sistemática de la literatura
title_full	Manejo médico de la contractura capsular en mamoplastia de aumento, una revisión sistemática de la literatura
title_fullStr	Manejo médico de la contractura capsular en mamoplastia de aumento, una revisión sistemática de la literatura
title_full_unstemmed	Manejo médico de la contractura capsular en mamoplastia de aumento, una revisión sistemática de la literatura
title_sort	Manejo médico de la contractura capsular en mamoplastia de aumento, una revisión sistemática de la literatura
dc.creator.fl_str_mv	Montoya González, David Octavio Gómez Díaz, Oswaldo
dc.contributor.advisor.none.fl_str_mv	Aguirre Serrano, Herley
dc.contributor.author.none.fl_str_mv	Montoya González, David Octavio Gómez Díaz, Oswaldo
dc.subject.ddc.spa.fl_str_mv	610 - Medicina y salud
topic	610 - Medicina y salud Contractura capsular Mamoplastia de aumento Ultrasonido Antagonistas leucotrienos Pirfenidona Breast augmentation Capsular contracture Ultrasound Leucotriene antagonist Pirfenidone Cirugía
dc.subject.proposal.spa.fl_str_mv	Contractura capsular Mamoplastia de aumento Ultrasonido Antagonistas leucotrienos Pirfenidona
dc.subject.proposal.eng.fl_str_mv	Breast augmentation Capsular contracture Ultrasound Leucotriene antagonist Pirfenidone
dc.subject.unesco.none.fl_str_mv	Cirugía
description	ilustraciones, diagramas, tablas,
publishDate	2021
dc.date.accessioned.none.fl_str_mv	2021-05-03T21:36:00Z
dc.date.available.none.fl_str_mv	2021-05-03T21:36:00Z
dc.date.issued.none.fl_str_mv	2021-04-29
dc.type.spa.fl_str_mv	Trabajo de grado - Especialidad Médica
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dc.type.content.spa.fl_str_mv	Text
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dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/79469 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
dc.relation.references.spa.fl_str_mv	Nahabedian, Maurice Y. Round Form-Stable Breast Implants: Diagnosis and Management of Complications. Plast Reconstr Surg. 2019, vol. 144, no 1S, p. 73S-81S. Adams WP- Capsular contracture: What is it? What causes it? How can it be prevented and managed? Clin Plast Surg. 2009;36:119–126, vii. Adams WP, Mallucci P. Breast augmentation. Plast Reconstr Surg. 2012;130:597e–611e. Berry MG, Cucchiara V, Davies DM. Breast augmentation: Part II. Adverse capsular contracture. J Plast Reconstr Aesthet Surg. 2010;63:2098–2107. Maxwell GP, Gabriel A. Non-cross-linked porcine acellular dermal matrix in revision breast surgery: Long-term outcomes and safety with neopectoral pockets. Aesthet Surg J. 2014;34:551–559. Maxwell GP, Gabriel A. Acellular dermal matrix for reoperative breast augmentation. Plast Reconstr Surg. 2014;134:932–938. Hester TR Jr, Ghazi BH, Moyer HR, Nahai FR, Wilton M, Stokes L. Use of dermal matrix to prevent capsular contracture in aesthetic breast surgery. Plast Reconstr Surg. 2012;130(Suppl 2):126S–136S. Baker JL Jr. Classification of spherical contractures. Paper presented at: Aesthetic Breast Symposium; November 23–26, 1975; Scottsdale, Ariz. Baker JL Jr. Augmentation mammaplasty. In: Proceedings of the Symposium of the Educational Foundation of the American Society of Plastic and Reconstructive Surgeons, and the American Society for Aesthetic Plastic Surgery. St. Louis: Mosby; 1978. Little G, Baker JL Jr. Results of closed compression capsulotomy for treatment of contracted breast implant capsules. Plast Reconstr Surg. 1980;65:30–33. Spear SL, Baker JL Jr. Classification of capsular contracture after prosthetic breast reconstruction. Plast Reconstr Surg. 1995;96:1119–1123; discussion 1124. Araco A, Caruso R, Araco F, Overton