Efectos del aislamiento social sobre la conducta exploratoria en ratas adolescentes expuestas a un ambiente novedoso

ilustraciones, diagramas

Autores:: Pérez contreras, David Rikardo

Tipo de recurso:

Fecha de publicación:: 2024

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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dc.title.spa.fl_str_mv	Efectos del aislamiento social sobre la conducta exploratoria en ratas adolescentes expuestas a un ambiente novedoso
dc.title.translated.eng.fl_str_mv	Effects of social isolation on exploratory behavior in adolescent rats exposed to a novel environment
title	Efectos del aislamiento social sobre la conducta exploratoria en ratas adolescentes expuestas a un ambiente novedoso
spellingShingle	Efectos del aislamiento social sobre la conducta exploratoria en ratas adolescentes expuestas a un ambiente novedoso Aislamiento Social Conducta Conducta del Adolescente Social Isolation Behavior Comportamento do Adolescente Adolescencia Exploración Home base Adolescence Exploration
title_short	Efectos del aislamiento social sobre la conducta exploratoria en ratas adolescentes expuestas a un ambiente novedoso
title_full	Efectos del aislamiento social sobre la conducta exploratoria en ratas adolescentes expuestas a un ambiente novedoso
title_fullStr	Efectos del aislamiento social sobre la conducta exploratoria en ratas adolescentes expuestas a un ambiente novedoso
title_full_unstemmed	Efectos del aislamiento social sobre la conducta exploratoria en ratas adolescentes expuestas a un ambiente novedoso
title_sort	Efectos del aislamiento social sobre la conducta exploratoria en ratas adolescentes expuestas a un ambiente novedoso
dc.creator.fl_str_mv	Pérez contreras, David Rikardo
dc.contributor.advisor.none.fl_str_mv	Lamprea Rodríguez, Marisol
dc.contributor.author.none.fl_str_mv	Pérez contreras, David Rikardo
dc.contributor.researchgroup.spa.fl_str_mv	Neurociencia Básica y Cognoscitiva
dc.subject.decs.spa.fl_str_mv	Aislamiento Social Conducta Conducta del Adolescente
topic	Aislamiento Social Conducta Conducta del Adolescente Social Isolation Behavior Comportamento do Adolescente Adolescencia Exploración Home base Adolescence Exploration
dc.subject.decs.eng.fl_str_mv	Social Isolation Behavior Comportamento do Adolescente
dc.subject.proposal.spa.fl_str_mv	Adolescencia Exploración Home base
dc.subject.proposal.eng.fl_str_mv	Adolescence Exploration
description	ilustraciones, diagramas
publishDate	2024
dc.date.accessioned.none.fl_str_mv	2024-08-08T18:16:18Z
dc.date.available.none.fl_str_mv	2024-08-08T18:16:18Z
dc.date.issued.none.fl_str_mv	2024
dc.type.spa.fl_str_mv	Trabajo de grado - Maestría
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dc.type.content.spa.fl_str_mv	Text
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dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/86705 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
dc.relation.references.spa.fl_str_mv	Ahumada, L. H., Morato, S., & Lamprea, M. R. (2022). Acute stress increases behaviors that optimize safety and decreases the exploration of aversive areas. Learning and Motivation, 80, 101855 Alstott, J., & Timberlake, W. (2009). Effects of rat sex differences and lighting on locomotor exploration of a circular open field with free-standing central corners and without peripheral walls. Behavioural brain research, 196(2), 214-219 Arakawa, H. (2005). Interaction between isolation rearing and social development on . exploratory behavior in male rats. Behavioural processes, 70(3), 223-234 Avital, A., & Richter-Levin, G. (2005). Exposure to juvenile stress exacerbates the behavioural consequences of exposure to stress in the adult rat. International Journal of Neuropsychopharmacology, 8(2), 163-173 Avital, I., Inderbitzin, D., Aoki, T., Tyan, D. B., Cohen, A. H., Ferraresso, C., ... & Demetriou, A. A. (2001). Isolation, characterization, and