Revisión sistemática de amplio alcance: Seguridad y efectividad de los métodos de anticoncepción hormonal versus métodos de anticoncepción no hormonal o no uso de métodos de anticoncepción para mujeres en edad reproductiva con deseo de fertilidad futura y alto riesgo cardiovascular
ilustraciones, diagramas, tablas
- Autores:
-
Losada Trujillo, Natalia
- Tipo de recurso:
- Fecha de publicación:
- 2023
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/86465
- Palabra clave:
- 100 - Filosofía y Psicología::107 - Educación, investigación, temas relacionados
500 - Ciencias naturales y matemáticas::507 - Educación, investigación, temas relacionados
610 - Medicina y salud::616 - Enfermedades
610 - Medicina y salud::618 - Ginecología, obstetricia, pediatría, geriatría
610 - Medicina y salud::613 - Salud y seguridad personal
610 - Medicina y salud::615 - Farmacología y terapéutica
600 - Tecnología (Ciencias aplicadas)::607 - Educación, investigación, temas relacionados
Anticonceptivos Femeninos
Anticoncepción Hormonal
Factores de Riesgo de Enfermedad Cardiaca
Contraceptive Agents, Female
Hormonal Contraception
Heart Disease Risk Factors
Hipertensión arterial
Anticoncepción hormonal
Seguridad
Efectividad
Hypertension
Hormonal contraception
Safety
Effectiveness
- Rights
- openAccess
- License
- Atribución-NoComercial-SinDerivadas 4.0 Internacional
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dc.title.spa.fl_str_mv |
Revisión sistemática de amplio alcance: Seguridad y efectividad de los métodos de anticoncepción hormonal versus métodos de anticoncepción no hormonal o no uso de métodos de anticoncepción para mujeres en edad reproductiva con deseo de fertilidad futura y alto riesgo cardiovascular |
dc.title.translated.eng.fl_str_mv |
Systematic review of broad scope: Safety and effectiveness of hormonal contraception methods versus non-hormonal contraception methods or non-use of contraception methods for women of reproductive age with desire for future fertility and high cardiovascular risk |
title |
Revisión sistemática de amplio alcance: Seguridad y efectividad de los métodos de anticoncepción hormonal versus métodos de anticoncepción no hormonal o no uso de métodos de anticoncepción para mujeres en edad reproductiva con deseo de fertilidad futura y alto riesgo cardiovascular |
spellingShingle |
Revisión sistemática de amplio alcance: Seguridad y efectividad de los métodos de anticoncepción hormonal versus métodos de anticoncepción no hormonal o no uso de métodos de anticoncepción para mujeres en edad reproductiva con deseo de fertilidad futura y alto riesgo cardiovascular 100 - Filosofía y Psicología::107 - Educación, investigación, temas relacionados 500 - Ciencias naturales y matemáticas::507 - Educación, investigación, temas relacionados 610 - Medicina y salud::616 - Enfermedades 610 - Medicina y salud::618 - Ginecología, obstetricia, pediatría, geriatría 610 - Medicina y salud::613 - Salud y seguridad personal 610 - Medicina y salud::615 - Farmacología y terapéutica 600 - Tecnología (Ciencias aplicadas)::607 - Educación, investigación, temas relacionados Anticonceptivos Femeninos Anticoncepción Hormonal Factores de Riesgo de Enfermedad Cardiaca Contraceptive Agents, Female Hormonal Contraception Heart Disease Risk Factors Hipertensión arterial Anticoncepción hormonal Seguridad Efectividad Hypertension Hormonal contraception Safety Effectiveness |
title_short |
Revisión sistemática de amplio alcance: Seguridad y efectividad de los métodos de anticoncepción hormonal versus métodos de anticoncepción no hormonal o no uso de métodos de anticoncepción para mujeres en edad reproductiva con deseo de fertilidad futura y alto riesgo cardiovascular |
title_full |
Revisión sistemática de amplio alcance: Seguridad y efectividad de los métodos de anticoncepción hormonal versus métodos de anticoncepción no hormonal o no uso de métodos de anticoncepción para mujeres en edad reproductiva con deseo de fertilidad futura y alto riesgo cardiovascular |
