Hongos Macromicetos: biofábricas alternativas de compuestos con potencial de aplicación en cosmecéutica y nutricosmecéutica

En los últimos años, las sociedades modernas se han vuelto más conscientes de los tratamientos “naturales”, lo que ha promovido el desarrollo de nuevos productos provenientes de fuentes naturales, a lo que no ha sido ajena la industria cosmética. El empleo de los biocompuestos en las formulaciones c...

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Autores:: Fuquene Bustos, Guinnet Paola

Tipo de recurso:

Fecha de publicación:: 2022

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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network_acronym_str	UNACIONAL2
network_name_str	Universidad Nacional de Colombia
repository_id_str
dc.title.none.fl_str_mv	Hongos Macromicetos: biofábricas alternativas de compuestos con potencial de aplicación en cosmecéutica y nutricosmecéutica
dc.title.translated.none.fl_str_mv	Macromycetes fungi: alternative biofactories of compounds with potential application in cosmeceuticals and nutricosmeceuticals
title	Hongos Macromicetos: biofábricas alternativas de compuestos con potencial de aplicación en cosmecéutica y nutricosmecéutica
spellingShingle	Hongos Macromicetos: biofábricas alternativas de compuestos con potencial de aplicación en cosmecéutica y nutricosmecéutica 540 - Química y ciencias afines Cosmeceutico Nutricosmeceutico Macromicetos Fermentación en estado liquido Nutricosmeceutic Cosmeceutic macromycetes liquid state fermentation
title_short	Hongos Macromicetos: biofábricas alternativas de compuestos con potencial de aplicación en cosmecéutica y nutricosmecéutica
title_full	Hongos Macromicetos: biofábricas alternativas de compuestos con potencial de aplicación en cosmecéutica y nutricosmecéutica
title_fullStr	Hongos Macromicetos: biofábricas alternativas de compuestos con potencial de aplicación en cosmecéutica y nutricosmecéutica
title_full_unstemmed	Hongos Macromicetos: biofábricas alternativas de compuestos con potencial de aplicación en cosmecéutica y nutricosmecéutica
title_sort	Hongos Macromicetos: biofábricas alternativas de compuestos con potencial de aplicación en cosmecéutica y nutricosmecéutica
dc.creator.fl_str_mv	Fuquene Bustos, Guinnet Paola
dc.contributor.advisor.none.fl_str_mv	Nieto Ramirez, Ivonne Jeannette
dc.contributor.author.none.fl_str_mv	Fuquene Bustos, Guinnet Paola
dc.contributor.researchgroup.spa.fl_str_mv	Química de Hongos Macromicetos Colombianos
dc.subject.ddc.spa.fl_str_mv	540 - Química y ciencias afines
topic	540 - Química y ciencias afines Cosmeceutico Nutricosmeceutico Macromicetos Fermentación en estado liquido Nutricosmeceutic Cosmeceutic macromycetes liquid state fermentation
dc.subject.proposal.none.fl_str_mv	Cosmeceutico Nutricosmeceutico Macromicetos Fermentación en estado liquido
dc.subject.proposal.eng.fl_str_mv	Nutricosmeceutic Cosmeceutic macromycetes liquid state fermentation
description	En los últimos años, las sociedades modernas se han vuelto más conscientes de los tratamientos “naturales”, lo que ha promovido el desarrollo de nuevos productos provenientes de fuentes naturales, a lo que no ha sido ajena la industria cosmética. El empleo de los biocompuestos en las formulaciones cosméticas ha permitido la aparición de los denominados “biocosméticos”, término que engloba a dos grupos de especial importancia que son los cosmeceúticos y los nutricosmeceúticos. La fuente tradicional y más estudiada para la búsqueda de bioactivos son las plantas, pero el empleo de este recurso natural tiene limitaciones como son crecimiento lento y variación apreciable en elcontenido y clase de sus bioactivos, particularidad no deseada en la producción de biocosméticos. Los macrohongos biosintetizan compuestos similares y, en algunas ocasiones, estructuralmente diferentes a los procedentes de las plantas y es esta fuentenatural poco explotada la que puede posicionarse como una promisoria alternativa para la obtención de bioactivos, con la ventaja de que pueden cultivarse rápidamente y de manera rentable, mediante la aplicación de procesos biotecnológicos como la Fermentación en Estado Líquido, convirtiéndose en una opción más sustentable. El objetivo de esta monografía es la recopilación exhaustiva de información que proporcione una visión actualizada del empleo de los productos naturales como ingredientes en la formulación de biocosméticos y evidenciar el potencial que los macrohongos exhiben en este campo. Esta revisión se convertirá en el soporte teórico para la creación de una nueva línea de investigación en el grupo Química de Hongos Macromicetos Colombianos. (Texto tomado de la fuente)
publishDate	2022
dc.date.accessioned.none.fl_str_mv	2022-08-04T15:03:55Z
dc.date.available.none.fl_str_mv	2022-08-04T15:03:55Z
dc.date.issued.none.fl_str_mv	2022-08-01
dc.type.spa.fl_str_mv	Trabajo de grado - Maestría
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.none.fl_str_mv	http://purl.org/redcol/resource_type/TM
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/81780
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/81780 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
dc.relation.references.spa.fl_str_mv	Abd Razak, D. L., Fadzil, N. H. M., Jamaluddin, A., Abd Rashid, N. Y., Sani, N. A., & Manan, M. A. (2019). Effects of different extracting conditions on anti-tyrosinase and antioxidant activities of Schizophyllum commune fruit bodies. Biocatalysis and agricultural biotechnology, 19, 101116. Abreu, H., Simas, F. F., Smiderle, F. R., Sovrani, V., Dallazen, J. L., Maria-Ferreira, D., ... & Iacomini, M. (2019). Gelling functional property, anti-inflammatory and antinociceptive bioactivities of β-D-glucan from the edible mushroom Pholiota nameko. International journal of biological macromolecules, 122, 1128-1135. Addor FAS .(2017). Antioxidants in dermatology. Anais Brasileiros de Dermatología 92: 356–362. Ademola, I. O., & Odeniran, P. O. (2017). Novel trypanocide from an extract of Pleurotus sajor-caju against Trypanosoma congolense. Pharmaceutical Biology, 55(1), 132-138. Agati, G., Galardi, C., Gravano, E., Romani, A., & Tattini, M. (2002). Flavonoid Distribution in Tissues of Phillyrea latifolia L. Leaves as Estimated by Microspectrofluorometry and Multispectral Fluorescence Microimaging. Photochemistry and Photobiology, 76(3), 350- 360. Ahmad, R., Riaz, M., Khan, A., Aljamea, A., Algheryafi, M., Sewaket, D., & Alqathama, A. (2021). Ganoderma lucidum (Reishi) an edible mushroom; a comprehensive and critical review of its nutritional, cosmeceutical, mycochemical, pharmacological, clinical, and toxicological properties. Phytotherapy Research, 35(11), 6030-6062. Ajose, F.O.,( 2007). Some nigerian plants of dermatologic importance. International. Alam, N., Yoon, K. N., & Lee, T. S. (2011). Evaluation of the antioxidant and antityrosinase activities of three extracts from Pleurotus nebrodensis fruiting bodies. African Journal of Biotechnology, 10(15), 2978-2986. Alam, N., Yoon, K. N., Lee, J. S., Cho, H. J., & Lee, T. S. (2012). Consequence of the antioxidant activities and tyrosinase inhibitory effects of various extracts from the fruiting bodies of Pleurotus ferulae. Saudi journal of biological sciences, 19(1), 111-118. Alam, N., Yoon, K. N., Lee, K. R., Shin, P. G., Cheong, J. C., Yoo, Y. B., ... & Lee, T. S. (2010). Antioxidant activities and tyrosinase inhibitory effects of different extracts from Pleurotus ostreatus fruiting bodies. Mycobiology, 38(4), 295-301. Ali, N., & Hadi, F. (2015). Phytoremediation of cadmium improved with the high production of endogenous phenolics and free proline contents in Parthenium hysterophorus plant treated exogenously with plant growth regulator and chelating agent. Environmental Science and Pollution Research, 22(17), 13305-13318. Almeida, I. F., & Bahia, M. F. (2006). Evaluation of the physical stability of two oleogels. International journal of pharmaceutics, 327(1-2), 73-77. Al-Niaimi F and Chiang NYZ (2017) Topical vitamin C and the skin: Mechanisms of action and clinical applications. The Journal of Clinical and Aesthetic Dermatology 10: 14–17. Alsterholm, M., Karami, N., & Faergemann, J. (2010). Antimicrobial activity of topical skin pharmaceuticals—an in vitro study. Acta dermato-venereologica, 90(3), 239. Alves, M. J., Ferreira, I. C., Dias, J., Teixeira, V., Martins, A., & Pintado, M. (2012). A review on antimicrobial activity of mushroom (Basidiomycetes) extracts and isolated compounds. Planta medica, 78(16), 1707-1718. Amer, M., & Maged, M. (2009). Cosmeceuticals versus pharmaceuticals. Clinics in dermatology, 27(5), 428-430. An, S. M., Kim, H. J., Kim, J. E., & Boo, Y. C. (2008). Flavonoids, taxifolin and luteolin attenuate cellular melanogenesis despite increasing tyrosinase protein levels. Phytotherapy Research, 22(9), 1200-1207. André P, Haneke E, Marini L, and Rowland-Payne C .(2016). Cosmetic medicine and surgery. CRC Press. Antille, C., Tran, C., Sorg, O., Carraux, P., Didierjean, L., & Saurat, J. H. (2003). Vitamin A exerts a photoprotective action in skin by absorbing ultraviolet B radiation. Journal of Investigative Dermatology, 121(5), 1163-1167. Anunciato, T. P., & da Rocha Filho, P. A. (2012). Carotenoids and polyphenols in nutricosmetics, nutraceuticals, and cosmeceuticals. Journal of cosmetic dermatology, 11(1), 51-54. Appendino, G., Scafati, O.T., Romano, A., Pollastro, F., Avonoto, C., Rubiolo, P., (2009). Genepolide, a sesquiterpene gamma lactone with a novel carbon skeleton from mountain wormwood (Artemisia umbelliformis L.). Journal of Natural Products 72 (3), 340–344. Archana, G., Sabina, K., Babuskin, S., Radhakrishnan, K., Fayidh, M. A., Babu, P. A. S., ... & Sukumar, M. (2013). Preparation and characterization of mucilage polysaccharide for biomedical applications. Carbohydrate polymers, 98(1), 89-94. Arct, J., & Pytkowska, K. (2008). Flavonoids as components of biologically active cosmeceuticals. Clinics in dermatology, 26(4), 347-357. Arenas Guzmán . (2014). Micología médica ilustrada.5ta ilustrada. 5ta edición. McGraw- Hill. ISBN 9786071511256 Ascenso, A., Pedrosa, T., Pinho, S., Pinho, F., Oliveira, J. M. P., Cabral Marques, H., ... & Santos, C. (2016). The effect of lycopene preexposure on UV-B-irradiated human keratinocytes. Oxidative Medicine and Cellular Longevity. Asserin, J., Lati, E., Shioya, T., & Prawitt, J. (2015). The effects of oral collagen peptide supplementation onskin moisture and the dermal collagen network:Evidence from an ex vivo model and randomized,placebo‐controlled clinical trials. Journal of Cosmetic Dermatology, 14,291–301. https://doi.org/10.1111/jocd.12174 Avila Rodriguez, M. I., Rodriguez Barroso, L. G., & Sanchez, M. L. (2018). Collagen: A review on its sources and potential cosmetic applications. Journal of Cosmetic Dermatology, 17(1), 20–26. https://doi.org/10.1111/jocd.12450. Ayele, Y., Kim, J.A., Park, E., Kim, Y.J., Retta, N., Dessie, G., Rhee, S.K., Koh, K., Nam, K.W., Kim, H.S.(2013). A methanol extract of Adansonia digitate L. leaves inhibits proinflammatory iNOS possibly via the inhibition of NF-kB activation. Biomolecular Therapeutics (Seoul) 21 (2), 146–152 Aytar, E. C., Akata, İ., & Leyla, A. Ç. I. K. (2020). Antioxidant and Antimicrobial Activities of Armillaria Mellea and Macrolepiota Procera Extracts. Mantar Dergisi, 11(2), 121-128. Baba, E., Uluköy, G., & Öntaş, C. (2015). Effects of feed supplemented with Lentinula edodes mushroom extract on the immune response of rainbow trout, Oncorhynchus mykiss, and disease resistance against Lactococcus garvieae. Aquaculture, 448, 476-482. Bach, F., Helm, C., P, A., Stafussa, A., Maciel, G., & Haminiuk, C. (2018). Atividade antioxidante e antimicrobiana do extrato de Lentinula edodes. In Embrapa Florestas-Artigo em anais de congresso (ALICE). In: congresso sul brasileiro de engenharia de alimentos, 4.; encontro paranaense de engenharia de alimentos. Badalyan, S. M. (2020). Medicinal coprinoid mushrooms (Agaricomycetes) distributed in Armenia. International Journal of Medicinal Mushrooms, 22(3). Bae, J. T., Sim, G. S., Lee, D. H., Lee, B. C., Pyo, H. B., Choe, T. B., & Yun, J. W. (2005). Production of exopolysaccharide from mycelial culture of Grifola frondosa and its inhibitory effect on matrix metalloproteinase-1 expression in UV-irradiated human dermal fibroblasts. FEMS Microbiology Letters, 251(2), 347-354. Baker LA, Marchetti B, Karsili TNVV, Stavros VG, and Ashfold MNRR. (2017). Photoprotection: Extending lessons learned from studying natural sunscreens to the design of artificial sunscreen constituents. Chemical Society Reviews 46: 3770–3791. Balupillai, A., Prasad, R. N., Ramasamy, K., Muthusamy, G., Shanmugham, M., Govindasamy, K., & Gunaseelan, S. (2015). Caffeic acid inhibits UVB‐induced inflammation and photocarcinogenesis through activation of peroxisome proliferator‐activated receptor‐γ in mouse skin. Photochemistry and Photobiology, 91(6), 1458-1468. Bandara, A. R., Rapior, S., Bhat, D. J., Kakumyan, P., Chamyuang, S., Xu, J., & Hyde, K. D. (2015). Polyporus umbellatus, an edible-medicinal cultivated mushroom with multiple developed health-care products as food, medicine and cosmetics: a review. Cryptogamie, Mycologie, 36(1), 3-42. Barnes, H. A. (2000). A handbook of elementary rheology (Vol. 1). Aberystwyth: University of Wales, Institute of Non-Newtonian Fluid Mechanics. Barquet, A. P., Funck, A. P. G., & Koester, L. S. (2006). Comparação entre alfa- hidroxiácidos e poli-hidroxiácidos na cosmiatria e dermatologia. Rev. Bras. Farm, 87(3), 67- 73. Barreira, J.C.M., Visnevschi-Necrasov, T., Nunes, E., Cunha, S.C., Pereira, G., Oliveira,M.B.P.P. (2015). Medicao spp., as potential sources of bioactive isoflavones: characterization according to phylogenetic and phonologic factors. Phytochemistry 116,230–238 Beeckman, D., Verhaeghe, S., Defloor, T., Schoonhoven, L., & Vanderwee, K. (2011). A 3- in-1 perineal care washcloth impregnated with dimethicone 3% versus water and pH neutral soap to prevent and treat incontinence-associated dermatitis: a randomized, controlled clinical trial. Journal of Wound Ostomy & Continence Nursing, 38(6), 627-634. Beitner H.(2003). Estudio aleatorizado, controlado con placebo, doble ciego sobre la eficacia clínica de una crema que contiene 5% de ácido alfa lipoico relacionada con el fotoenvejecimiento de la piel del rostro. Br J Dermatol 149 (4): 841-9 Beltrán Rodríguez, D. F. (2020). Estudio prospectivo para la caracterización macroscópica de macromicetos en la zona norte de la Provincia del Sumapáz (Tesis de Grado Uniandes). Berg, A., Reiber, K., Dorfelt, H., Walther, G., Schlegel, B., & Graefe, U. (2000). Laccaridiones A and B, new protease inhibitors from Laccaria amethystea. The Journal of Antibiotics, 53(11), 1313-1316. Bernard, B. A. (1993). Adapalene, a new chemical entity with retinoid activity. Skin Pharmacology and Physiology, 6(Suppl. 