transplantation of bone marrow-derived hepatocyte stem cells. Biochemical and biophysical research communications, 288(1), 156-164 Bekris, S., Antoniou, K., Daskas, S., & Papadopoulou-Daifoti, Z. (2005). Behavioural and neurochemical effects induced by chronic mild stress applied to two different rat strains. Behavioural brain research, 161(1), 45-59. Bishnoi, I. R., Ossenkopp, K. P., & Kavaliers, M. (2021). Sex and age differences in locomotor and anxiety‐like behaviors in rats: From adolescence to adulthood. Developmental psychobiology, 63(3), 496-511. Bondar, N. P., Lepeshko, A. A., & Reshetnikov, V. V. (2018). Effects of early-life stress on social and anxiety-like behaviors in adult mice: sex-specific effects. Behavioural neurology, 2018. Bystritsky, A., & Kronemyer, D. (2014). Stress and anxiety: counterpart elements of the stress/anxiety complex. Psychiatric Clinics, 37(4), 489-518. Carola, V., D'Olimpio, F., Brunamonti, E., Mangia, F., & Renzi, P. (2002). Evaluation of the elevated plus-maze and open-field tests for the assessment of anxiety-related behaviour in inbred mice. Behavioural brain research, 134(1-2), 49-57. Casarrubea, M., Di Giovanni, G., Aiello, S., & Crescimanno, G. (2023). The Hole-Board apparatus in the study of anxiety. Physiology & Behavior, 114346. Casarrubea, M., Jonsson, G. K., Faulisi, F., Sorbera, F., Di Giovanni, G., Benigno, A., ... & Magnusson, M. S. (2015). T-pattern analysis for the study of temporal structure of animal and human behavior: a comprehensive review. Journal of neuroscience methods, 239, 34-46 Chmelova, M., Balagova, L., Marko, M., Vrankova, S., Cebova, M., Jezova, D., ... & Hlavacova, N. (2019). Behavioral alterations induced by post-weaning isolation rearing of rats are accompanied by reduced VGF/BDNF/TrkB signaling in the hippocampus. Neurochemistry International, 129, 104473 De Kloet, E. R., Oitzl, M. S., & Joëls, M. (1999). Stress and cognition: are corticosteroids good or bad guys?. Trends in neurosciences, 22(10), 422-426 Dey, T. K., Shi, D., & Wang, Y. (2019). Simba: An efficient tool for approximating rips-filtration persistence via sim plicial ba tch collapse. Journal of Experimental Algorithmics (JEA), 24, 1-16 Doremus, T. L., Varlinskaya, E. I., & Spear, L. P. (2004). Age‐related differences in elevated plus maze behavior between adolescent and adult rats. Annals of the New York Academy of Sciences, 1021(1), 427-430 Drai, D., & Golani, I. (2001). SEE: a tool for the visualization and analysis of rodent exploratory behavior. Neuroscience & Biobehavioral Reviews, 25(5), 409-426. Eilam, D., & Golani, I. (1989). Home base behavior of rats (Rattus norvegicus) exploring a novel environment. Behavioural brain research, 34(3), 199-211 Eilam, D., & Golani, I. (1990). Home base behavior in amphetamine-treated tame wild rats (Rattus norvegicus). Behavioural Brain Research, 36(1-2), 161-170 File, S. E. (1978). Exploration, distraction, and habituation in rats reared in isolation. Developmental Psychobiology: The Journal of the International Society for Developmental Psychobiology, 11(1), 73-81 Galef Jr. BG (1981). The ecology of weaning: Parasitism and the achievement of independence by altricial mammals. In: Gubernick DJ, Klopfer PH, editors. Parental care in mammals, New York, NY:Plenum Press, 1981. p. 211–41 Gould, T.D., Dao, D.T., Kovacsics, C.E. (2009). The Open Field Test. In: Gould, T. (eds) Mood and Anxiety Related Phenotypes in Mice. Neuromethods, vol 42. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-303-9_1 Haj-Mirzaian, A., Nikbakhsh, R., Ramezanzadeh, K., Rezaee, M., Amini-Khoei, H., Haj-Mirzaian, A., Ghesmati, M., Afshari, K., Haddadi, N.