Desarrollo de una estrategia de control predictivo no lineal y estimación de entradas desconocidas con aplicaciones a procesos biomédicos

ilustraciones, diagramas

Autores:
Alzate Torres, Carlos Mauricio
Tipo de recurso:
Fecha de publicación:
2022
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/82684
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/82684
https://repositorio.unal.edu.co/
Palabra clave:
620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería
610 - Medicina y salud
Nonlinear systems
Linear systems
Sistemas no lineales
Sistemas lineales
Cáncer
Control predictivo basado en modelo
Diabetes mellitus tipo 1
Control no lineal
Estimación de entradas desconocidas
Terapia viral
Model-based predictive control
Nonlinear control
Estimation of unknown inputs
Type 1 diabetes mellitus
Viral therapy
Rights
openAccess
License
Atribución-NoComercial-SinDerivadas 4.0 Internacional
id UNACIONAL2_0f3749da04c82714cee80ee6b51afb90
oai_identifier_str oai:repositorio.unal.edu.co:unal/82684
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Desarrollo de una estrategia de control predictivo no lineal y estimación de entradas desconocidas con aplicaciones a procesos biomédicos
dc.title.translated.eng.fl_str_mv Development of a non-linear predictive control strategy with applications oriented to biomedical systems
title Desarrollo de una estrategia de control predictivo no lineal y estimación de entradas desconocidas con aplicaciones a procesos biomédicos
spellingShingle Desarrollo de una estrategia de control predictivo no lineal y estimación de entradas desconocidas con aplicaciones a procesos biomédicos
620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería
610 - Medicina y salud
Nonlinear systems
Linear systems
Sistemas no lineales
Sistemas lineales
Cáncer
Control predictivo basado en modelo
Diabetes mellitus tipo 1
Control no lineal
Estimación de entradas desconocidas
Terapia viral
Model-based predictive control
Nonlinear control
Estimation of unknown inputs
Type 1 diabetes mellitus
Viral therapy
title_short Desarrollo de una estrategia de control predictivo no lineal y estimación de entradas desconocidas con aplicaciones a procesos biomédicos
title_full Desarrollo de una estrategia de control predictivo no lineal y estimación de entradas desconocidas con aplicaciones a procesos biomédicos
title_fullStr Desarrollo de una estrategia de control predictivo no lineal y estimación de entradas desconocidas con aplicaciones a procesos biomédicos
title_full_unstemmed Desarrollo de una estrategia de control predictivo no lineal y estimación de entradas desconocidas con aplicaciones a procesos biomédicos
title_sort Desarrollo de una estrategia de control predictivo no lineal y estimación de entradas desconocidas con aplicaciones a procesos biomédicos
dc.creator.fl_str_mv Alzate Torres, Carlos Mauricio
dc.contributor.advisor.none.fl_str_mv Rivadeneira Paz, Pablo Santiago
Villa Tamayo, María Fernanda
dc.contributor.author.none.fl_str_mv Alzate Torres, Carlos Mauricio
dc.contributor.researchgroup.spa.fl_str_mv Grupo de Investigación en Tecnologías Aplicadas Gita
dc.contributor.orcid.spa.fl_str_mv Villa Tamayo, María Fernanda [0000-0002-0839-4070]
dc.subject.ddc.spa.fl_str_mv 620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería
610 - Medicina y salud
topic 620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería
610 - Medicina y salud
Nonlinear systems
Linear systems
Sistemas no lineales
Sistemas lineales
Cáncer
Control predictivo basado en modelo
Diabetes mellitus tipo 1
Control no lineal
Estimación de entradas desconocidas
Terapia viral
Model-based predictive control
Nonlinear control
Estimation of unknown inputs
Type 1 diabetes mellitus
Viral therapy
dc.subject.lemb.eng.fl_str_mv Nonlinear systems
Linear systems
dc.subject.lemb.spa.fl_str_mv Sistemas no lineales
Sistemas lineales
Cáncer
dc.subject.proposal.spa.fl_str_mv Control predictivo basado en modelo
Diabetes mellitus tipo 1
Control no lineal
Estimación de entradas desconocidas
Terapia viral
dc.subject.proposal.eng.fl_str_mv Model-based predictive control
Nonlinear control
Estimation of unknown inputs
Type 1 diabetes mellitus
Viral therapy
description ilustraciones, diagramas
publishDate 2022
dc.date.accessioned.none.fl_str_mv 2022-11-11T14:39:07Z
dc.date.available.none.fl_str_mv 2022-11-11T14:39:07Z
dc.date.issued.none.fl_str_mv 2022
dc.type.spa.fl_str_mv Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/82684
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/82684
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.indexed.spa.fl_str_mv RedCol
LaReferencia
dc.relation.references.spa.fl_str_mv Anelone, Anet J. ; Spurgeon, Sarah K.: Prediction of the containment of HIV infection by antiretroviral therapy - A variable structure control approach. En: IET Systems Biology 11 (2017), Nr. 1, p. 44{53. { ISSN 17518849
Anelone, Anet J. ; Villa-Tamayo, Mar a F. ; Rivadeneira, Pablo S.: Oncolytic virus therapy bene ts from control theory: Oncolytic virus enhanced therapy. En: Royal Society Open Science 7 (2020), Nr. 7. { ISBN 0000000183
Atlas, Eran ; Nimri, Revital ; Miller, Shahar ; Grunberg, Eli A. ; Phillip, Moshe: MD-logic arti cial pancreas system: A pilot study in adults with type 1 diabetes. En: Diabetes Care 33 (2010), Nr. 5, p. 1072{1076. { ISSN 01495992
Batmani, Yazdan: Blood glucose concentration control for type 1 diabetic patients: a non-linear suboptimal approach. En: IET Systems Biology 11 (2017), Nr. 4, p. 119{125. { ISSN 17518849
Bergman, R. N. ; Phillips, L. S. ; Cobelli, C.: Physiologic evaluation of factors controlling glucose tolerance in man. Measurement of insulin sensitivity and cell glucose sensitivity from the response to intravenous glucose. En: Journal of Clinical Investigation 68 (1981), Nr. 6, p. 1456{1467. { ISSN 00219738
Bock, Alain ; Franc ois, Gr egory ; Gillet, Denis: A therapy parameter-based model for predicting blood glucose concentrations in patients with type 1 diabetes. En: Computer Methods and Programs in Biomedicine 118 (2015), feb, Nr. 2, p. 107{123. { ISSN 0169{2607
Chernikova, Oksana S.: An Adaptive Unscented Kalman Filter Approach for State Estimation of Nonlinear Continuous-Discrete System. En: 2018 14th International Scienti c-Technical Conference on Actual Problems of Electronic Instrument Enginee- ring, APEIE 2018 - Proceedings (2018), p. 37{40. ISBN 9781538670545