1), 61-69. Bernard BA. Adapalene, a new chemical entity with retinoid activity. Skin Pharmacol 1993;6 (Suppl 1):61-69. Betancur, A., & P ́erez, M. M. (2016). Parques y páramos naturales de Colombia como zonas de importancia para el desarrollo minero energ ́etico del país. Revista del CESLA, 19, 33-56. https://www.redalyc.org/articulo.oa?id= 243349208002 Bisang, R., Campi, M., & Cesa, V. (2009). Biotecnología y desarrollo.CEPAL .Naciones Unidas. Bisen, P. S., Baghel, R. K., Sanodiya, B. S., Thakur, G. S., & Prasad, G. B. K. S. (2010). Lentinus edodes: a macrofungus with pharmacological activities. Current medicinal chemistry, 17(22), 2419-2430. Bissett DL, Miyamoto K, Sun P y col. (2004).La niacinamida tópica reduce el color amarillento, las arrugas, las manchas rojas y las manchas hiperpigmentadas en la piel facial envejecida. Int J Cosmet Sci 26 (5): 231-8 Brand-Garnys, E. E., Denzer, H., Meijer, H., & Brand, H. M. (2007). Flavonoids: A review for cosmetic application. part two. Journal of applied cosmetology, 25(4), 145-159. Brandt, F. S., Cazzaniga, A., & Hann, M. (2011). Cosmeceuticals: current trends and market analysis. In Seminars in cutaneous medicine and surgery (Vol. 30, No. 3, pp. 141-143). WB Saunders. Briganti, S., Camera, E., & Picardo, M. (2003). Chemical and instrumental approaches to treat hyperpigmentation. Pigment Cell Research, 16(2), 101-110. Brizuela, M. A., García, L., Pérez, L., & Mansur, M. (1998). Basidiomicetos: nueva fuente de metabolitos secundarios. Revista Iberoamericana de Micología, 15(6974), 1998-15. Brummer, R. (2006b). Rheology essentials of cosmetic and food emulsions. Springer Science & Business Media.Brody HJ. Relevance of cosmeceuticals to the dermatologic surgeon. Dermatol Surg. 2005;31(7):796–8. Burger, P., Landreau, A., Azoulay, S., Michel, T., & Fernandez, X. (2016). Skin whitening cosmetics: Feedback and challenges in the development of natural skin lighteners. Cosmetics, 3(4), 36. Campos, P. M. B. G., G. Mercurio, D., O. Melo, M., & Closs-Gonthier, B. (2017). Cichorium intybus root extract: a “vitamin D-like” active ingredient to improve skin barrier function. Journal of Dermatological Treatment, 28(1), 78-81. Carrasco, A., Martinez-Gutierrez, R., Tomas, V., & Tudela, J. (2016). Lavandula angustifolia and Lavandula latifolia essential oils from Spain: Aromatic profile and bioactivities. Planta Med, 82(1-2), 163-170. Carrau, M. J., Gimeno, M., Ibáñez, O., Organero, A., & Rey, P. (2010). Plantas limpias. Mètode, 65, 120-121. Cavinato, M. (2020). Cosmetics and cosmeceuticals. In: Ratan, S.I. (Ed.), Reference Module in Biomedical Sciences. Elsevier, pp. 446–461. https://doi.org/10.1016/B978-0-12- 801238-3.62150-5. Cepero de García, M. C. (2012). Biología de hongos. Ediciones Uniandes-Universidad de los Andes. Chakraborty, A. K., Funasaka, Y., Komoto, M., & Ichihashi, M. (1998). Effect of arbutin on melanogenic proteins in human melanocytes. Pigment cell research, 11(4), 206-212. Chandrawanshi, K.N., Tandia, D.K. and Jadhav, S.K. (2017). Nutraceutical properties evaluation of Schizophyllum commune. Indian J. Sci. Res., 13: 57–62. Chang, A. K. T., Frias Jr, R. R., Alvarez, L. V., Bigol, U. G., & Guzman, J. P. M. D. (2019). Comparative antibacterial activity of commercial chitosan and chitosan extracted from Auricularia sp. Biocatalysis and agricultural biotechnology, 17, 189-195. Chang, S. T., & Miles, P. G. (2004). Mushrooms: cultivation, nutritional value, medicinal effect, and environmental impact. CRC press. Chang, T. S. (2009). An updated review of tyrosinase inhibitors. International journal of molecular sciences, 10(6), 2440-2475. Chen, M. H., Chang, S. S., Dong, B., Yu, L. Y., Wu, Y. X., Wang, R. Z., ... & Si, S. Y. (2018). Ahmpatinin i Bu, a new HIV-1 protease inhibitor, from Streptomyces sp. CPCC 202950. RSC advances, 8(10), 5138-5144. Cheng, S. L., Liu, R. H., Sheu, J. N., Chen, S. T., Sinchaikul, S., & Tsay, G. J. (2006). Toxicogenomics of kojic acid on gene expression profiling of a375 human malignant melanoma cells. Biological and Pharmaceutical Bulletin, 29(4), 655-669. Cheung, L. M., Cheung, P. C., & Ooi, V. E. (2003). Antioxidant activity and total phenolics of edible mushroom extracts. Food chemistry, 81(2), 249-255. Chien, C. C., Tsai, M. L., Chen, C. C., Chang, S. J., & Tseng, C. H. (2008). Effects on tyrosinase activity by the extracts of Ganoderma lucidum and related mushrooms. Mycopathologia, 166(2), 117-120. Chithra, P., Sajithlal G.B. y Chandrakasan G. (1998). Influence of Aloe vera on collagen turnover in healing of dermal wounds in rats. Indian Journal of Experimental Biology 36, 896- 901. Choi CM, Berson DS.(2006). Cosmecéuticos Semin Cutan Med Surg 25 (3): 163-8 Cohen, L. E., & Grant, R. T. (2016). Sun protection: current management strategies addressing UV exposure. Clinics in Plastic Surgery, 43(3), 605-610. Corey, M. E., Beelman, R. B., & Seetharman, K. (2009). Potential for nutritional enrichment of whole-wheat bread with portabella mushroom powder (Agaricus bisporus (J. Lge) Imbach, Agaricomycetideae). International Journal of Medicinal Mushrooms, 11(2). Costa A. (2012). Tratado Internacional de Cosmecêuticos. Rio de Janeiro: Guanabara Koogan. Couto, S. R. y M. Á. Sanromán (2006). Application of solid-state fermentation to food industry—A review. Journal of Food Engineering 76(3): 291-302. Crueger, W. y A. Crueger (1993). Biotecnología. Manual de Microbiología Industrial., Ed. Acribia. Delinasios GJ, Karbaschi M, Cooke MS, and Young AR .(2018). Vitamin E inhibits the UVAI induction of “light” and “dark” cyclobutane pyrimidine dimers, and oxidatively generated DNA damage, in keratinocytes. Scientific Reports 8: 423. Domínguez-Fernández, R. N., Arzate-Vazquez, I., Chanona-Perez, J. J., Welti-Chanes, J. S., Alvarado-González, J. S., Calderon-Dominguez, G., ... & Gutierrez-Lopez, G. F. (2012). El gel de Aloe vera: estructura, composición química, procesamiento, actividad biológica e importancia en la industria farmacéutica y alimentaria. Revista mexicana de ingeniería química, 11(1), 23-43. Dorni, A. C., Amalraj, A., Gopi, S., Varma, K., & Anjana, S. N. (2017). Novel cosmeceuticals from plants—An industry guided review. Journal of applied research on medicinal and aromatic plants, 7, 1-26. Draelos ZD (2018) The science behind skin care: Moisturizers. Journal of Cosmetic Dermatology 17: 138–144. Draelos, Z. D. (2010). Nutrition and enhancing youthful-appearing skin. Clinics in Dermatology, 28(4), 400–408. https://doi.org/10.1016/j.clindermatol.2010.03.019 Draelos, Z. D. (2014). Cosmeceuticals: efficacy and influence on skin tone. Dermatologic clinics, 32(2), 137-143. Driscoll, M. S., Kwon, E. K., Skupsky, H., Kwon, S. Y., & Grant-Kels, J. M. (2010). Nutrition and the deleterious side effects of nutritional supplements. Clinics in Dermatology, 28(4), 371–379. https://doi:10.1016/j.clindermatol.2010.03.023 Dubost NJ, Beelman RB, Royse DJ .(2007). Influence of selected cultural factors and postharvest storage on ergothioneine content of common button mushroom Agaricus bisporus (J. Lge) Imbach (Agaricomycetideae). Int J Med Mushrooms 9:163–176 Dubost, N. J., Beelman, R. B., Peterson, D., & Royse, D. J. (2006). Identification and quantification of ergothioneine in cultivated mushrooms by liquid chromatography-mass spectroscopy. International Journal of Medicinal Mushrooms, 8(3). Dudhgaonkar, S., Thyagarajan, A., & Sliva, D. (2009). Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum. International immunopharmacology, 9(11), 1272-1280. El-Enshasy, H., A. Daba, et al. (2010). Bioprocess development for large scale production of anticancer exo-polysaccharide by Pleurotus ostreatus in submerged culture. Journal of Applied Sciences 10(21): 2523-2529. Elisashvili, V. I., Kachlishvili, E. T., & Wasser, S. P. (2009). Carbon and nitrogen source effects on basidiomycetes exopolysaccharide production. Applied Biochemistry and Microbiology, 45(5), 531-535. El‐Mahdy , M. A., Zhu, Q., Wang, Q. E., Wani, G., Patnaik, S., Zhao, Q., ... & Wani, A. A. (2008). Naringenin protects HaCaT human keratinocytes against UVB‐induced apoptosis and enhances the removal of cyclobutane pyrimidine dimers from the genome. Photochemistry and photobiology, 84(2), 307-316. Elsner, P. (2006). Antimicrobials and the skin physiological and pathological flora. Biofunctional Textiles and the Skin, 33, 35-41. Eltahir, M. E., & Elsayed, M. E. (2019). Adansonia digitata: phytochemical constituents, bioactive compounds, traditional and medicinal uses. In Wild Fruits: Composition, Nutritional Value and Products (pp. 133-142). Springer, Cham. Emer, J. J., Frankel, A., Sohn, A., & Lebwohl, M. (2011). A bilateral comparison study of pimecrolimus cream 1% and a topical medical device cream in the treatment of patients with atopic dermatitis. Journal of drugs in dermatology: JDD, 10(7), 735-743. Esgleyes-Ribot, T., Chandraratna, R. A., Lew-Kaya, D. A., Sefton, J., & Duvic, M. (1994). Response of psoriasis to a new topical retinoid, AGN 190168. Journal of the American Academy of Dermatology, 30(4), 581-590. Faria-Silva, C., Ascenso, A., Costa, A. M., Marto, J., Carvalheiro, M., Ribeiro, H. M., & Simões, S. (2020). Feeding the skin: A new trend in food and cosmetics convergence. Trends in Food Science & Technology, 95, 21-32. Farris, PK (20134). Cosmecéutica y práctica cosmética. cosmética. John Wiley & Sons. Fernandes, M. B. A., Habu, S., De Lima, M. A., Thomaz-Soccol, V., & Soccol, C. R. (2011). Influence of drying methods over in vitro antitumoral effects of exopolysaccharides produced by Agaricus blazei LPB 03 on submerged fermentation. Bioprocess and biosystems engineering, 34(3), 253-261. Ferranti-Ramos, A., Garza-Garza, G., Bátiz-Armenta, J., Martínez-Delgado, G., la Garza- Álvarez, D., Martínez-Menchaca, H. R., & Rivera-Silva, G. (2017). Metaloproteinasas de la matriz extracelular y su participación en el proceso de cicatrización. Medicas UIS, 30(2), 55-62. Ferreira, I. C., Heleno, S. A., Reis, F. S., Stojkovic, D., Queiroz, M. J. R., Vasconcelos, M. H., & Sokovic, M. (2015). Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities. Phytochemistry, 114, 38-55. Ferreira, P. R., Marins, J. C. B., de Oliveira, L. L., Bastos, D. S. S., Júnior, D. T. S., da Silva, C. D., & Fontes, E. A. F. (2020). Beverage based on whey permeate with phenolic extract of jabuticaba peel: A pilot study on effects on muscle and oxidative stress in trained individuals. Journal of Functional Foods, 65, 103749. Finimundy, T. C., Barros, L., Calhelha, R. C., Alves, M. J., Prieto, M. A., Abreu, R. M., ... & Ferreira, I. C. (2018). Multifunctions of Pleurotus sajor-caju (Fr.) Singer: A highly nutritious food and a source for bioactive compounds. Food chemistry, 245, 150-158. Firenzuoli F, Gori L, Lombardo G (2008). The medicinal mushroom Agaricus blazei Murrill: Review of literature and pharmaco- toxicological problems. Evid Based Complement Altern Med 5:3–15 Fisk WA, Agbai O, Lev-Tov HA, and Sivamani RK (2014) The use of botanically derived agents for hyperpigmentation: A systematic review. Journal of the American Academy of Dermatology 70: 352–365. Florez-White M. (2013). Antioxidantes tópicos: su papel en el manejo del fotoenvejecimiento. Más Dermatol; 19:3–4. Fongnzossie, E. F., Tize, Z., Nde, P. F., Biyegue, C. N., Ntsama, I. B., Dibong, S. D., & Nkongmeneck, B. A. (2017). Ethnobotany and pharmacognostic perspective of plant species used as traditional cosmetics and cosmeceuticals among the Gbaya ethnic group in Eastern Cameroon. South African Journal of Botany, 112, 29-39. Fongnzossie, E. F., Tize, Z., Nde, P. F., Biyegue, C. N., Ntsama, I. B., Dibong, S. D., & Nkongmeneck, B. A. (2017). Ethnobotany and pharmacognostic perspective of plant species used as traditional cosmetics and cosmeceuticals among the Gbaya ethnic group in Eastern Cameroon. South African Journal of Botany, 112, 29-39. Friedman, M. (2015). Chemistry, nutrition, and health-promoting properties of Hericium erinaceus (Lion’s Mane) mushroom fruiting bodies and mycelia and their bioactive compounds. Journal of Agricultural and Food Chemistry, 63(32), 7108-7123. Ganceviciene R, Liakou AI, Theodoridis A, Makrantonaki E, and Zouboulis CC. (2012). Skin anti-aging strategies. Dermatoendocrinology 4: 308–319 Gao J-M, Zhang A-L, Chen H, Liu J-K .(2004) .Molecular species of ceramides from the ascomycete truffle Tuber indicum. Chem Phys Lipids 131:205–213 Gao, H., & Gu, W. Y. (2007). Optimization of polysaccharide and ergosterol production from Agaricus brasiliensis by fermentation process. Biochemical Engineering Journal, 33(3), 202- 210. Gao, X. H., Zhang, L., Wei, H., & Chen, H. D. (2008). Efficacy and safety of innovative cosmeceuticals. Clinics in Dermatology, 26(4), 367-374. Gao, Y., Zhou, S., Jiang, W., Huang, M., & Dai, X. (2003). Effects of Ganopoly (A Ganoderma lucidum polysaccharide extract) on the immune functions in Advanced‐Stage cancer patients. Immunological investigations, 32(3), 201-215. Garcés, E. M., Correa, B., Coba, M. O., Zapata, A., Anacona, A., & Sabogal, S. (2003). Morfología y clasificación de los hongos. Univ. Nacional de Colombia. Bogotá. García-Abuín, A., Gómez-Díaz, D., Navaza, J. M., Regueiro, L., & Vidal-Tato, I. (2011). Viscosimetric behaviour of hyaluronic acid in different aqueous solutions. Carbohydrate polymers, 85(3), 500-505. Gąsecka, M., Magdziak, Z., Siwulski, M., & Mleczek, M. (2018). Profile of phenolic and organic acids, antioxidant properties and ergosterol content in cultivated and wild growing species of Agaricus. European Food Research and Technology, 244(2), 259-268. Gasparetto, J. C., Martins, C. A. F., Hayashi, S. S., Otuky, M. F., & Pontarolo, R. (2012). Ethnobotanical and scientific aspects of Malva sylvestris L.: a millennial herbal medicine. Journal of Pharmacy and Pharmacology, 64(2), 172-189. Gautier S, Xhauflaire-Uhoda E, Gonry P, Piérard GE .(2008).Chitin- glucan, a natural cell scaffold for skin moisturization and rejuvenation. Int J Cosmet Sci 30:459–469 Gaya E, Vasco-Palacios AM, Vargas-Estupiñan N, Lücking R, Carretero J, Sanjuan T, Moncada B, Allkin B, Bolaños-Rojas AC, Castellanos-Castro C. et al...(2021) ColFungi: Colombian resources for fungi made accessible. Royal Botanic Gardens, Kew. https://doi.org/10.34885/8yvp-z538 Gohil, K. J., Patel, J. A., & Gajjar, A. K. (2010). Pharmacological review on Centella asiatica: a potential herbal cure-all. Indian journal of pharmaceutical sciences, 72(5), 546. González Matute, R., Figlas, D., & Curvetto, N. (2011). Agaricus blazei production on non- composted substrates based on sunflower seed hulls and spent oyster mushroom substrate. World Journal of Microbiology and Biotechnology, 27(6), 1331-1339. González Minero, F. J., & Bravo Díaz, L. (2017). Historia y actualidad de productos para la piel, cosméticos y fragancias. Especialmente los derivados de las plantas. Ars Pharmaceutica (Internet), 58(1), 5-12 Goufo, P., & Trindade, H. (2014). Rice antioxidants: Phenolic acids, flavonoids, anthocyanins, proanthocyanidins, tocopherols, tocotrienols, γ-oryzanol, and phytic acid. Food Sciences and Nutrition, 2(2), 75–104 Goufo, P., Pereira, J., Moutinho-Pereira, J., Correia, C. M., Figueiredo, N., Carranca, C., ... & Trindade, H. (2014). Rice (Oryza sativa L.) phenolic compounds under elevated carbon dioxide (CO2) concentration. Environmental and Experimental Botany, 99, 28-37. Grimrath, A., Berends, P., Rabe, S., Berger, R. G., & Linke, D. (2011). Koji fermentation based on extracellular peptidases of Flammulina velutipes. European Food Research and Technology, 232(3), 415-424. Gupta, A. K., Gover, M. D., Nouri, K., & Taylor, S. (2006). The treatment of melasma: a review of clinical trials. Journal of the American Academy of Dermatology, 55(6), 1048-1065. Gwon, H. J., Lim, Y. M., Nho, Y. C., & Baik, S. H. (2010). Humectants effect on aqueous fluids absorption of γ-irradiated PVA hydrogel followed by freeze thawing. Radiation Physics and Chemistry, 79(5), 650-653. Harcharik, S., & Emer, J. (2014). Steroid-sparing properties of emollients in dermatology. Skin Therapy Lett, 19(1), 5-10. Hawksworth DL. (2001). The magnitude of fungal diversity: The 1.5 million species estimate revisited. Mycological Research, 105: 1422-1432. Heinrich, U., Neukam, K., Tronnier, H., Sies, H., & Stahl, W. (2006). Long-term ingestion of high flavanol cocoa provides photoprotection against UV-induced erythema and improves skin condition in women. The Journal of nutrition, 136(6), 1565-1569. Hernandez, D. F., Cervantes, E. L., Luna-Vital, D. A., & Mojica, L. (2021). Food-derived bioactive compounds with anti-aging potential for nutricosmetic and cosmeceutical products. Critical Reviews in Food Science and Nutrition, 61(22), 3740-3755. Hosoe, T., Sakai, H., Ichikawa, M., Itabashi, T., Ishizaki, T., & Kawai, K. I. (2007). Lepidepyrone, a new γ-pyrone derivative, from Neolentinus lepideus, inhibits hyaluronidase. The journal of antibiotics, 60(6), 388-390. Hu, Y. N., Sung, T. J., Chou, C. H., Liu, K. L., Hsieh, L. P., & Hsieh, C. W. (2019). Characterization and antioxidant activities of yellow strain Flammulina velutipes (Jinhua mushroom) polysaccharides and their effects on ROS content in L929 cell. Antioxidants, 8(8), 298. Huang, H.