Design of scaffolds for bone tissue regeneration through diagnostic imaging and generative design

ilustraciones, fotografías a color

Autores:: Castañeda Parra, Fahir Dario

Tipo de recurso:

Fecha de publicación:: 2023

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: eng

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network_acronym_str	UNACIONAL2
network_name_str	Universidad Nacional de Colombia
repository_id_str
dc.title.eng.fl_str_mv	Design of scaffolds for bone tissue regeneration through diagnostic imaging and generative design
dc.title.translated.spa.fl_str_mv	Diseño de scaffolds para regeneración de tejido óseo mediante imágenes diagnósticas y diseño generativo
title	Design of scaffolds for bone tissue regeneration through diagnostic imaging and generative design
spellingShingle	Design of scaffolds for bone tissue regeneration through diagnostic imaging and generative design 610 - Medicina y salud 600 - Tecnología (Ciencias aplicadas) Matriz extracelular Ingeniería de tejidos Extracellular Matrix Tissue Engineering Cellular materials Generative design Finite element method Bone scaffold Materiales celulares Diseño generativo Método de elementos finitos Andamio óseo
title_short	Design of scaffolds for bone tissue regeneration through diagnostic imaging and generative design
title_full	Design of scaffolds for bone tissue regeneration through diagnostic imaging and generative design
title_fullStr	Design of scaffolds for bone tissue regeneration through diagnostic imaging and generative design
title_full_unstemmed	Design of scaffolds for bone tissue regeneration through diagnostic imaging and generative design
title_sort	Design of scaffolds for bone tissue regeneration through diagnostic imaging and generative design
dc.creator.fl_str_mv	Castañeda Parra, Fahir Dario
dc.contributor.advisor.none.fl_str_mv	Garzón Alvarado, Diego Alexander
dc.contributor.author.none.fl_str_mv	Castañeda Parra, Fahir Dario
dc.contributor.researchgroup.spa.fl_str_mv	Gnum Grupo de Modelado y Métodos Numericos en Ingeniería
dc.contributor.orcid.spa.fl_str_mv	Castañeda Parra, Fahir Dario [0000-0002-7191-5940]
dc.subject.ddc.spa.fl_str_mv	610 - Medicina y salud 600 - Tecnología (Ciencias aplicadas)
topic	610 - Medicina y salud 600 - Tecnología (Ciencias aplicadas) Matriz extracelular Ingeniería de tejidos Extracellular Matrix Tissue Engineering Cellular materials Generative design Finite element method Bone scaffold Materiales celulares Diseño generativo Método de elementos finitos Andamio óseo
dc.subject.decs.spa.fl_str_mv	Matriz extracelular Ingeniería de tejidos
dc.subject.decs.eng.fl_str_mv	Extracellular Matrix Tissue Engineering
dc.subject.proposal.eng.fl_str_mv	Cellular materials Generative design Finite element method Bone scaffold
dc.subject.proposal.spa.fl_str_mv	Materiales celulares Diseño generativo Método de elementos finitos Andamio óseo
description	ilustraciones, fotografías a color
publishDate	2023
dc.date.accessioned.none.fl_str_mv	2023-04-12T16:26:12Z
dc.date.available.none.fl_str_mv	2023-04-12T16:26:12Z
dc.date.issued.none.fl_str_mv	2023-03-31
dc.type.spa.fl_str_mv	Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TM
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/83700
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/83700 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	eng
language	eng