Choi, Yoonhyuk ; Mok, Sunghoon ; Bang, Hyochoong: Impulsive formation control using orbital energy and angular momentum vector. En: Acta Astronautica 67 (2010), Nr. 5-6, p. 613{622. { ISSN 00945765
Cobelli, Claudio ; Man, Chiara D. ; Toffolo, Gianna ; Basu, Rita ; Vella, Adrian ; Rizza, Robert: The oral minimal model method. En: Diabetes 63 (2014), Nr. 4, p. 1203{1213. { ISSN 00121797
Cong, Tran H. ; Kim, Young J. ; Lim, Myo T.: Hybrid Extended Kalman Filterbased localization with a highly accurate odometry model of a mobile robot. En: 2008 International Conference on Control, Automation and Systems, ICCAS 2008 (2008), p. 738{743. ISBN 9788995003893
Dalla Man, Chiara ; Rizza, Robert A. ; Cobelli, Claudio: Meal simulation model of the glucose-insulin system. En: IEEE Transactions on Biomedical Engineering 54 (2007), Nr. 10, p. 1740{1749. { ISSN 00189294
D'Jorge, A. ; Anderson, A. L. ; Ferramosca, A. ; Gonz alez, A. H. ; Actis, Marcelo: On stability of nonzero set-point for non linear impulsive control systems. En: arXiv (2020), p. 1{16. { ISSN 23318422
Ellingsen, Christian ; Dassau, Eyal ; Zisser, Howard ; Grosman, Benyamin ; Percival, Matthew W. ; Jovanovi c, Lois ; Doyle, Francis J.: Safety constraints in an arti cial pancreatic cell: An implementation of model predictive control with insulin on board. En: Journal of Diabetes Science and Technology 3 (2009), Nr. 3, p. 536{544. { ISSN 19322968
Fisher, Michael E. A Semiclosed-Loop Algorithm for the Control of Blood Glucose Levels in Diabetics. 1991
Godoy, J. L. ; Sereno, J. E. ; Rivadeneira, P. S.: Meal detection and carbohydrate estimation based on a feedback scheme with application to the arti cial pancreas. En: Biomedical Signal Processing and Control 68 (2021), jul, p. 102715. { ISSN 1746{8094
Goradel, Nasser H. ; Mohajel, Nasir ; Malekshahi, Ziba V. ; Jahangiri, Samira ; Najafi, Masoud ; Farhood, Bagher ; Mortezaee, Keywan ; Negahdari, Babak ; Arashkia, Arash: Oncolytic adenovirus: A tool for cancer therapy in combination with other therapeutic approaches. En: Journal of Cellular Physiology 234 (2019), Nr. 6, p. 8636{8646. { ISSN 10974652
Grosman, Benyamin ; Dassau, Eyal ; Zisser, Howard C. ; Jovanovi c, Lois ; Doyle, Francis J.: Zone model predictive control: A strategy to minimize hyper- and hypoglycemic events. En: Journal of Diabetes Science and Technology 4 (2010), Nr. 4, p. 961{975. { ISSN 19322968
Hartnell, Sara ; Fuchs, Julia ; Boughton, Charlotte K. ; Hovorka, Roman: Closed loop technology: a practical guide. En: Practical Diabetes 38 (2021), jul, Nr. 4, p. 33{39. { ISSN 2047{2897
Harvey, Rebecca A. ; Dassau, Eyal ; Zisser, Howard ; Seborg, Dale E. ; Doyle, Francis J.: Design of the glucose rate increase detector: A meal detection module for the health monitoring system. En: Journal of Diabetes Science and Technology 8 (2014), Nr. 2, p. 307{320. { ISSN 19322968
Hovorka, Roman ; Allen, Janet M. ; Elleri, Daniela ; Chassin, Ludovic J. ; Harris, Julie ; Xing, Dongyuan ; Kollman, Craig ; Hovorka, Tomas ; Larsen, Anne Mette F. ; Nodale, Marianna ; De Palma, Alessandra ; Wilinska, Malgorzata E. ; Acerini, Carlo L. ; Dunger, David B.: Manual closed-loop insulin delivery in children and adolescents with type 1 diabetes: a phase 2 randomised crossover trial. En: The Lancet 375 (2010), Nr. 9716, p. 743{751. { ISSN 01406736
Hoyos, J. D. ; Villa-Tamayo, M. F. ; Builes-Montano, C. E. ; Ramirez-Rincon, A. ; Godoy, J. L. ; Garcia-Tirado, J. ; Rivadeneira, P. S.: Identi ability of Control-Oriented Glucose-Insulin Linear Models: Review and Analysis. En: IEEE Access 9 (2021), Nr. Mdi, p. 69173{69188. { ISSN 21693536
Institute, National C. Breast Cancer - Patient Version. https://www.cancer.gov/types/breast
Institute, National C. Breast Cancer Treatment. https://www.cancer.gov/types/breast/patient/breast-treatment-pdq
Institute, National C. Cancer Staging. https://www.cancer.gov/aboutcancer/ diagnosis-staging/staging
Institute, National C. What Is Cancer? https://www.cancer.gov/aboutcancer/ understanding/what-is-cancer
Jenner, Adrianne L. ; Kim, Peter S. ; Frascoli, Federico: Oncolytic virotherapy for tumours following a Gompertz growth law. En: Journal of Theoretical Biology 480 (2019), p. 129{140. { ISSN 10958541
Jenner, Adrianne L. ; Yun, Chae O. ; Kim, Peter S. ; Coster, Adelle C.: Mathematical Modelling of the Interaction Between Cancer Cells and an Oncolytic Virus: Insights into the E ects of Treatment Protocols. En: Bulletin of Mathematical Biology 80 (2018), Nr. 6, p. 1615{1629. { ISSN 15229602
Kandepu, Rambabu ; Foss, Bjarne ; Imsland, Lars: Applying the unscented Kalman lter for nonlinear state estimation. En: Journal of Process Control 18 (2008), Nr. 7-8, p. 753{768. { ISSN 09591524
Kasper, Dennis L. ; Braunwald, Eugene ; Faucy, Antony S. ; Hauser, Stephen L. ; Longo, Dan L. ; Jameson, J. L. ; McGraw-hill (Ed.): Harrison's Principles of Internal Medicine. New York, 2006. { ISBN 9780333227794
Kim, Pyung H. ; Sohn, Joo H. ; Choi, Joung W. ; Jung, Yukyung ; Kim, Sung W. ; Haam, Seungjoo ; Yun, Chae O.: Active targeting and safety pro le of PEG-modi ed adenovirus conjugated with herceptin. En: Biomaterials 32 (2011), Nr. 9, p. 2314{2326. { ISSN 01429612
K olle, Konstanze ; Biester, Torben ; Christiansen, Sverre ; Fougner, Anders L. ; Stavdahl, yvind: Pattern Recognition Reveals Characteristic Postprandial Glucose Changes: Non-Individualized Meal Detection in Diabetes Mellitus Type 1. En: IEEE Journal of Biomedical and Health Informatics 24 (2020), Nr. 2, p. 594{602. { ISSN 21682208
Limon, Daniel ; Ferramosca, Antonio ; Alvarado, Ignacio ; Alamo, Teodoro: Nonlinear MPC for Tracking Piece-Wise Constant Reference Signals. En: IEEE Transactions on Automatic Control 63 (2018), Nr. 11, p. 3735{3750. { ISSN 15582523
Magdelaine, Nicolas ; Chaillous, Lucy ; Guilhem, Isabelle ; Poirier, Jean Y. ; Krempf, Michel ; Moog, Claude H. ; Le Carpentier, Eric: A long-term model of the glucose-insulin dynamics of type 1 diabetes. En: IEEE Transactions on Biomedical Engineering 62 (2015), Nr. 6, p. 1546{1552. { ISSN 15582531
Mahmoudi, Zeinab ; Boiroux, Dimitri ; Cameron, Faye ; Poulsen, Niels K. ; Bequette, B. W. ; J rgensen, John B. An automated meal detector and bolus calculator in combination with closed-loop blood glucose control. 2018