-C. y Y.-C. Liu (2008). Enhancement of polysaccharide production by optimization of culture conditions in shake flask submerged cultivation of Grifola umbellata. Journal of the Chinese Institute of Chemical Engineers 39(4): 307-311. Hui, L. I. U. (2012). Comparison of the moisture retention capacity of Tremella polysaccharides and hyaluronic acid. Journal of Anhui Agricultural Sciences, 26. Husein el Hadmed, H., & Castillo, R. F. (2016). Cosmeceuticals: peptides, proteins, and growth factors. Journal of cosmetic dermatology, 15(4), 514-519. Hwang, T. L., Chen, H. Y., Changchien, T. T., Wang, C. C., & Wu, C. M. (2013). The cytotoxicity of mercury chloride to the keratinocytes is associated with metallothionein expression. Biomedical Reports, 1(3), 379-382. Hyde, K. D., Bahkali, A. H., & Moslem, M. A. (2010). Fungi—an unusual source for cosmetics. Fungal diversity, 43(1), 1-9. Ito, T., Kato, M., Tsuchida, H., Harada, E., Niwa, T., & Osawa, T. (2011). Ergothioneine as an anti-oxidative/anti-inflammatory component in several edible mushrooms. Food science and technology research, 17(2), 103-110. Jeong, Y. T., S. C. Jeong, et al. (2010). Antitumor and immunomodulating activities of endo- bioplymers obtained from a submerged culture of Pleurotus eryngii. Food Science and Biotechnology 19: 399-404. Jeong, Y. T., Yang, B. K., Jeong, S. C., Kim, S. M., & Song, C. H. (2008). Ganoderma applanatum: a promising mushroom for antitumor and immunomodulating activity. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 22(5), 614-619. Jiang, Z., Jin, M., Zhou, W., Li, R., Zhao, Y., Jin, X., & Li, G. (2018). Anti-inflammatory activity of chemical constituents isolated from the willow bracket medicinal mushroom Phellinus igniarius (Agaricomycetes). International journal of medicinal mushrooms, 20(2).Journal of Dermatology 46 (1), 48–55. Kalaras, M. D., Richie, J. P., Calcagnotto, A., & Beelman, R. B. (2017). Mushrooms: A rich source of the antioxidants ergothioneine and glutathione. Food chemistry, 233, 429-433. Kamakshi, R. (2012). Fairness via formulations: a review of cosmetic skin-lightening ingredients. Journal of cosmetic science, 63(1), 43-54. Kan, Y., Chen, T., Wu, Y., & Wu, J. (2015). Antioxidant activity of polysaccharide extracted from Ganoderma lucidum using response surface methodology. International journal of biological macromolecules, 72, 151-157. Katayama K, Armendariz-Borunda J, Raghow R, et al. (1993). Un pentapéptido del procolágeno tipo I promueve la producción de matriz extracelular. J Biol Chem 268 (14): 9941-4 Kerdudo, A., Burger, P., Merck, F., Dingas, A., Rolland, Y., Michel, T., & Fernandez, X. (2016). Development of a natural ingredient–Natural preservative: A case study. Comptes Rendus Chimie, 19(9), 1077-1089. Khan, M. A., & Tania, M. (2012). Nutritional and medicinal importance of Pleurotus mushrooms: an overview. Food Reviews International, 28(3), 313–329. Kim, J., Lee, K.W., Lee, H.J.(2011). Chapter 42 – Cocoa (Theobroma cacao) seeds and phytochemicals in human health. Nuts and Seeds in Health and Disease Prevention. pp. 351–360 Kim, K. C., Lee, I. S., Yoo, I. D., & Ha, B. J. (2015). Sesquiterpenes from the fruiting bodies of Ramaria formosa and their human neutrophil elastase inhibitory activity. Chemical and Pharmaceutical Bulletin, 63(7), 554-557. Kim, M., Yoon, H., Kim, Y. E., Kim, Y. J., Kong, W. S., & Kim, J. G. (2014). Comparative analysis of bacterial diversity and communities inhabiting the fairy ring of Tricholoma matsutake by barcoded pyrosequencing. Journal of applied microbiology, 117(3), 699-710. Kim, S. H., Nam, G. W., Kang, B. Y., Lee, H. K., Moon, S. J., & Chang, I. S. (2005). The Effect of Kaempferol, guercetin on Hyaluronan-Synthesis Stimulation in Human Keratinocytes (HaCaT). Journal of the Society of Cosmetic Scientists of Korea, 31(1), 97- 102. Kim, S. W., Hwang, H. J., Lee, B. C., & Yun, J. W. (2007). Submerged production and characterization of Grifola frondosa polysaccharides–a new application to cosmeceuticals. Food Technology and Biotechnology, 45(3), 295-305. Kim, S. Y., Kong, W. S., & Cho, J. Y. (2011). Identification of differentially expressed genes in Flammulina velutipes with anti-tyrosinase activity. Current microbiology, 62(2), 452-457. King'Ori, A. M. (2011). A review of the uses of poultry eggshells and shell membranes. International Journal of Poultry Science, 10(11), 908–912. Kinthali, U., & Shaheen, B. (2021). A complete review on Avena sativa. Journal of Pharmacognosy and Phytochemistry.vol 9 Kligman, A. M. (2005). O que são cosmecêuticos. Cosmecêuticos. Rio de Janeiro: Elsevier, 1-2. Kligman AM. O que são cosmecêuticos. In: Draelos ZD, Dover JS, editors. Cosmecêuticos. Rio de Janeiro: Elsevier; 2005. p. 1–2. Kligman, D. (2000). Cosmeceuticals. Dermatologic clinics, 18(4), 609-615. Kotilainen, T., Tegelberg, R., Julkunen‐tiitto, R. I. I. T. T. A., Lindfors, A., & Aphalo, P. J. (2008). Metabolite specific effects of solar UV‐A and UV‐B on alder and birch leaf phenolics. Global change biology, 14(6), 1294-1304. Kozhemyakina, N. V., E. P. Ananyeva, et al. (2010). Conditions of cultivation, composition, and biological activity of mycelium of Flammulina velutipes (Fr) P Karst. Applied Biochemistry and Microbiology 46: 536-539. Lage R., Mendes C., Abdalla B.M.Z., Arbiser J., Costa A. (2017). Cosmeceutical Ingredients: Botanical and Nonbotanical Sources. In: Issa M., Tamura B. (eds) Daily Routine in Cosmetic Dermatology. Clinical Approaches and Procedures in Cosmetic Dermatology. Springer, Cham. Langholz, O., Röckel, D., Mauch, C., Kozlowska, E., Bank, I., Krieg, T., & Eckes, B. (1995). Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins. The Journal of cell biology, 131(6), 1903-1915. Lee, C. M. (2016). Fifty years of research and development of cosmeceuticals: a contemporary review. Journal of cosmetic dermatology, 15(4), 527-539. Lee, I. S., Ryoo, I. J., Kwon, K. Y., Ahn, J. S., & Yoo, I. D. (2011). Pleurone, a novel human neutrophil elastase inhibitor from the fruiting bodies of the mushroom Pleurotus eryngii var. ferulae. The Journal of Antibiotics, 64(8), 587-589. Lee, J. E., Lee, I. S., Kim, K. C., Yoo, I. D., & Yang, H. M. (2017). ROS scavenging and anti-wrinkle effects of clitocybin a isolated from the mycelium of the mushroom Clitocybe aurantiaca. Journal of microbiology and biotechnology, 27(5), 933-938. Lemus, C., Angelis, A., Halabalaki, M., & Skaltsounis, A. L. (2014). γ-Oryzanol: An attractive bioactive component from rice bran. In Wheat and rice in disease prevention and health (pp. 409-430). Academic Press. Leyden, J. J., Stevens, T., Finkey, M. B., & Barkovic, S. (2002). Skin care benefits of copper peptide containing facial cream. In American Academy of Dermatology 60th Annual Meeting (p. 29). American Academy of Dermatology. Lima, A. T., Santos, M. N., de Souza, L. A., Pinheiro, T. S., Paiva, A. A., Dore, C. M., ... & Leite, E. L. (2016). Chemical characteristics of a heteropolysaccharide from Tylopilus ballouii mushroom and its antioxidant and anti-inflammatory activities. Carbohydrate polymers, 144, 400-409. Lima, L. F. O., Habu, S., Gern, J. C., Nascimento, B. M., Parada, J. L., Noseda, M. D., ... & Soccol, C. R. (2008). Production and characterization of the exopolysaccharides produced by Agaricus brasiliensis in submerged fermentation. Applied biochemistry and biotechnology, 151(2), 283-294. Lin, J. G., Fan, M. J., Tang, N. Y., Yang, J. S., Hsia, T. C., Lin, J. J., ... & Chung, J. G. (2012). An extract of Agaricus blazei Murill administered orally promotes immune responses in murine leukemia BALB/c mice in vivo. Integrative cancer therapies, 11(1), 29-36. Lin, Z., & Deng, A. (2019). Antioxidative and free radical scavenging activity of Ganoderma (Lingzhi). Ganoderma and Health, 271-297. Liu, G. Q., W. J. Han, et al. (2010). Polysaccharides extraction from submerged-cultured mycelium of Grifola frondosa. 2010 International Conference on Bioinformatics and Biomedical Technology. ICBBT 2010: 111-114. Liu, K., Xiao, X., Wang, J., Chen, C. Y. O., & Hu, H. (2017). Polyphenolic composition and antioxidant, antiproliferative, and antimicrobial activities of mushroom Inonotus sanghuang. LWT-food science and technology, 82, 154-161. Londoño Londoño, J. (2012). Antioxidantes: importancia biológica y métodos para medir su actividad. In Desarrollo y transversalidad serie Lasallista Investigación y Ciencia. Corporación Universitaria Lasallista. Lorencini M, Brohem CA, Dieamant GC, Zanchin NIT, and Maibach HI .(2014) .Active ingredients against human epidermal aging. Ageing Research Reviews 15: 100–115 Lourenço A, Lobo AM, Rodríguez B, Jimeno M-L .(1996). Ceramides from the fungus Phellinus pini. Phytochemistry 43:617–620 Lupo, M. L., Cohen, J. L., & Rendon, M. I. (2007). Novel eye cream containing a mixture of human growth factors and cytokines for periorbital skin rejuvenation. Journal of drugs in dermatology: JDD, 6(7), 725-729. Ma, K., Han, J., Bao, L., Wei, T., & Liu, H. (2014). Two sarcoviolins with antioxidative and α-glucosidase inhibitory activity from the edible mushroom Sarcodon leucopus collected in Tibet. Journal of natural products, 77(4), 942-947. Maddin, S., Lauharanta, J., Agache, P., Burrows, L., Zultak, M., & Bulger, L. (2000). Isotretinoin improves the appearance of photodamaged skin: results of a 36-week, multicenter, double-blind, placebo-controlled trial. Journal of the American Academy of Dermatology, 42(1), 56-63. Mancuso JB, Maruthi R, Wang SQ, and Lim HW. (2017). Sunscreens: An update. American Journal of Clinical Dermatology 18: 643–650. Mazzio, E., Badisa, R., Mack, N., Deiab, S., & Soliman, K. F. A. (2014). High throughput screening of natural products for anti‐mitotic effects in MDA‐MB‐231 human breast carcinoma cells. Phytotherapy Research, 28(6), 856-867. McCook JP.(2016). Topical products for the aging face. Clinics in Plastic Surgery 43: 597– 604. McDaniel DH, Mazur C, Wortzman MS, and Nelson DB .(2017). Efficacy and tolerability of a double-conjugated retinoid cream vs 1.0% retinol cream or 0.025% tretinoin cream in subjects with mild to severe photoaging. Journal of Cosmetic Dermatology 16: 542–548. Meng, T. X., Furuta, S., Fukamizu, S., Yamamoto, R., Ishikawa, H., Arung, E. T., ... & Kondo, R. (2011). Evaluation of biological activities of extracts from the fruiting body of Pleurotus citrinopileatus for skin cosmetics. Journal of wood science, 57(5), 452-458. Millikan, L. E. (2000). Adapalene: an update on newer comparative studies between the various retinoids. International journal of dermatology, 39(10), 784-788 Mingarro, D. M., Plaza, A., Galán, A., Vicente, J. A., Martínez, M. P., & Acero, N. (2015). The effect of five Taraxacum species on in vitro and in vivo antioxidant and antiproliferative activity. Food & Function, 6(8), 2787-2793. Mitani, H., Ryu, A., Suzuki, T., Yamashita, M., Arakane, K., Koide, C.(2007). Topical application of plant extracts containing xanthine derivatives can prevent UV-induced wrinkle formation in hairless mice. Photodermatology and Photoimmunology Photomedicine 23 (2), 86–94 Miyake, M., Yamamoto, S., Sano, O., Fujii, M., Kohno, K., Ushio, S., ... & Fukuda, S. (2010). Inhibitory effects of 2-Amino-3 H-phenoxazin-3-one on the melanogenesis of murine B16 melanoma cell line. Bioscience, biotechnology, and biochemistry, 74(4), 753-758. Moreno, M. I., & Moreno, L. H. (2010). Fotoprotección. Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica, 18(1), 31-39. Mueller, G. M., & Schmit, J. P. (2007). Fungal biodiversity: what do we know? What can we predict? Biodiversity and conservation, 16(1), 1-5. Mukherjee, P. K., Maity, N., Nema, N. K., & Sarkar, B. K. (2011). Bioactive compounds from natural resources against skin aging. Phytomedicine, 19(1), 64-73. Nabors, M. (2005).Introduccion a la botanica.Pearson Education .ISBN 8478290737, 9788478290734 Nakagawa, M., Kawai, K., & Kawai, K. (1995). Contact allergy to kojic acid in skin care products. Contact dermatitis, 32(1), 9-13 Nakamura, K. (2006). Bottle cultivation of culinary-medicinal Bunashimeji mushroom Hypsizygus marmoreus (Peck) bigel.(Agaricomycetideae) in Nagano Prefecture (Japan). International Journal of Medicinal Mushrooms, 8(2). Nan, W., Zhaoqing, Z., Yuexuan, Y., Hua, Z., Jinhao, W., & Ang, L. (2016). Evaluation for Whitening Efficacy of Cosmetics Containning Extract from Tricholoma Matsutake Sing. Ngai, P. H., & Ng, T. B. (2004). A ribonuclease with antimicrobial, antimitogenic and antiproliferative activities from the edible mushroom Pleurotus sajor-caju. Peptides, 25(1), 11-17. Nguyen, T. L., Chen, J., Hu, Y., Wang, D., Fan, Y., Wang, J., ... & Dang, B. K. (2012). In vitro antiviral activity of sulfated Auricularia auricula polysaccharides. Carbohydrate polymers, 90(3), 1254-1258. Novak, A. C., Sydney, E. B., & Soccol, C. R. (2014). Biocosmetics. In Biotransformation of waste biomass into high value biochemicals (pp. 389-411). Springer, New York, NY. Ohiri, R. C., & Bassey, E. E. (2017). Evaluation and characterization of nutritive properties of the jelly ear culinary-medicinal mushroom Auricularia auricula-judae (Agaricomycetes) from Nigeria. International Journal of Medicinal Mushrooms, 19(2). Onar, H. C., Yusufoglu, A., Turker, G., & Yanardag, R. (2012). Elastase, tyrosinase and lipoxygenase inhibition and antioxidant activity of an aqueous extract from Epilobium angustifolium L. leaves. Journal of Medicinal Plants Research, 6(5), 716-726. Orjuela Rodriguez, A. A. (2015). Determinación de actividad antioxidante de extractos y fracciones de hojas de Chromolaena perglabra (BL Robinson) RM King y H. Robinson . (Tesis de Pregrado), Universidad de Ciencias Aplicadas y Ambientales U.D.C.A Oumeish, O. Y. (2001). The cultural and philosophical concepts of cosmetics in beauty and art through the medical history of mankind. Clinics in dermatology, 19(4), 375-386 Padilha, M. M., Avila, A. A., Sousa, P. J., Cardoso, L. G. V., Perazzo, F. F., & Carvalho, J. C. T. (2009). Anti-inflammatory activity of aqueous and alkaline extracts from mushrooms (Agaricus blazei Murill). Journal of medicinal food, 12(2), 359-364. Palacios, I., Lozano, M., Moro, C., D’arrigo, M., Rostagno, M. A., Martínez, J. A., ... & Villares, A. (2011). Antioxidant properties of phenolic compounds occurring in edible mushrooms. Food Chemistry, 128(3), 674-678. Papaspyridi, L.