Caracterización de las lesiones patológicas del complejo respiratorio porcino como una herramienta de diagnóstico en la línea de producción de granjas porcinas
Ilustraciones, diagramas, fotografías, tablas
- Autores:
-
Ruiz Linares, Juan Sebastian
- Tipo de recurso:
- Fecha de publicación:
- 2024
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/87065
- Palabra clave:
- 630 - Agricultura y tecnologías relacionadas::636 - Producción animal
590 - Animales::599 - Mamíferos
MICOLOGIA VETERINARIA
HISTOLOGIA PATOLOGICA
ENFERMEDADES DE LOS PULMONES
Veterinary mycology
Histology, pathological
Lung diseases
Complejo respiratorio porcino-CRP
Patrones neumónicos
Daño pulmonar
Enfermedad multifactorial
Porcine respiratory complex (PRDC)
Pneumonic patterns
Lung damage
Multifactorial disease
- Rights
- openAccess
- License
- Atribución-NoComercial 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Caracterización de las lesiones patológicas del complejo respiratorio porcino como una herramienta de diagnóstico en la línea de producción de granjas porcinas |
| dc.title.translated.eng.fl_str_mv |
Pathological characterization of swine respiratory complex lesions as a diagnostic tool in nursery and fattening pigs from an intensive swine farm |
| title |
Caracterización de las lesiones patológicas del complejo respiratorio porcino como una herramienta de diagnóstico en la línea de producción de granjas porcinas |
| spellingShingle |
Caracterización de las lesiones patológicas del complejo respiratorio porcino como una herramienta de diagnóstico en la línea de producción de granjas porcinas 630 - Agricultura y tecnologías relacionadas::636 - Producción animal 590 - Animales::599 - Mamíferos MICOLOGIA VETERINARIA HISTOLOGIA PATOLOGICA ENFERMEDADES DE LOS PULMONES Veterinary mycology Histology, pathological Lung diseases Complejo respiratorio porcino-CRP Patrones neumónicos Daño pulmonar Enfermedad multifactorial Porcine respiratory complex (PRDC) Pneumonic patterns Lung damage Multifactorial disease |
| title_short |
Caracterización de las lesiones patológicas del complejo respiratorio porcino como una herramienta de diagnóstico en la línea de producción de granjas porcinas |
| title_full |
Caracterización de las lesiones patológicas del complejo respiratorio porcino como una herramienta de diagnóstico en la línea de producción de granjas porcinas |
| title_fullStr |
Caracterización de las lesiones patológicas del complejo respiratorio porcino como una herramienta de diagnóstico en la línea de producción de granjas porcinas |
| title_full_unstemmed |
Caracterización de las lesiones patológicas del complejo respiratorio porcino como una herramienta de diagnóstico en la línea de producción de granjas porcinas |
| title_sort |
Caracterización de las lesiones patológicas del complejo respiratorio porcino como una herramienta de diagnóstico en la línea de producción de granjas porcinas |
| dc.creator.fl_str_mv |
Ruiz Linares, Juan Sebastian |
| dc.contributor.advisor.spa.fl_str_mv |
Mogollon, Jose Darío Correa, Jairo Jaime |
| dc.contributor.author.spa.fl_str_mv |
Ruiz Linares, Juan Sebastian |
| dc.subject.ddc.spa.fl_str_mv |
630 - Agricultura y tecnologías relacionadas::636 - Producción animal 590 - Animales::599 - Mamíferos |
| topic |
630 - Agricultura y tecnologías relacionadas::636 - Producción animal 590 - Animales::599 - Mamíferos MICOLOGIA VETERINARIA HISTOLOGIA PATOLOGICA ENFERMEDADES DE LOS PULMONES Veterinary mycology Histology, pathological Lung diseases Complejo respiratorio porcino-CRP Patrones neumónicos Daño pulmonar Enfermedad multifactorial Porcine respiratory complex (PRDC) Pneumonic patterns Lung damage Multifactorial disease |
| dc.subject.lemb.spa.fl_str_mv |
MICOLOGIA VETERINARIA HISTOLOGIA PATOLOGICA ENFERMEDADES DE LOS PULMONES |
| dc.subject.lemb.eng.fl_str_mv |
Veterinary mycology Histology, pathological Lung diseases |
| dc.subject.proposal.spa.fl_str_mv |
Complejo respiratorio porcino-CRP Patrones neumónicos Daño pulmonar Enfermedad multifactorial |
| dc.subject.proposal.eng.fl_str_mv |
Porcine respiratory complex (PRDC) Pneumonic patterns Lung damage Multifactorial disease |
| description |
Ilustraciones, diagramas, fotografías, tablas |
| publishDate |
2024 |
| dc.date.accessioned.none.fl_str_mv |
2024-10-25T15:47:25Z |
| dc.date.available.none.fl_str_mv |
