Approaches and perspectives to toxicogenetics and toxicogenomics
Toxicology is one of the scientific disciplines that has most evolved in recent years due to scientific and technological advances that have created a deeper understanding of the genetic and molecular basis for appreciative variability in toxic response from one person to another. The application of...
- Autores:
-
Ancizar-Aristizábal, Fabio
Castiblanco-Rodríguez, Ana Lucia
Márquez, Diana Cecilia
Rodríguez, Alba Isabel
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2014
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/65377
- Acceso en línea:
- https://repositorio.unal.edu.co/handle/unal/65377
http://bdigital.unal.edu.co/66400/
- Palabra clave:
- 61 Ciencias médicas; Medicina / Medicine and health
Toxicogenetics
Toxicology
Genome
Toxicogenética
Toxicología
Genoma
- Rights
- openAccess
- License
- Atribución-NoComercial 4.0 Internacional
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Approaches and perspectives to toxicogenetics and toxicogenomics |
| title |
Approaches and perspectives to toxicogenetics and toxicogenomics |
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Approaches and perspectives to toxicogenetics and toxicogenomics 61 Ciencias médicas; Medicina / Medicine and health Toxicogenetics Toxicology Genome Toxicogenética Toxicología Genoma |
| title_short |
Approaches and perspectives to toxicogenetics and toxicogenomics |
| title_full |
Approaches and perspectives to toxicogenetics and toxicogenomics |
| title_fullStr |
Approaches and perspectives to toxicogenetics and toxicogenomics |
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Approaches and perspectives to toxicogenetics and toxicogenomics |
| title_sort |
Approaches and perspectives to toxicogenetics and toxicogenomics |
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Ancizar-Aristizábal, Fabio Castiblanco-Rodríguez, Ana Lucia Márquez, Diana Cecilia Rodríguez, Alba Isabel |
| dc.contributor.author.spa.fl_str_mv |
Ancizar-Aristizábal, Fabio Castiblanco-Rodríguez, Ana Lucia Márquez, Diana Cecilia Rodríguez, Alba Isabel |
| dc.subject.ddc.spa.fl_str_mv |
61 Ciencias médicas; Medicina / Medicine and health |
| topic |
61 Ciencias médicas; Medicina / Medicine and health Toxicogenetics Toxicology Genome Toxicogenética Toxicología Genoma |
| dc.subject.proposal.spa.fl_str_mv |
Toxicogenetics Toxicology Genome Toxicogenética Toxicología Genoma |
| description |
Toxicology is one of the scientific disciplines that has most evolved in recent years due to scientific and technological advances that have created a deeper understanding of the genetic and molecular basis for appreciative variability in toxic response from one person to another. The application of this knowledge in toxicology is known as toxicogenetics and toxicogenomics. The latter is the discipline that studies the genomic response of organisms exposed to chemical agents, including drugs, environmental pollutants, food additives, and other commonly used chemical products. The use of emerging omic technologies, such as genomics, transcriptomics, proteomics, metabolomics and bioinformatics techniques, permits the analysis of many variants of genes simultaneously in an organism exposed to toxic agents in order to search for genes susceptible to damage, to detect patterns and mechanisms of toxicity, and determine specific profiles of gene expression that give origin to biomarkers of exposure and risk. This constitutes predictive toxicology. |
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2014 |
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2019-07-03T00:15:28Z |
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2019-07-03T00:15:28Z |
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Artículo de revista |
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ISSN: 2357-3848 |
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https://repositorio.unal.edu.co/handle/unal/65377 |
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ISSN: 2357-3848 |
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spa |
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spa |
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https://revistas.unal.edu.co/index.php/revfacmed/article/view/45218 |
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Universidad Nacional de Colombia Revistas electrónicas UN Revista de la Facultad de Medicina Revista de la Facultad de Medicina |
| dc.relation.references.spa.fl_str_mv |