-M., N. Aligiannis, et al. (2011). Production of bioactive metabolites with pharmaceutical and nutraceutical interest by submerged fermentation of Pleurotus ostreatus in a batch stirred tank bioreactor. Procedia Food Science 1(0): 1746-1752. Park, H. S., Hwang, Y. H., Kim, M. K., Hong, G. E., Lee, H. J., Nagappan, A., ... & Kim, G. S. (2015). Functional polysaccharides from Grifola frondosa aqueous extract inhibit atopic dermatitis-like skin lesions in NC/Nga mice. Bioscience, biotechnology, and biochemistry, 79(1), 147-154. Park, K. M., Kwon, K. M., & Lee, S. H. (2015). Evaluation of the antioxidant activities and tyrosinase inhibitory property from mycelium culture extracts. Evidence-based complementary and alternative medicine, 2015. Peixoto, F. M., Borguini, R. G., Machado, A. M. R., Gôuvea, A. C. M. S., Pacheco, S., & Godoy, R. D. O. (2013). Teor de carotenoides em nutricosméticos: análise da adequação e qualidade do produto. Embrapa Agroindústria de Alimentos-Artigo em periódico indexado (ALICE). Pillaiyar T, Namasivayam V, Manickam M, and Jung S-H (2018) Inhibitors of Melanogenesis: An updated review. Journal of Medicinal Chemistry 61: 7395–7418. Piwowarski, J. P., Kiss, A. K., & Kozłowska-Wojciechowska, M. (2011). Anti-hyaluronidase and anti-elastase activity screening of tannin-rich plant materials used in traditional Polish medicine for external treatment of diseases with inflammatory background. Journal of Ethnopharmacology, 137(1), 937-941. Plensdorf S .(2017). Pigmentation disorders: Diagnosis and management. American Family Physician 96(12): 797–804. Pontón, J. (2008). La pared celular de los hongos y el mecanismo de acción de la anidulafungina. Revista Iberoamericana de Micología, 25(2), 78-82. Pullar JM, Carr AC, and Vissers MCM (2017) The roles of vitamin C in skin health. Nutrients 9: 866. Puttaraju, N. G., Venkateshaiah, S. U., Dharmesh, S. M., Urs, S. M. N., & Somasundaram, R. (2006). Antioxidant activity of indigenous edible mushrooms. Journal of agricultural and food chemistry, 54(26), 9764-9772. Queiroz, L. S., Nascimento, M. S., Cruz, A. K., Castro, A. J., Maria de Fátima, V. M., Baseia, I. G., & Leite, E. L. (2010). Glucans from the Caripia montagnei mushroom present anti- inflammatory activity. International immunopharmacology, 10(1), 34-42. Rahul, J., Jain, MK, Singh, SP, Kamal, RK, Naz, A., Gupta, AK y Mrityunjay, SK (2015). Adansonia digitata L. (baobab): una revisión de la información tradicional y la descripción taxonómica. Asian Pacific Journal of Tropical Biomedicine , 5 (1), 79-84. Rajan, P., & Grimes, P. E. (2002). Skin barrier changes induced by aluminum oxide and sodium chloride microdermabrasion. Dermatologic surgery, 28(5), 390-393. Ramos, G. I. C., & Pérez, D. A. (2010). Antioxidantes en dermatología. Dermatología Cosmética, Médica y Quirúrgica, 8(4), 272-277. Rangel, J. O. (2005). La biodiversidad de Colombia. Palimpsestvs, 5, 292-304. https://revistas.unal.edu.co/index. php/palimpsestvs/article/view/8083 Razavi, S. M., Zarrini, G., Molavi, G., & Ghasemi, G. (2011). Bioactivity of Malva sylvestris L., a medicinal plant from Iran. Iranian journal of basic medical sciences, 14(6), 574. Rendon, M., Berneburg, M., Arellano, I., & Picardo, M. (2006). Treatment of melasma. Journal of the American Academy of Dermatology, 54(5), S272-S281. Reynolds, T. (1985). The compounds in Aloe leaf exudates: A review. Botanical Journal of the Linnean Society 90, 157-177. Reynolds, T. (Ed.). (2004). Aloes: the genus Aloe. CRC press. Ribeiro, A. P. D., Andrade, M. C., Bagnato, V. S., Vergani, C. E., Primo, F. L., Tedesco, A. C., & Pavarina, A. C. (2015). Antimicrobial photodynamic therapy against pathogenic bacterial suspensions and biofilms using chloro-aluminum phthalocyanine encapsulated in nanoemulsions. Lasers in medical science, 30(2), 549-559. Rivers, J. K. (2008). The role of cosmeceuticals in antiaging therapy. Skin Therapy Lett, 13(8), 5-9. Rodan K, Fields K, Majewski G, and Falla T (2016) Skincare bootcamp. Plastic and Reconstructive Surgery – Global Open 4: e1152. Rojas, T., Cortés, C., Noguera, M., Rojas, N., Cely, M., Garzón, C., ... & Velandia, G. (2020).Diagnóstico de experiencias locales de bioproductos y negocios verdes en comunidades locales ubicadas en zonas con alto valor ecológico y frentes de deforestación: Contribuciones de la Naturaleza y Bienestar. Romana-Souza B, Silva-Xavier W, and Monte-Alto-Costa A .(2018). Topical retinol attenuates stress-induced ageing signs in human skin ex vivo, throughEGFR activation viaEGF, but notERK andAP-1 activation. Experimental Dermatology. Epub ahead of print. Ruthes, A. C., Carbonero, E. R., Córdova, M. M., Baggio, C. H., Sassaki, G. L., Gorin, P. A. J., & Iacomini, M. (2013). Fucomannogalactan and glucan from mushroom Amanita muscaria: Structure and inflammatory pain inhibition. Carbohydrate polymers, 98(1), 761- 769. Salud, M. (2020). Análisis de las tres capas de la piel: estructura y funciones - Meditip. Retrieved 22 May 2020, from https://www.meditip.lat/el-cuerpo-humano/tres-capas-de-la- piel/ Samyor, D., Deka, S. C., & Das, A. B. (2016). Phytochemical and antioxidant profile of pigmented and non-pigmented rice cultivars of Arunachal Pradesh, India. International Journal of Food Properties, 19, 1104–1114. Sandargo, B., Chepkirui, C., Cheng, T., Chaverra-Muñoz, L., Thongbai, B., Stadler, M., & Hüttel, S. (2019). Biological and chemical diversity go hand in hand: Basidiomycota as source of new pharmaceuticals and agrochemicals. Biotechnology advances, 37(6), 107344. Sarmiento, C. R., Gómez-Montoya, N., Zora-Vergara, B., Benjumea-Aristizabal, C., Santa- Santa, D. J., Zuluaga-Moreno, M., & Franco-Molano, A. E. (2022). Diversidad de macrohongos (Basidiomycota) de Colombia: Listado de especies. Actualidades Biológicas, 44(116). Serna, J., Vitales, M., López, M. C., & Molina, A. (2002). 4. Dermatología. Sevinsky, R. E., Stewart, D. W., & Harirforoosh, S. (2017). Nonsteroidal anti-inflammatory drugs: Is there a link between cardiovascular and renal adverse effects?. Journal of Integrative Nephrology and Andrology, 4(1), 1. Shaheen, F., Rasoola, S., Shah, Z.A., Soomro, S., Jabeen, A., Mesaik, M.A., Choudhary, M.I. (2014). Chemical constituents of Marrubium vulgare as potential inhibitors of nitric oxide and respiratory burst. Natural Product Communications 9 (7), 903–906. Shin, Y. J., & Lee, S. C. (2014). Antioxidant activity and β-glucan contents of hydrothermal extracts from maitake (Grifola frondosa). Food Science and Biotechnology, 23(1), 277-282. Shu, C. H., Lin, K. J., & Wen, B. J. (2007). Effects of culture temperature on the production of bioactive polysaccharides by Agaricus blazei in batch cultures. Journal of Chemical Technology & Biotechnology: International Research in Process, Environmental & Clean Technology, 82(9), 831-836. Siriamornpun, S., Kaisoon, O., & Meeso, N. (2012). Changes in colour, antioxidant activities and carotenoids (lycopene, β-carotene, lutein) of marigold flower (Tagetes erecta L.) resulting from different drying processes. Journal of Functional Foods, 4(4), 757-766. Skorek, M., Jurczyk, K., Sajewicz, M., & Kowalska, T. (2016). Thin-layer chromatographic identification of flavonoids and phenolic acids contained in cosmetic raw materials. Journal of Liquid Chromatography & Related Technologies, 39(5-6), 286-291. Slade, H. B., Fowler, J., Draelos, Z. D., Reece, B. T., & Cargill, D. I. (2008). Clinical efficacy evaluation of a novel barrier protection cream. Cutis, 82(4), 21-28. Slominski, A., Wortsman, J., Paus, R., Elias, P. M., Tobin, D. J., & Feingold, K. R. (2008). Skin as an endocrine organ: implications for its function. Drug Discovery Today: Disease Mechanisms, 5(2), e137-e144. Sorg, O., Antille, C., Kaya, G., & Saurat, J. H. (2006). Retinoids in cosmeceuticals. Dermatologic Therapy, 19(5), 289-296. Souilem, F., Fernandes, Â., Calhelha, R. C., Barreira, J. C., Barros, L., Skhiri, F., ... & Ferreira, I. C. (2017). Wild mushrooms and their mycelia as sources of bioactive compounds: Antioxidant, anti-inflammatory and cytotoxic properties. Food chemistry, 230, 40-48. Southall, M., Pappas, A., Suhyoun, C., (2014). Oat (Avena sativa) oil activates the PPAR? and PPAR β/δ pathways, resulting in keratinocyte differentiation and upregulation of ceramide synthesis. Journal of the American Academy of Dermatology 70 (5), AB64 (Sul.1). Souyoul SA, Saussy KP, and Lupo MP. (2018). Nutraceuticals: A review. Dermatology and Therapy 8: 5–16. Sridhar, K. R., & Deshmukh, S. K. (Eds.). (2019). Advances in Macrofungi: Diversity, Ecology and Biotechnology. CRC Press. Stahl, W., & Sies, H. (2005). Bioactivity and protective effects of natural carotenoids. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1740(2), 101-107. Suárez .A. & Nieto. R. (2012). Utilización de la fermentación líquida de Lentinula edodes (shiitake), para la producción de metabolitos secundarios bioactivos y evaluación de su potencial empleo en la producción de un alimento funcional. Instituto de Ciencia y Tecnología de Alimentos (ICTA). Sun, S., Zhang, X., Sun, S., Zhang, L., Shan, S., & Zhu, H. (2016). Production of natural melanin by Auricularia auricula and study on its molecular structure. Food Chemistry, 190, 801-807. Tada, R., Y. Adachi, et al. (2009). An unambiguous structural elucidation of a 1,3-β-dglucan obtained from liquid-cultured Grifola frondosa by solution NMR experiments. Carbohydrate Research 344(3): 400-404. Talbourdet, S., Sadick, N.S., Lazou, K., Bonnet-Duguennoy, M., Kurfurst, R., Neveu, M.,Heusele, C., Andre, P., Schnebert, S., Draelos, Z.D., Perrier, E. (, 2007). Modulation of gene expression as a new skin anti-ageing strategy. Journal Drugs and Dermatology 6(Suppl. 6), S25–33 Tamrakar, S., Nishida, M., Amen, Y., Tran, H. B., Suhara, H., Fukami, K., ... & Shimizu, K. (2017). Antibacterial activity of Nepalese wild mushrooms against Staphylococcus aureus and Propionibacterium acnes. Journal of Wood Science, 63(4), 379-387. Taofiq, O., Calhelha, R. C., Heleno, S., Barros, L., Martins, A., Santos-Buelga, C., ... & Ferreira, I. C. (2015). The contribution of phenolic acids to the anti-inflammatory activity of mushrooms: Screening in phenolic extracts, individual parent molecules and synthesized glucuronated and methylated derivatives. Food Research International, 76, 821-827. Taofiq, O., González-Paramás, A.M., Martins, A., Barreiro, M.F. and Ferreira, I.C.F.R. (2016a). Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics—A review. Ind. Crops Prod., 90: 38–48. Taofiq, O., Heleno, S. A., Calhelha, R. C., Alves, M. J., Barros, L., Barreiro, M. F., ... & Ferreira, I. C. (2016b). Development of mushroom-based cosmeceutical formulations with anti-inflammatory, anti-tyrosinase, antioxidant, and antibacterial properties. Molecules, 21(10), 1372. Taofiq, O., Heleno, S.A., Calhelha, R.C., Alves, M.J., Barros, L., Gonzalez-Paramas, A.M., Barreiro, M.F. and Ferreira, I.C.F.R. (2017). The potential of Ganoderma lucidum extracts as bioactive ingredients in topical formulations, beyond its nutritional benefits. Food Chem. Toxicol., 108: 139–147. Taofiq, O., Martins, A., Barreiro, M. F., & Ferreira, I. C. (2016c). Anti-inflammatory potential of mushroom extracts and isolated metabolites. Trends in Food Science & Technology, 50, 193-210. Tepwong, P., Giri, A., & Ohshima, T. (2012). Effect of mycelial morphology on ergothioneine production during liquid fermentation of Lentinula edodes. Mycoscience, 53(2), 102-112. Thomas JRRegan JT, Dixon TK, and Bhattacharyya TK. (2013). Effects of Topicals on the aging skin process. Facial Plastic Surgery Clinics of North America 21: 55–60. Tontowiputro, D. K., Sargowo, D., Tjokroprawiro, A., & Rifa’i, M. (2018). Anti-inflammatory activity of Agaricus blazei Murill extract in the spleen of mice fed a high-fat diet. Tropical Journal of Pharmaceutical Research, 17(3), 483-489. Torres, KLQ, Suzuki, V., Fanaro, GB, de Oliveira, AF, Leite, JATM, Namur, CRM, ... & Ferreira, LM (2020). ¿licopeno y fotoprotección?. Avances en Ciencias Nutricionales , 1 (1), 80-88. Tuna, D., Udvarhelyi, A., Sobolewski, A. L., Domcke, W., & Domratcheva, T. (2016). Onset of the electronic absorption spectra of isolated and π-stacked oligomers of 5, 6- dihydroxyindole: An ab initio study of the building blocks of eumelanin. The Journal of Physical Chemistry B, 120(14), 3493-3502. Turło, J., B. Gutkowska, et al. (2010). Effect of selenium enrichment on antioxidant activities and chemical composition of Lentinula edodes (Berk.) Pegl. mycelial extracts. Food and Chemical Toxicology 48(4): 1085-1091. Usman, M., Murtaza, G., & Ditta, A. (2021). Nutritional, medicinal, and cosmetic value of bioactive compounds in button mushroom (Agaricus bisporus): a review. Applied Sciences, 11(13), 5943. Uter, W., Benz, M., Mayr, A., Gefeller, O., & Pfahlberg, A. (2013). Assessing skin pigmentation in epidemiological studies: The reliability of measurements under different conditions. Skin Research and Technology, 19(2), 100-106. Valenzuela, A., & Nieto, S. (1996). Synthetic and natural antioxidants: food quality protectors. Grasas y aceites. Vasco-Palacios, A. M., & Franco-Molano, A. E. (2013). Diversity of Colombian macrofungi (Ascomycota-Basidiomycota). Mycotaxon, 121(1), 100-158. Verma, D. K., & Srivastav, P. P. (2020). Bioactive compounds of rice (Oryza sativa L.): review on paradigm and its potential benefit in human health. Trends in Food Science & Technology, 97, 355-365. Vozmediano, J. M. F., & Hita, J. C. A. (2003). Retinoids in Dermatology. Medicina Cutánea Ibero-Latino-Americana, 31(5), 271-294. Wasser, S.P. (2010). Medicinal mushroom science: History, current status, future trends, and unsolved problems. Int. J. Med. Mushrooms, 12: 1–16. Wasser, S.P. and Weiss, A.L. (1999). Therapeutic effects of substances occurring in higher Basidiomycetes mushrooms: A modern perspective. Crit. Rev. Immunol., 19: 65–96. Wei, J., Guo, W. H., Cao, C. Y., Kou, R. W., Xu, Y. Z., Górecki, M., ... & Gao, J. M. (2018). Polyoxygenated cyathane diterpenoids from the mushroom Cyathus africanus, and their neurotrophic and anti-neuroinflammatory activities. Scientific reports, 8(1), 1-15. Witkowski, J. A., & Parish, L. C. (2001). You’ve come a long way baby: a history of cosmetic lead toxicity. Clinics in dermatology, 19(4), 367-370. Wu, C. Y., J. L. Mau, et al. (2008). The influence of cultivation conditions on mycelial growth and exopolysaccharide production of culinary-medicinal mushroom Pleurotus citrinopileatus singer (Agaricomycetideae). International Journal of Medicinal Mushrooms 10(279-292): 279. Wu, X., Guan, W., Yan, R., Lei, J., Xu, L., & Wang, Z. (2016a). Effects of UV-C on antioxidant activity, total phenolics and main phenolic compounds of the melanin biosynthesis pathway in different tissues of button mushroom. Postharvest Biology and Technology, 118, 51-58. Wu, Y., Choi, M. H., Li, J., Yang, H., & Shin, H. J. (2016b). Mushroom cosmetics: the present and future. Cosmetics, 3(3), 22. Xu, G. H., Kim, Y. H., Choo, S. J., Ryoo, I. J., Zheng, C. J., Seok, S. J., ... & Yoo, I. D. (2009). Isodeoxyhelicobasidin, a novel human neutrophil elastase inhibitor from the culture broth of Volvariella bombycina. The Journal of Antibiotics, 62(6), 333-334. Yahaya, Y. A., & Don, M. M. (2012). Evaluation of Trametes lactinea extracts on the inhibition of hyaluronidase, lipoxygenase and xanthine oxidase activities in vitro. Journal of Physical Science, 23(2), 1-15. Yan, Z. F., Yang, Y., Tian, F. H., Mao, X. X., Li, Y., & Li, C. T. (2014). Inhibitory and acceleratory effects of Inonotus obliquus on tyrosinase activity and melanin formation in B16 melanoma cells. Evidence-Based Complementary and Alternative Medicine, 2014. Yoon, K. N., Alam, N., Lee, J. S., Cho, H. J., Kim, H. Y., Shim, M. J., ... & Lee, T. S. (2011). Antihyperlipidemic effect of dietary Lentinus edodes on plasma, feces and hepatic tissues in hypercholesterolemic rats. Mycobiology, 39(2), 96-102. Zhang S and Duan E. (2018). Fighting against Skin Aging. Cell Transplantation 27: 729– 738.