-S., & Dehpour, A. R. (2019). Involvement of opioid system in behavioral despair induced by social isolation stress in mice. Biomedicine & Pharmacotherapy, 109, 938–944. https://doi.org/10.1016/j.biopha.2018.10.144 Hall, F. S., Humby, T., Wilkinson, L. S., & Robbins, T. W. (1997). The effects of isolation-rearing of rats on behavioural responses to food and environmental novelty. Physiology & Behavior, 62(2), 281-290. Hogg, S. (1996). A review of the validity and variability of the elevated plus-maze as an animal model of anxiety. Pharmacology Biochemistry and Behavior, 54(1), 21-30 Hoops, D., & Flores, C. (2017). Making Dopamine Connections in Adolescence. Trends in Neurosciences, 40(12), 709–719. https://doi.org/10.1016/j.tins.2017.09.004 Hughes, R. N., & Syme, L. A. (1972). The role of social isolation and sex in determining effects of chlordiazepoxide and methylphenidate on exploratory behaviour. Psychopharmacologia, 27(4), 359-366 Joëls, M., Pu, Z., Wiegert, O., Oitzl, M. S., & Krugers, H. J. (2006). Learning under stress: how does it work?. 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Risk-taking behavior in adolescent mice: psychobiological determinants and early epigenetic influence. Neuroscience & Biobehavioral Reviews, 27(1-2), 19–31. https://doi.org/10.1016/s0149-7634(03)00006-x Lever, C., Burton, S., & Ο'Keefe, J. (2006). Rearing on hind legs, environmental novelty, and the hippocampal formation. Reviews in the Neurosciences, 17(1-2), 111-134. Lipkind, D., Sakov, A., Kafkafi, N., Elmer, G. I., Benjamini, Y., & Golani, I. (2004). New replicable anxiety-related measures of wall vs. center behavior of mice in the open field. Journal of applied physiology, 97(1), 347-359 Lukkes, J. L., Mokin, M. V., Scholl, J. L., & Forster, G. L. (2009). Adult rats exposed to early-life social isolation exhibit increased anxiety and conditioned fear behavior, and altered hormonal stress responses. Hormones and behavior, 55(1), 248-256 Lynn, D. A., & Brown, G. R. (2010). The ontogeny of anxiety‐like behavior in rats from adolescence to adulthood. Developmental psychobiology, 52(8), 731-739 Macrı̀, S., Adriani, W., Chiarotti, F., & Laviola, G. (2002). Risk taking during exploration of a plus-maze is greater in adolescent than in juvenile or adult mice. Animal Behaviour, 64(4), 541-546. Maier, S. E., Vandenhoff, P., & Crowne, D. P. (1988). Multivariate analysis of putative measures of activity, exploration, emotionality, and spatial behavior in the hooded rat (Rattus norvegicus). Journal of Comparative Psychology, 102(4), 378 Maisonnette, S., Morato, S., & Brandao, M. L. (1993). Role of resocialization and of 5-HT1A receptor activation on the anxiogenic effects induced by isolation in the elevated plus-maze test. Physiology & behavior, 54(4), 753-758 Martinez, R., & Morato, S. (2004). Thigmotaxis and exploration in adult and pup rats. Revista de Etologia, 6(1), 49-54. McCutcheon, J. E., & Marinelli, M. (2009). Age matters. European Journal of Neuroscience, 29(5), 997–1014 McLaughlin, K. A., Garrad, M. C., & Somerville, L. H. (2015). What develops during emotional development? A component process approach to identifying sources of psychopathology risk in adolescence. Dialogues in clinical neuroscience, 17(4), 403-410. Moser, M. B., Rowland, D. C., & Moser, E. I. (2015). Place cells, grid cells, and memory. Cold Spring Harbor perspectives in biology, 7(2), a021808. Mumtaz, F., Khan, M. I., Zubair, M., & Dehpour, A. R. (2018). Neurobiology and consequences of social isolation stress in animal model—A comprehensive review. Biomedicine & Pharmacotherapy, 105, 1205–1222. https://doi.org/10.1016/j.biopha.2018.05.086 Organización Mundial de la Salud (17 de noviembre de 2021). Salud mental del adolescente. Organización Mundial de la Salud. https://www.who.int/es/news-room/fact-sheets/detail/adolescent-mental-health Paulus, M. P., & Geyer, M. A. (1993). Three independent factors characterize spontaneous rat motor