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Bonassar and C. a Vacanti, “Tissue engineering: the first decade and beyond.,” J Cell Biochem Suppl, vol. 30–31, no. September, pp. 297–303, 1998, doi: 10.1002/(SICI)1097- 4644(1998)72. W. M. Saltzman and T. R. Kyriakides, Cell interactions with polymers_Lanza19.pdf, Third Edit. Elsevier Inc., 2014. doi: 10.1016/B978-0-12-370615-7.50024-X L. J. Gibson and M. F. Ashby, Cellular Solids, vol. 22, no. 4. Cambridge: Cambridge University Press, 1997. doi: 10.1017/CBO9781139878326. M. Scheffler and P. Colombo, Cellular Ceramics. Wiley, 2005. doi: 10.1002/3527606696. L. J. Gibson, M. F. Ashby, G. N. Karam, U. Wegst, and H. R. Shercliff, “The Mechanical Properties of Natural Materials. II. Microstructures for Mechanical Efficiency,” Proceedings: Mathematical and Physical Sciences, vol. 450. Royal Society, pp. 141–162. doi: 10.2307/52663. J. G. Skedros and S. L. Baucom, “Mathematical analysis of trabecular ‘trajectories’ in apparent trajectorial structures: the unfortunate historical emphasis on the human proximal femur,” J Theor Biol, vol. 244, no. 1, pp. 15–45, Jan. 2007, doi: 10.1016/j.jtbi.2006.06.029. C. H. Turner, “On Wolff’s law of trabecular architecture,” J Biomech, vol. 25, no. 1, pp. 1– 9, Jan. 1992, doi: 10.1016/0021-9290(92)90240-2. L. Esteban-Tejeda et al., “Bone tissue scaffolds based on antimicrobial SiO2-Na2OAl2O3-CaO-B2O3 glass,” J Non Cryst Solids, vol. 432, pp. 73–80, 2016, doi: 10.1016/j.jnoncrysol.2015.05.040. Q. Fu, Bioactive Glass Scaffolds for Bone Tissue Engineering. Elsevier Ltd., 2019. doi: 10.1016/b978-0-08-102196-5.00015-x. Y. Kim, J. Y. Lim, G. H. Yang, J.-H. Seo, H.-S. Ryu, and G. Kim, “3D-printed PCL/bioglass (BGS-7) composite scaffolds with high toughness and cell-responses for bone tissue regeneration,” Journal of Industrial and Engineering Chemistry, 2019, doi: 10.1016/j.jiec.2019.06.027. Z. 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Martin, Principles of Bone Biology 3, vol. 1, no. 9. Academic Press, 2008. doi: 10.3174/ajnr.A1712. D. Alfredo and Q. Rodríguez, “MODELO COMPUTACIONAL DE REMODELAMIENTO ÓSEO MEDIANTE ESTRUCTURAS DISCRETAS,” Universidad Nacional de Colombia, Bogotá, 2021. M. P. Bendsøe and O. Sigmund, Topology Optimization. Berlin, Heidelberg: Springer Berlin Heidelberg, 2004. doi: 10.1007/978-3-662-05086-6. M. P. Bendsøe, “Optimal shape design as a material distribution problem,” Structural Optimization, vol. 1, no. 4, pp. 193–202, 1989, doi: 10.1007/BF01650949. M. Yliperttula, B. G. Chung, A. Navaladi, A. Manbachi, and A. Urtti, “High-throughput screening of cell responses to biomaterials,” European Journal of Pharmaceutical Sciences, vol. 35, no. 3. pp. 151–160, Oct. 02, 2008. doi: 10.1016/j.ejps.2008.04.012. R. Dimitriou, E. Jones, D. McGonagle, and P. v Giannoudis, “Bone regeneration: current concepts and future directions,” BMC Med, vol. 9, no. 1, p. 66, Dec. 2011, doi: 10.1186/1741-7015-9-66. V. Karageorgiou and D. Kaplan, “Porosity of 3D biomaterial scaffolds and osteogenesis,” Biomaterials, vol. 26, no. 27, pp. 5474–5491, 2005, doi: 10.1016/j.biomaterials.2005.02.002. S. Hofmann et al., “Control of in vitro tissue-engineered bone-like structures using human mesenchymal stem cells and porous silk scaffolds,” Biomaterials, vol. 28, no. 6, pp. 1152– 1162, Feb. 2007, doi: 10.1016/j.biomaterials.2006.10.019. A. C. Jones, C. H. Arns, D. W. Hutmacher, B. K. Milthorpe, A. P. Sheppard, and M. A. Knackstedt, “The correlation of pore morphology, interconnectivity and physical properties of 3D ceramic scaffolds with bone ingrowth,” Biomaterials, vol. 30, no. 7, pp. 1440–1451, Mar. 2009, doi: 10.1016/j.biomaterials.2008.10.056. Y. Wang, U. J. Kim, D. J. Blasioli, H. J. Kim, and D. L. Kaplan, “In vitro cartilage tissue engineering with 3D porous aqueous-derived silk scaffolds and mesenchymal stem cells,” Biomaterials, vol. 26, no. 34, pp. 7082–7094, Dec. 2005, doi: 10.1016/j.biomaterials.2005.05.022. L. Meinel et al., “Engineering bone-like tissue in vitro using human bone marrow stem cells and silk scaffolds,” J Biomed Mater Res A, vol. 71, no. 1, pp. 25–34, Oct. 2004, doi: 10.1002/jbm.a.30117. L. Meinel et al., “Silk implants for the healing of critical size bone defects,” Bone, vol. 37, no. 5, pp. 688–698, 2005, doi: 10.1016/j.bone.2005.06.010. L. Meinel et al., “Engineering cartilage-like tissue using human mesenchymal stem cells and silk protein scaffolds,” Biotechnol Bioeng, vol. 88, no. 3, pp. 379–391, Nov. 2004, doi: 10.1002/bit.20252. L. Uebersax et al., “Effect of Scaffold Design on Bone Morphology In Vitro.” X. Liu and P. X. Ma, “Polymeric Scaffolds for Bone Tissue Engineering,” 2004. W. L. Murphy, R. G. Dennis, J. L. Kileny, and D. J. 