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spelling	Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Nieto Ramirez, Ivonne Jeannette5883b07c5c8f3fb634e2929296d3bc45Fuquene Bustos, Guinnet Paolaf555aeb87a9564443f7c8876a6da57e7Química de Hongos Macromicetos Colombianos2022-08-04T15:03:55Z2022-08-04T15:03:55Z2022-08-01https://repositorio.unal.edu.co/handle/unal/81780Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/En los últimos años, las sociedades modernas se han vuelto más conscientes de los tratamientos “naturales”, lo que ha promovido el desarrollo de nuevos productos provenientes de fuentes naturales, a lo que no ha sido ajena la industria cosmética. El empleo de los biocompuestos en las formulaciones cosméticas ha permitido la aparición de los denominados “biocosméticos”, término que engloba a dos grupos de especial importancia que son los cosmeceúticos y los nutricosmeceúticos. La fuente tradicional y más estudiada para la búsqueda de bioactivos son las plantas, pero el empleo de este recurso natural tiene limitaciones como son crecimiento lento y variación apreciable en elcontenido y clase de sus bioactivos, particularidad no deseada en la producción de biocosméticos. Los macrohongos biosintetizan compuestos similares y, en algunas ocasiones, estructuralmente diferentes a los procedentes de las plantas y es esta fuentenatural poco explotada la que puede posicionarse como una promisoria alternativa para la obtención de bioactivos, con la ventaja de que pueden cultivarse rápidamente y de manera rentable, mediante la aplicación de procesos biotecnológicos como la Fermentación en Estado Líquido, convirtiéndose en una opción más sustentable. El objetivo de esta monografía es la recopilación exhaustiva de información que proporcione una visión actualizada del empleo de los productos naturales como ingredientes en la formulación de biocosméticos y evidenciar el potencial que los macrohongos exhiben en este campo. Esta revisión se convertirá en el soporte teórico para la creación de una nueva línea de investigación en el grupo Química de Hongos Macromicetos Colombianos. (Texto tomado de la fuente)In recent years, modern societies have become more aware of "natural" treatments, which has promoted the development of new products from natural sources and the cosmetic industry has been no stranger to this. The use of biocompounds in cosmetic formulationshas led to the emergence of the so-called "biocosmetics", a term that encompasses two groups of particular importance: cosmeceuticals and nutricosmeceuticals. The traditional and most studied source for the search of bioactives are plants,however the use of this natural resource has limitations such as slow growth and appreciable variation in the content and class of its bioactives, a particularity not desired in the production of biocosmetics. Macrofungi biosynthesize similar compounds and in some occasions, structurally different to those coming from plants and it is this little exploited natural source that can be positioned as a promising alternative for obtaining bioactives. It has the advantage that they can be cultivated quickly and in a profitable way,through the application of biotechnological processes such as Liquid State Fermentation, becoming a more sustainable option. The objective of this monograph is the exhaustive compilation of information that provides an updated vision of the use of natural products as ingredients in the formulation of biocosmetics and evidences the potential that macrofungi exhibit in this field. This review will become the theoretical support for the creation of a new line of research in the Chemistry of Colombian Macromycetes Fungi group.MaestríaMagister en ciencias quimicasapplication/pdfspa540 - Química y ciencias afinesCosmeceuticoNutricosmeceuticoMacromicetosFermentación en estado liquidoNutricosmeceuticCosmeceuticmacromycetesliquid state fermentationHongos Macromicetos: biofábricas alternativas de compuestos con potencial de aplicación en cosmecéutica y nutricosmecéuticaMacromycetes fungi: alternative biofactories of compounds with potential application in cosmeceuticals and nutricosmeceuticalsTrabajo de grado - MaestríaTexthttp://purl.org/redcol/resource_type/TMBogotá - Ciencias - Maestría en Ciencias - QuímicaDepartamento de QuímicaFacultad de CienciasUniversidad Nacional de Colombia - Sede BogotáAbd Razak, D. L., Fadzil, N. H. M., Jamaluddin, A., Abd Rashid, N. Y., Sani, N. A., & Manan, M. A. (2019). Effects of different extracting conditions on anti-tyrosinase and antioxidant activities of Schizophyllum commune fruit bodies. Biocatalysis and agricultural biotechnology, 19, 101116.Abreu, H., Simas, F. F., Smiderle, F. R., Sovrani, V., Dallazen, J. L., Maria-Ferreira, D., ... & Iacomini, M. (2019). Gelling functional property, anti-inflammatory and antinociceptive bioactivities of β-D-glucan from the edible mushroom Pholiota nameko. International journal of biological macromolecules, 122, 1128-1135.Addor FAS .(2017). Antioxidants in dermatology. Anais Brasileiros de Dermatología 92: 356–362.Ademola, I. O., & Odeniran, P. O. (2017). Novel trypanocide from an extract of Pleurotus sajor-caju against Trypanosoma congolense. Pharmaceutical Biology, 55(1), 132-138.Agati, G., Galardi, C., Gravano, E., Romani, A., & Tattini, M. (2002). Flavonoid Distribution in Tissues of Phillyrea latifolia L. Leaves as Estimated by Microspectrofluorometry and Multispectral Fluorescence Microimaging. Photochemistry and Photobiology, 76(3), 350- 360.Ahmad, R., Riaz, M., Khan, A., Aljamea, A., Algheryafi, M., Sewaket, D., & Alqathama, A. (2021). Ganoderma lucidum (Reishi) an edible mushroom; a comprehensive and critical review of its nutritional, cosmeceutical, mycochemical, pharmacological, clinical, and toxicological properties. Phytotherapy Research, 35(11), 6030-6062.Ajose, F.O.,( 2007). Some nigerian plants of dermatologic importance. International.Alam, N., Yoon, K. N., & Lee, T. S. (2011). Evaluation of the antioxidant and antityrosinase activities of three extracts from Pleurotus nebrodensis fruiting bodies. African Journal of Biotechnology, 10(15), 2978-2986.Alam, N., Yoon, K. N., Lee, J. S., Cho, H. J., & Lee, T. S. (2012). Consequence of the antioxidant activities and tyrosinase inhibitory effects of various extracts from the fruiting bodies of Pleurotus ferulae. Saudi journal of biological sciences, 19(1), 111-118.Alam, N., Yoon, K. N., Lee, K. R., Shin, P. G., Cheong, J. C., Yoo, Y. B., ... & Lee, T. S. (2010). Antioxidant activities and tyrosinase inhibitory effects of different extracts from Pleurotus ostreatus fruiting bodies. Mycobiology, 38(4), 295-301.Ali, N., & Hadi, F. (2015). Phytoremediation of cadmium improved with the high production of endogenous phenolics and free proline contents in Parthenium hysterophorus plant treated exogenously with plant growth regulator and chelating agent. Environmental Science and Pollution Research, 22(17), 13305-13318.Almeida, I. F., & Bahia, M. F. (2006). Evaluation of the physical stability of two oleogels. International journal of pharmaceutics, 327(1-2), 73-77.Al-Niaimi F and Chiang NYZ (2017) Topical vitamin C and the skin: Mechanisms of action and clinical applications. The Journal of Clinical and Aesthetic Dermatology 10: 14–17.Alsterholm, M., Karami, N., & Faergemann, J. (2010). Antimicrobial activity of topical skin pharmaceuticals—an in vitro study. Acta dermato-venereologica, 90(3), 239.Alves, M. J., Ferreira, I. C., Dias, J., Teixeira, V., Martins, A., & Pintado, M. (2012). A review on antimicrobial activity of mushroom (Basidiomycetes) extracts and isolated compounds. Planta medica, 78(16), 1707-1718.Amer, M., & Maged, M. (2009). Cosmeceuticals versus pharmaceuticals. Clinics in dermatology, 27(5), 428-430.An, S. M., Kim, H. J., Kim, J. E., & Boo, Y. C. (2008). Flavonoids, taxifolin and luteolin attenuate cellular melanogenesis despite increasing tyrosinase protein levels. Phytotherapy Research, 22(9), 1200-1207.André P, Haneke E, Marini L, and Rowland-Payne C .(2016). Cosmetic medicine and surgery. CRC Press.Antille, C., Tran, C., Sorg, O., Carraux, P., Didierjean, L., & Saurat, J. H. (2003). Vitamin A exerts a photoprotective action in skin by absorbing ultraviolet B radiation. Journal of Investigative Dermatology, 121(5), 1163-1167.Anunciato, T. P., & da Rocha Filho, P. A. (2012). Carotenoids and polyphenols in nutricosmetics, nutraceuticals, and cosmeceuticals. Journal of cosmetic dermatology, 11(1), 51-54.Appendino, G., Scafati, O.T., Romano, A., Pollastro, F., Avonoto, C., Rubiolo, P., (2009). Genepolide, a sesquiterpene gamma lactone with a novel carbon skeleton from mountain wormwood (Artemisia umbelliformis L.). Journal of Natural Products 72 (3), 340–344.Archana, G., Sabina, K., Babuskin, S., Radhakrishnan, K., Fayidh, M. A., Babu, P. A. S., ... & Sukumar, M. (2013). Preparation and characterization of mucilage polysaccharide for biomedical applications. Carbohydrate polymers, 98(1), 89-94.Arct, J., & Pytkowska, K. (2008). Flavonoids as components of biologically active cosmeceuticals. Clinics in dermatology, 26(4), 347-357.Arenas Guzmán . (2014). Micología médica ilustrada.5ta ilustrada. 5ta edición. McGraw- Hill. ISBN 9786071511256Ascenso, A., Pedrosa, T., Pinho, S., Pinho, F., Oliveira, J. M. P., Cabral Marques, H., ... & Santos, C. (2016). The effect of lycopene preexposure on UV-B-irradiated human keratinocytes. Oxidative Medicine and Cellular Longevity.Asserin, J., Lati, E., Shioya, T., & Prawitt, J. (2015). The effects of oral collagen peptide supplementation onskin moisture and the dermal collagen network:Evidence from an ex vivo model and randomized,placebo‐controlled clinical trials. Journal of Cosmetic Dermatology, 14,291–301. https://doi.org/10.1111/jocd.12174Avila Rodriguez, M. I., Rodriguez Barroso, L. G., & Sanchez, M. L. (2018). Collagen: A review on its sources and potential cosmetic applications. Journal of Cosmetic Dermatology, 17(1), 20–26. https://doi.org/10.1111/jocd.12450.Ayele, Y., Kim, J.A., Park, E., Kim, Y.J., Retta, N., Dessie, G., Rhee, S.K., Koh, K., Nam, K.W., Kim, H.S.(2013). A methanol extract of Adansonia digitate L. leaves inhibits proinflammatory iNOS possibly via the inhibition of NF-kB activation. Biomolecular Therapeutics (Seoul) 21 (2), 146–152Aytar, E. C., Akata, İ., & Leyla, A. Ç. I. K. (2020). Antioxidant and Antimicrobial Activities of Armillaria Mellea and Macrolepiota Procera Extracts. Mantar Dergisi, 11(2), 121-128.Baba, E., Uluköy, G., & Öntaş, C. (2015). Effects of feed supplemented with Lentinula edodes mushroom extract on the immune response of rainbow trout, Oncorhynchus mykiss, and disease resistance against Lactococcus garvieae. Aquaculture, 448, 476-482.Bach, F., Helm, C., P, A., Stafussa, A., Maciel, G., & Haminiuk, C. (2018). Atividade antioxidante e antimicrobiana do extrato de Lentinula edodes. In Embrapa Florestas-Artigo em anais de congresso (ALICE). In: congresso sul brasileiro de engenharia de alimentos, 4.; encontro paranaense de engenharia de alimentos.Badalyan, S. M. (2020). Medicinal coprinoid mushrooms (Agaricomycetes) distributed in Armenia. International Journal of Medicinal Mushrooms, 22(3).Bae, J. T., Sim, G. S., Lee, D. H., Lee, B. C., Pyo, H. B., Choe, T. B., & Yun, J. W. (2005). Production of exopolysaccharide from mycelial culture of Grifola frondosa and its inhibitory effect on matrix metalloproteinase-1 expression in UV-irradiated human dermal fibroblasts. FEMS Microbiology Letters, 251(2), 347-354.Baker LA, Marchetti B, Karsili TNVV, Stavros VG, and Ashfold MNRR. (2017). Photoprotection: Extending lessons learned from studying natural sunscreens to the design of artificial sunscreen constituents. Chemical Society Reviews 46: 3770–3791.Balupillai, A., Prasad, R. N., Ramasamy, K., Muthusamy, G., Shanmugham, M., Govindasamy, K., & Gunaseelan, S. (2015). Caffeic acid inhibits UVB‐induced inflammation and photocarcinogenesis through activation of peroxisome proliferator‐activated receptor‐γ in mouse skin. Photochemistry and Photobiology, 91(6), 1458-1468.Bandara, A. R., Rapior, S., Bhat, D. J., Kakumyan, P., Chamyuang, S., Xu, J., & Hyde, K. D. (2015). Polyporus umbellatus, an edible-medicinal cultivated mushroom with multiple developed health-care products as food, medicine and cosmetics: a review. Cryptogamie, Mycologie, 36(1), 3-42.Barnes, H. A. (2000). A handbook of elementary rheology (Vol. 1). Aberystwyth: University of Wales, Institute of Non-Newtonian Fluid Mechanics.Barquet, A. P., Funck, A. P. G., & Koester, L. S. (2006). Comparação entre alfa- hidroxiácidos e poli-hidroxiácidos na cosmiatria e dermatologia. Rev. Bras. Farm, 87(3), 67- 73.Barreira, J.C.M., Visnevschi-Necrasov, T., Nunes, E., Cunha, S.C., Pereira, G., Oliveira,M.B.P.P. (2015). Medicao spp., as potential sources of bioactive isoflavones: characterization according to phylogenetic and phonologic factors. Phytochemistry 116,230–238Beeckman, D., Verhaeghe, S., Defloor, T., Schoonhoven, L., & Vanderwee, K. (2011). A 3- in-1 perineal care washcloth impregnated with dimethicone 3% versus water and pH neutral soap to prevent and treat incontinence-associated dermatitis: a randomized, controlled clinical trial. Journal of Wound Ostomy & Continence Nursing, 38(6), 627-634.Beitner H.(2003). Estudio aleatorizado, controlado con placebo, doble ciego sobre la eficacia clínica de una crema que contiene 5% de ácido alfa lipoico relacionada con el fotoenvejecimiento de la piel del rostro. Br J Dermatol 149 (4): 841-9Beltrán Rodríguez, D. F. (2020). Estudio prospectivo para la caracterización macroscópica de macromicetos en la zona norte de la Provincia del Sumapáz (Tesis de Grado Uniandes).Berg, A., Reiber, K., Dorfelt, H., Walther, G., Schlegel, B., & Graefe, U. (2000). Laccaridiones A and B, new protease inhibitors from Laccaria amethystea. The Journal of Antibiotics, 53(11), 1313-1316.Bernard, B. A. (1993). Adapalene, a new chemical entity with retinoid activity. Skin Pharmacology and Physiology, 6(Suppl. 