Papel de los péptidos natriuréticos en la reversibilidad del daño miocárdico en el Síndrome de Takotsubo: una perspectiva fisiológica

ilustraciones, diagramas

Autores:
Paternina Álvarez, Mariel Cecilia
Tipo de recurso:
Fecha de publicación:
2023
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/86167
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/86167
https://repositorio.unal.edu.co/
Palabra clave:
610 - Medicina y salud::612 - Fisiología humana
Cardiomiopatía de Takotsubo
Péptidos Natriuréticos/uso terapéutico
Aturdimiento Miocárdico/tratamiento farmacológico
Takotsubo Cardiomyopathy
Natriuretic Peptides/therapeutic use
Myocardial Stunning/drug therapy
Síndrome de Takotsubo
cGMP
Aturdimiento miocárdico
Péptidos natriuréticos
Takotsubo Syndrome
cGMP
myocardial stunning
Natriuretic peptides
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openAccess
License
Atribución-NoComercial 4.0 Internacional
id UNACIONAL2_186be7365762491bd1e91dbefb66fdc8
oai_identifier_str oai:repositorio.unal.edu.co:unal/86167
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Papel de los péptidos natriuréticos en la reversibilidad del daño miocárdico en el Síndrome de Takotsubo: una perspectiva fisiológica
dc.title.translated.eng.fl_str_mv Role of natriuretic peptides in the reversibility of myocardial damage in Takotsubo Syndrome: a physiological perspective
title Papel de los péptidos natriuréticos en la reversibilidad del daño miocárdico en el Síndrome de Takotsubo: una perspectiva fisiológica
spellingShingle Papel de los péptidos natriuréticos en la reversibilidad del daño miocárdico en el Síndrome de Takotsubo: una perspectiva fisiológica
610 - Medicina y salud::612 - Fisiología humana
Cardiomiopatía de Takotsubo
Péptidos Natriuréticos/uso terapéutico
Aturdimiento Miocárdico/tratamiento farmacológico
Takotsubo Cardiomyopathy
Natriuretic Peptides/therapeutic use
Myocardial Stunning/drug therapy
Síndrome de Takotsubo
cGMP
Aturdimiento miocárdico
Péptidos natriuréticos
Takotsubo Syndrome
cGMP
myocardial stunning
Natriuretic peptides
title_short Papel de los péptidos natriuréticos en la reversibilidad del daño miocárdico en el Síndrome de Takotsubo: una perspectiva fisiológica
title_full Papel de los péptidos natriuréticos en la reversibilidad del daño miocárdico en el Síndrome de Takotsubo: una perspectiva fisiológica
title_fullStr Papel de los péptidos natriuréticos en la reversibilidad del daño miocárdico en el Síndrome de Takotsubo: una perspectiva fisiológica
title_full_unstemmed Papel de los péptidos natriuréticos en la reversibilidad del daño miocárdico en el Síndrome de Takotsubo: una perspectiva fisiológica
title_sort Papel de los péptidos natriuréticos en la reversibilidad del daño miocárdico en el Síndrome de Takotsubo: una perspectiva fisiológica
dc.creator.fl_str_mv Paternina Álvarez, Mariel Cecilia
dc.contributor.advisor.spa.fl_str_mv Mockus Sivickas, Ismena Vilte Ona
dc.contributor.author.spa.fl_str_mv Paternina Álvarez, Mariel Cecilia
dc.subject.ddc.spa.fl_str_mv 610 - Medicina y salud::612 - Fisiología humana
topic 610 - Medicina y salud::612 - Fisiología humana
Cardiomiopatía de Takotsubo
Péptidos Natriuréticos/uso terapéutico
Aturdimiento Miocárdico/tratamiento farmacológico
Takotsubo Cardiomyopathy
Natriuretic Peptides/therapeutic use
Myocardial Stunning/drug therapy
Síndrome de Takotsubo
cGMP
Aturdimiento miocárdico
Péptidos natriuréticos
Takotsubo Syndrome
cGMP
myocardial stunning
Natriuretic peptides
dc.subject.decs.spa.fl_str_mv Cardiomiopatía de Takotsubo
Péptidos Natriuréticos/uso terapéutico
Aturdimiento Miocárdico/tratamiento farmacológico
dc.subject.decs.eng.fl_str_mv Takotsubo Cardiomyopathy
Natriuretic Peptides/therapeutic use
Myocardial Stunning/drug therapy
dc.subject.proposal.spa.fl_str_mv Síndrome de Takotsubo
cGMP
Aturdimiento miocárdico
Péptidos natriuréticos
dc.subject.proposal.eng.fl_str_mv Takotsubo Syndrome
cGMP
myocardial stunning
Natriuretic peptides
description ilustraciones, diagramas
publishDate 2023
dc.date.issued.none.fl_str_mv 2023-11-21
dc.date.accessioned.none.fl_str_mv 2024-05-27T21:14:31Z
dc.date.available.none.fl_str_mv 2024-05-27T21:14:31Z
dc.type.spa.fl_str_mv Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/86167
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/86167
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.indexed.spa.fl_str_mv Bireme
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dc.publisher.faculty.spa.fl_str_mv Facultad de Medicina
dc.publisher.place.spa.fl_str_mv Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv Universidad Nacional de Colombia - Sede Bogotá
institution Universidad Nacional de Colombia