J, Gravante G. Capsular contractures: A systematic review. Plast Reconstr Surg. 2009;124:1808–1819. Handel N, Cordray T, Gutierrez J, Jensen JA. A long-term study of outcomes, complications, and patient satisfaction with breast implants. Plast Reconstr Surg. 2006;117:757–767; discussion 768–772. Tebbetts JB. “Out points” criteria for breast implant removal without replacement and criteria to minimize reoperations following breast augmentation. Plast Reconstr Surg. 2004;114:1258–1262. Dickson John K, Gorman Mark Palmer John. The V–Y capsulotomy release for correcting capsular contracture. Journal of Plastic, Reconstructive & Aesthetic Surgery, 2015, vol. 68, no 12, p. 1768-1769. Schlesinger SL, Ellenbogen R, Desvigne MN, Svehlak S, Heck R. Zafirlukast (Accolate): a new treatment for capsular contracture. Aesthet Surg J 2002;22 (4): 329-36. Wan, Dinah; Rohrich, Rod J. Revisiting the management of capsular contracture in breast augmentation: a systematic review. Plastic and reconstructive surgery, 2016, vol. 137, no 3, p. 826-841. Liu Xing et al. Comparison of the postoperative incidence rate of capsular contracture among different breast implants: a cumulative meta-analysis. PloS one, 2015, vol. 10, no 2. Samargardi Osama A et al. Antibiotic irrigation of pocket for implant-based breast augmentation to prevent capsular contracture: a systematic review. Plastic Surgery, 2018, vol. 26, no 2, p. 110-119. Headon, Hannah; Kasem, Adbul; Mokbel, Kefah. Capsular contracture after breast augmentation: an update for clinical practice. Arch Plast Surg. 2015; vol. 42, no 5, p. 532. Namnoum JD, Largent J, Kaplan HM, Oefelein MG, Brown MH. Primary breast augmentation clinical trial outcomes stratified by surgical incision, anatomical placement and implant device type. J Plast Reconstr Aesthet Surg. 2013;66:1165–1172. Sood, Aditya, et al. Breast massage, implant displacement, and prevention of capsular contracture after breast augmentation with implants: a review of the literature. Eplasty, 2017, vol. 17. Piña Martínez V, Castro Sierra A. Factores etiológicos implicados en la contractura capsular en mamoplastia de aumento estética: estudio prospectivo observacional. Cir. plást. iberolatinoam. 2016; 42(1), 13-20. Calobrace, M. Bradley, et al. Risk factor analysis for capsular contracture: a 10-year Sientra study using round, smooth, and textured implants for breast augmentation. Plast Reconstr Surg. 2018; vol. 141, no 4S, p. 20S-28S. Chong, Simon J.; Deva, Anand K. Understanding the etiology and prevention of capsular contracture. Clin Plast Surg, 2015, vol. 42, p. 427-36. Hidalgo David A.; Spector Jason A. Breast augmentation. Plast Reconstr Surg. 2014, vol. 133, no 4, p. 567e-583e. Namnoum JD, Moyer HR. The role of acellular dermal matrix in the treatment of capsular contracture. Clin Plast Surg. 2012 Apr;39(2):127-136. Doi: 10.1016/j.cps.2012.02.005. PubMed PMID: 22482354. Eulufi, Alex, et al. Mamoplastia de aumento:¿ en qué estamos hoy?. Contacto Científico, 2017, vol. 7, no 4. Henriksen TF, Hölmich LR, Fryzek, JP, Friis S, McLaughlin JK, Høyer A. P, Olsen JH. Incidence and severity of short-term complications after breast augmentation: results from a nationwide breast implant registry. Annals of plastic surgery, 2003; 51(6), 531-539. Puskas, Judit E.; Luebbers, Matthew T. Breast implants: the good, the bad and the ugly. Can nanotechnology improve implants?. Wiley Interdisciplinary Rev Nanomed Nanobiotechnol. 