Ancizar-Aristizábal, Fabio and Castiblanco-Rodríguez, Ana Lucia and Márquez, Diana Cecilia and Rodríguez, Alba Isabel (2014) Approaches and perspectives to toxicogenetics and toxicogenomics. Revista de la Facultad de Medicina, 62 (4). pp. 605-615. ISSN 2357-3848 |
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Derechos reservados - Universidad Nacional de Colombia |
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Atribución-NoComercial 4.0 Internacional |
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Atribución-NoComercial 4.0 InternacionalDerechos reservados - Universidad Nacional de Colombiahttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Ancizar-Aristizábal, Fabio19c46dbf-0c39-4ee7-81ec-d6e43057ee5b300Castiblanco-Rodríguez, Ana Lucia8eec915d-cde6-4d0b-ada2-ff31349b55f4300Márquez, Diana Ceciliaf6826549-ac3d-4a93-a4f8-970ad0a5559a300Rodríguez, Alba Isabel2203f894-cc1f-4f5b-afbf-2b4798e88ee23002019-07-03T00:15:28Z2019-07-03T00:15:28Z2014-10-01ISSN: 2357-3848https://repositorio.unal.edu.co/handle/unal/65377http://bdigital.unal.edu.co/66400/Toxicology is one of the scientific disciplines that has most evolved in recent years due to scientific and technological advances that have created a deeper understanding of the genetic and molecular basis for appreciative variability in toxic response from one person to another. The application of this knowledge in toxicology is known as toxicogenetics and toxicogenomics. The latter is the discipline that studies the genomic response of organisms exposed to chemical agents, including drugs, environmental pollutants, food additives, and other commonly used chemical products. The use of emerging omic technologies, such as genomics, transcriptomics, proteomics, metabolomics and bioinformatics techniques, permits the analysis of many variants of genes simultaneously in an organism exposed to toxic agents in order to search for genes susceptible to damage, to detect patterns and mechanisms of toxicity, and determine specific profiles of gene expression that give origin to biomarkers of exposure and risk. This constitutes predictive toxicology.La toxicología es una de las disciplinas científicas que más ha evolucionado en los últimos años; esto se ha dado gracias a los avances científicos y tecnológicos que han generado un conocimiento cada vez más profundo de las bases genéticas y moleculares de la variabilidad en la respuesta tóxica de unas personas a otras. La aplicación de estos conocimientos a la toxicología se conoce como toxicogenética y toxicogenómica; esta última es la disciplina que estudia la respuesta genómica de los organismos expuestos a agentes químicos, dentro de los que se incluyen fármacos, contaminantes ambientales, aditivos alimentarios y otros productos químicos de uso común. Dichos estudios se adelantan mediante el empleo de las tecnologías ómicas emergentes, como genómica, trascriptómica, proteómica, metabolómica y las técnicas bioinformáticas, las cuales permiten analizar múltiples variantes de genes simultáneamente de un organismo expuesto a agentes tóxicos, con el propósito de buscar los relacionados con susceptibilidad al daño, detectar de patrones y mecanismos de toxicidad, determinar moléculas endógenas susceptibles al ataque de agentes tóxicos y determinar perfiles específicos de expresión de genes que pueden originar biomarcadores de exposición y riesgo, constituyendo la toxicología predictiva.application/pdfspaUniversidad Nacional de Colombia - Sede Bogotá - Facultad de Medicinahttps://revistas.unal.edu.co/index.php/revfacmed/article/view/45218Universidad Nacional de Colombia Revistas electrónicas UN Revista de la Facultad de MedicinaRevista de la Facultad de MedicinaAncizar-Aristizábal, Fabio and Castiblanco-Rodríguez, Ana Lucia and Márquez, Diana Cecilia and Rodríguez, Alba Isabel (2014) Approaches and perspectives to toxicogenetics and toxicogenomics. Revista de la Facultad de Medicina, 62 (4). pp. 605-615. ISSN 2357-384861 Ciencias médicas; Medicina / Medicine and healthToxicogeneticsToxicologyGenomeToxicogenéticaToxicologíaGenomaApproaches and perspectives to toxicogenetics and toxicogenomicsArtículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/ARTORIGINAL45218-246773-1-PB.pdfapplication/pdf746945https://repositorio.unal.edu.co/bitstream/unal/65377/1/45218-246773-1-PB.pdf38c778e14d808341a6a44a6aa41c5357MD51THUMBNAIL45218-246773-1-PB.pdf.jpg45218-246773-1-PB.pdf.jpgGenerated Thumbnailimage/jpeg7849https://repositorio.unal.edu.co/bitstream/unal/65377/2/45218-246773-1-PB.pdf.jpgad4b768f3db3c48e60ef9ac5dcb72d33MD52unal/65377oai:repositorio.unal.edu.co:unal/653772023-05-19 23:46:47.085Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.co |