Approaches and perspectives to toxicogenetics and toxicogenomics

Toxicology is one of the scientific disciplines that has most evolved in recent years due to scientific and technological advances that have created a deeper understanding of the genetic and molecular basis for appreciative variability in toxic response from one person to another. The application of...

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Autores:
Ancizar-Aristizábal, Fabio
Castiblanco-Rodríguez, Ana Lucia
Márquez, Diana Cecilia
Rodríguez, Alba Isabel
Tipo de recurso:
Article of journal
Fecha de publicación:
2014
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/65377
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/65377
http://bdigital.unal.edu.co/66400/
Palabra clave:
61 Ciencias médicas; Medicina / Medicine and health
Toxicogenetics
Toxicology
Genome
Toxicogenética
Toxicología
Genoma
Rights
openAccess
License
Atribución-NoComercial 4.0 Internacional
Description
Summary:Toxicology is one of the scientific disciplines that has most evolved in recent years due to scientific and technological advances that have created a deeper understanding of the genetic and molecular basis for appreciative variability in toxic response from one person to another. The application of this knowledge in toxicology is known as toxicogenetics and toxicogenomics. The latter is the discipline that studies the genomic response of organisms exposed to chemical agents, including drugs, environmental pollutants, food additives, and other commonly used chemical products. The use of emerging omic technologies, such as genomics, transcriptomics, proteomics, metabolomics and bioinformatics techniques, permits the analysis of many variants of genes simultaneously in an organism exposed to toxic agents in order to search for genes susceptible to damage, to detect patterns and mechanisms of toxicity, and determine specific profiles of gene expression that give origin to biomarkers of exposure and risk. This constitutes predictive toxicology.