title_fullStr |
Revisión sistemática de amplio alcance: Seguridad y efectividad de los métodos de anticoncepción hormonal versus métodos de anticoncepción no hormonal o no uso de métodos de anticoncepción para mujeres en edad reproductiva con deseo de fertilidad futura y alto riesgo cardiovascular |
title_full_unstemmed |
Revisión sistemática de amplio alcance: Seguridad y efectividad de los métodos de anticoncepción hormonal versus métodos de anticoncepción no hormonal o no uso de métodos de anticoncepción para mujeres en edad reproductiva con deseo de fertilidad futura y alto riesgo cardiovascular |
title_sort |
Revisión sistemática de amplio alcance: Seguridad y efectividad de los métodos de anticoncepción hormonal versus métodos de anticoncepción no hormonal o no uso de métodos de anticoncepción para mujeres en edad reproductiva con deseo de fertilidad futura y alto riesgo cardiovascular |
dc.creator.fl_str_mv |
Losada Trujillo, Natalia |
dc.contributor.advisor.none.fl_str_mv |
Gaitán Duarte, Hernando Estrada Orozco, Kelly Patricia |
dc.contributor.author.none.fl_str_mv |
Losada Trujillo, Natalia |
dc.contributor.orcid.spa.fl_str_mv |
Losada Trujillo, Natalia [0000-0002-8682-4072] |
dc.contributor.cvlac.spa.fl_str_mv |
Losada-Trujillo, Natalia |
dc.contributor.researchgate.spa.fl_str_mv |
Losada-Trujillo, Natalia |
dc.contributor.googlescholar.spa.fl_str_mv |
Losada-Trujillo, Natalia |
dc.subject.ddc.spa.fl_str_mv |
100 - Filosofía y Psicología::107 - Educación, investigación, temas relacionados 500 - Ciencias naturales y matemáticas::507 - Educación, investigación, temas relacionados 610 - Medicina y salud::616 - Enfermedades 610 - Medicina y salud::618 - Ginecología, obstetricia, pediatría, geriatría 610 - Medicina y salud::613 - Salud y seguridad personal 610 - Medicina y salud::615 - Farmacología y terapéutica 600 - Tecnología (Ciencias aplicadas)::607 - Educación, investigación, temas relacionados |
topic |
100 - Filosofía y Psicología::107 - Educación, investigación, temas relacionados 500 - Ciencias naturales y matemáticas::507 - Educación, investigación, temas relacionados 610 - Medicina y salud::616 - Enfermedades 610 - Medicina y salud::618 - Ginecología, obstetricia, pediatría, geriatría 610 - Medicina y salud::613 - Salud y seguridad personal 610 - Medicina y salud::615 - Farmacología y terapéutica 600 - Tecnología (Ciencias aplicadas)::607 - Educación, investigación, temas relacionados Anticonceptivos Femeninos Anticoncepción Hormonal Factores de Riesgo de Enfermedad Cardiaca Contraceptive Agents, Female Hormonal Contraception Heart Disease Risk Factors Hipertensión arterial Anticoncepción hormonal Seguridad Efectividad Hypertension Hormonal contraception Safety Effectiveness |
dc.subject.decs.spa.fl_str_mv |
Anticonceptivos Femeninos Anticoncepción Hormonal Factores de Riesgo de Enfermedad Cardiaca |
dc.subject.decs.eng.fl_str_mv |
Contraceptive Agents, Female Hormonal Contraception Heart Disease Risk Factors |
dc.subject.proposal.spa.fl_str_mv |
Hipertensión arterial Anticoncepción hormonal Seguridad Efectividad |
dc.subject.proposal.eng.fl_str_mv |
Hypertension Hormonal contraception Safety Effectiveness |
description |
ilustraciones, diagramas, tablas |
publishDate |
2023 |
dc.date.issued.none.fl_str_mv |
2023 |
dc.date.accessioned.none.fl_str_mv |
2024-07-16T17:40:11Z |
dc.date.available.none.fl_str_mv |
2024-07-16T17:40:11Z |
dc.type.spa.fl_str_mv |
Trabajo de grado - Maestría |
dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/masterThesis |
dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/acceptedVersion |
dc.type.content.spa.fl_str_mv |
Text |
dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/TM |
status_str |
acceptedVersion |
dc.identifier.uri.none.fl_str_mv |
https://repositorio.unal.edu.co/handle/unal/86465 |