Mauseth, Richard ; Hirsch, Irl B. ; Bollyky, Jennifer ; Kircher, Robert ; Matheson, Don ; Sanda, Srinath ; Greenbaum, Carla. Use of a "fuzzy logic controller in a closed-loop arti cial pancreas. 2013
Mayne, D. Q. ; Rawlings, J. B. ; Rao, C. V. ; Scokaert, P. O.: Constrained model predictive control: Stability and optimality. En: Automatica 36 (2000), Nr. 6, p. 789{814. { ISSN 00051098
Mayne, David Q.: Model predictive control: Recent developments and future promise. En: Automatica 50 (2014), Nr. 12, p. 2967{2986. { ISSN 00051098
Moscoso-Vasquez, Marcela ; Colmegna, Patricio ; Rosales, Nicolas ; Garelli, Fabricio ; Sanchez-Pena, Ricardo: Control-Oriented Model with Intra-Patient Variations for an Arti cial Pancreas. En: IEEE Journal of Biomedical and Health Informatics 24 (2020), Nr. 9, p. 2681{2689. { ISSN 21682208
Moscoso-Vasquez, Marcela ; Colmegna, Patricio ; Sanchez-Pena, Ricardo S.: Intra-Patient dynamic variations in type 1 diabetes: A review. En: 2016 IEEE Conference on Control Applications, CCA 2016 (2016), p. 416{421. ISBN 9781509007554
Nath, Anirudh ; Deb, Dipankar ; Dey, Rajeeb ; Das, Sipon: Blood glucose regulation in type 1 diabetic patients: An adaptive parametric compensation control-based approach. En: IET Systems Biology 12 (2018), Nr. 5, p. 19{225. { ISSN 17518849
Pannocchia, Gabriele ; Gabiccini, Marco ; Artoni, Alessio: O set-free MPC explained: Novelties, subtleties, and applications. En: IFAC-PapersOnLine 48 (2015), Nr. 23, p. 342{351. { ISSN 24058963
Papadakis, Maxine A. ; McPhee, Stephen J. ; Rabow, Michael W.: Diagnostico Clinico y Tratamiento. 2017. { ISBN 9786071514103
Powers, Alvin C. ; D'Alessio, David ; McGraw-hill (Ed.): Goodman and Gilman: Las bases farmacol ogicas de la terap eutica. Vol. 12. 12. New York, 2012. { ISBN 9701057392
Prakash, J. ; Patwardhan, Sachin C. ; Shah, Sirish L.: State estimation and nonlinear predictive control of autonomous hybrid system using derivative free state estimators. En: Journal of Process Control 20 (2010), Nr. 7, p. 787{799. { ISSN 09591524
Ramkissoon, Charrise M. ; Herrero, Pau ; Bondia, Jorge ; Vehi, Josep: Unannounced meals in the arti cial pancreas: Detection using continuous glucose monitoring. En: Sensors (Switzerland) 18 (2018), Nr. 3, p. 1{18. { ISSN 14248220
Rawlings, J.B. ; Meadows, E.S. ; Muske, K.R.: Nonlinear Model Predictive Control: A Tutorial and Survey. En: IFAC Proceedings Volumes 27 (1994), Nr. 2, p. 185{197. { ISSN 14746670
Rivadeneira, P. S. ; Moog, C. H.: Impulsive control of single-input nonlinear systems with application to HIV dynamics. En: Applied Mathematics and Computation 218 (2012), Nr. 17, p. 8462{8474. { ISSN 00963003
Rivadeneira, Pablo S. ; Ferramosca, Antonio ; Gonz alez, Alejandro H.: Control Strategies for Nonzero Set-Point Regulation of Linear Impulsive Systems. En: IEEE Transactions on Automatic Control 63 (2018), Nr. 9, p. 2994{3001. { ISSN 15582523
Rivadeneira, Pablo S. ; Moog, Claude H.: Observability criteria for impulsive control systems with applications to biomedical engineering processes. En: Automatica 55 (2015), p. 125{131. { ISSN 00051098
SA, Brown ; BP, Kovatchev ; D, Raghinaru ; JW, Lum ; BA, Buckingham ; YC, Kudva ; LM, La el ; CJ, Levy ; JE, Pinsker ; RP, Wadwa ; E, Dassau ; FJ, Doyle ; SM, Anderson ; MM, Church ; V, Dadlani ; L, Ekhlaspour ; GP, Forlenza ; E, Isganaitis ; DW, Lam ; C, Kollman ; RW, Beck ; IDCL, Trial Research G. Six-month randomized, multicenter trial of closed-loop control in type 1 diabetes. 2020
Samadi, Sediqeh ; Turksoy, Kamuran ; Hajizadeh, Iman ; Feng, Jianyuan ; Sevil, Mert ; Cinar, Ali: Meal Detection and Carbohydrate Estimation Using Continuous Glucose Sensor Data. En: IEEE Journal of Biomedical and Health Informatics 21 (2017), Nr. 3, p. 619{627. { ISSN 21682194
Society, American C. Alcohol Use and Cancer. https://www.cancer.org/cancer/cancer-causes/diet-physical-activity/alcohol-use and cancer.html
Society, American C. American Cancer Society Recommendations for the Early Detection of Breast Cancer. https://www.cancer.org/cancer/breast-cancer/screeningtests-and-early-detection/american-cancer-society-recommendations-for-the-early detection-of-breast-cancer.html
Society, American C. Bacteria that Can Lead to Cancer. https://www.cancer.org/cancer/cancer-causes/infectious-agents/infections-that-canlead-to-cancer/bacteria.html
Society, American C. Breast Biopsy. https://www.cancer.org/cancer/breastcancer/screening-tests-and-early-detection/breast-biopsy.html
Society, American C. Breast Cancer Grades. https://www.cancer.org/cancer/breastcancer/understanding-a-breast-cancer-diagnosis/breast-cancer-grades.html
Society, American C. Breast Cancer HER2 Status. https://www.cancer.org/cancer/breast-cancer/understanding-a-breast-cancerdiagnosis/breast-cancer-her2-status.html
Society, American C. Breast Cancer Hormone Receptor Status. https://www.cancer.org/cancer/breast-cancer/understanding-a-breast-cancerdiagnosis/breast-cancer-hormone-receptor-status.html
Society, American C. Breast Cancer Stages. https://www.cancer.org/cancer/breastcancer/understanding-a-breast-cancer-diagnosis/stages-of-breast-cancer.html
Society, American C. Breast MRI. https://www.cancer.org/cancer/breastcancer/screening-tests-and-early-detection/breast-mri-scans.html
Society, American C. Breast Ultrasound. https://www.cancer.org/cancer/breastcancer/screening-tests-and-early-detection/breast-ultrasound.html
Society, American C. Cancer Staging. https://www.cancer.org/treatment/understandingyour-diagnosis/staging.html
Society, American C. Chemotherapy for Breast Cancer. https://www.cancer.org/cancer/breast-cancer/treatment/chemotherapy-for-breastcancer.html
Society, American C. Diet and Physical Activity: What's the Cancer Connec- tion? https://www.cancer.org/cancer/cancer-causes/diet-physical-activity/diet-andphysical-activity.html
Society, American C. Do X-rays and Gamma Rays Cause Cancer? https://www.cancer.org/cancer/cancer-causes/radiation-exposure/x-rays-gammarays/do-xrays-and-gamma-rays-cause-cancer.html
Society, American C. Does Body Weight A ect Cancer Risk? https://www.cancer.org/cancer/cancer-causes/diet-physical-activity/body-weightand-cancer-risk/e ects.html
