Interacción de la estimulación somatosensorial periférica y cortical sobre el procesamiento de la información somatosensorial en la corteza motora primaria de las vibrisas en ratas
ilustraciones, diagramas
- Autores:
-
Niño Hernández, Angélica Beatriz
- Tipo de recurso:
- Fecha de publicación:
- 2024
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/86667
- Palabra clave:
- 570 - Biología::571 - Fisiología y temas relacionados
570 - Biología::573 - Sistemas fisiológicos específicos en animales, histología regional y fisiología en los animales
RECEPTORES SENSORIALES
LOBULO PARIETAL
GENERALIZACION DEL ESTIMULO
Sensory receptors
Parietal lobes
Stimulus generalization
Sistema de las vibrisas
Corteza motora de las vibrisas
Corteza de los barriles
Integración sensoriomotora
Whisker system
Vibrissal motor cortex
Barrel cortex
Sensorimotor integration
- Rights
- openAccess
- License
- Reconocimiento 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Interacción de la estimulación somatosensorial periférica y cortical sobre el procesamiento de la información somatosensorial en la corteza motora primaria de las vibrisas en ratas |
| dc.title.translated.eng.fl_str_mv |
Interaction of peripheral and cortical somatosensory stimulation on somatosensory information processing in the vibrissal primary motor cortex in rats |
| title |
Interacción de la estimulación somatosensorial periférica y cortical sobre el procesamiento de la información somatosensorial en la corteza motora primaria de las vibrisas en ratas |
| spellingShingle |
Interacción de la estimulación somatosensorial periférica y cortical sobre el procesamiento de la información somatosensorial en la corteza motora primaria de las vibrisas en ratas 570 - Biología::571 - Fisiología y temas relacionados 570 - Biología::573 - Sistemas fisiológicos específicos en animales, histología regional y fisiología en los animales RECEPTORES SENSORIALES LOBULO PARIETAL GENERALIZACION DEL ESTIMULO Sensory receptors Parietal lobes Stimulus generalization Sistema de las vibrisas Corteza motora de las vibrisas Corteza de los barriles Integración sensoriomotora Whisker system Vibrissal motor cortex Barrel cortex Sensorimotor integration |
| title_short |
Interacción de la estimulación somatosensorial periférica y cortical sobre el procesamiento de la información somatosensorial en la corteza motora primaria de las vibrisas en ratas |
| title_full |
Interacción de la estimulación somatosensorial periférica y cortical sobre el procesamiento de la información somatosensorial en la corteza motora primaria de las vibrisas en ratas |
| title_fullStr |
Interacción de la estimulación somatosensorial periférica y cortical sobre el procesamiento de la información somatosensorial en la corteza motora primaria de las vibrisas en ratas |
| title_full_unstemmed |
Interacción de la estimulación somatosensorial periférica y cortical sobre el procesamiento de la información somatosensorial en la corteza motora primaria de las vibrisas en ratas |
| title_sort |
Interacción de la estimulación somatosensorial periférica y cortical sobre el procesamiento de la información somatosensorial en la corteza motora primaria de las vibrisas en ratas |
| dc.creator.fl_str_mv |
Niño Hernández, Angélica Beatriz |
| dc.contributor.advisor.none.fl_str_mv |
Múnera Galarza, Francisco Alejandro |
| dc.contributor.author.none.fl_str_mv |
Niño Hernández, Angélica Beatriz |
| dc.contributor.researchgroup.spa.fl_str_mv |
Neurofisiología comportamental |
| dc.contributor.cvlac.spa.fl_str_mv |
Angelica Beatriz Niño |
| dc.subject.ddc.spa.fl_str_mv |
570 - Biología::571 - Fisiología y temas relacionados 570 - Biología::573 - Sistemas fisiológicos específicos en animales, histología regional y fisiología en los animales |
| topic |
570 - Biología::571 - Fisiología y temas relacionados 570 - Biología::573 - Sistemas fisiológicos específicos en animales, histología regional y fisiología en los animales RECEPTORES SENSORIALES LOBULO PARIETAL GENERALIZACION DEL ESTIMULO Sensory receptors Parietal lobes Stimulus generalization Sistema de las vibrisas Corteza motora de las vibrisas Corteza de los barriles Integración sensoriomotora Whisker system Vibrissal motor cortex Barrel cortex Sensorimotor integration |
| dc.subject.lemb.spa.fl_str_mv |
RECEPTORES SENSORIALES LOBULO PARIETAL GENERALIZACION DEL ESTIMULO |
| dc.subject.lemb.eng.fl_str_mv |
Sensory receptors Parietal lobes Stimulus generalization |
| dc.subject.proposal.spa.fl_str_mv |
Sistema de las vibrisas Corteza motora de las vibrisas Corteza de los barriles Integración sensoriomotora |
| dc.subject.proposal.eng.fl_str_mv |
Whisker system Vibrissal motor cortex Barrel cortex Sensorimotor integration |