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Bai et al., “The effect of pore size on tissue ingrowth and neovascularization in porous bioceramics of controlled architecture in vivo Biomed.” Mater, 2011. A. P. Roberts and E. J. Garboczi, “ELASTIC MODULI OF MODEL RANDOM THREEDIMENSIONAL CLOSED-CELL CELLULAR SOLIDS,” 2001. [Online]. Available: www.elsevier.com/locate/actamat Y. X. Gan, C. Chen, and Y. P. Shen, “Three-dimensional modeling of the mechanical property of linearly elastic open cell foams,” Int J Solids Struct, vol. 42, no. 26, pp. 6628– 6642, Dec. 2005, doi: 10.1016/j.ijsolstr.2005.03.002. B. Herath et al., “Mechanical and geometrical study of 3D printed Voronoi scaffold design for large bone defects,” Mater Des, vol. 212, p. 110224, 2021, doi: 10.1016/j.matdes.2021.110224. S. Gómez, M. D. Vlad, J. López, and E. Fernández, “Design and properties of 3D scaffolds for bone tissue engineering,” Acta Biomater, vol. 42, no. June, pp. 341–350, 2016, doi: 10.1016/j.actbio.2016.06.032. V. Karageorgiou and D. Kaplan, “Porosity of 3D biomaterial scaffolds and osteogenesis,” Biomaterials, vol. 26, no. 27. Elsevier BV, pp. 5474–5491, 2005. doi: 10.1016/j.biomaterials.2005.02.002. C. K. Chua, K. F. Leong, C. M. Cheah, and S. W. Chua, “Development of a Tissue Engineering Scaffold Structure Library for Rapid Prototyping . Part 2 : Parametric Library and Assembly Program,” Advanced manufacturing technology, vol. 21, pp. 302–312, 2003. N. Chantarapanich, P. Puttawibul, S. Sucharitpwatskul, P. Jeamwatthanachai, S. Inglam, and K. Sitthiseripratip, “Scaffold Library for Tissue Engineering : A Geometric Evaluation,” vol. 2012, 2012, doi: 10.1155/2012/407805. M. A. Wettergreen, B. S. Bucklen, B. Starly, E. Yuksel, W. Sun, and M. A. K. Liebschner, “Creation of a unit block library of architectures for use in assembled scaffold engineering,” Computer-Aided Design, vol. 37, no. 11, pp. 1141–1149, Sep. 2005, doi: DOI: 10.1016/j.cad.2005.02.005.
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dc.rights.license.spa.fl_str_mv	Atribución-NoComercial-SinDerivadas 4.0 Internacional
dc.rights.uri.spa.fl_str_mv	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.accessrights.spa.fl_str_mv	info:eu-repo/semantics/openAccess
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dc.format.extent.spa.fl_str_mv	x, 64 páginas
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dc.publisher.spa.fl_str_mv	Universidad Nacional de Colombia
dc.publisher.program.spa.fl_str_mv	Bogotá - Ingeniería - Maestría en Ingeniería - Materiales y Procesos
dc.publisher.faculty.spa.fl_str_mv	Facultad de Ingeniería
dc.publisher.place.spa.fl_str_mv	Bogotá,Colombia
dc.publisher.branch.spa.fl_str_mv	Universidad Nacional de Colombia - Sede Bogotá
institution	Universidad Nacional de Colombia