Society, American C. Family Cancer Syndromes. https://www.cancer.org/cancer/cancer-causes/genetics/family-cancer-syndromes.html
Society, American C. Harmful Chemicals in Tobacco Products. https://www.cancer.org/about-us.html
Society, American C. Hormone Therapy for Breast Cancer. https://www.cancer.org/cancer/breast-cancer/treatment/hormone-therapy-for-breastcancer.html
Society, American C. How Common Is Breast Cancer? https://www.cancer.org/cancer/breast-cancer/about/how-common-is-breastcancer.html
Society, American C. Immunotherapy for Breast Cancer. https://www.cancer.org/cancer/breast-cancer/treatment/immunotherapy.html
Society, American C. Inflammatory Breast Cancer -American Cancer So- ciety. https://www.cancer.org/cancer/breast-cancer/understanding-a-breast-cancerdiagnosis/types-of-breast-cancer/inflammatory-breast-cancer.html
Society, American C. Lymph Nodes and Cancer. https://www.cancer.org/cancer/cancer-basics/lymph-nodes-and-cancer.html
Society, American C. Parasites that Can Lead to Cancer. https://www.cancer.org/cancer/cancer-causes/infectious-agents/infections-that-canlead-to-cancer/parasites.html
Society, American C. Radiation for Breast Cancer. https://www.cancer.org/cancer/breast-cancer/treatment/radiation-for-breastcancer.html
Society, American C. Radon and Cancer. https://www.cancer.org/cancer/cancercauses/radiation-exposure/radon.html
Society, American C. Surgery for Breast Cancer. https://www.cancer.org/cancer/breast-cancer/treatment/surgery-for-breastcancer.html
Society, American C. Targeted Drug Therapy for Breast Cancer. https://www.cancer.org/cancer/breast-cancer/treatment/targeted-therapy-for-breastcancer.html
Society, American C. Types of Breast Cancer. https://www.cancer.org/cancer/breastcancer/understanding-a-breast-cancer-diagnosis/types-of-breast-cancer.html
Society, American C. Ultraviolet (UV) Radiation. https://www.cancer.org/cancer/cancer-causes/radiation-exposure/uv-radiation.html
Society, American C. Viruses that Can Lead to Cancer. https://www.cancer.org/cancer/cancer-causes/infectious-agents/infections-that-canlead-to-cancer/viruses.html
Society, American C. What Is Breast Cancer? https://www.cancer.org/cancer/breast-cancer/about/what-is-breast-cancer.html
Society, American C. What Is Cancer? https://www.cancer.org/cancer/cancerbasics/what-is-cancer.html
Steil, Garry M. ; Rebrin, Kerstin ; Darwin, Christine ; Hariri, Farzam ; Saad, Mohammed F.: Feasibility of automating insulin delivery for the treatment of type 1 diabetes. En: Diabetes 55 (2006), Nr. 12, p. 3344{3350. { ISSN 00121797
Straka, Ond A™ej ; Dun k, Jind A™ich ; Simandl, Miroslav: Automatica Unscented Kalman lter with advanced adaptation of. En: Automatica 50 (2014), Nr. 10, p.2657{2664. { ISSN 0005{1098
Sun, Jitao: Impulsive control of a new chaotic system. En: Mathematics and Computers in Simulation 64 (2004), Nr. 6, p. 669{677. { ISSN 0378{4754
Tang, Liu ; Chang, Shwu J. ; Chen, Ching J. ; Liu, Jen T.: Non-invasive blood glucose monitoring technology: A review. En: Sensors (Switzerland) 20 (2020), Nr. 23,p. 1{32. { ISSN 14248220
Villa-tamayo, Maria F.: Compensación del efecto de variaciones fisioló cas en la glucemia de pacientes diabéticos tipo 1 utilizando control predictivo con entradas impulsivas., Universidad Nacional de Colombia, Tesis de Magisten en Ingeniería - Automatización industrial, 2021
Villa-Tamayo, Maria F. ; Anelone, Anet J. ; Rivadeneira, Pablo S.: Tumor Reduction Using Oncolytic Viruses under an Impulsive Nonlinear Estimation and Predictive Control Scheme. En: IEEE Control Systems Letters 5 (2021), Nr. 5, p. 1705{1710. {ISSN 24751456
Villa-Tamayo, Mar a F. ; Caicedo, Michelle A. ; Rivadeneira, Pablo S.: O set-free MPC strategy for nonzero regulation of linear impulsive systems. En: ISA Transactions 101 (2020), p. 91{101. { ISSN 00190578
Villa Tamayo, Mar a F. ; Caicedo Alvarez, Michelle A. ; Rivadeneira, Pablo S.: Handling Parameter Variations during the Treatment of Type 1 Diabetes Mellitus: In Silico Results. En: Mathematical Problems in Engineering 2019 (2019). { ISSN 15635147
Villa Tamayo, Mar a F. ; Caicedo Alvarez, Michelle A. ; Rivadeneira, Pablo S.: Handling Parameter Variations during the Treatment of Type 1 Diabetes Mellitus: In Silico Results. En: Mathematical Problems in Engineering 2019 (2019). { ISSN 15635147
Villa-Tamayo, Mar a F. ; Garc a-Jaramillo, Maira ; Le on-Vargas, Fabian; Rivadeneira, Pablo S.: Interval Safety Layer Coupled With an Impulsive MPC for Arti cial Pancreas to Handle Intrapatient Variability. En: Frontiers in Endocrinology 13 (2022), Nr. February, p. 1{13. { ISSN 16642392
Xiong, Binyu ; Zhang, Huajun ; Deng, Xiangtian ; Tang, Jinrui: State of charge estimation based on sliding mode observer for vanadium redox ow battery. En: IEEE Power and Energy Society General Meeting 2018-January (2018), Nr. 4, p. 1{5. { ISBN 9781538622124
Yu, Hengguo ; Zhong, Shouming ; Agarwal, Ravi P.: Mathematics analysis and chaos in an ecological model with an impulsive control strategy. En: Communications in Nonlinear Science and Numerical Simulation 16 (2011), Nr. 2, p. 776{786. { ISSN 10075704
Zhao, Linhui ; Liu, Zhiyuan ; Chen, Hong: Vehicle state and friction force estimation using nonlinear observer strategies. En: Proceedings of the 27th Chinese Control Conference, CCC 2 (2008), Nr. 2, p. 667{671. ISBN 9787900719706
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spelling Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Rivadeneira Paz, Pablo Santiago04730d3951ae0b8d3cad652e1130f609Villa Tamayo, María Fernandaf1c18ec19cef41f56d39fba098092eb3600Alzate Torres, Carlos Mauricioab7cdc98f24acc396485a2a68b1a05cfGrupo de Investigación en Tecnologías Aplicadas GitaVilla Tamayo, María Fernanda [0000-0002-0839-4070]2022-11-11T14:39:07Z2022-11-11T14:39:07Z2022https://repositorio.unal.edu.co/handle/unal/82684Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramasLos sistemas no lineales representan, en muchos casos, un ideal en el campo del control pues tienen la capacidad de representar con alta delidad las dinámicas presentes en sistemas propios de diversos campos; sin embargo, se presenta una di ficultad a la hora de acceder a los benefi cios y detalles brindados teniendo en cuenta la complejidad asociada a estos modelos. Ahora, para acceder a estos bene cios, una práctica común