dc.identifier.instname.spa.fl_str_mv |
Universidad Nacional de Colombia |
dc.identifier.reponame.spa.fl_str_mv |
Repositorio Institucional Universidad Nacional de Colombia |
dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.unal.edu.co/ |
url |
https://repositorio.unal.edu.co/handle/unal/86465 https://repositorio.unal.edu.co/ |
identifier_str_mv |
Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia |
dc.language.iso.spa.fl_str_mv |
spa |
language |
spa |
dc.relation.references.spa.fl_str_mv |
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United States of America; 2016. 467–2770 p. 13. Organisation for economic co-operation and development. OECD.Stat. [citado 7 de octubre de 2023]. Organisation for economic co-operation and development: Family Database. Disponible en: https://stats.oecd.org/Index.aspx?DataSetCode=FAMILY 14. Pan American Health Organization, World Health Organization. Noncommunicable Diseases - PAHO/WHO [Internet]. 2021 [citado 6 de diciembre de 2021]. Disponible en: https://www.paho.org/en/topics/noncommunicable-diseases 15. World Health Organization. Noncommunicable diseases [Internet]. Noncommunicable disease. 2021 [citado 6 de diciembre de 2021]. Disponible en: https://www.who.int/health-topics/noncommunicable-diseases#tab=tab_1 16. Division of Reproductive Health NC for CDP, Promotion H, Centers for Disease Control and Prevention. Unintended Pregnancy, Reproductive Health [Internet]. CDC. 2021 [citado 15 de enero de 2022]. 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Universidad Nacional de Colombia, editor. Bogotá D.C., Colombia: Universidad Nacional de Colombia; 2013. 1–206 p. 41. World Health Organization. Global action plan for the prevention and control of noncommunicable diseases 2013-2020. World Health Organ [Internet]. 2013;102. Disponible en: http://apps.who.int/iris/bitstream/10665/94384/1/9789241506236_eng.pdf 42. World Health Organization. Medical eligibility criteria for contraceptive use. 5.a ed. WHO Library Cataloguing-in-Publication Data, editor. Geneva: World Health Organization; 2015. 1–276 p. 43. Quarini CA. History of contraception. Womens Health Med [Internet]. septiembre de 2005;2(5):28-30. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/S1744187006000874 44. World Health Organization Department of Reproductive Health and Research (WHO/RHR), Johns Hopkins Bloomberg School of Public Health/Center for Communication Program. Family Planning: A Global Handbook for Providers [Internet]. 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Bergendal A, Persson I, Odeberg J, Sundström A, Holmström M, Schulman S, et al. Association of venous thromboembolism with hormonal contraception and thrombophilic genotypes. Obstet Gynecol. septiembre de 2014;124(3):600-9. 50. Dinger J, Assmann A, Möhner S, Minh TD. Risk of venous thromboembolism and the use of dienogest- and drospirenone-containing oral contraceptives: results from a German case-control study. J Fam Plann Reprod Health Care. julio de 2010;36(3):123-9. 51. Farmer RD, Lawrenson RA, Thompson CR, Kennedy JG, Hambleton IR. Population-based study of risk of venous thromboembolism associated with various oral contraceptives. Lancet Lond Engl. 11 de enero de 1997;349(9045):83-8. 52. Vademecum. Implanon NXT Implante 68 mg [Internet]. 2020 [citado 8 de diciembre de 2021]. Disponible en: https://www.vademecum.es/equivalencia-lista-implanon+nxt-colombia-g03ac08-19002715-co_1 53. Vademecum. Jadelle Implante 75 mg [Internet]. 2015 [citado 8 de diciembre de 2021]. 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The use of oral contraceptives and the occurrence of acute myocardial infarction in young women: Results from the transnational study on oral contraceptives and the health of young women. Contraception [Internet]. 