activity. Behavioural Brain Research, 53(1-2), 11-20 Pennington, Z. T., Dong, Z., Feng, Y., Vetere, L. M., Page-Harley, L., Shuman, T., & Cai, D. J. (2019). ezTrack: An open-source video analysis pipeline for the investigation of animal behavior. Scientific reports, 9(1), 19979. Quan, M. N., Tian, Y. T., Xu, K. H., Zhang, T., & Yang, Z. (2010). Post weaning social isolation influences spatial cognition, prefrontal cortical synaptic plasticity and hippocampal potassium ion channels in Wistar rats. Neuroscience, 169(1), 214-222 Rodgers, R. J., & Dalvi, A. (1997). Anxiety, defence and the elevated plus-maze. Neuroscience & Biobehavioral Reviews, 21(6), 801-810 Rojas-Carvajal, M., Fornaguera, J., Mora-Gallegos, A., & Brenes, J. C. (2018). Testing experience and environmental enrichment potentiated open-field habituation and grooming behaviour in rats. Animal Behaviour, 137, 225-23 Romeo, R. D. (2017). The impact of stress on the structure of the adolescent brain: Implications for adolescent mental health. Brain research, 1654, 185-191. Romeo, R. D., & McEwen, B. S. (2006). Stress and the adolescent brain. Annals of the New York Academy of Sciences, 1094(1), 202-214 Romeo, R.D., 2010b. Adolescence: a central event in shaping stress reactivity. Dev.Psychobiol. 52, 244-253. Sahakian, B.J., Robbins, T.W. & Iversen, S.D. (1997). The effects of isolation rearing on exploration in the rat. Animal Learning & Behavior 5, 193–198 https://doi.org/10.3758/BF03214077 Shanazz, K., Dixon-Melvin, R., Bunting, K. M., Nalloor, R., & Vazdarjanova, A. I. (2021). Light-Dark Open Field (LDOF): A novel task for sensitive assessment of anxiety. Journal of neuroscience methods, 363, 109325. Spear, L. P. (2000). The adolescent brain and age-related behavioral manifestations. Neuroscience & Biobehavioral Reviews, 24(4), 417–463. https://doi.org/10.1016/s0149-7634(00)00014-2 Stansfield, K. H., & Kirstein, C. L. (2006). Effects of novelty on behavior in the adolescent and adult rat. 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Neuroscience, 93(1), 243-251 Thompson, S. M., Berkowitz, L. E., & Clark, B. J. (2018). Behavioral and neural subsystems of rodent exploration. Learning and motivation, 61, 3-15 Trauth, J. A., Seidler, F. J., McCook, E. C., & Slotkin, T. A. (1999). Adolescent nicotine exposure causes persistent upregulation of nicotinic cholinergic receptors in rat brain regions. Brain research, 851(1-2), 9-19 Treit, D., & Fundytus, M. (1988). Thigmotaxis as a test for anxiolytic activity in rats. Pharmacology Biochemistry and Behavior, 31(4), 959-962 Valle, F. P. (1972). Free and forced exploration in rats as a function of between-vs within-Ss design. Psychonomic science, 29(1), 11-13. Varlinskaya, E. I., Spear, L. P., & Spear, N. E. (1999). Social behavior and social motivation in adolescent rats: role of housing conditions and partner's activity. Physiology & behavior, 67(4), 475-482. Varty, G. B., Paulus, M. P., Braff, D. L., & Geyer, M. A. (2000). Environmental enrichment and isolation rearing in the rat: effects on locomotor behavior and startle response plasticity. Biological psychiatry, 47(10), 864-873 Wahlstrom, D., White, T., & Luciana, M. (2010). Neurobehavioral evidence for changes in dopamine system activity during adolescence. Neuroscience & Biobehavioral Reviews, 34(5), 631–648. https://doi.org/10.1016/j.neubiorev.2009.12.007 Walf, A. A., & Frye, C. A. (2007). The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. Nature protocols, 2(2), 322-328 Walsh, R. N., & Cummins, R. A. (1976). The open-field test: a critical review. Psychological bulletin, 83(3), 482 Wang, Y.-C., Ho, U.-C., Ko, M.-C., Liao, C.-C., & Lee, L.