2012, vol. 4, no 2, p. 153-168. Iwuagwu FC, Frame JD. Silicone breast implants: complications. British journal of plastic surgery, 1997, vol. 50, no 8, p. 632-636. Leite, Luís Pereira; SÁ, Inês Correia; Marques, Marisa. Etiopatogenia e Tratamento da Contractura Capsular Mamária. Acta Med Port, 2013, vol. 26, no 6, p. 737-745. Steiert AE, Boyce M, Sorg H. Capsular contracture by silicone breast implants: possible causes, biocompatibility, and prophylactic strategies. Medical Devices (Auckland, NZ), 2013; 6, 211. Le Louarn C, Buis J, Auclair E. Flector tissugel used to treat capsular contracture after breast augmentation surgery. Aesthetic Plast Surg. 2008;32:453-8. Veras Castillo, ER et al. Controlled clinical trial with pirfenidone in the treatment of breast capsular contracture: Association of TGF-β polymorphisms. Annals of plastic surgery, 2013, vol. 70, no 1, p. 16-22. Sconfienza LM, Murolo C, Callegari S, Calabrese M, Savarino E, Santi P, et al. Ultrasound-guided percutaneous injection of triamcinolone acetonide for treating capsular contracture in patients with augmented and reconstructed breast. Eur Radiol. 2011;21:575-81. Schünemann HJ, Cuello C, Akl EA, et al. GRADE guidelines: 18. How ROBINS-I and other tools to assess risk of bias in nonrandomized studies should be used to rate the certainty of a body of evidence. J Clin Epidemiol. 2019;111:105-114. Planas J, Migliano E, Wagenfuhr J Jr, Castillo S. External ultrasonic treatment of capsular contractures in breast implants. Aesthetic Plast Surg. 1997;21(6):395-397. Planas J, Cervelli V, Planas G. Five-year experience on ultrasonic treatment of breast contractures. Aesthetic Plast Surg. 2001;25(2):89-93. Mazzocchi M, Dessy LA, Alfano C, Scuderi N. Effects of zafirlukast on capsular contracture: long-term results. Int J Immunopathol Pharmacol. 2012;25(4):935-944. Young VL. Guidelines and indications for breast implant capsulectomy. Plast Reconstr Surg 1998;102:884-891. Moufarrege R, Beauregard G, Bosse JP, Papillion J, Perras C. Outcome of mammary capsulotomies. Ann Plast Surg 1987;19:62. Dolores W, Rainer C, Niederegger H, et al. Cellular and molecular composition of fibrous capsules formed around silicone breast implants with special focus on local immune reactions. J Autoimmunity. 2004;23:81Y91. Ulrich D, Lichtenegger F, Eblenkamp M, et al. Matrix metalloproteinases, tissue inhibitors of metalloproteinases, aminoterminal propeptide of procollagen type III, and hyaluronan in sera and tissue of patients with capsular contracture after augmentation with Trilucent breast implants. Plast Reconstr Surg. 2004; 114:229Y236. D’Andrea F, Nicoletti GF, Grella E, et al. Modification of cysteinyl leuko-triene receptor expression in capsular contracture. Ann Plast Surg. 2007;58: 212Y214. Kuhn A, Singh S, Smith PD, et al. Periprosthetic breast capsules contain the fibrogenic cytokines TGF-A1 and TGF-A2, suggesting possible new treatment approaches. Ann Plast Surg. 2000;44):387Y391. Brohim RM, Foresman PA, Hildebrandt PK, et al. Early tissue reaction to textured breast implant surfaces. Ann Plast Surg. 1992;28:354Y362. Huang CK, Handel N. Effects of Singulair (montelukast) treatment for capsular contracture. Aesthet Surg J. 2010;30(3):404-408. Baker JL. Commentary: investigation of accolate and singulair for treatment of capsular contracture yields safety concerns. Aesthet Surg J. 2003;23(2):101. Caffe HH. Intracapsular injection of triamcinolone for intractable capsule contracture. Plast Reconstr Surg. 1994;94(6):824-828. Baker JL Jr, Chandler ML, LeVier RR. Occurrence and activity of myofibroblasts in human capsular tissue surrounding mammary implants. Plast Reconstr Surg 1981;68:905-911. Moufarrege R, Beauregard G, Bosse JP, Papillion J, Perras C. Outcome of mammary capsulotomies. Ann Plast Surg 1987;19:62.