1 de septiembre de 1997 [citado 7 de octubre de 2023];56(3):129-40. Disponible en: https://www.sciencedirect.com/science/article/pii/S0010782497001182 62. Beller FK, Ebert C. Effects of oral contraceptives on blood coagulation. A review. Obstet Gynecol Surv. julio de 1985;40(7):425-36. 63. Notelovitz M. Oral contraception and coagulation. Clin Obstet Gynecol. marzo de 1985;28(1):73-83. 64. Bonnar J. Coagulation effects of oral contraception. Am J Obstet Gynecol. octubre de 1987;157(4 Pt 2):1042-8. 65. Jakes A, Coad F, Nelson-Piercy C. A review of contraceptive methods for women with cardiac disease. Obstet Gynaecol. 28 de enero de 2018;20:21-9. 66. Cilia La Corte AL, Carter AM, Turner AJ, Grant PJ, Hooper NM. 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Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Gaitán Duarte, Hernando01177b4c0a0b59e8b102e877d35febf5Estrada Orozco, Kelly Patriciaa821859c2bf07fd8f05f494636089380Losada Trujillo, Natalia3d452251e9616d30cadccfc42947f003Losada Trujillo, Natalia [0000-0002-8682-4072]Losada-Trujillo, NataliaLosada-Trujillo, NataliaLosada-Trujillo, Natalia2024-07-16T17:40:11Z2024-07-16T17:40:11Z2023https://repositorio.unal.edu.co/handle/unal/86465Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramas, tablasIntroducción: En los últimos años, la edad de las mujeres al momento del parto ha aumentado. La edad avanzada a su vez es un factor de riesgo para la aparición de enfermedades crónicas. Es necesario evaluar la seguridad y efectividad de los métodos anticonceptivos en mujeres con enfermedades crónicas y alto riesgo cardiovascular. Objetivo: Evaluar la seguridad y efectividad de los métodos anticonceptivos hormonales versus los métodos no hormonales o no uso de anticoncepción en las mujeres en edad reproductiva con deseo de fertilidad futura e hipertensión arterial. Métodos: Revisión sistemática de la literatura de amplio alcance. Se buscó en las bases de datos Medline, Embase, CENTRAL y LILACS, y en literatura gris, registros de experimentos clínicos (ECAS), agencias reguladoras, bases de datos de eventos adversos y postcomercialización. Se consideraron elegibles: ECAS, estudios de cohortes, casos y controles, series de casos, reportes de casos, registros de ECAS y reportes de eventos adversos. Se realizó la tamización por título y resumen, revisión del texto completo, selección de los estudios, extracción de la información y evaluación del riesgo de sesgo (ROBINS-I para cohortes), calidad metodológica (Newcastle Ottawa para cohortes y casos y controles) y aproximación crítica (Joanna Briggs Institute para series de casos), según el tipo de estudio, de manera independiente por dos revisores. Se realizó evaluación de la certeza de la evidencia de los desenlaces identificados mediante el enfoque GRADE de manera independiente. Se sintetizó la evidencia según el tipo de anticonceptivo hormonal y desenlace de manera cuantitativa (estimador de asociación, conteo de votos y metaanálisis) y cualitativa (síntesis narrativa). Resultados: La búsqueda arrojó 32.494 referencias, luego del proceso de selección se incluyeron 17 estudios. Se incluyeron estudios de casos y controles, cohortes y series de casos. Los desenlaces identificados y evaluados por tipo de anticonceptivo, fueron: a) Anticonceptivos orales combinados (ACOS): gestaciones no deseadas, eventos cardiovasculares adversos mayores (MACE), tromboembolismo venoso, empeoramiento de la condición de base, aumento de peso, alteración función renal y perfil metabólico, b) Anillo vaginal: gestaciones no deseadas, empeoramiento de la condición de base y del perfil metabólico, c) Anticonceptivo inyectable combinado, píldoras de sólo progestágeno (POP) e inyectables de sólo progestágeno: MACE y tromboembolismo venoso, d) ACOS o POP: MACE y enfermedad arterial periférica. Se observó que las mujeres hipertensas usando ACOS tenían un OR de 1,64 (IC95% 1,08-2,50) para eventos cerebrovasculares hemorrágicos (certeza de la evidencia: baja), y un OR para infarto agudo de miocardio en usuarias de ACOS o POP de 1,15 (IC95% 0,60-2,19) (certeza de la evidencia: muy baja), sin controlar posibles variables de confusión. La certeza de la evidencia de los otros desenlaces es muy baja. Conclusiones: Los estudios sugieren que los anticonceptivos orales combinados podrían aumentar el riesgo de eventos cerebrovasculares hemorrágicos en mujeres hipertensas, aunque la certeza de la evidencia es baja. Debido a la alta incertidumbre, lo ideal sería realizar experimentos clínicos pragmáticos o estudios de cohortes con análisis de inferencia causal. Por el momento, se deben continuar las recomendaciones por consenso de expertos, salvo en el caso de los ACOS y los eventos cerebrovasculares hemorrágicos, donde la evidencia sugiere un posible aumento del riesgo (Texto tomado de la fuente).Introduction: In recent years, the age at which women give birth has increased. Advanced maternal age is a risk factor for the development of chronic diseases. It is necessary to evaluate the safety and effectiveness of contraceptive methods in women with chronic diseases and high cardiovascular risk. Objective: To evaluate the safety and effectiveness of hormonal contraceptive methods versus non-hormonal methods or no contraception in women of reproductive age with a desire for future fertility and hypertension. Methods: A comprehensive systematic literature review was conducted. Searches were performed in the databases Medline, Embase, CENTRAL, and LILACS, as well as in grey literature, clinical trial registries (RCTs), regulatory agencies, adverse event databases, and post-marketing databases. Eligible studies included RCTs, cohort studies, case-control studies, case series, case reports, RCT registries, and adverse event reports. Screening was performed by title and abstract, followed by full-text review, study selection, data extraction, and risk of bias assessment (ROBINS-I for cohort studies), methodological quality (Newcastle Ottawa for cohort and case-control studies), and critical appraisal (Joanna Briggs Institute for case series), all conducted independently by two reviewers. The certainty of the evidence for identified outcomes was independently evaluated using the GRADE approach. Evidence was synthesized by type of hormonal contraceptive and outcome both quantitatively (association estimator, vote counting, and meta-analysis) and qualitatively (narrative synthesis). Results: The search yielded 32,494 references, and 17 studies were included after the selection process. Included studies were case-control, cohort, and case series studies. The outcomes identified and evaluated by contraceptive type were: a) Combined oral contraceptives (COCs): unintended pregnancies, major adverse cardiovascular events (MACE), venous thromboembolism, worsening of the underlying condition, weight gain, alteration of renal function and metabolic profile. b) Vaginal ring: unintended pregnancies, worsening of the underlying condition and metabolic profile. c) Combined injectable contraceptives, progestogen-only pills (POPs), and progestogen-only injectables: MACE and venous thromboembolism. d) COCs or POPs: MACE and peripheral arterial disease. It was observed that hypertensive women using COCs had an OR of 1.64 (95% CI 1.08-2.50) for hemorrhagic cerebrovascular events (certainty of the evidence: low), and an OR for acute myocardial infarction in users of COCs or POPs of 1.15 (95% CI 0.60-2.19) (certainty of the evidence: very low), without controlling for possible confounding variables. The certainty of the evidence for other outcomes is very low. Conclusions: The studies suggest that combined oral contraceptives may increase the risk of hemorrhagic cerebrovascular events in hypertensive women, although the certainty of the evidence is low. Due to the high uncertainty, pragmatic clinical trials or cohort studies