-J. (2012). Differential neuronal changes in medial prefrontal cortex, basolateral amygdala and nucleus accumbens after postweaning social isolation. Brain Structure & Function, 217(2), 337–351. https://doi.org/10.1007/s00429-011-0355-4 Whishaw, I. Q., Gharbawie, O. A., Clark, B. J., & Lehmann, H. (2006). The exploratory behavior of rats in an open environment optimizes security. Behavioural brain research, 171(2), 230-239 Ye, S., Lauer, J., Zhou, M., Mathis, A., & Mathis, M. (2024). AmadeusGPT: a natural language interface for interactive animal behavioral analysis. Advances in Neural Information Processing Systems, 36 Zadicario, P., Avni, R., Zadicario, E., & Eilam, D. (2005). ‘Looping’—an exploration mechanism in a dark open field. Behavioural Brain Research, 159(1), 27-36.
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dc.format.extent.spa.fl_str_mv	69 páginas
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dc.publisher.spa.fl_str_mv	Universidad Nacional de Colombia
dc.publisher.program.spa.fl_str_mv	Bogotá - Ciencias Humanas - Maestría en Psicología
dc.publisher.faculty.spa.fl_str_mv	Facultad de Ciencias Humanas
dc.publisher.place.spa.fl_str_mv	Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv	Universidad Nacional de Colombia - Sede Bogotá
institution	Universidad Nacional de Colombia
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spelling	Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Lamprea Rodríguez, Marisola14f7906338f9d662885067f2e6abfe0600Pérez contreras, David Rikardo69981acd81a60bef18580c2fe3497750Neurociencia Básica y Cognoscitiva2024-08-08T18:16:18Z2024-08-08T18:16:18Z2024https://repositorio.unal.edu.co/handle/unal/86705Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramasEl estrés y la ansiedad forman son factores de riesgo bastante comunes actualmente. Una población que es particularmente susceptible a los efectos del estrés sobre la respuesta emocional es la adolescencia. Dentro de esta etapa del desarrollo se ha encontrado que el tipo de estrés que tiene mayores afecciones es el aislamiento social. Algunas de las conductas que se ven principalmente afectadas por el estrés durante esta etapa del desarrollo es la respuesta emocional ante la novedad. La gran mayoría de esta literatura se ha enfocado principalmente en los indicadores de la ansiedad relacionada a un ambiente novedoso, sin vincularla directamente con los efectos sobre la exploración del espacio, como puede la conducta natural de los animales de formar un refugio (home base). Los resultados mostraron un aumento de los empinamientos y de la respuesta tigmotáxica de los animales Aislados. Además, se mostró que el desarrollo de la Home Base requiere de un componente emocional y exploratorio. Se describe la importancia de utilizar indicadores más detallados para la medición del comportamiento exploratorio y la respuesta emocional con el objetivo de generar un marco más extenso sobre la complejidad de la respuesta ante la novedad. (Texto tomado de la fuente)Stress and anxiety form are fairly common risk factors today. One population that is particularly susceptible to the effects of stress on emotional response is adolescence. Within this stage of development, it has been found that the type of stress that has the greatest affect is social isolation. Some of the behaviors that are primarily affected by stress during this stage of development is the emotional response to novelty. The vast majority of this literature has focused mainly on indicators of anxiety related to a novel environment, without linking it directly to the effects on space exploration, such as the natural behavior of animals to form a home base. The results showed an increase in the steepness and tigmotaxic response of the Isolated animals. In addition, it was shown that the development of the home base requires an emotional and exploratory component. The importance of using more detailed indicators for the measurement of exploratory behavior and emotional response is described in order to