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dc.publisher.spa.fl_str_mv	Universidad Nacional de Colombia
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dc.publisher.place.spa.fl_str_mv	Bogotá
dc.publisher.branch.spa.fl_str_mv	Universidad Nacional de Colombia - Sede Bogotá
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spelling	Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Aguirre Serrano, Herley2fd2d1d2ebdaf8531744137ea58b23ccMontoya González, David Octaviodaa6aeea7f41c3474fb0825eaf649cc5Gómez Díaz, Oswaldo625b90c5af40882e465e751d1912a6323002021-05-03T21:36:00Z2021-05-03T21:36:00Z2021-04-29https://repositorio.unal.edu.co/handle/unal/79469Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramas, tablas,El objetivo principal de la presente revisión sistemática fue determinar la eficacia y seguridad de las diferentes opciones de tratamiento médico de la contractura capsular posterior a mamoplastia de aumento cosmética. Se realizó una búsqueda sistemática de publicaciones en las bases de datos: PUBMED/MEDLINE ,EMBASE y LILACS por parte de dos revisores independientes, cada autor seleccionó las referencias que correspondían a los criterios de inclusión de la revisión con base en el título y el abstract. En caso de no encontrar información suficiente de cada referencia, se buscó el texto completo, de no estar disponible, se intentó contactar al autor. Los autores registraron por cada estudio los motivos por los cuales era o no elegible cada referencia, incluyendo duplicación de referencias entre bases de datos. En caso de duda, la selección final se realizó consultando a un tercer evaluador independiente. Se encontraron siete publicaciones que cumplían con los criterios descritos, todas evaluaron algún tipo de intervención médica no quirúrgica para la CCM, sólo una de ellas con grupo comparador (Capsulectomía). Los desenlaces fueron evaluados en su mayoría a los 12 meses de tratamiento. No se encontró ningún estudio intervencional con diseño aleatorizado controlado. No fue posible extraer conclusiones fidedignas que impacten en el manejo médico actual de la enfermedad en cuestión en el campo de la cirugía cosmética dada la baja calidad de evidencia y alto riesgo de sesgo de los estudios que soportan el uso de estos tratamientos y el riesgo de reacciones adversas respectivas.The main objective of this systematic review was to determine the effectiveness and safety of the different available medical therapies for the treatment of capsular contracture posterior to cosmetic augmentation mammaplasty. A systematic research was done in the following databases: PUBMED/MEDLINE, EMBASE and LILACS by two independent reviewers, each author selectioned the references according to the inclusion criteria based on title and abstract if available. In cases where information was not complete, the original manuscript was searched and in case it was not available either, an attempt to contact the respective author was done. The authors registered the reasons to add or exclude each of the selected references, including those that were duplicated in the different databases. In cases of doubt the article was evaluated by a third independent revisor, who decided if the article met the inclusion criteria. The final decision was taken in consensus by the three authors. Seven publications fulfilled the required criteria, all of them evaluated non surgical treatments for patients diagnosed with capsular contracture, only one study used a comparative group (Capsulectomy). The outcomes were evaluated in the vast majority to twelve months follow up. No interventional, randomized and controlled designed study was found. It was not possible to make strong conclusions that lead to changes in the current approach of the mentioned illness in the field of cosmetic surgery because of the quality of evidence and high risk of bias behind the studies that support those therapies and their respective adverse effects.Especialidades MédicasSe realizó una revisión sistemática de la literatura de estudios