| description |
ilustraciones, diagramas |
| publishDate |
2024 |
| dc.date.accessioned.none.fl_str_mv |
2024-07-31T16:51:40Z |
| dc.date.available.none.fl_str_mv |
2024-07-31T16:51:40Z |
| dc.date.issued.none.fl_str_mv |
2024 |
| dc.type.spa.fl_str_mv |
Trabajo de grado - Maestría |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/masterThesis |
| dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/acceptedVersion |
| dc.type.content.spa.fl_str_mv |
Text |
| dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/TM |
| status_str |
acceptedVersion |
| dc.identifier.uri.none.fl_str_mv |
https://repositorio.unal.edu.co/handle/unal/86667 |
| dc.identifier.instname.spa.fl_str_mv |
Universidad Nacional de Colombia |
| dc.identifier.reponame.spa.fl_str_mv |
Repositorio Institucional Universidad Nacional de Colombia |
| dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.unal.edu.co/ |
| url |
https://repositorio.unal.edu.co/handle/unal/86667 https://repositorio.unal.edu.co/ |
| identifier_str_mv |
Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia |
| dc.language.iso.spa.fl_str_mv |
spa |
| language |
spa |
| dc.relation.references.spa.fl_str_mv |
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Reconocimiento 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Múnera Galarza, Francisco Alejandro8eaff4d83985b7abb5f6eda6c8090c13Niño Hernández, Angélica Beatrizf166eb675511e869b3e7cd88556d12b9Neurofisiología comportamentalAngelica Beatriz Niño2024-07-31T16:51:40Z2024-07-31T16:51:40Z2024https://repositorio.unal.edu.co/handle/unal/86667Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramasEl sistema de las vibrisas en roedores constituye un modelo de investigación de gran importancia para entender el proceso de integración sensoriomotora. Esto se debe a su bien definida representación somatotópica en la corteza somatosensorial de los barriles (S1b) y a la extensa investigación sobre las vías de transducción de estímulos táctiles a señales eléctricas. En este trabajo, se estudió la interacción de la estimulación somatosensorial periférica y cortical sobre el procesamiento de esta información en la corteza motora primaria de las vibrisas (vM1). Para ello, se emplearon protocolos de pares de pulsos, pre-estimulación y se evaluó el comportamiento oscilatorio en el dominio de tiempo y frecuencia. En este contexto, se amplió la caracterización de la respuesta en vM1 y S1b ante estímulos únicos en el parche de vibrisas (WP). Además, se caracterizó por primera vez en ratas la respuesta provocada en vM1 ante estimulación en S1b. Los hallazgos indican que la información somatosensorial de las vibrisas llega simultáneamente a S1b y vM1. Mediante protocolos de pares de pulsos en WP, se evidenció activación sostenida de circuitos inhibidores en vM1 y S1b por parte de las entradas tálamo-corticales, asociada con oscilaciones gamma. Al administrar pares de pulsos en S1b, se evidenció la naturaleza monosináptica de las proyecciones desde S1b a vM1, que tienen un efecto temprano excitador y uno tardío inhibidor. Finalmente, para evaluar las interacciones funcionales de vM1 con S1b, se utilizó el protocolo de pre-estimulación. La estimulación en S1b antecediendo la estimulación en WP, desfacilitó las oscilaciones lentas del potencial provocado en vM1 en dos ventanas de tiempo asociado con una actividad en la banda theta y gamma alta. Por otro lado, la administración de estímulos en WP antecediendo la estimulación en S1b, facilitó las oscilaciones lentas del potencial provocado en vM1 a intervalos entre estímulos (IEEs) cortos, relacionado con la coincidencia de entradas excitadoras cortico-corticales desde S1b con las entradas intracorticales de vM1 procedentes de la activación tálamo-cortical. Sin embargo, en IEEs mayores, esta pre-estimulación incrementa la actividad inhibitoria en la banda theta y gamma. Este estudio complementa el conocimiento previo sobre la respuesta provocada en vM1 ante estimulación periférica y revela, por primera vez en ratas, la caracterización de la respuesta provocada en vM1 ante estimulación en S1b mediante un enfoque electrofisiológico y de análisis espectral en el dominio del tiempo y frecuencia (Texto tomado de la fuente).The whisker system in rodents constitutes a research model of great importance for understanding the process of sensorimotor integration. Its significance lies in the well-defined somatotopic representation in the barrel cortex (S1b) and to the extensive research on the transduction pathways of tactile stimuli to electrical signals. In this study, the interaction of peripheral and cortical somatosensory stimulation on the processing of this