1), 61-69. Bernard BA. Adapalene, a new chemical entity with retinoid activity. Skin Pharmacol 1993;6 (Suppl 1):61-69.Betancur, A., & P ́erez, M. M. (2016). Parques y páramos naturales de Colombia como zonas de importancia para el desarrollo minero energ ́etico del país. Revista del CESLA, 19, 33-56. https://www.redalyc.org/articulo.oa?id= 243349208002Bisang, R., Campi, M., & Cesa, V. (2009). Biotecnología y desarrollo.CEPAL .Naciones Unidas.Bisen, P. S., Baghel, R. K., Sanodiya, B. S., Thakur, G. S., & Prasad, G. B. K. S. (2010). Lentinus edodes: a macrofungus with pharmacological activities. Current medicinal chemistry, 17(22), 2419-2430.Bissett DL, Miyamoto K, Sun P y col. (2004).La niacinamida tópica reduce el color amarillento, las arrugas, las manchas rojas y las manchas hiperpigmentadas en la piel facial envejecida. Int J Cosmet Sci 26 (5): 231-8Brand-Garnys, E. E., Denzer, H., Meijer, H., & Brand, H. M. (2007). Flavonoids: A review for cosmetic application. part two. Journal of applied cosmetology, 25(4), 145-159.Brandt, F. S., Cazzaniga, A., & Hann, M. (2011). Cosmeceuticals: current trends and market analysis. In Seminars in cutaneous medicine and surgery (Vol. 30, No. 3, pp. 141-143). WB Saunders.Briganti, S., Camera, E., & Picardo, M. (2003). Chemical and instrumental approaches to treat hyperpigmentation. Pigment Cell Research, 16(2), 101-110.Brizuela, M. A., García, L., Pérez, L., & Mansur, M. (1998). Basidiomicetos: nueva fuente de metabolitos secundarios. Revista Iberoamericana de Micología, 15(6974), 1998-15.Brummer, R. (2006b). Rheology essentials of cosmetic and food emulsions. Springer Science & Business Media.Brody HJ. Relevance of cosmeceuticals to the dermatologic surgeon. Dermatol Surg. 2005;31(7):796–8.Burger, P., Landreau, A., Azoulay, S., Michel, T., & Fernandez, X. (2016). Skin whitening cosmetics: Feedback and challenges in the development of natural skin lighteners. Cosmetics, 3(4), 36.Campos, P. M. B. G., G. Mercurio, D., O. Melo, M., & Closs-Gonthier, B. (2017). Cichorium intybus root extract: a “vitamin D-like” active ingredient to improve skin barrier function. Journal of Dermatological Treatment, 28(1), 78-81.Carrasco, A., Martinez-Gutierrez, R., Tomas, V., & Tudela, J. (2016). Lavandula angustifolia and Lavandula latifolia essential oils from Spain: Aromatic profile and bioactivities. Planta Med, 82(1-2), 163-170.Carrau, M. J., Gimeno, M., Ibáñez, O., Organero, A., & Rey, P. (2010). Plantas limpias. Mètode, 65, 120-121.Cavinato, M. (2020). Cosmetics and cosmeceuticals. In: Ratan, S.I. (Ed.), Reference Module in Biomedical Sciences. Elsevier, pp. 446–461. https://doi.org/10.1016/B978-0-12- 801238-3.62150-5.Cepero de García, M. C. (2012). Biología de hongos. Ediciones Uniandes-Universidad de los Andes.Chakraborty, A. K., Funasaka, Y., Komoto, M., & Ichihashi, M. (1998). Effect of arbutin on melanogenic proteins in human melanocytes. Pigment cell research, 11(4), 206-212.Chandrawanshi, K.N., Tandia, D.K. and Jadhav, S.K. (2017). Nutraceutical properties evaluation of Schizophyllum commune. Indian J. Sci. Res., 13: 57–62.Chang, A. K. T., Frias Jr, R. R., Alvarez, L. V., Bigol, U. G., & Guzman, J. P. M. D. (2019). Comparative antibacterial activity of commercial chitosan and chitosan extracted from Auricularia sp. Biocatalysis and agricultural biotechnology, 17, 189-195.Chang, S. T., & Miles, P. G. (2004). Mushrooms: cultivation, nutritional value, medicinal effect, and environmental impact. CRC press.Chang, T. S. (2009). An updated review of tyrosinase inhibitors. International journal of molecular sciences, 10(6), 2440-2475.Chen, M. H., Chang, S. S., Dong, B., Yu, L. Y., Wu, Y. X., Wang, R. Z., ... & Si, S. Y. (2018). Ahmpatinin i Bu, a new HIV-1 protease inhibitor, from Streptomyces sp. CPCC 202950. RSC advances, 8(10), 5138-5144.Cheng, S. L., Liu, R. H., Sheu, J. N., Chen, S. T., Sinchaikul, S., & Tsay, G. J. (2006). Toxicogenomics of kojic acid on gene expression profiling of a375 human malignant melanoma cells. Biological and Pharmaceutical Bulletin, 29(4), 655-669.Cheung, L. M., Cheung, P. C., & Ooi, V. E. (2003). Antioxidant activity and total phenolics of edible mushroom extracts. Food chemistry, 81(2), 249-255.Chien, C. C., Tsai, M. L., Chen, C. C., Chang, S. J., & Tseng, C. H. (2008). Effects on tyrosinase activity by the extracts of Ganoderma lucidum and related mushrooms. Mycopathologia, 166(2), 117-120.Chithra, P., Sajithlal G.B. y Chandrakasan G. (1998). Influence of Aloe vera on collagen turnover in healing of dermal wounds in rats. Indian Journal of Experimental Biology 36, 896- 901.Choi CM, Berson DS.(2006). Cosmecéuticos Semin Cutan Med Surg 25 (3): 163-8Cohen, L. E., & Grant, R. T. (2016). Sun protection: current management strategies addressing UV exposure. Clinics in Plastic Surgery, 43(3), 605-610.Corey, M. E., Beelman, R. B., & Seetharman, K. (2009). Potential for nutritional enrichment of whole-wheat bread with portabella mushroom powder (Agaricus bisporus (J. Lge) Imbach, Agaricomycetideae). International Journal of Medicinal Mushrooms, 11(2).Costa A. (2012). Tratado Internacional de Cosmecêuticos. Rio de Janeiro: Guanabara Koogan.Couto, S. R. y M. Á. Sanromán (2006). Application of solid-state fermentation to food industry—A review. Journal of Food Engineering 76(3): 291-302.Crueger, W. y A. Crueger (1993). Biotecnología. Manual de Microbiología Industrial., Ed. Acribia.Delinasios GJ, Karbaschi M, Cooke MS, and Young AR .(2018). Vitamin E inhibits the UVAI induction of “light” and “dark” cyclobutane pyrimidine dimers, and oxidatively generated DNA damage, in keratinocytes. Scientific Reports 8: 423.Domínguez-Fernández, R. N., Arzate-Vazquez, I., Chanona-Perez, J. J., Welti-Chanes, J. S., Alvarado-González, J. S., Calderon-Dominguez, G., ... & Gutierrez-Lopez, G. F. (2012). El gel de Aloe vera: estructura, composición química, procesamiento, actividad biológica e importancia en la industria farmacéutica y alimentaria. Revista mexicana de ingeniería química, 11(1), 23-43.Dorni, A. C., Amalraj, A., Gopi, S., Varma, K., & Anjana, S. N. (2017). Novel cosmeceuticals from plants—An industry guided review. Journal of applied research on medicinal and aromatic plants, 7, 1-26.Draelos ZD (2018) The science behind skin care: Moisturizers. Journal of Cosmetic Dermatology 17: 138–144.Draelos, Z. D. (2010). Nutrition and enhancing youthful-appearing skin. Clinics in Dermatology, 28(4), 400–408. https://doi.org/10.1016/j.clindermatol.2010.03.019Draelos, Z. D. (2014). Cosmeceuticals: efficacy and influence on skin tone. Dermatologic clinics, 32(2), 137-143.Driscoll, M. S., Kwon, E. K., Skupsky, H., Kwon, S. Y., & Grant-Kels, J. M. (2010). Nutrition and the deleterious side effects of nutritional supplements. Clinics in Dermatology, 28(4), 371–379. https://doi:10.1016/j.clindermatol.2010.03.023Dubost NJ, Beelman RB, Royse DJ .(2007). Influence of selected cultural factors and postharvest storage on ergothioneine content of common button mushroom Agaricus bisporus (J. Lge) Imbach (Agaricomycetideae). Int J Med Mushrooms 9:163–176Dubost, N. J., Beelman, R. B., Peterson, D., & Royse, D. J. (2006). Identification and quantification of ergothioneine in cultivated mushrooms by liquid chromatography-mass spectroscopy. International Journal of Medicinal Mushrooms, 8(3).Dudhgaonkar, S., Thyagarajan, A., & Sliva, D. (2009). Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum. International immunopharmacology, 9(11), 1272-1280.El-Enshasy, H., A. Daba, et al. (2010). Bioprocess development for large scale production of anticancer exo-polysaccharide by Pleurotus ostreatus in submerged culture. Journal of Applied Sciences 10(21): 2523-2529.Elisashvili, V. I., Kachlishvili, E. T., & Wasser, S. P. (2009). Carbon and nitrogen source effects on basidiomycetes exopolysaccharide production. Applied Biochemistry and Microbiology, 45(5), 531-535.El‐Mahdy , M. A., Zhu, Q., Wang, Q. E., Wani, G., Patnaik, S., Zhao, Q., ... & Wani, A. A. (2008). Naringenin protects HaCaT human keratinocytes against UVB‐induced apoptosis and enhances the removal of cyclobutane pyrimidine dimers from the genome. Photochemistry and photobiology, 84(2), 307-316.Elsner, P. (2006). Antimicrobials and the skin physiological and pathological flora. Biofunctional Textiles and the Skin, 33, 35-41.Eltahir, M. E., & Elsayed, M. E. (2019). Adansonia digitata: phytochemical constituents, bioactive compounds, traditional and medicinal uses. In Wild Fruits: Composition, Nutritional Value and Products (pp. 133-142). Springer, Cham.Emer, J. J., Frankel, A., Sohn, A., & Lebwohl, M. (2011). A bilateral comparison study of pimecrolimus cream 1% and a topical medical device cream in the treatment of patients with atopic dermatitis. Journal of drugs in dermatology: JDD, 10(7), 735-743.Esgleyes-Ribot, T., Chandraratna, R. A., Lew-Kaya, D. A., Sefton, J., & Duvic, M. (1994). Response of psoriasis to a new topical retinoid, AGN 190168. Journal of the American Academy of Dermatology, 30(4), 581-590.Faria-Silva, C., Ascenso, A., Costa, A. M., Marto, J., Carvalheiro, M., Ribeiro, H. M., & Simões, S. (2020). Feeding the skin: A new trend in food and cosmetics convergence. Trends in Food Science & Technology, 95, 21-32.Farris, PK (20134). Cosmecéutica y práctica cosmética. cosmética. John Wiley & Sons.Fernandes, M. B. A., Habu, S., De Lima, M. A., Thomaz-Soccol, V., & Soccol, C. R. (2011). Influence of drying methods over in vitro antitumoral effects of exopolysaccharides produced by Agaricus blazei LPB 03 on submerged fermentation. Bioprocess and biosystems engineering, 34(3), 253-261.Ferranti-Ramos, A., Garza-Garza, G., Bátiz-Armenta, J., Martínez-Delgado, G., la Garza- Álvarez, D., Martínez-Menchaca, H. R., & Rivera-Silva, G. (2017). Metaloproteinasas de la matriz extracelular y su participación en el proceso de cicatrización. Medicas UIS, 30(2), 55-62.Ferreira, I. C., Heleno, S. A., Reis, F. S., Stojkovic, D., Queiroz, M. J. R., Vasconcelos, M. H., & Sokovic, M. (2015). Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities. Phytochemistry, 114, 38-55.Ferreira, P. R., Marins, J. C. B., de Oliveira, L. L., Bastos, D. S. S., Júnior, D. T. S., da Silva, C. D., & Fontes, E. A. F. (2020). Beverage based on whey permeate with phenolic extract of jabuticaba peel: A pilot study on effects on muscle and oxidative stress in trained individuals. Journal of Functional Foods, 65, 103749.Finimundy, T. C., Barros, L., Calhelha, R. C., Alves, M. J., Prieto, M. A., Abreu, R. M., ... & Ferreira, I. C. (2018). Multifunctions of Pleurotus sajor-caju (Fr.) Singer: A highly nutritious food and a source for bioactive compounds. Food chemistry, 245, 150-158.Firenzuoli F, Gori L, Lombardo G (2008). The medicinal mushroom Agaricus blazei Murrill: Review of literature and pharmaco- toxicological problems. Evid Based Complement Altern Med 5:3–15Fisk WA, Agbai O, Lev-Tov HA, and Sivamani RK (2014) The use of botanically derived agents for hyperpigmentation: A systematic review. Journal of the American Academy of Dermatology 70: 352–365.Florez-White M. (2013). Antioxidantes tópicos: su papel en el manejo del fotoenvejecimiento. Más Dermatol; 19:3–4.Fongnzossie, E. F., Tize, Z., Nde, P. F., Biyegue, C. N., Ntsama, I. B., Dibong, S. D., & Nkongmeneck, B. A. (2017). Ethnobotany and pharmacognostic perspective of plant species used as traditional cosmetics and cosmeceuticals among the Gbaya ethnic group in Eastern Cameroon. South African Journal of Botany, 112, 29-39.Fongnzossie, E. F., Tize, Z., Nde, P. F., Biyegue, C. N., Ntsama, I. B., Dibong, S. D., & Nkongmeneck, B. A. (2017). Ethnobotany and pharmacognostic perspective of plant species used as traditional cosmetics and cosmeceuticals among the Gbaya ethnic group in Eastern Cameroon. South African Journal of Botany, 112, 29-39.Friedman, M. (2015). Chemistry, nutrition, and health-promoting properties of Hericium erinaceus (Lion’s Mane) mushroom fruiting bodies and mycelia and their bioactive compounds. Journal of Agricultural and Food Chemistry, 63(32), 7108-7123.Ganceviciene R, Liakou AI, Theodoridis A, Makrantonaki E, and Zouboulis CC. (2012). Skin anti-aging strategies. Dermatoendocrinology 4: 308–319Gao J-M, Zhang A-L, Chen H, Liu J-K .(2004) .Molecular species of ceramides from the ascomycete truffle Tuber indicum. Chem Phys Lipids 131:205–213Gao, H., & Gu, W. Y. (2007). Optimization of polysaccharide and ergosterol production from Agaricus brasiliensis by fermentation process. Biochemical Engineering Journal, 33(3), 202- 210.Gao, X. H., Zhang, L., Wei, H., & Chen, H. D. (2008). Efficacy and safety of innovative cosmeceuticals. Clinics in Dermatology, 26(4), 367-374.Gao, Y., Zhou, S., Jiang, W., Huang, M., & Dai, X. (2003). Effects of Ganopoly (A Ganoderma lucidum polysaccharide extract) on the immune functions in Advanced‐Stage cancer patients. Immunological investigations, 32(3), 201-215.Garcés, E. M., Correa, B., Coba, M. O., Zapata, A., Anacona, A., & Sabogal, S. (2003). Morfología y clasificación de los hongos. Univ. Nacional de Colombia. Bogotá.García-Abuín, A., Gómez-Díaz, D., Navaza, J. M., Regueiro, L., & Vidal-Tato, I. (2011). Viscosimetric behaviour of hyaluronic acid in different aqueous solutions. Carbohydrate polymers, 85(3), 500-505.Gąsecka, M., Magdziak, Z., Siwulski, M., & Mleczek, M. (2018). Profile of phenolic and organic acids, antioxidant properties and ergosterol content in cultivated and wild growing species of Agaricus. European Food Research and Technology, 244(2), 259-268.Gasparetto, J. C., Martins, C. A. F., Hayashi, S. S., Otuky, M. F., & Pontarolo, R. (2012). Ethnobotanical and scientific aspects of Malva sylvestris L.: a millennial herbal medicine. Journal of Pharmacy and Pharmacology, 64(2), 172-189.Gautier S, Xhauflaire-Uhoda E, Gonry P, Piérard GE .(2008).Chitin- glucan, a natural cell scaffold for skin moisturization and rejuvenation. Int J Cosmet Sci 30:459–469Gaya E, Vasco-Palacios AM, Vargas-Estupiñan N, Lücking R, Carretero J, Sanjuan T, Moncada B, Allkin B, Bolaños-Rojas AC, Castellanos-Castro C. et al...(2021) ColFungi: Colombian resources for fungi made accessible. Royal Botanic Gardens, Kew. https://doi.org/10.34885/8yvp-z538Gohil, K. J., Patel, J. A., & Gajjar, A. K. (2010). Pharmacological review on Centella asiatica: a potential herbal cure-all. Indian journal of pharmaceutical sciences, 72(5), 546.González Matute, R., Figlas, D., & Curvetto, N. (2011). Agaricus blazei production on non- composted substrates based on sunflower seed hulls and spent oyster mushroom substrate. World Journal of Microbiology and Biotechnology, 27(6), 1331-1339.González Minero, F. J., & Bravo Díaz, L. (2017). Historia y actualidad de productos para la piel, cosméticos y fragancias. Especialmente los derivados de las plantas. Ars Pharmaceutica (Internet), 58(1), 5-12Goufo, P., & Trindade, H. (2014). Rice antioxidants: Phenolic acids, flavonoids, anthocyanins, proanthocyanidins, tocopherols, tocotrienols, γ-oryzanol, and phytic acid. Food Sciences and Nutrition, 2(2), 75–104Goufo, P., Pereira, J., Moutinho-Pereira, J., Correia, C. M., Figueiredo, N., Carranca, C., ... & Trindade, H. (2014). Rice (Oryza sativa L.) phenolic compounds under elevated carbon dioxide (CO2) concentration. Environmental and Experimental Botany, 99, 28-37.Grimrath, A., Berends, P., Rabe, S., Berger, R. G., & Linke, D. (2011). Koji fermentation based on extracellular peptidases of Flammulina velutipes. European Food Research and Technology, 232(3), 415-424.Gupta, A. K., Gover, M. D., Nouri, K., & Taylor, S. (2006). The treatment of melasma: a review of clinical trials. Journal of the American Academy of Dermatology, 55(6), 1048-1065.Gwon, H. J., Lim, Y. M., Nho, Y. C., & Baik, S. H. (2010). Humectants effect on aqueous fluids absorption of γ-irradiated PVA hydrogel followed by freeze thawing. Radiation Physics and Chemistry, 79(5), 650-653.Harcharik, S., & Emer, J. (2014). Steroid-sparing properties of emollients in dermatology. Skin Therapy Lett, 19(1), 5-10.Hawksworth DL. (2001). The magnitude of fungal diversity: The 1.5 million species estimate revisited. Mycological Research, 105: 1422-1432.Heinrich, U., Neukam, K., Tronnier, H., Sies, H., & Stahl, W. (2006). Long-term ingestion of high flavanol cocoa provides photoprotection against UV-induced erythema and improves skin condition in women. The Journal of nutrition, 136(6), 1565-1569.Hernandez, D. F., Cervantes, E. L., Luna-Vital, D. A., & Mojica, L. (2021). Food-derived bioactive compounds with anti-aging potential for nutricosmetic and cosmeceutical products. Critical Reviews in Food Science and Nutrition, 61(22), 3740-3755.Hosoe, T., Sakai, H., Ichikawa, M., Itabashi, T., Ishizaki, T., & Kawai, K. I. (2007). Lepidepyrone, a new γ-pyrone derivative, from Neolentinus lepideus, inhibits hyaluronidase. The journal of antibiotics, 60(6), 388-390.Hu, Y. N., Sung, T. J., Chou, C. H., Liu, K. L., Hsieh, L. P., & Hsieh, C. W. (2019). Characterization and antioxidant activities of yellow strain Flammulina velutipes (Jinhua mushroom) polysaccharides and their effects on ROS content in L929 cell. Antioxidants, 8(8), 298.Huang, H.-C. y Y.