ha sido la linealización de estos sistemas. Este proceso simpli ca el diseño, pero a la vez causa pérdida de propiedades o características de los sistemas no lineales, además de implicar la limitaci on del rango de operación dependiendo de la exactitud de la aproximación. Para solucionar estos inconvenientes, la presente tesis propone esquemas de control en MPC no lineales de tal manera que se acceda a los bene cios asociados a la realización de aproximaciones en cada paso de tiempo. Estos esquemas consisten, primero, en una estructura de control MPC impulsivo con variables arti ciales y, segundo, en un MPC con garantía de eliminación de offset con el objetivo de contrarrestar variaciones paramétricas que puedan presentar los sistemas. También se propone una serie de condiciones necesarias para que se verifiquen las propiedades de convergencia y atractividad de las formulaciones planteadas. Además, se evalúa el desempeño de estos esquemas frente a planteamientos lineales al implementarlos en problemas biomédicos descritos por dinámicas no lineales impulsivas, específicamente el tratamiento de cáncer de pecho con terapias virales de adenovirus y la regulación de niveles de glucosa en sangre en pacientes de diabetes mellitus tipo 1 con terapias de insulina aplicando una variación del modelo mínimo de Bergman. Posteriormente, se propone una generalización de las condiciones necesarias para el diseño de estimadores de entrada desconocida en sistemas lineales, se evalúa su influencia y el cómo estos pueden brindar bene ficios al acoplarse a esquemas de control para brindar informacón y atenuar el efecto de perturbaciones desconocidas en el caso específi co de la estimación de carbohidratos consumidos por un paciente en el tratamiento de diabetes mellitus tipo 1, considerando dinámicas lineales. (Texto tomado de la fuente)Nonlinear systems represent, in many cases, an ideal in the field of control as they have the ability to represent with high fidelity the dynamics present in systems from various fields; however, there is difficulty in accessing the benefits and details provided, taking into account the complexity associated with these models. Now, to access these benefits, a common practice has been the linearization of these systems. This process simplifies the design, but at the same time causes loss of properties or characteristics of nonlinear systems, in addition to implying the limitation of the operating range depending on the accuracy of the approximation. To solve these drawbacks, this thesis proposes nonlinear MPC control schemes in such a way as to access the benefits associated with making approximations at each time step. These schemes consist, first, of an impulsive MPC control structure with artificial variables and, second, of an MPC with offset elimination guarantee in order to counteract parametric variations that the systems may present. A series of necessary conditions are also proposed to verify the properties of convergence and attractiveness of the proposed formulations. In addition, the performance of these schemes against linear approaches is evaluated when implemented in biomedical problems described by impulsive nonlinear dynamics, specifically the treatment of breast cancer with adenovirus viral therapies and the regulation of blood glucose levels in diabetes patients. type 1 mellitus with insulin therapies applying a variation of Bergman’s minimal model. Subsequently, a generalization of the necessary conditions for the design of unknown input estimators in linear systems is proposed, their influence is evaluated and how they can provide benefits when coupled to control schemes to provide information and attenuate the effect of unknown disturbances in linear systems. the specific case of estimating carbohydrates consumed by a patient in the treatment of type 1 diabetes mellitus, considering linear dynamics.MaestríaMagíster en Ingeniería - Automatización IndustrialIngeniería BiomédicaÁrea Curricular de Ingeniería Eléctrica e Ingeniería de Controlxvii, 127 páginasapplication/pdfspaUniversidad Nacional de Colombia - Sede MedellínMedellín - Minas - Maestría en Ingeniería - Automatización IndustrialFacultad de MinasMedellín, ColombiaUniversidad Nacional de Colombia - Sede Medellín620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería610 - Medicina y saludNonlinear systemsLinear systemsSistemas no linealesSistemas linealesCáncerControl predictivo basado en modeloDiabetes mellitus tipo 1Control no linealEstimación de entradas desconocidasTerapia viralModel-based predictive controlNonlinear controlEstimation of unknown inputsType 1 diabetes mellitusViral therapyDesarrollo de una estrategia de control predictivo no lineal y estimación de entradas desconocidas con aplicaciones a procesos biomédicosDevelopment of a non-linear predictive control strategy with applications oriented to biomedical systemsTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMRedColLaReferenciaAnelone, Anet J. ; Spurgeon, Sarah K.: Prediction of the containment of HIV infection by antiretroviral therapy - A variable structure control approach. En: IET Systems Biology 11 (2017), Nr. 1, p. 44{53. { ISSN 17518849Anelone, Anet J. ; Villa-Tamayo, Mar a F. ; Rivadeneira, Pablo S.: Oncolytic virus therapy bene ts from control theory: Oncolytic virus enhanced therapy. En: Royal Society Open Science 7 (2020), Nr. 7. { ISBN 0000000183Atlas, Eran ; Nimri, Revital ; Miller, Shahar ; Grunberg, Eli A. ; Phillip, Moshe: MD-logic arti cial pancreas system: A pilot study in adults with type 1 diabetes. En: Diabetes Care 33 (2010), Nr. 5, p. 1072{1076. { ISSN 01495992Batmani, Yazdan: Blood glucose concentration control for type 1 diabetic patients: a non-linear suboptimal approach. En: IET Systems Biology 11 (2017), Nr. 4, p. 119{125. { ISSN 17518849Bergman, R. N. ; Phillips, L. S. ; Cobelli, C.: Physiologic evaluation of factors controlling glucose tolerance in man. Measurement of insulin sensitivity and cell glucose sensitivity from the response to intravenous glucose. En: Journal of Clinical Investigation 68 (1981), Nr. 6, p. 1456{1467. { ISSN 00219738Bock, Alain ; Franc ois, Gr egory ; Gillet, Denis: A therapy parameter-based model for predicting blood glucose concentrations in patients with type 1 