observacionales y experimentales en las bases de datos (PUBMED/MEDLINE, EMBASE, LILACS) que evaluaron la eficacia y seguridad de las diferentes opciones de tratamiento médico para pacientes con diagnóstico de Contractura Capsular Mamaria hasta octubre de 2020. No se aplicaron restricciones de idioma, tiempo de seguimiento o estado de publicación. La extracción de datos se enfocó en desenlaces centrados en el paciente (resolución/mejoría de la enfermedad, recidiva y seguridad; evaluación de riesgo de sesgo y nivel de evidencia).Especialidad en Cirugía PlásticaRevisión sistemática de la literatura1 recurso en linea (56 paginas)application/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Especialidad en Cirugía PlásticaFacultad de MedicinaBogotáUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y saludContractura capsularMamoplastia de aumentoUltrasonidoAntagonistas leucotrienosPirfenidonaBreast augmentationCapsular contractureUltrasoundLeucotriene antagonistPirfenidoneCirugíaManejo médico de la contractura capsular en mamoplastia de aumento, una revisión sistemática de la literaturaMedical treatment of capsular contracture in breast augmentation, a systematic review of the literatureTrabajo de grado - Especialidad Médicainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMNahabedian, Maurice Y. Round Form-Stable Breast Implants: Diagnosis and Management of Complications. Plast Reconstr Surg. 2019, vol. 144, no 1S, p. 73S-81S.Adams WP- Capsular contracture: What is it? What causes it? How can it be prevented and managed? Clin Plast Surg. 2009;36:119–126, vii.Adams WP, Mallucci P. Breast augmentation. Plast Reconstr Surg. 2012;130:597e–611e.Berry MG, Cucchiara V, Davies DM. Breast augmentation: Part II. Adverse capsular contracture. J Plast Reconstr Aesthet Surg. 2010;63:2098–2107.Maxwell GP, Gabriel A. Non-cross-linked porcine acellular dermal matrix in revision breast surgery: Long-term outcomes and safety with neopectoral pockets. Aesthet Surg J. 2014;34:551–559.Maxwell GP, Gabriel A. Acellular dermal matrix for reoperative breast augmentation. Plast Reconstr Surg. 2014;134:932–938.Hester TR Jr, Ghazi BH, Moyer HR, Nahai FR, Wilton M, Stokes L. Use of dermal matrix to prevent capsular contracture in aesthetic breast surgery. Plast Reconstr Surg. 2012;130(Suppl 2):126S–136S.Baker JL Jr. Classification of spherical contractures. Paper presented at: Aesthetic Breast Symposium; November 23–26, 1975; Scottsdale, Ariz.Baker JL Jr. Augmentation mammaplasty. In: Proceedings of the Symposium of the Educational Foundation of the American Society of Plastic and Reconstructive Surgeons, and the American Society for Aesthetic Plastic Surgery. St. Louis: Mosby; 1978.Little G, Baker JL Jr. Results of closed compression capsulotomy for treatment of contracted breast implant capsules. Plast Reconstr Surg. 1980;65:30–33.Spear SL, Baker JL Jr. Classification of capsular contracture after prosthetic breast reconstruction. Plast Reconstr Surg. 1995;96:1119–1123; discussion 1124.Araco A, Caruso R, Araco F, Overton J, Gravante G. Capsular contractures: A systematic review. Plast Reconstr Surg. 2009;124:1808–1819.Handel N, Cordray T, Gutierrez J, Jensen JA. A long-term study of outcomes, complications, and patient satisfaction with breast implants. Plast Reconstr Surg. 2006;117:757–767; discussion 768–772.Tebbetts JB. “Out points” criteria for breast implant removal without replacement and criteria to minimize reoperations following breast augmentation. Plast Reconstr Surg. 2004;114:1258–1262.Dickson John K, Gorman Mark Palmer John. The V–Y capsulotomy release for correcting capsular contracture. Journal of Plastic, Reconstructive & Aesthetic Surgery, 2015, vol. 68, no 12, p. 1768-1769.Schlesinger SL, Ellenbogen R, Desvigne MN, Svehlak S, Heck R. Zafirlukast (Accolate): a new treatment for capsular contracture. Aesthet Surg J 2002;22 (4): 329-36.Wan, Dinah; Rohrich, Rod J. Revisiting the management of capsular contracture in breast augmentation: a systematic review. Plastic and reconstructive surgery, 2016, vol. 