-C. Liu (2008). Enhancement of polysaccharide production by optimization of culture conditions in shake flask submerged cultivation of Grifola umbellata. Journal of the Chinese Institute of Chemical Engineers 39(4): 307-311.Hui, L. I. U. (2012). Comparison of the moisture retention capacity of Tremella polysaccharides and hyaluronic acid. Journal of Anhui Agricultural Sciences, 26.Husein el Hadmed, H., & Castillo, R. F. (2016). Cosmeceuticals: peptides, proteins, and growth factors. Journal of cosmetic dermatology, 15(4), 514-519.Hwang, T. L., Chen, H. Y., Changchien, T. T., Wang, C. C., & Wu, C. M. (2013). The cytotoxicity of mercury chloride to the keratinocytes is associated with metallothionein expression. Biomedical Reports, 1(3), 379-382.Hyde, K. D., Bahkali, A. H., & Moslem, M. A. (2010). Fungi—an unusual source for cosmetics. Fungal diversity, 43(1), 1-9.Ito, T., Kato, M., Tsuchida, H., Harada, E., Niwa, T., & Osawa, T. (2011). Ergothioneine as an anti-oxidative/anti-inflammatory component in several edible mushrooms. Food science and technology research, 17(2), 103-110.Jeong, Y. T., S. C. Jeong, et al. (2010). Antitumor and immunomodulating activities of endo- bioplymers obtained from a submerged culture of Pleurotus eryngii. Food Science and Biotechnology 19: 399-404.Jeong, Y. T., Yang, B. K., Jeong, S. C., Kim, S. M., & Song, C. H. (2008). Ganoderma applanatum: a promising mushroom for antitumor and immunomodulating activity. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 22(5), 614-619.Jiang, Z., Jin, M., Zhou, W., Li, R., Zhao, Y., Jin, X., & Li, G. (2018). Anti-inflammatory activity of chemical constituents isolated from the willow bracket medicinal mushroom Phellinus igniarius (Agaricomycetes). International journal of medicinal mushrooms, 20(2).Journal of Dermatology 46 (1), 48–55.Kalaras, M. D., Richie, J. P., Calcagnotto, A., & Beelman, R. B. (2017). Mushrooms: A rich source of the antioxidants ergothioneine and glutathione. Food chemistry, 233, 429-433.Kamakshi, R. (2012). Fairness via formulations: a review of cosmetic skin-lightening ingredients. Journal of cosmetic science, 63(1), 43-54.Kan, Y., Chen, T., Wu, Y., & Wu, J. (2015). Antioxidant activity of polysaccharide extracted from Ganoderma lucidum using response surface methodology. International journal of biological macromolecules, 72, 151-157.Katayama K, Armendariz-Borunda J, Raghow R, et al. (1993). Un pentapéptido del procolágeno tipo I promueve la producción de matriz extracelular. J Biol Chem 268 (14): 9941-4Kerdudo, A., Burger, P., Merck, F., Dingas, A., Rolland, Y., Michel, T., & Fernandez, X. (2016). Development of a natural ingredient–Natural preservative: A case study. Comptes Rendus Chimie, 19(9), 1077-1089.Khan, M. A., & Tania, M. (2012). Nutritional and medicinal importance of Pleurotus mushrooms: an overview. Food Reviews International, 28(3), 313–329.Kim, J., Lee, K.W., Lee, H.J.(2011). Chapter 42 – Cocoa (Theobroma cacao) seeds and phytochemicals in human health. Nuts and Seeds in Health and Disease Prevention. pp. 351–360Kim, K. C., Lee, I. S., Yoo, I. D., & Ha, B. J. (2015). Sesquiterpenes from the fruiting bodies of Ramaria formosa and their human neutrophil elastase inhibitory activity. Chemical and Pharmaceutical Bulletin, 63(7), 554-557.Kim, M., Yoon, H., Kim, Y. E., Kim, Y. J., Kong, W. S., & Kim, J. G. (2014). Comparative analysis of bacterial diversity and communities inhabiting the fairy ring of Tricholoma matsutake by barcoded pyrosequencing. Journal of applied microbiology, 117(3), 699-710.Kim, S. H., Nam, G. W., Kang, B. Y., Lee, H. K., Moon, S. J., & Chang, I. S. (2005). The Effect of Kaempferol, guercetin on Hyaluronan-Synthesis Stimulation in Human Keratinocytes (HaCaT). Journal of the Society of Cosmetic Scientists of Korea, 31(1), 97- 102.Kim, S. W., Hwang, H. J., Lee, B. C., & Yun, J. W. (2007). Submerged production and characterization of Grifola frondosa polysaccharides–a new application to cosmeceuticals. Food Technology and Biotechnology, 45(3), 295-305.Kim, S. Y., Kong, W. S., & Cho, J. Y. (2011). Identification of differentially expressed genes in Flammulina velutipes with anti-tyrosinase activity. Current microbiology, 62(2), 452-457.King'Ori, A. M. (2011). A review of the uses of poultry eggshells and shell membranes. International Journal of Poultry Science, 10(11), 908–912.Kinthali, U., & Shaheen, B. (2021). A complete review on Avena sativa. Journal of Pharmacognosy and Phytochemistry.vol 9Kligman, A. M. (2005). O que são cosmecêuticos. Cosmecêuticos. Rio de Janeiro: Elsevier, 1-2. Kligman AM. O que são cosmecêuticos. In: Draelos ZD, Dover JS, editors. Cosmecêuticos. Rio de Janeiro: Elsevier; 2005. p. 1–2.Kligman, D. (2000). Cosmeceuticals. Dermatologic clinics, 18(4), 609-615.Kotilainen, T., Tegelberg, R., Julkunen‐tiitto, R. I. I. T. T. A., Lindfors, A., & Aphalo, P. J. (2008). Metabolite specific effects of solar UV‐A and UV‐B on alder and birch leaf phenolics. Global change biology, 14(6), 1294-1304.Kozhemyakina, N. V., E. P. Ananyeva, et al. (2010). Conditions of cultivation, composition, and biological activity of mycelium of Flammulina velutipes (Fr) P Karst. Applied Biochemistry and Microbiology 46: 536-539.Lage R., Mendes C., Abdalla B.M.Z., Arbiser J., Costa A. (2017). Cosmeceutical Ingredients: Botanical and Nonbotanical Sources. In: Issa M., Tamura B. (eds) Daily Routine in Cosmetic Dermatology. Clinical Approaches and Procedures in Cosmetic Dermatology. Springer, Cham.Langholz, O., Röckel, D., Mauch, C., Kozlowska, E., Bank, I., Krieg, T., & Eckes, B. (1995). Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins. The Journal of cell biology, 131(6), 1903-1915.Lee, C. M. (2016). Fifty years of research and development of cosmeceuticals: a contemporary review. Journal of cosmetic dermatology, 15(4), 527-539.Lee, I. S., Ryoo, I. J., Kwon, K. Y., Ahn, J. S., & Yoo, I. D. (2011). Pleurone, a novel human neutrophil elastase inhibitor from the fruiting bodies of the mushroom Pleurotus eryngii var. ferulae. The Journal of Antibiotics, 64(8), 587-589.Lee, J. E., Lee, I. S., Kim, K. C., Yoo, I. D., & Yang, H. M. (2017). ROS scavenging and anti-wrinkle effects of clitocybin a isolated from the mycelium of the mushroom Clitocybe aurantiaca. Journal of microbiology and biotechnology, 27(5), 933-938.Lemus, C., Angelis, A., Halabalaki, M., & Skaltsounis, A. L. (2014). γ-Oryzanol: An attractive bioactive component from rice bran. In Wheat and rice in disease prevention and health (pp. 409-430). Academic Press.Leyden, J. J., Stevens, T., Finkey, M. B., & Barkovic, S. (2002). Skin care benefits of copper peptide containing facial cream. In American Academy of Dermatology 60th Annual Meeting (p. 29). American Academy of Dermatology.Lima, A. T., Santos, M. N., de Souza, L. A., Pinheiro, T. S., Paiva, A. A., Dore, C. M., ... & Leite, E. L. (2016). Chemical characteristics of a heteropolysaccharide from Tylopilus ballouii mushroom and its antioxidant and anti-inflammatory activities. Carbohydrate polymers, 144, 400-409.Lima, L. F. O., Habu, S., Gern, J. C., Nascimento, B. M., Parada, J. L., Noseda, M. D., ... & Soccol, C. R. (2008). Production and characterization of the exopolysaccharides produced by Agaricus brasiliensis in submerged fermentation. Applied biochemistry and biotechnology, 151(2), 283-294.Lin, J. G., Fan, M. J., Tang, N. Y., Yang, J. S., Hsia, T. C., Lin, J. J., ... & Chung, J. G. (2012). An extract of Agaricus blazei Murill administered orally promotes immune responses in murine leukemia BALB/c mice in vivo. Integrative cancer therapies, 11(1), 29-36.Lin, Z., & Deng, A. (2019). Antioxidative and free radical scavenging activity of Ganoderma (Lingzhi). Ganoderma and Health, 271-297.Liu, G. Q., W. J. Han, et al. (2010). Polysaccharides extraction from submerged-cultured mycelium of Grifola frondosa. 2010 International Conference on Bioinformatics and Biomedical Technology. ICBBT 2010: 111-114.Liu, K., Xiao, X., Wang, J., Chen, C. Y. O., & Hu, H. (2017). Polyphenolic composition and antioxidant, antiproliferative, and antimicrobial activities of mushroom Inonotus sanghuang. LWT-food science and technology, 82, 154-161.Londoño Londoño, J. (2012). Antioxidantes: importancia biológica y métodos para medir su actividad. In Desarrollo y transversalidad serie Lasallista Investigación y Ciencia. Corporación Universitaria Lasallista.Lorencini M, Brohem CA, Dieamant GC, Zanchin NIT, and Maibach HI .(2014) .Active ingredients against human epidermal aging. Ageing Research Reviews 15: 100–115Lourenço A, Lobo AM, Rodríguez B, Jimeno M-L .(1996). Ceramides from the fungus Phellinus pini. Phytochemistry 43:617–620Lupo, M. L., Cohen, J. L., & Rendon, M. I. (2007). Novel eye cream containing a mixture of human growth factors and cytokines for periorbital skin rejuvenation. Journal of drugs in dermatology: JDD, 6(7), 725-729.Ma, K., Han, J., Bao, L., Wei, T., & Liu, H. (2014). Two sarcoviolins with antioxidative and α-glucosidase inhibitory activity from the edible mushroom Sarcodon leucopus collected in Tibet. Journal of natural products, 77(4), 942-947.Maddin, S., Lauharanta, J., Agache, P., Burrows, L., Zultak, M., & Bulger, L. (2000). Isotretinoin improves the appearance of photodamaged skin: results of a 36-week, multicenter, double-blind, placebo-controlled trial. Journal of the American Academy of Dermatology, 42(1), 56-63.Mancuso JB, Maruthi R, Wang SQ, and Lim HW. (2017). Sunscreens: An update. American Journal of Clinical Dermatology 18: 643–650.Mazzio, E., Badisa, R., Mack, N., Deiab, S., & Soliman, K. F. A. (2014). High throughput screening of natural products for anti‐mitotic effects in MDA‐MB‐231 human breast carcinoma cells. Phytotherapy Research, 28(6), 856-867.McCook JP.(2016). Topical products for the aging face. Clinics in Plastic Surgery 43: 597– 604.McDaniel DH, Mazur C, Wortzman MS, and Nelson DB .(2017). Efficacy and tolerability of a double-conjugated retinoid cream vs 1.0% retinol cream or 0.025% tretinoin cream in subjects with mild to severe photoaging. Journal of Cosmetic Dermatology 16: 542–548.Meng, T. X., Furuta, S., Fukamizu, S., Yamamoto, R., Ishikawa, H., Arung, E. T., ... & Kondo, R. (2011). Evaluation of biological activities of extracts from the fruiting body of Pleurotus citrinopileatus for skin cosmetics. Journal of wood science, 57(5), 452-458.Millikan, L. E. (2000). Adapalene: an update on newer comparative studies between the various retinoids. International journal of dermatology, 39(10), 784-788Mingarro, D. M., Plaza, A., Galán, A., Vicente, J. A., Martínez, M. P., & Acero, N. (2015). The effect of five Taraxacum species on in vitro and in vivo antioxidant and antiproliferative activity. Food & Function, 6(8), 2787-2793.Mitani, H., Ryu, A., Suzuki, T., Yamashita, M., Arakane, K., Koide, C.(2007). Topical application of plant extracts containing xanthine derivatives can prevent UV-induced wrinkle formation in hairless mice. Photodermatology and Photoimmunology Photomedicine 23 (2), 86–94Miyake, M., Yamamoto, S., Sano, O., Fujii, M., Kohno, K., Ushio, S., ... & Fukuda, S. (2010). Inhibitory effects of 2-Amino-3 H-phenoxazin-3-one on the melanogenesis of murine B16 melanoma cell line. Bioscience, biotechnology, and biochemistry, 74(4), 753-758.Moreno, M. I., & Moreno, L. H. (2010). Fotoprotección. Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica, 18(1), 31-39.Mueller, G. M., & Schmit, J. P. (2007). Fungal biodiversity: what do we know? What can we predict? Biodiversity and conservation, 16(1), 1-5.Mukherjee, P. K., Maity, N., Nema, N. K., & Sarkar, B. K. (2011). Bioactive compounds from natural resources against skin aging. Phytomedicine, 19(1), 64-73.Nabors, M. (2005).Introduccion a la botanica.Pearson Education .ISBN 8478290737, 9788478290734Nakagawa, M., Kawai, K., & Kawai, K. (1995). Contact allergy to kojic acid in skin care products. Contact dermatitis, 32(1), 9-13Nakamura, K. (2006). Bottle cultivation of culinary-medicinal Bunashimeji mushroom Hypsizygus marmoreus (Peck) bigel.(Agaricomycetideae) in Nagano Prefecture (Japan). International Journal of Medicinal Mushrooms, 8(2).Nan, W., Zhaoqing, Z., Yuexuan, Y., Hua, Z., Jinhao, W., & Ang, L. (2016). Evaluation for Whitening Efficacy of Cosmetics Containning Extract from Tricholoma Matsutake Sing.Ngai, P. H., & Ng, T. B. (2004). A ribonuclease with antimicrobial, antimitogenic and antiproliferative activities from the edible mushroom Pleurotus sajor-caju. Peptides, 25(1), 11-17.Nguyen, T. L., Chen, J., Hu, Y., Wang, D., Fan, Y., Wang, J., ... & Dang, B. K. (2012). In vitro antiviral activity of sulfated Auricularia auricula polysaccharides. Carbohydrate polymers, 90(3), 1254-1258.Novak, A. C., Sydney, E. B., & Soccol, C. R. (2014). Biocosmetics. In Biotransformation of waste biomass into high value biochemicals (pp. 389-411). Springer, New York, NY.Ohiri, R. C., & Bassey, E. E. (2017). Evaluation and characterization of nutritive properties of the jelly ear culinary-medicinal mushroom Auricularia auricula-judae (Agaricomycetes) from Nigeria. International Journal of Medicinal Mushrooms, 19(2).Onar, H. C., Yusufoglu, A., Turker, G., & Yanardag, R. (2012). Elastase, tyrosinase and lipoxygenase inhibition and antioxidant activity of an aqueous extract from Epilobium angustifolium L. leaves. Journal of Medicinal Plants Research, 6(5), 716-726.Orjuela Rodriguez, A. A. (2015). Determinación de actividad antioxidante de extractos y fracciones de hojas de Chromolaena perglabra (BL Robinson) RM King y H. Robinson . (Tesis de Pregrado), Universidad de Ciencias Aplicadas y Ambientales U.D.C.AOumeish, O. Y. (2001). The cultural and philosophical concepts of cosmetics in beauty and art through the medical history of mankind. Clinics in dermatology, 19(4), 375-386Padilha, M. M., Avila, A. A., Sousa, P. J., Cardoso, L. G. V., Perazzo, F. F., & Carvalho, J. C. T. (2009). Anti-inflammatory activity of aqueous and alkaline extracts from mushrooms (Agaricus blazei Murill). Journal of medicinal food, 12(2), 359-364.Palacios, I., Lozano, M., Moro, C., D’arrigo, M., Rostagno, M. A., Martínez, J. A., ... & Villares, A. (2011). Antioxidant properties of phenolic compounds occurring in edible mushrooms. Food Chemistry, 128(3), 674-678.Papaspyridi, L.-M., N. Aligiannis, et al. (2011). Production of bioactive metabolites with pharmaceutical and nutraceutical interest by submerged fermentation of Pleurotus ostreatus in a batch stirred tank bioreactor. Procedia Food Science 1(0): 1746-1752.Park, H. S., Hwang, Y. H., Kim, M. K., Hong, G. E., Lee, H. J., Nagappan, A., ... & Kim, G. S. (2015). Functional polysaccharides from Grifola frondosa aqueous extract inhibit atopic dermatitis-like skin lesions in NC/Nga mice. Bioscience, biotechnology, and biochemistry, 79(1), 147-154.Park, K. M., Kwon, K. M., & Lee, S. H. (2015). Evaluation of the antioxidant activities and tyrosinase inhibitory property from mycelium culture extracts. Evidence-based complementary and alternative medicine, 2015.Peixoto, F. M., Borguini, R. G., Machado, A. M. R., Gôuvea, A. C. M. S., Pacheco, S., & Godoy, R. D. O. (2013). Teor de carotenoides em nutricosméticos: análise da adequação e qualidade do produto. Embrapa Agroindústria de Alimentos-Artigo em periódico indexado (ALICE).Pillaiyar T, Namasivayam V, Manickam M, and Jung S-H (2018) Inhibitors of Melanogenesis: An updated review. Journal of Medicinal Chemistry 61: 7395–7418.Piwowarski, J. P., Kiss, A. K., & Kozłowska-Wojciechowska, M. (2011). Anti-hyaluronidase and anti-elastase activity screening of tannin-rich plant materials used in traditional Polish medicine for external treatment of diseases with inflammatory background. Journal of Ethnopharmacology, 137(1), 937-941.Plensdorf S .