with causal inference analysis are ideal. In the meantime, expert consensus recommendations should continue to be followed, except for the case of COCs and hemorrhagic cerebrovascular events, where the evidence suggests a possible increased risk.MaestríaMagister en Epidemiología ClínicaMétodos: Revisión sistemática de la literatura de amplio alcance. Se buscó en las bases de datos Medline, Embase, CENTRAL y LILACS, y en literatura gris, registros de experimentos clínicos (ECAS), agencias reguladoras, bases de datos de eventos adversos y postcomercialización. Se consideraron elegibles: ECAS, estudios de cohortes, casos y controles, series de casos, reportes de casos, registros de ECAS y reportes de eventos adversos. Se realizó la tamización por título y resumen, revisión del texto completo, selección de los estudios, extracción de la información y evaluación del riesgo de sesgo (ROBINS-I para cohortes), calidad metodológica (Newcastle Ottawa para cohortes y casos y controles) y aproximación crítica (Joanna Briggs Institute para series de casos), según el tipo de estudio, de manera independiente por dos revisores. Se realizó evaluación de la certeza de la evidencia de los desenlaces identificados mediante el enfoque GRADE de manera independiente. Se sintetizó la evidencia según el tipo de anticonceptivo hormonal y desenlace de manera cuantitativa (estimador de asociación, conteo de votos y metaanálisis) y cualitativa (síntesis narrativa).xxi, 181 páginas + anexosapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Maestría en Epidemiología ClínicaFacultad de MedicinaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá100 - Filosofía y Psicología::107 - Educación, investigación, temas relacionados500 - Ciencias naturales y matemáticas::507 - Educación, investigación, temas relacionados610 - Medicina y salud::616 - Enfermedades610 - Medicina y salud::618 - Ginecología, obstetricia, pediatría, geriatría610 - Medicina y salud::613 - Salud y seguridad personal610 - Medicina y salud::615 - Farmacología y terapéutica600 - Tecnología (Ciencias aplicadas)::607 - Educación, investigación, temas relacionadosAnticonceptivos FemeninosAnticoncepción HormonalFactores de Riesgo de Enfermedad CardiacaContraceptive Agents, FemaleHormonal ContraceptionHeart Disease Risk FactorsHipertensión arterialAnticoncepción hormonalSeguridadEfectividadHypertensionHormonal contraceptionSafetyEffectivenessRevisión sistemática de amplio alcance: Seguridad y efectividad de los métodos de anticoncepción hormonal versus métodos de anticoncepción no hormonal o no uso de métodos de anticoncepción para mujeres en edad reproductiva con deseo de fertilidad futura y alto riesgo cardiovascularSystematic review of broad scope: Safety and effectiveness of hormonal contraception methods versus non-hormonal contraception methods or non-use of contraception methods for women of reproductive age with desire for future fertility and high cardiovascular riskTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TM1. 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Am J Prev Med. abril de 2001;20(3 Suppl):21-35.AdministradoresBibliotecariosEstudiantesInvestigadoresMaestrosMedios de comunicaciónPúblico generalORIGINAL1024563440.anexos.pdf1024563440.anexos.pdfAnexos Tesis de Maestría en Epidemiología Clínicaapplication/pdf959572https://repositorio.unal.edu.co/bitstream/unal/86465/3/1024563440.anexos.pdf069e72664f9144c83fe3b72a1495daddMD531024563440.2024.pdf1024563440.2024.pdfTesis de Maestría en Epidemiología Clínicaapplication/pdf1099252https://repositorio.unal.edu.co/bitstream/unal/86465/5/1024563440.2024.pdf27230557b8a632a95ea33604ba739c6dMD55LICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/86465/4/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD54THUMBNAIL1024563440.anexos.pdf.jpg1024563440.anexos.pdf.jpgGenerated 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