diabetes. En: Computer Methods and Programs in Biomedicine 118 (2015), feb, Nr. 2, p. 107{123. { ISSN 0169{2607Chernikova, Oksana S.: An Adaptive Unscented Kalman Filter Approach for State Estimation of Nonlinear Continuous-Discrete System. En: 2018 14th International Scienti c-Technical Conference on Actual Problems of Electronic Instrument Enginee- ring, APEIE 2018 - Proceedings (2018), p. 37{40. ISBN 9781538670545Choi, Yoonhyuk ; Mok, Sunghoon ; Bang, Hyochoong: Impulsive formation control using orbital energy and angular momentum vector. En: Acta Astronautica 67 (2010), Nr. 5-6, p. 613{622. { ISSN 00945765Cobelli, Claudio ; Man, Chiara D. ; Toffolo, Gianna ; Basu, Rita ; Vella, Adrian ; Rizza, Robert: The oral minimal model method. En: Diabetes 63 (2014), Nr. 4, p. 1203{1213. { ISSN 00121797Cong, Tran H. ; Kim, Young J. ; Lim, Myo T.: Hybrid Extended Kalman Filterbased localization with a highly accurate odometry model of a mobile robot. En: 2008 International Conference on Control, Automation and Systems, ICCAS 2008 (2008), p. 738{743. ISBN 9788995003893Dalla Man, Chiara ; Rizza, Robert A. ; Cobelli, Claudio: Meal simulation model of the glucose-insulin system. En: IEEE Transactions on Biomedical Engineering 54 (2007), Nr. 10, p. 1740{1749. { ISSN 00189294D'Jorge, A. ; Anderson, A. L. ; Ferramosca, A. ; Gonz alez, A. H. ; Actis, Marcelo: On stability of nonzero set-point for non linear impulsive control systems. En: arXiv (2020), p. 1{16. { ISSN 23318422Ellingsen, Christian ; Dassau, Eyal ; Zisser, Howard ; Grosman, Benyamin ; Percival, Matthew W. ; Jovanovi c, Lois ; Doyle, Francis J.: Safety constraints in an arti cial pancreatic cell: An implementation of model predictive control with insulin on board. En: Journal of Diabetes Science and Technology 3 (2009), Nr. 3, p. 536{544. { ISSN 19322968Fisher, Michael E. A Semiclosed-Loop Algorithm for the Control of Blood Glucose Levels in Diabetics. 1991Godoy, J. L. ; Sereno, J. E. ; Rivadeneira, P. S.: Meal detection and carbohydrate estimation based on a feedback scheme with application to the arti cial pancreas. En: Biomedical Signal Processing and Control 68 (2021), jul, p. 102715. { ISSN 1746{8094Goradel, Nasser H. ; Mohajel, Nasir ; Malekshahi, Ziba V. ; Jahangiri, Samira ; Najafi, Masoud ; Farhood, Bagher ; Mortezaee, Keywan ; Negahdari, Babak ; Arashkia, Arash: Oncolytic adenovirus: A tool for cancer therapy in combination with other therapeutic approaches. En: Journal of Cellular Physiology 234 (2019), Nr. 6, p. 8636{8646. { ISSN 10974652Grosman, Benyamin ; Dassau, Eyal ; Zisser, Howard C. ; Jovanovi c, Lois ; Doyle, Francis J.: Zone model predictive control: A strategy to minimize hyper- and hypoglycemic events. En: Journal of Diabetes Science and Technology 4 (2010), Nr. 4, p. 961{975. { ISSN 19322968Hartnell, Sara ; Fuchs, Julia ; Boughton, Charlotte K. ; Hovorka, Roman: Closed loop technology: a practical guide. En: Practical Diabetes 38 (2021), jul, Nr. 4, p. 33{39. { ISSN 2047{2897Harvey, Rebecca A. ; Dassau, Eyal ; Zisser, Howard ; Seborg, Dale E. ; Doyle, Francis J.: Design of the glucose rate increase detector: A meal detection module for the health monitoring system. En: Journal of Diabetes Science and Technology 8 (2014), Nr. 2, p. 307{320. { ISSN 19322968Hovorka, Roman ; Allen, Janet M. ; Elleri, Daniela ; Chassin, Ludovic J. ; Harris, Julie ; Xing, Dongyuan ; Kollman, Craig ; Hovorka, Tomas ; Larsen, Anne Mette F. ; Nodale, Marianna ; De Palma, Alessandra ; Wilinska, Malgorzata E. ; Acerini, Carlo L. ; Dunger, David B.: Manual closed-loop insulin delivery in children and adolescents with type 1 diabetes: a phase 2 randomised crossover trial. En: The Lancet 375 (2010), Nr. 9716, p. 743{751. { ISSN 01406736Hoyos, J. D. ; Villa-Tamayo, M. F. ; Builes-Montano, C. E. ; Ramirez-Rincon, A. ; Godoy, J. L. ; Garcia-Tirado, J. ; Rivadeneira, P. S.: Identi ability of Control-Oriented Glucose-Insulin Linear Models: Review and Analysis. En: IEEE Access 9 (2021), Nr. Mdi, p. 69173{69188. { ISSN 21693536Institute, National C. Breast Cancer - Patient Version. https://www.cancer.gov/types/breastInstitute, National C. Breast Cancer Treatment. https://www.cancer.gov/types/breast/patient/breast-treatment-pdqInstitute, National C. Cancer Staging. https://www.cancer.gov/aboutcancer/ diagnosis-staging/stagingInstitute, National C. What Is Cancer? https://www.cancer.gov/aboutcancer/ understanding/what-is-cancerJenner, Adrianne L. ; Kim, Peter S. ; Frascoli, Federico: Oncolytic virotherapy for tumours following a Gompertz growth law. En: Journal of Theoretical Biology 480 (2019), p. 129{140. { ISSN 10958541Jenner, Adrianne L. ; Yun, Chae O. ; Kim, Peter S. ; Coster, Adelle C.: Mathematical Modelling of the Interaction Between Cancer Cells and an Oncolytic Virus: Insights into the E ects of Treatment Protocols. En: Bulletin of Mathematical Biology 80 (2018), Nr. 6, p. 1615{1629. { ISSN 15229602Kandepu, Rambabu ; Foss, Bjarne ; Imsland, Lars: Applying the unscented Kalman lter for nonlinear state estimation. En: Journal of Process Control 18 (2008), Nr. 7-8, p. 753{768. { ISSN 09591524Kasper, Dennis L. ; Braunwald, Eugene ; Faucy, Antony S. ; Hauser, Stephen L. ; Longo, Dan L. ; Jameson, J. L. ; McGraw-hill (Ed.): Harrison's Principles of Internal Medicine. New York, 2006. { ISBN 9780333227794Kim, Pyung H. ; Sohn, Joo H. ; Choi, Joung W. ; Jung, Yukyung ; Kim, Sung W. ; Haam, Seungjoo ; Yun, Chae O.: Active targeting and safety pro le of PEG-modi ed adenovirus conjugated with herceptin. En: Biomaterials 32 (2011), Nr. 9, p. 2314{2326. { ISSN 01429612K olle, Konstanze ; Biester, Torben ; Christiansen, Sverre ; Fougner, Anders L. ; Stavdahl, yvind: Pattern Recognition Reveals Characteristic Postprandial Glucose Changes: Non-Individualized Meal Detection in Diabetes Mellitus Type 1. En: IEEE Journal of Biomedical and Health Informatics 24 (2020), Nr. 2, p. 594{602. { ISSN 21682208Limon, Daniel ; Ferramosca, Antonio ; Alvarado, Ignacio ; Alamo, Teodoro: Nonlinear MPC for Tracking Piece-Wise Constant Reference Signals. En: IEEE Transactions on Automatic Control 63 (2018), Nr. 11, p. 3735{3750. { ISSN 15582523Magdelaine, Nicolas ; Chaillous, Lucy ; Guilhem, Isabelle ; Poirier, Jean Y. ; Krempf, Michel ; Moog, Claude H. ; Le Carpentier, Eric: A long-term model of the glucose-insulin dynamics of type 1 diabetes. En: IEEE Transactions on Biomedical Engineering 62 (2015), Nr. 6, p. 1546{1552. { ISSN 15582531Mahmoudi, Zeinab ; Boiroux, Dimitri ; Cameron, Faye ; Poulsen, Niels K. ; Bequette, B. W. ; J rgensen, John B. An automated meal detector and bolus calculator in combination with closed-loop blood glucose control. 