information in the vibrissal primary motor cortex (vM1) was examined. For this aim, paired-pulse, pre-stimulation protocols and oscillatory behavior in the time and frequency domain were used. In this context, the characterization of the response in vM1 and S1b to single stimuli in the whisker pad (WP) was extended. In addition, the response evoked in vM1 to stimulation in S1b was characterized for the first time in rats. The findings indicate that somatosensory information from the whiskers simultaneously reaches both S1b and vM1. Using paired-pulse protocols in WP, sustained activation of inhibitory circuits in vM1 and S1b by thalamocortical inputs, associated with gamma oscillations, was evidenced. When administering paired pulses in S1b, the monosynaptic nature of the projections from S1b to vM1, which have an early excitatory and a late inhibitory effect, was evidenced. Finally, to evaluate the functional interactions of vM1 with S1b, the pre-stimulation protocol was used. S1b stimulation preceding WP stimulation defacilitated slow oscillations of the evoked potential in vM1 in two-time windows associated with theta and high gamma activity. On the other hand, WP stimulus preceding S1b stimulation facilitated slow oscillations of the evoked potential in vM1 at short interstimulus intervals (ISIs), related to the coincidence of cortico-cortical excitatory inputs from S1b and intracortical inputs vM1 from thalamocortical activation. However, at longer ISIs, this pre-stimulation increased inhibitory activity in the theta and gamma bands. This study complements prior knowledge on the evoked response in vM1 to peripheral stimulation and reveals, for the first time in rats, the characterization of the evoked response in vM1 to stimulation in S1b by an electrophysiological approach and spectral analysis in the time and frequency domain.MaestríaMagister en Ciencias - BiologíaSe emplearon nueve ratas macho Wistar adultas, con un peso entre 300 g y 400 g. Estos animales fueron obtenidos del Bioterio Central de la Universidad Nacional de Colombia, sede Bogotá, en la Facultad de Medicina Veterinaria y Zootecnia. En el bioterio, los sujetos experimentales fueron mantenidos en una sala con atenuación de ruido, con control de humedad (40 ± 5%) y temperatura (20 ± 1 °C), con ciclo de luz / oscuridad de 12 horas y con suministro de alimento y agua fresca potable ad libitum. Minutos antes de iniciar cada experimento, el animal fue trasladado al laboratorio de Neurofisiología Comportamental de la Facultad de Medicina de la Universidad Nacional de Colombia. Para ello, se utilizaron cajas de policarbonato (38 x 32 x 18 cm) con una capa de viruta de madera en el fondo y cubierta de una tela negra para evitar estrés del animal durante su traslado.Fisiología del control motor facial96 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ciencias - Maestría en Ciencias - BiologíaFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá570 - Biología::571 - Fisiología y temas relacionados570 - Biología::573 - Sistemas fisiológicos específicos en animales, histología regional y fisiología en los animalesRECEPTORES SENSORIALESLOBULO PARIETALGENERALIZACION DEL ESTIMULOSensory receptorsParietal lobesStimulus generalizationSistema de las vibrisasCorteza motora de las vibrisasCorteza de los barrilesIntegración sensoriomotoraWhisker systemVibrissal motor cortexBarrel cortexSensorimotor integrationInteracción de la estimulación somatosensorial periférica y cortical sobre el procesamiento de la información somatosensorial en la corteza motora primaria de las vibrisas en ratasInteraction of peripheral and cortical somatosensory stimulation on somatosensory information processing in the vibrissal primary motor cortex in ratsTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMAbbott, L., & Regehr, W. 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Annual Review of Physiology, 64(1), 355–405. https://doi.org/10.1146/annurev.physiol.64.092501.114547InvestigadoresLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/86667/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1024543251.2024.pdf1024543251.2024.pdfTesis de Maestría en Ciencias - Biologíaapplication/pdf4074354https://repositorio.unal.edu.co/bitstream/unal/86667/2/1024543251.2024.pdfec5b738955ec1280ef17b9413482c51bMD52THUMBNAIL1024543251.2024.pdf.jpg1024543251.2024.pdf.jpgGenerated Thumbnailimage/jpeg4683https://repositorio.unal.edu.co/bitstream/unal/86667/3/1024543251.2024.pdf.jpgf936261789c2eeb68604d5d9b9a84fadMD53unal/86667oai:repositorio.unal.edu.co:unal/866672024-08-27 23:11:04.725Repositorio Institucional Universidad Nacional de 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