Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity

Compound usnic acid (1), isolated from lichen Evernia prunastri (Cajamarca-Peru) and the synthesis and characterization of its acyl-hydrazone (2), from the condensation reaction between usnic acid and isoniazid in an ethanol solution under reflux, giving an overall yield of 95%, were evaluated. Both compounds were evaluated and compared with isoniazid according to its anti-Mycobacterium tuberculosis activity based on the tetrazolium microplate assay (TEMA). Compound 1 had MIC (minimal inhibitory concentration) value of 16.0 μg/mL in each test of H37Rv (susceptible type), TB DM 97 (resistant wild type) and MDR DM 1098 (multi drug resistances type) strains. In similar tests, compound 2 MIC values were 2.0, 64.0 and 64.0 μg/mL respectively.

• Autores: Barrera Tomas, Melissa; Tomas Chota, Gloria Eva; Sheen Cortavarría, Patricia; Fuentes Bonilla, Patricia; Inocente Camones, Miguel Angel; Santiago Contreras, Julio Cesar
• Tipo de recurso: Article of journal
• Fecha de publicación: 2017
• Institución: Universidad Nacional de Colombia
• Repositorio: Universidad Nacional de Colombia
• Idioma: spa
• OAI Identifier: oai:repositorio.unal.edu.co:unal/66260
• Acceso en línea: https://repositorio.unal.edu.co/handle/unal/66260; http://bdigital.unal.edu.co/67284/
• Palabra clave: 54 Química y ciencias afines / Chemistry; Evernia prunastri; condensation reaction; TEMA; MIC.; Evernia prunastri; reacción de condensación; TEMA; MIC
• Rights: openAccess
• License: Atribución-NoComercial 4.0 Internacional