2018Mauseth, Richard ; Hirsch, Irl B. ; Bollyky, Jennifer ; Kircher, Robert ; Matheson, Don ; Sanda, Srinath ; Greenbaum, Carla. Use of a "fuzzy logic controller in a closed-loop arti cial pancreas. 2013Mayne, D. Q. ; Rawlings, J. B. ; Rao, C. V. ; Scokaert, P. O.: Constrained model predictive control: Stability and optimality. En: Automatica 36 (2000), Nr. 6, p. 789{814. { ISSN 00051098Mayne, David Q.: Model predictive control: Recent developments and future promise. En: Automatica 50 (2014), Nr. 12, p. 2967{2986. { ISSN 00051098Moscoso-Vasquez, Marcela ; Colmegna, Patricio ; Rosales, Nicolas ; Garelli, Fabricio ; Sanchez-Pena, Ricardo: Control-Oriented Model with Intra-Patient Variations for an Arti cial Pancreas. En: IEEE Journal of Biomedical and Health Informatics 24 (2020), Nr. 9, p. 2681{2689. { ISSN 21682208Moscoso-Vasquez, Marcela ; Colmegna, Patricio ; Sanchez-Pena, Ricardo S.: Intra-Patient dynamic variations in type 1 diabetes: A review. En: 2016 IEEE Conference on Control Applications, CCA 2016 (2016), p. 416{421. ISBN 9781509007554Nath, Anirudh ; Deb, Dipankar ; Dey, Rajeeb ; Das, Sipon: Blood glucose regulation in type 1 diabetic patients: An adaptive parametric compensation control-based approach. En: IET Systems Biology 12 (2018), Nr. 5, p. 19{225. { ISSN 17518849Pannocchia, Gabriele ; Gabiccini, Marco ; Artoni, Alessio: O set-free MPC explained: Novelties, subtleties, and applications. En: IFAC-PapersOnLine 48 (2015), Nr. 23, p. 342{351. { ISSN 24058963Papadakis, Maxine A. ; McPhee, Stephen J. ; Rabow, Michael W.: Diagnostico Clinico y Tratamiento. 2017. { ISBN 9786071514103Powers, Alvin C. ; D'Alessio, David ; McGraw-hill (Ed.): Goodman and Gilman: Las bases farmacol ogicas de la terap eutica. Vol. 12. 12. New York, 2012. { ISBN 9701057392Prakash, J. ; Patwardhan, Sachin C. ; Shah, Sirish L.: State estimation and nonlinear predictive control of autonomous hybrid system using derivative free state estimators. En: Journal of Process Control 20 (2010), Nr. 7, p. 787{799. { ISSN 09591524Ramkissoon, Charrise M. ; Herrero, Pau ; Bondia, Jorge ; Vehi, Josep: Unannounced meals in the arti cial pancreas: Detection using continuous glucose monitoring. En: Sensors (Switzerland) 18 (2018), Nr. 3, p. 1{18. { ISSN 14248220Rawlings, J.B. ; Meadows, E.S. ; Muske, K.R.: Nonlinear Model Predictive Control: A Tutorial and Survey. En: IFAC Proceedings Volumes 27 (1994), Nr. 2, p. 185{197. { ISSN 14746670Rivadeneira, P. S. ; Moog, C. H.: Impulsive control of single-input nonlinear systems with application to HIV dynamics. En: Applied Mathematics and Computation 218 (2012), Nr. 17, p. 8462{8474. { ISSN 00963003Rivadeneira, Pablo S. ; Ferramosca, Antonio ; Gonz alez, Alejandro H.: Control Strategies for Nonzero Set-Point Regulation of Linear Impulsive Systems. En: IEEE Transactions on Automatic Control 63 (2018), Nr. 9, p. 2994{3001. { ISSN 15582523Rivadeneira, Pablo S. ; Moog, Claude H.: Observability criteria for impulsive control systems with applications to biomedical engineering processes. En: Automatica 55 (2015), p. 125{131. { ISSN 00051098SA, Brown ; BP, Kovatchev ; D, Raghinaru ; JW, Lum ; BA, Buckingham ; YC, Kudva ; LM, La el ; CJ, Levy ; JE, Pinsker ; RP, Wadwa ; E, Dassau ; FJ, Doyle ; SM, Anderson ; MM, Church ; V, Dadlani ; L, Ekhlaspour ; GP, Forlenza ; E, Isganaitis ; DW, Lam ; C, Kollman ; RW, Beck ; IDCL, Trial Research G. Six-month randomized, multicenter trial of closed-loop control in type 1 diabetes. 2020Samadi, Sediqeh ; Turksoy, Kamuran ; Hajizadeh, Iman ; Feng, Jianyuan ; Sevil, Mert ; Cinar, Ali: Meal Detection and Carbohydrate Estimation Using Continuous Glucose Sensor Data. En: IEEE Journal of Biomedical and Health Informatics 21 (2017), Nr. 3, p. 619{627. { ISSN 21682194Society, American C. Alcohol Use and Cancer. https://www.cancer.org/cancer/cancer-causes/diet-physical-activity/alcohol-use and cancer.htmlSociety, American C. American Cancer Society Recommendations for the Early Detection of Breast Cancer. https://www.cancer.org/cancer/breast-cancer/screeningtests-and-early-detection/american-cancer-society-recommendations-for-the-early detection-of-breast-cancer.htmlSociety, American C. Bacteria that Can Lead to Cancer. https://www.cancer.org/cancer/cancer-causes/infectious-agents/infections-that-canlead-to-cancer/bacteria.htmlSociety, American C. Breast Biopsy. https://www.cancer.org/cancer/breastcancer/screening-tests-and-early-detection/breast-biopsy.htmlSociety, American C. Breast Cancer Grades. https://www.cancer.org/cancer/breastcancer/understanding-a-breast-cancer-diagnosis/breast-cancer-grades.htmlSociety, American C. Breast Cancer HER2 Status. https://www.cancer.org/cancer/breast-cancer/understanding-a-breast-cancerdiagnosis/breast-cancer-her2-status.htmlSociety, American C. Breast Cancer Hormone Receptor Status. https://www.cancer.org/cancer/breast-cancer/understanding-a-breast-cancerdiagnosis/breast-cancer-hormone-receptor-status.htmlSociety, American C. Breast Cancer Stages. https://www.cancer.org/cancer/breastcancer/understanding-a-breast-cancer-diagnosis/stages-of-breast-cancer.htmlSociety, American C. Breast MRI. https://www.cancer.org/cancer/breastcancer/screening-tests-and-early-detection/breast-mri-scans.htmlSociety, American C. Breast Ultrasound. https://www.cancer.org/cancer/breastcancer/screening-tests-and-early-detection/breast-ultrasound.htmlSociety, American C. Cancer Staging. https://www.cancer.org/treatment/understandingyour-diagnosis/staging.htmlSociety, American C. Chemotherapy for Breast Cancer. https://www.cancer.org/cancer/breast-cancer/treatment/chemotherapy-for-breastcancer.htmlSociety, American C. Diet and Physical Activity: What's the Cancer Connec- tion? https://www.cancer.org/cancer/cancer-causes/diet-physical-activity/diet-andphysical-activity.htmlSociety, American C. Do X-rays and Gamma Rays Cause