generate a more extensive framework on the complexity of the response to noveltyMaestríaMagíster en Psicología69 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ciencias Humanas - Maestría en PsicologíaFacultad de Ciencias HumanasBogotá, ColombiaUniversidad Nacional de Colombia - Sede BogotáEfectos del aislamiento social sobre la conducta exploratoria en ratas adolescentes expuestas a un ambiente novedosoEffects of social isolation on exploratory behavior in adolescent rats exposed to a novel environmentTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMAhumada, L. H., Morato, S., & Lamprea, M. R. (2022). Acute stress increases behaviors that optimize safety and decreases the exploration of aversive areas. Learning and Motivation, 80, 101855Alstott, J., & Timberlake, W. (2009). Effects of rat sex differences and lighting on locomotor exploration of a circular open field with free-standing central corners and without peripheral walls. Behavioural brain research, 196(2), 214-219Arakawa, H. (2005). Interaction between isolation rearing and social development on . exploratory behavior in male rats. Behavioural processes, 70(3), 223-234Avital, A., & Richter-Levin, G. (2005). Exposure to juvenile stress exacerbates the behavioural consequences of exposure to stress in the adult rat. International Journal of Neuropsychopharmacology, 8(2), 163-173Avital, I., Inderbitzin, D., Aoki, T., Tyan, D. B., Cohen, A. H., Ferraresso, C., ... & Demetriou, A. A. (2001). Isolation, characterization, and transplantation of bone marrow-derived hepatocyte stem cells. Biochemical and biophysical research communications, 288(1), 156-164Bekris, S., Antoniou, K., Daskas, S., & Papadopoulou-Daifoti, Z. (2005). Behavioural and neurochemical effects induced by chronic mild stress applied to two different rat strains. Behavioural brain research, 161(1), 45-59.Bishnoi, I. R., Ossenkopp, K. P., & Kavaliers, M. (2021). Sex and age differences in locomotor and anxiety‐like behaviors in rats: From adolescence to adulthood. Developmental psychobiology, 63(3), 496-511.Bondar, N. P., Lepeshko, A. A., & Reshetnikov, V. V. (2018). Effects of early-life stress on social and anxiety-like behaviors in adult mice: sex-specific effects. Behavioural neurology, 2018.Bystritsky, A., & Kronemyer, D. (2014). Stress and anxiety: counterpart elements of the stress/anxiety complex. Psychiatric Clinics, 37(4), 489-518.Carola, V., D'Olimpio, F., Brunamonti, E., Mangia, F., & Renzi, P. (2002). Evaluation of the elevated plus-maze and open-field tests for the assessment of anxiety-related behaviour in inbred mice. Behavioural brain research, 134(1-2), 49-57.Casarrubea, M., Di Giovanni, G., Aiello, S., & Crescimanno, G. 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Behavioural Brain Research, 159(1), 27-36.Aislamiento SocialConductaConducta del AdolescenteSocial IsolationBehaviorComportamento do AdolescenteAdolescenciaExploraciónHome baseAdolescenceExplorationEstudiantesInvestigadoresLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/86705/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1010112416.2024.pdf1010112416.2024.pdfTesis de Maestría en Psicologíaapplication/pdf3022141https://repositorio.unal.edu.co/bitstream/unal/86705/2/1010112416.2024.pdf9a33628ea1a415ca0a2e84d2e638f1a7MD52THUMBNAIL1010112416.2024.pdf.jpg1010112416.2024.pdf.jpgGenerated Thumbnailimage/jpeg3847https://repositorio.unal.edu.co/bitstream/unal/86705/3/1010112416.2024.pdf.jpg633619361c4d546cda3c887be28b112fMD53unal/86705oai:repositorio.unal.edu.co:unal/867052024-08-27 23:11:14.434Repositorio Institucional Universidad Nacional de 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Efectos del aislamiento social sobre la conducta exploratoria en ratas adolescentes expuestas a un ambiente novedoso

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