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spelling	Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Garzón Alvarado, Diego Alexandera780fc0a2dd14ac611c37bca9998c94bCastañeda Parra, Fahir Dario4d79bd7b048f04f316d7678d4517ec9cGnum Grupo de Modelado y Métodos Numericos en IngenieríaCastañeda Parra, Fahir Dario [0000-0002-7191-5940]2023-04-12T16:26:12Z2023-04-12T16:26:12Z2023-03-31https://repositorio.unal.edu.co/handle/unal/83700Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, fotografías a colorilustraciones, fotografías principalmente colorBone tissue engineering focuses, in addition to other things, on the understanding of bone structures to promote their formation with scaffolds. The manufacturing processes of scaffolds with variable density are complicated for traditional manufacturing methods, where localized holes are drilled in structures to mimic bone architecture. In recent years, tissue engineering has benefited from advances in the development of additive manufacturing, which allows the creation of complex geometries such as scaffolds. To explore this method, the use of image-based design is proposed. In this thesis, a scaffold with variable internal density is developed, which can be fabricated by additive manufacturing by controlling the external and internal geometry of the structure, porosity, and pore size from diagnostic images. (Texto tomado de la fuente)La ingeniería de tejidos ósea se encarga, entre otros, de la comprensión de las estructuras de los huesos para tratar de promover su formación con scaffolds. Los procesos de fabricación de scaffolds con densidad variable se dificultan para métodos tradicionales de manufactura en donde se realizan agujeros localizados en estructuras con el objetivo de lograr imitar la arquitectura del hueso. En los últimos años, la Ingeniería de Tejidos se ha visto beneficiada de los avances que se han realizado en el desarrollo de la manufactura aditiva, la cual permite la creación de geometrías complejas como las de los scaffolds. Para incursionar en este método, se propone el uso del diseño basado en imágenes diagnosticas. En esta tesis se desarrolla un scaffold con densidad interna variable, que puede ser llevado a su fabricación por manufactura aditiva controlando geometría externa e interna de la estructura, porosidad y tamaño de poro a partir de imágenes diagnosticas.MaestríaMagíster en Ingeniería - Materiales y ProcesosIngeniería de tejidosx, 64 páginasapplication/pdfengUniversidad Nacional de ColombiaBogotá - Ingeniería - Maestría en Ingeniería - Materiales y ProcesosFacultad de IngenieríaBogotá,ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud600 - Tecnología (Ciencias aplicadas)Matriz extracelularIngeniería de tejidosExtracellular MatrixTissue EngineeringCellular materialsGenerative designFinite element methodBone scaffoldMateriales celularesDiseño generativoMétodo de elementos finitosAndamio óseoDesign of scaffolds for bone tissue regeneration through diagnostic imaging and generative designDiseño de scaffolds para regeneración de tejido óseo mediante imágenes diagnósticas y diseño generativoTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMM. 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Liebschner, “Creation of a unit block library of architectures for use in assembled scaffold engineering,” Computer-Aided Design, vol. 37, no. 11, pp. 1141–1149, Sep. 2005, doi: DOI: 10.1016/j.cad.2005.02.005.EstudiantesInvestigadoresORIGINAL1032457113_2023.pdf1032457113_2023.pdfTesis de Maestría en Ingeniería - Materiales y Procesosapplication/pdf9585081https://repositorio.unal.edu.co/bitstream/unal/83700/4/1032457113_2023.pdf5d7593ac387b8093dfb73b7b275bc55cMD54LICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/83700/3/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD53THUMBNAIL1032457113_2023.pdf.jpg1032457113_2023.pdf.jpgGenerated Thumbnailimage/jpeg4697https://repositorio.unal.edu.co/bitstream/unal/83700/5/1032457113_2023.pdf.jpg104d2dd745fe3e2fdf6962d3dc3c4b9bMD55unal/83700oai:repositorio.unal.edu.co:unal/837002024-08-01 23:09:37.006Repositorio Institucional Universidad Nacional de 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Design of scaffolds for bone tissue regeneration through diagnostic imaging and generative design

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