Cancer? https://www.cancer.org/cancer/cancer-causes/radiation-exposure/x-rays-gammarays/do-xrays-and-gamma-rays-cause-cancer.htmlSociety, American C. Does Body Weight A ect Cancer Risk? https://www.cancer.org/cancer/cancer-causes/diet-physical-activity/body-weightand-cancer-risk/e ects.htmlSociety, American C. Family Cancer Syndromes. https://www.cancer.org/cancer/cancer-causes/genetics/family-cancer-syndromes.htmlSociety, American C. Harmful Chemicals in Tobacco Products. https://www.cancer.org/about-us.htmlSociety, American C. Hormone Therapy for Breast Cancer. https://www.cancer.org/cancer/breast-cancer/treatment/hormone-therapy-for-breastcancer.htmlSociety, American C. How Common Is Breast Cancer? https://www.cancer.org/cancer/breast-cancer/about/how-common-is-breastcancer.htmlSociety, American C. Immunotherapy for Breast Cancer. https://www.cancer.org/cancer/breast-cancer/treatment/immunotherapy.htmlSociety, American C. Inflammatory Breast Cancer -American Cancer So- ciety. https://www.cancer.org/cancer/breast-cancer/understanding-a-breast-cancerdiagnosis/types-of-breast-cancer/inflammatory-breast-cancer.htmlSociety, American C. Lymph Nodes and Cancer. https://www.cancer.org/cancer/cancer-basics/lymph-nodes-and-cancer.htmlSociety, American C. Parasites that Can Lead to Cancer. https://www.cancer.org/cancer/cancer-causes/infectious-agents/infections-that-canlead-to-cancer/parasites.htmlSociety, American C. Radiation for Breast Cancer. https://www.cancer.org/cancer/breast-cancer/treatment/radiation-for-breastcancer.htmlSociety, American C. Radon and Cancer. https://www.cancer.org/cancer/cancercauses/radiation-exposure/radon.htmlSociety, American C. Surgery for Breast Cancer. https://www.cancer.org/cancer/breast-cancer/treatment/surgery-for-breastcancer.htmlSociety, American C. Targeted Drug Therapy for Breast Cancer. https://www.cancer.org/cancer/breast-cancer/treatment/targeted-therapy-for-breastcancer.htmlSociety, American C. Types of Breast Cancer. https://www.cancer.org/cancer/breastcancer/understanding-a-breast-cancer-diagnosis/types-of-breast-cancer.htmlSociety, American C. Ultraviolet (UV) Radiation. https://www.cancer.org/cancer/cancer-causes/radiation-exposure/uv-radiation.htmlSociety, American C. Viruses that Can Lead to Cancer. https://www.cancer.org/cancer/cancer-causes/infectious-agents/infections-that-canlead-to-cancer/viruses.htmlSociety, American C. What Is Breast Cancer? https://www.cancer.org/cancer/breast-cancer/about/what-is-breast-cancer.htmlSociety, American C. What Is Cancer? https://www.cancer.org/cancer/cancerbasics/what-is-cancer.htmlSteil, Garry M. ; Rebrin, Kerstin ; Darwin, Christine ; Hariri, Farzam ; Saad, Mohammed F.: Feasibility of automating insulin delivery for the treatment of type 1 diabetes. En: Diabetes 55 (2006), Nr. 12, p. 3344{3350. { ISSN 00121797Straka, Ond A™ej ; Dun k, Jind A™ich ; Simandl, Miroslav: Automatica Unscented Kalman lter with advanced adaptation of. En: Automatica 50 (2014), Nr. 10, p.2657{2664. { ISSN 0005{1098Sun, Jitao: Impulsive control of a new chaotic system. En: Mathematics and Computers in Simulation 64 (2004), Nr. 6, p. 669{677. { ISSN 0378{4754Tang, Liu ; Chang, Shwu J. ; Chen, Ching J. ; Liu, Jen T.: Non-invasive blood glucose monitoring technology: A review. En: Sensors (Switzerland) 20 (2020), Nr. 23,p. 1{32. { ISSN 14248220Villa-tamayo, Maria F.: Compensación del efecto de variaciones fisioló cas en la glucemia de pacientes diabéticos tipo 1 utilizando control predictivo con entradas impulsivas., Universidad Nacional de Colombia, Tesis de Magisten en Ingeniería - Automatización industrial, 2021Villa-Tamayo, Maria F. ; Anelone, Anet J. ; Rivadeneira, Pablo S.: Tumor Reduction Using Oncolytic Viruses under an Impulsive Nonlinear Estimation and Predictive Control Scheme. En: IEEE Control Systems Letters 5 (2021), Nr. 5, p. 1705{1710. {ISSN 24751456Villa-Tamayo, Mar a F. ; Caicedo, Michelle A. ; Rivadeneira, Pablo S.: O set-free MPC strategy for nonzero regulation of linear impulsive systems. En: ISA Transactions 101 (2020), p. 91{101. { ISSN 00190578Villa Tamayo, Mar a F. ; Caicedo Alvarez, Michelle A. ; Rivadeneira, Pablo S.: Handling Parameter Variations during the Treatment of Type 1 Diabetes Mellitus: In Silico Results. En: Mathematical Problems in Engineering 2019 (2019). { ISSN 15635147Villa Tamayo, Mar a F. ; Caicedo Alvarez, Michelle A. ; Rivadeneira, Pablo S.: Handling Parameter Variations during the Treatment of Type 1 Diabetes Mellitus: In Silico Results. En: Mathematical Problems in Engineering 2019 (2019). { ISSN 15635147Villa-Tamayo, Mar a F. ; Garc a-Jaramillo, Maira ; Le on-Vargas, Fabian; Rivadeneira, Pablo S.: Interval Safety Layer Coupled With an Impulsive MPC for Arti cial Pancreas to Handle Intrapatient Variability. En: Frontiers in Endocrinology 13 (2022), Nr. February, p. 1{13. { ISSN 16642392Xiong, Binyu ; Zhang, Huajun ; Deng, Xiangtian ; Tang, Jinrui: State of charge estimation based on sliding mode observer for vanadium redox ow battery. En: IEEE Power and Energy Society General Meeting 2018-January (2018), Nr. 4, p. 1{5. { ISBN 9781538622124Yu, Hengguo ; Zhong, Shouming ; Agarwal, Ravi P.: Mathematics analysis and chaos in an ecological model with an impulsive control strategy. En: Communications in Nonlinear Science and Numerical Simulation 16 (2011), Nr. 2, p. 776{786. { ISSN 10075704Zhao, Linhui ; Liu, Zhiyuan ; Chen, Hong: Vehicle state and friction force estimation using nonlinear observer strategies. En: Proceedings of the 27th Chinese Control Conference, CCC 2 (2008), Nr. 2, p. 667{671. ISBN 9787900719706EstudiantesInvestigadoresMaestrosLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/82684/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1152218627.2022.pdf1152218627.2022.pdfTesis de Maestría en Ingeniería - Automatización Industrialapplication/pdf4629411https://repositorio.unal.edu.co/bitstream/unal/82684/3/1152218627.2022.pdf4b5e4e3fdf45489f0cb496ed48dd7107MD53THUMBNAIL1152218627.2022.pdf.jpg1152218627.2022.pdf.jpgGenerated Thumbnailimage/jpeg4902https://repositorio.unal.edu.co/bitstream/unal/82684/4/1152218627.2022.pdf.jpgf3dd51ae4aa10e5e91012e430ce64a17MD54unal/82684oai:repositorio.unal.edu.co:unal/826842023-08-10 23:04:28.79Repositorio Institucional Universidad Nacional de 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