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spelling Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Mockus Sivickas, Ismena Vilte Onaa8ec1b15b568053ef6e35df78f61f79e600Paternina Álvarez, Mariel Cecilia3c213300f216ce2f1d6e93d9c04aedb32024-05-27T21:14:31Z2024-05-27T21:14:31Z2023-11-21https://repositorio.unal.edu.co/handle/unal/86167Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramasEl Síndrome de Takotsubo (ST) es un síndrome de falla cardíaca aguda con características similares al síndrome coronario agudo, salvo la mayor elevación de péptidos natriuréticos (NP) en sangre en la fase aguda y la recuperación completa de la función miocárdica en días posteriores al evento inicial. Su aparición se asocia con efectos directos e indirectos de las catecolaminas sobre las células miocárdicas, desencadenando aturdimiento miocárdico transitorio. Dada las características diferenciales, especialmente el aumento tres veces mayor de los péptidos natriuréticos, el objetivo de esta revisión narrativa es determinar a través de la revisión de información actual si los péptidos natriuréticos podrían estar implicados en la reversibilidad del daño miocárdico en pacientes adultos con Síndrome de Takotsubo y dilucidar las posibles vías moleculares implicadas en su acción cardioprotectora. Los péptidos natriuréticos, especialmente ANP y BNP, ejercen funciones cardioprotectoras sobre el miocardio en respuesta a cambios hemodinámicos cardíacos, presencia de hipoxia, isquemia y exceso de catecolaminas. De hecho, los péptidos natriuréticos no solamente disminuyen la cantidad de catecolaminas liberadas en respuesta a la activación simpática, sino que su uso como agente farmacológico bloquea la aparición de aturdimiento miocárdico, disfunción miocárdica parecida a ST y arritmias ventriculares en respuesta a un estímulo estresante o presencia de agonistas adrenérgicos; además, disminuyen el tamaño del infarto en SCA, y bloquean la inducción de isquemia irreversible durante la reperfusión. Los estudios sugieren a la vía de ANP-BNP/NPR-A/cGMP/PKG como la principal implicada en los efectos protectores de los péptidos natriuréticos sobre el miocardio. (Texto tomado de la fuente).The Takotsubo Syndrome (TS) is a syndrome of acute heart failure with characteristics similar to acute coronary syndrome, except for the higher elevation of natriuretic peptides (NP) in the blood during the acute phase and the complete recovery of myocardial function in the days following the initial event. Its onset is associated with direct and indirect effects of catecholamines on myocardial cells, triggering transient myocardial stunning. Given the differential characteristics, especially the threefold increase in natriuretic peptides, the aim of this narrative review is to determine through the examination of current information whether natriuretic peptides could be involved in the reversibility of myocardial damage in adult patients with Takotsubo Syndrome and to elucidate the possible molecular pathways involved in their cardioprotective action. Natriuretic peptides, especially ANP and BNP, exert cardioprotective functions on the myocardium in response to cardiac hemodynamic changes, hypoxia, ischemia, and excess catecholamines. In fact, natriuretic peptides not only reduce the amount of catecholamines released in response to sympathetic activation but also, when used as a pharmacological agent, block the occurrence of myocardial stunning, myocardial dysfunction similar to TS, and ventricular arrhythmias in response to a stressful stimulus or the presence of adrenergic agonists. Additionally, they reduce the infarct size in ACS and block the induction of irreversible ischemia during reperfusion. Studies suggest the ANP-BNP/NPR-A/cGMP/PKG pathway as the main player in the protective effects of natriuretic peptides on the myocardium.MaestríaMagíster en FisiologíaLínea de profundizaciónx, 134 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Maestría en FisiologíaFacultad de MedicinaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud::612 - Fisiología humanaCardiomiopatía de TakotsuboPéptidos Natriuréticos/uso terapéuticoAturdimiento Miocárdico/tratamiento farmacológicoTakotsubo CardiomyopathyNatriuretic Peptides/therapeutic useMyocardial Stunning/drug therapySíndrome de TakotsubocGMPAturdimiento miocárdicoPéptidos natriuréticosTakotsubo SyndromecGMPmyocardial stunningNatriuretic peptidesPapel de los péptidos natriuréticos en la reversibilidad del daño miocárdico en el Síndrome de Takotsubo: una perspectiva fisiológicaRole of natriuretic peptides in the reversibility of myocardial damage in Takotsubo Syndrome: a physiological perspectiveTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMBiremeGupta, S., & Gupta, M. 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European journal of pharmacology, 695(1-3), 13–19. https://doi.org/10.1016/j.ejphar.2012.07.053Universidad Nacional de ColombiaInvestigadoresLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/86167/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1108765651.2023.pdf1108765651.2023.pdfTesis de Maestría en Fisiologíaapplication/pdf3824960https://repositorio.unal.edu.co/bitstream/unal/86167/2/1108765651.2023.pdfbaaa77940f939d1269adf161a2c04bfdMD52THUMBNAIL1108765651.2023.pdf.jpg1108765651.2023.pdf.jpgGenerated Thumbnailimage/jpeg5031https://repositorio.unal.edu.co/bitstream/unal/86167/3/1108765651.2023.pdf.jpg80b50ba241665d7ca2649b4348958fceMD53unal/86167oai:repositorio.unal.edu.co:unal/861672024-05-27 23:04:43.553Repositorio Institucional Universidad Nacional de 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