137, no 3, p. 826-841.Liu Xing et al. Comparison of the postoperative incidence rate of capsular contracture among different breast implants: a cumulative meta-analysis. PloS one, 2015, vol. 10, no 2.Samargardi Osama A et al. Antibiotic irrigation of pocket for implant-based breast augmentation to prevent capsular contracture: a systematic review. Plastic Surgery, 2018, vol. 26, no 2, p. 110-119.Headon, Hannah; Kasem, Adbul; Mokbel, Kefah. Capsular contracture after breast augmentation: an update for clinical practice. Arch Plast Surg. 2015; vol. 42, no 5, p. 532.Namnoum JD, Largent J, Kaplan HM, Oefelein MG, Brown MH. Primary breast augmentation clinical trial outcomes stratified by surgical incision, anatomical placement and implant device type. J Plast Reconstr Aesthet Surg. 2013;66:1165–1172.Sood, Aditya, et al. Breast massage, implant displacement, and prevention of capsular contracture after breast augmentation with implants: a review of the literature. Eplasty, 2017, vol. 17.Piña Martínez V, Castro Sierra A. Factores etiológicos implicados en la contractura capsular en mamoplastia de aumento estética: estudio prospectivo observacional. Cir. plást. iberolatinoam. 2016; 42(1), 13-20.Calobrace, M. Bradley, et al. Risk factor analysis for capsular contracture: a 10-year Sientra study using round, smooth, and textured implants for breast augmentation. Plast Reconstr Surg. 2018; vol. 141, no 4S, p. 20S-28S.Chong, Simon J.; Deva, Anand K. Understanding the etiology and prevention of capsular contracture. Clin Plast Surg, 2015, vol. 42, p. 427-36.Hidalgo David A.; Spector Jason A. Breast augmentation. Plast Reconstr Surg. 2014, vol. 133, no 4, p. 567e-583e.Namnoum JD, Moyer HR. The role of acellular dermal matrix in the treatment of capsular contracture. Clin Plast Surg. 2012 Apr;39(2):127-136. Doi: 10.1016/j.cps.2012.02.005. PubMed PMID: 22482354.Eulufi, Alex, et al. Mamoplastia de aumento:¿ en qué estamos hoy?. Contacto Científico, 2017, vol. 7, no 4.Henriksen TF, Hölmich LR, Fryzek, JP, Friis S, McLaughlin JK, Høyer A. P, Olsen JH. Incidence and severity of short-term complications after breast augmentation: results from a nationwide breast implant registry. Annals of plastic surgery, 2003; 51(6), 531-539.Puskas, Judit E.; Luebbers, Matthew T. Breast implants: the good, the bad and the ugly. Can nanotechnology improve implants?. Wiley Interdisciplinary Rev Nanomed Nanobiotechnol. 2012, vol. 4, no 2, p. 153-168.Iwuagwu FC, Frame JD. Silicone breast implants: complications. British journal of plastic surgery, 1997, vol. 50, no 8, p. 632-636.Leite, Luís Pereira; SÁ, Inês Correia; Marques, Marisa. Etiopatogenia e Tratamento da Contractura Capsular Mamária. Acta Med Port, 2013, vol. 26, no 6, p. 737-745.Steiert AE, Boyce M, Sorg H. Capsular contracture by silicone breast implants: possible causes, biocompatibility, and prophylactic strategies. Medical Devices (Auckland, NZ), 2013; 6, 211.Le Louarn C, Buis J, Auclair E. Flector tissugel used to treat capsular contracture after breast augmentation surgery. Aesthetic Plast Surg. 2008;32:453-8.Veras Castillo, ER et al. Controlled clinical trial with pirfenidone in the treatment of breast capsular contracture: Association of TGF-β polymorphisms. Annals of plastic surgery, 2013, vol. 70, no 1, p. 16-22.Sconfienza LM, Murolo C, Callegari S, Calabrese M, Savarino E, Santi P, et al. Ultrasound-guided percutaneous injection of triamcinolone acetonide for treating capsular contracture in patients with augmented and reconstructed breast. Eur Radiol. 2011;21:575-81.Schünemann HJ, Cuello C, Akl EA, et al. GRADE guidelines: 18. How ROBINS-I and other tools to assess risk of bias in nonrandomized studies should be used to rate the certainty of a body of evidence. J Clin Epidemiol. 2019;111:105-114.Planas J, Migliano E, Wagenfuhr J Jr, Castillo S. 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Manejo médico de la contractura capsular en mamoplastia de aumento, una revisión sistemática de la literatura

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