(2017). Pigmentation disorders: Diagnosis and management. American Family Physician 96(12): 797–804.Pontón, J. (2008). La pared celular de los hongos y el mecanismo de acción de la anidulafungina. Revista Iberoamericana de Micología, 25(2), 78-82.Pullar JM, Carr AC, and Vissers MCM (2017) The roles of vitamin C in skin health. Nutrients 9: 866.Puttaraju, N. G., Venkateshaiah, S. U., Dharmesh, S. M., Urs, S. M. N., & Somasundaram, R. (2006). Antioxidant activity of indigenous edible mushrooms. Journal of agricultural and food chemistry, 54(26), 9764-9772.Queiroz, L. S., Nascimento, M. S., Cruz, A. K., Castro, A. J., Maria de Fátima, V. M., Baseia, I. G., & Leite, E. L. (2010). Glucans from the Caripia montagnei mushroom present anti- inflammatory activity. International immunopharmacology, 10(1), 34-42.Rahul, J., Jain, MK, Singh, SP, Kamal, RK, Naz, A., Gupta, AK y Mrityunjay, SK (2015). Adansonia digitata L. (baobab): una revisión de la información tradicional y la descripción taxonómica. Asian Pacific Journal of Tropical Biomedicine , 5 (1), 79-84.Rajan, P., & Grimes, P. E. (2002). Skin barrier changes induced by aluminum oxide and sodium chloride microdermabrasion. Dermatologic surgery, 28(5), 390-393.Ramos, G. I. C., & Pérez, D. A. (2010). Antioxidantes en dermatología. Dermatología Cosmética, Médica y Quirúrgica, 8(4), 272-277.Rangel, J. O. (2005). La biodiversidad de Colombia. Palimpsestvs, 5, 292-304. https://revistas.unal.edu.co/index. php/palimpsestvs/article/view/8083Razavi, S. M., Zarrini, G., Molavi, G., & Ghasemi, G. (2011). Bioactivity of Malva sylvestris L., a medicinal plant from Iran. Iranian journal of basic medical sciences, 14(6), 574.Rendon, M., Berneburg, M., Arellano, I., & Picardo, M. (2006). Treatment of melasma. Journal of the American Academy of Dermatology, 54(5), S272-S281.Reynolds, T. (1985). The compounds in Aloe leaf exudates: A review. Botanical Journal of the Linnean Society 90, 157-177.Reynolds, T. (Ed.). (2004). Aloes: the genus Aloe. CRC press.Ribeiro, A. P. D., Andrade, M. C., Bagnato, V. S., Vergani, C. E., Primo, F. L., Tedesco, A. C., & Pavarina, A. C. (2015). Antimicrobial photodynamic therapy against pathogenic bacterial suspensions and biofilms using chloro-aluminum phthalocyanine encapsulated in nanoemulsions. Lasers in medical science, 30(2), 549-559.Rivers, J. K. (2008). The role of cosmeceuticals in antiaging therapy. Skin Therapy Lett, 13(8), 5-9.Rodan K, Fields K, Majewski G, and Falla T (2016) Skincare bootcamp. Plastic and Reconstructive Surgery – Global Open 4: e1152.Rojas, T., Cortés, C., Noguera, M., Rojas, N., Cely, M., Garzón, C., ... & Velandia, G. (2020).Diagnóstico de experiencias locales de bioproductos y negocios verdes en comunidades locales ubicadas en zonas con alto valor ecológico y frentes de deforestación: Contribuciones de la Naturaleza y Bienestar.Romana-Souza B, Silva-Xavier W, and Monte-Alto-Costa A .(2018). Topical retinol attenuates stress-induced ageing signs in human skin ex vivo, throughEGFR activation viaEGF, but notERK andAP-1 activation. Experimental Dermatology. Epub ahead of print.Ruthes, A. C., Carbonero, E. R., Córdova, M. M., Baggio, C. H., Sassaki, G. L., Gorin, P. A. J., & Iacomini, M. (2013). Fucomannogalactan and glucan from mushroom Amanita muscaria: Structure and inflammatory pain inhibition. Carbohydrate polymers, 98(1), 761- 769.Salud, M. (2020). Análisis de las tres capas de la piel: estructura y funciones - Meditip. Retrieved 22 May 2020, from https://www.meditip.lat/el-cuerpo-humano/tres-capas-de-la- piel/Samyor, D., Deka, S. C., & Das, A. B. (2016). Phytochemical and antioxidant profile of pigmented and non-pigmented rice cultivars of Arunachal Pradesh, India. International Journal of Food Properties, 19, 1104–1114.Sandargo, B., Chepkirui, C., Cheng, T., Chaverra-Muñoz, L., Thongbai, B., Stadler, M., & Hüttel, S. (2019). Biological and chemical diversity go hand in hand: Basidiomycota as source of new pharmaceuticals and agrochemicals. Biotechnology advances, 37(6), 107344.Sarmiento, C. R., Gómez-Montoya, N., Zora-Vergara, B., Benjumea-Aristizabal, C., Santa- Santa, D. J., Zuluaga-Moreno, M., & Franco-Molano, A. E. (2022). Diversidad de macrohongos (Basidiomycota) de Colombia: Listado de especies. Actualidades Biológicas, 44(116).Serna, J., Vitales, M., López, M. C., & Molina, A. (2002). 4. Dermatología.Sevinsky, R. E., Stewart, D. W., & Harirforoosh, S. (2017). Nonsteroidal anti-inflammatory drugs: Is there a link between cardiovascular and renal adverse effects?. Journal of Integrative Nephrology and Andrology, 4(1), 1.Shaheen, F., Rasoola, S., Shah, Z.A., Soomro, S., Jabeen, A., Mesaik, M.A., Choudhary, M.I. (2014). Chemical constituents of Marrubium vulgare as potential inhibitors of nitric oxide and respiratory burst. Natural Product Communications 9 (7), 903–906.Shin, Y. J., & Lee, S. C. (2014). Antioxidant activity and β-glucan contents of hydrothermal extracts from maitake (Grifola frondosa). Food Science and Biotechnology, 23(1), 277-282.Shu, C. H., Lin, K. J., & Wen, B. J. (2007). Effects of culture temperature on the production of bioactive polysaccharides by Agaricus blazei in batch cultures. Journal of Chemical Technology & Biotechnology: International Research in Process, Environmental & Clean Technology, 82(9), 831-836.Siriamornpun, S., Kaisoon, O., & Meeso, N. (2012). Changes in colour, antioxidant activities and carotenoids (lycopene, β-carotene, lutein) of marigold flower (Tagetes erecta L.) resulting from different drying processes. Journal of Functional Foods, 4(4), 757-766.Skorek, M., Jurczyk, K., Sajewicz, M., & Kowalska, T. (2016). Thin-layer chromatographic identification of flavonoids and phenolic acids contained in cosmetic raw materials. Journal of Liquid Chromatography & Related Technologies, 39(5-6), 286-291.Slade, H. B., Fowler, J., Draelos, Z. D., Reece, B. T., & Cargill, D. I. (2008). Clinical efficacy evaluation of a novel barrier protection cream. Cutis, 82(4), 21-28.Slominski, A., Wortsman, J., Paus, R., Elias, P. M., Tobin, D. J., & Feingold, K. R. (2008). Skin as an endocrine organ: implications for its function. Drug Discovery Today: Disease Mechanisms, 5(2), e137-e144.Sorg, O., Antille, C., Kaya, G., & Saurat, J. H. (2006). Retinoids in cosmeceuticals. Dermatologic Therapy, 19(5), 289-296.Souilem, F., Fernandes, Â., Calhelha, R. C., Barreira, J. C., Barros, L., Skhiri, F., ... & Ferreira, I. C. (2017). Wild mushrooms and their mycelia as sources of bioactive compounds: Antioxidant, anti-inflammatory and cytotoxic properties. Food chemistry, 230, 40-48.Southall, M., Pappas, A., Suhyoun, C., (2014). Oat (Avena sativa) oil activates the PPAR? and PPAR β/δ pathways, resulting in keratinocyte differentiation and upregulation of ceramide synthesis. Journal of the American Academy of Dermatology 70 (5), AB64 (Sul.1).Souyoul SA, Saussy KP, and Lupo MP. (2018). Nutraceuticals: A review. Dermatology and Therapy 8: 5–16.Sridhar, K. R., & Deshmukh, S. K. (Eds.). (2019). Advances in Macrofungi: Diversity, Ecology and Biotechnology. CRC Press.Stahl, W., & Sies, H. (2005). Bioactivity and protective effects of natural carotenoids. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1740(2), 101-107.Suárez .A. & Nieto. R. (2012). Utilización de la fermentación líquida de Lentinula edodes (shiitake), para la producción de metabolitos secundarios bioactivos y evaluación de su potencial empleo en la producción de un alimento funcional. Instituto de Ciencia y Tecnología de Alimentos (ICTA).Sun, S., Zhang, X., Sun, S., Zhang, L., Shan, S., & Zhu, H. (2016). Production of natural melanin by Auricularia auricula and study on its molecular structure. Food Chemistry, 190, 801-807.Tada, R., Y. Adachi, et al. (2009). An unambiguous structural elucidation of a 1,3-β-dglucan obtained from liquid-cultured Grifola frondosa by solution NMR experiments. Carbohydrate Research 344(3): 400-404.Talbourdet, S., Sadick, N.S., Lazou, K., Bonnet-Duguennoy, M., Kurfurst, R., Neveu, M.,Heusele, C., Andre, P., Schnebert, S., Draelos, Z.D., Perrier, E. (, 2007). Modulation of gene expression as a new skin anti-ageing strategy. Journal Drugs and Dermatology 6(Suppl. 6), S25–33Tamrakar, S., Nishida, M., Amen, Y., Tran, H. B., Suhara, H., Fukami, K., ... & Shimizu, K. (2017). Antibacterial activity of Nepalese wild mushrooms against Staphylococcus aureus and Propionibacterium acnes. Journal of Wood Science, 63(4), 379-387.Taofiq, O., Calhelha, R. C., Heleno, S., Barros, L., Martins, A., Santos-Buelga, C., ... & Ferreira, I. C. (2015). The contribution of phenolic acids to the anti-inflammatory activity of mushrooms: Screening in phenolic extracts, individual parent molecules and synthesized glucuronated and methylated derivatives. Food Research International, 76, 821-827.Taofiq, O., González-Paramás, A.M., Martins, A., Barreiro, M.F. and Ferreira, I.C.F.R. (2016a). Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics—A review. Ind. Crops Prod., 90: 38–48.Taofiq, O., Heleno, S. A., Calhelha, R. C., Alves, M. J., Barros, L., Barreiro, M. F., ... & Ferreira, I. C. (2016b). Development of mushroom-based cosmeceutical formulations with anti-inflammatory, anti-tyrosinase, antioxidant, and antibacterial properties. Molecules, 21(10), 1372.Taofiq, O., Heleno, S.A., Calhelha, R.C., Alves, M.J., Barros, L., Gonzalez-Paramas, A.M., Barreiro, M.F. and Ferreira, I.C.F.R. (2017). The potential of Ganoderma lucidum extracts as bioactive ingredients in topical formulations, beyond its nutritional benefits. Food Chem. Toxicol., 108: 139–147.Taofiq, O., Martins, A., Barreiro, M. F., & Ferreira, I. C. (2016c). Anti-inflammatory potential of mushroom extracts and isolated metabolites. Trends in Food Science & Technology, 50, 193-210.Tepwong, P., Giri, A., & Ohshima, T. (2012). Effect of mycelial morphology on ergothioneine production during liquid fermentation of Lentinula edodes. Mycoscience, 53(2), 102-112.Thomas JRRegan JT, Dixon TK, and Bhattacharyya TK. (2013). Effects of Topicals on the aging skin process. Facial Plastic Surgery Clinics of North America 21: 55–60.Tontowiputro, D. K., Sargowo, D., Tjokroprawiro, A., & Rifa’i, M. (2018). Anti-inflammatory activity of Agaricus blazei Murill extract in the spleen of mice fed a high-fat diet. Tropical Journal of Pharmaceutical Research, 17(3), 483-489.Torres, KLQ, Suzuki, V., Fanaro, GB, de Oliveira, AF, Leite, JATM, Namur, CRM, ... & Ferreira, LM (2020). ¿licopeno y fotoprotección?. Avances en Ciencias Nutricionales , 1 (1), 80-88.Tuna, D., Udvarhelyi, A., Sobolewski, A. L., Domcke, W., & Domratcheva, T. (2016). Onset of the electronic absorption spectra of isolated and π-stacked oligomers of 5, 6- dihydroxyindole: An ab initio study of the building blocks of eumelanin. The Journal of Physical Chemistry B, 120(14), 3493-3502.Turło, J., B. Gutkowska, et al. (2010). Effect of selenium enrichment on antioxidant activities and chemical composition of Lentinula edodes (Berk.) Pegl. mycelial extracts. Food and Chemical Toxicology 48(4): 1085-1091.Usman, M., Murtaza, G., & Ditta, A. (2021). Nutritional, medicinal, and cosmetic value of bioactive compounds in button mushroom (Agaricus bisporus): a review. Applied Sciences, 11(13), 5943.Uter, W., Benz, M., Mayr, A., Gefeller, O., & Pfahlberg, A. (2013). Assessing skin pigmentation in epidemiological studies: The reliability of measurements under different conditions. Skin Research and Technology, 19(2), 100-106.Valenzuela, A., & Nieto, S. (1996). Synthetic and natural antioxidants: food quality protectors. Grasas y aceites.Vasco-Palacios, A. M., & Franco-Molano, A. E. (2013). Diversity of Colombian macrofungi (Ascomycota-Basidiomycota). Mycotaxon, 121(1), 100-158.Verma, D. K., & Srivastav, P. P. (2020). Bioactive compounds of rice (Oryza sativa L.): review on paradigm and its potential benefit in human health. Trends in Food Science & Technology, 97, 355-365.Vozmediano, J. M. F., & Hita, J. C. A. (2003). Retinoids in Dermatology. Medicina Cutánea Ibero-Latino-Americana, 31(5), 271-294.Wasser, S.P. (2010). Medicinal mushroom science: History, current status, future trends, and unsolved problems. Int. J. Med. Mushrooms, 12: 1–16.Wasser, S.P. and Weiss, A.L. (1999). Therapeutic effects of substances occurring in higher Basidiomycetes mushrooms: A modern perspective. Crit. Rev. Immunol., 19: 65–96.Wei, J., Guo, W. H., Cao, C. Y., Kou, R. W., Xu, Y. Z., Górecki, M., ... & Gao, J. M. (2018). Polyoxygenated cyathane diterpenoids from the mushroom Cyathus africanus, and their neurotrophic and anti-neuroinflammatory activities. Scientific reports, 8(1), 1-15.Witkowski, J. A., & Parish, L. C. (2001). You’ve come a long way baby: a history of cosmetic lead toxicity. Clinics in dermatology, 19(4), 367-370.Wu, C. Y., J. L. Mau, et al. (2008). The influence of cultivation conditions on mycelial growth and exopolysaccharide production of culinary-medicinal mushroom Pleurotus citrinopileatus singer (Agaricomycetideae). International Journal of Medicinal Mushrooms 10(279-292): 279.Wu, X., Guan, W., Yan, R., Lei, J., Xu, L., & Wang, Z. (2016a). Effects of UV-C on antioxidant activity, total phenolics and main phenolic compounds of the melanin biosynthesis pathway in different tissues of button mushroom. Postharvest Biology and Technology, 118, 51-58.Wu, Y., Choi, M. H., Li, J., Yang, H., & Shin, H. J. (2016b). Mushroom cosmetics: the present and future. Cosmetics, 3(3), 22.Xu, G. H., Kim, Y. H., Choo, S. J., Ryoo, I. J., Zheng, C. J., Seok, S. J., ... & Yoo, I. D. (2009). Isodeoxyhelicobasidin, a novel human neutrophil elastase inhibitor from the culture broth of Volvariella bombycina. The Journal of Antibiotics, 62(6), 333-334.Yahaya, Y. A., & Don, M. M. (2012). Evaluation of Trametes lactinea extracts on the inhibition of hyaluronidase, lipoxygenase and xanthine oxidase activities in vitro. Journal of Physical Science, 23(2), 1-15.Yan, Z. F., Yang, Y., Tian, F. H., Mao, X. X., Li, Y., & Li, C. T. (2014). Inhibitory and acceleratory effects of Inonotus obliquus on tyrosinase activity and melanin formation in B16 melanoma cells. Evidence-Based Complementary and Alternative Medicine, 2014.Yoon, K. N., Alam, N., Lee, J. S., Cho, H. J., Kim, H. Y., Shim, M. J., ... & Lee, T. S. (2011). Antihyperlipidemic effect of dietary Lentinus edodes on plasma, feces and hepatic tissues in hypercholesterolemic rats. Mycobiology, 39(2), 96-102.Zhang S and Duan E. (2018). Fighting against Skin Aging. Cell Transplantation 27: 729– 738.EstudiantesORIGINAL1022408660.2022(3).pdf1022408660.2022(3).pdfTesis de Maestría en Ciencias - Químicaapplication/pdf2728891https://repositorio.unal.edu.co/bitstream/unal/81780/3/1022408660.2022%283%29.pdf50e855799e42756ae150ef798fc7f9e9MD53LICENSElicense.txtlicense.txttext/plain; charset=utf-84074https://repositorio.unal.edu.co/bitstream/unal/81780/4/license.txt8153f7789df02f0a4c9e079953658ab2MD54THUMBNAIL1022408660.2022(3).pdf.jpg1022408660.2022(3).pdf.jpgGenerated Thumbnailimage/jpeg5013https://repositorio.unal.edu.co/bitstream/unal/81780/5/1022408660.2022%283%29.pdf.jpgd5bb35af797889ba45473f7217810ea3MD55unal/81780oai:repositorio.unal.edu.co:unal/817802024-08-07 23:10:37.858Repositorio Institucional Universidad Nacional de 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EVESURBIFBPUiBMQSBTRUNSRVRBUsONQSBHRU5FUkFMLiAqTEEgVEVTSVMgQSBQVUJMSUNBUiBERUJFIFNFUiBMQSBWRVJTScOTTiBGSU5BTCBBUFJPQkFEQS4gCgpBbCBoYWNlciBjbGljIGVuIGVsIHNpZ3VpZW50ZSBib3TDs24sIHVzdGVkIGluZGljYSBxdWUgZXN0w6EgZGUgYWN1ZXJkbyBjb24gZXN0b3MgdMOpcm1pbm9zLiBTaSB0aWVuZSBhbGd1bmEgZHVkYSBzb2JyZSBsYSBsaWNlbmNpYSwgcG9yIGZhdm9yLCBjb250YWN0ZSBjb24gZWwgYWRtaW5pc3RyYWRvciBkZWwgc2lzdGVtYS4KClVOSVZFUlNJREFEIE5BQ0lPTkFMIERFIENPTE9NQklBIC0gw5psdGltYSBtb2RpZmljYWNpw7NuIDE5LzEwLzIwMjEK

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