2024-10-25T15:47:25Z |
| dc.date.issued.none.fl_str_mv |
2024 |
| dc.type.spa.fl_str_mv |
Trabajo de grado - Especialidad Médica |
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info:eu-repo/semantics/masterThesis |
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info:eu-repo/semantics/acceptedVersion |
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Text |
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http://purl.org/redcol/resource_type/TM |
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acceptedVersion |
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https://repositorio.unal.edu.co/handle/unal/87065 |
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Universidad Nacional de Colombia |
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Repositorio Institucional Universidad Nacional de Colombia |
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https://repositorio.unal.edu.co/ |
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https://repositorio.unal.edu.co/handle/unal/87065 https://repositorio.unal.edu.co/ |
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Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia |
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spa |
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spa |
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Betlach AM, Valeris-Chacin R, Singer RS, Allerson M, Pieters M. 2020. Natural transmission and detection of Mycoplasma hyopneumoniae in a naïve gilt population. Vet Microbiol. 248:108819. doi:10.1016/j.vetmic.2020.108819. Bochsler PN. S DO. 2002. Inflammation and repair of tissue in mechanisms of disease. In: Do Hauson BJ C, editor. A textbook of comparative general pathology. 3rd ed. p. 140–245. Brockmeier SL, Halbur PG, Thacker EL. 2002. Porcine Respiratory Disease Complex. In: Brogden KA GJ, editor. Polymicrobial disease. Washington (DC): AMS Press. https://www.ncbi.nlm.nih.gov/books/NBK2481/. Burgara-Estrella A, Montalvo-Corral M, Bolaños A, Ramírez-Mendoza H, Valenzuela O, Hernández J. 2012. Naturally Co-Infected Boars with both Porcine Reproductive and Respiratory Syndrome Virus and Porcine Circovirus Type 2. Transbound Emerg Dis. 59(6):532–538. doi:10.1111/j.1865-1682.2012.01313.x. Carvallo FR, Stevenson VB. 2022. Interstitial pneumonia and diffuse alveolar damage in domestic animals. Vet Pathol. 59(4):586–601. doi:10.1177/03009858221082228. Caswell J, Williams K. 2016. Respiratory System. In: M. Grant Maxie, Jubb K& P, editor. Pathology of Domestic Animals. Sixth, Vol. p. 465–591. Chae C. 2016. Porcine respiratory disease complex: Interaction of vaccination and porcine circovirus type 2, porcine reproductive and respiratory syndrome virus, and Mycoplasma hyopneumoniae. The Veterinary Journal. 212:1–6. doi:10.1016/j.tvjl.2015.10.030. Chiou MT, Lin CN, Chuang MS, Chiang HC, Tsai CP (2004) Etiological and epidemiological survey of PRDC associated pathogens in Taiwan. In: Proceedings of the 18th International Pig Veterinary Society Congress, Hamburg, p. 191. Choi YK, Goyal SM, Joo HS. 2003. Retrospective analysis of etiologic agents associated with respiratory diseases in pigs. Can Vet J. 44(9):735–7. D’Annunzio G, Ostanello F, Muscatello LV, Orioles M, Jacumin N, Tommasini N, Leotti G, Luppi A, Mandrioli L, Sarli G. 2023. Porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus alone or associated are frequent intralesional detected viruses in porcine respiratory disease complex cases in Northern Italy. Front Vet Sci. 10. doi:10.3389/fvets.2023.1234779. Fablet C, Marois-Créhan C, Simon G, Grasland B, Jestin A, Kobisch M, Madec F, Rose N. 2012. Infectious agents associated with respiratory diseases in 125 farrow-to-finish pig herds: A cross-sectional study. Vet Microbiol. 157(1–2):152–163. doi:10.1016/j.vetmic.2011.12.015. Galdeano JVB, Baraldi TG, Ferraz MES, de Souza Almeida HM, Mechler-Dreibi ML, Costa WMT, Montassier HJ, Mathias LA, de Oliveira LG. 2019. Cross-sectional study of seropositivity, lung lesions and associated risk factors of the main pathogens of Porcine Respiratory Diseases Complex (PRDC) in Goiás, Brazil. Porcine Health Manag. 5(1):23. doi:10.1186/s40813-019-0130-0. Garcia-Morante B, Segalés J, Fraile L, Pérez de Rozas A, Maiti H, Coll T, Sibila M. 2016. Assessment of Mycoplasma hyopneumoniae-induced Pneumonia using Different Lung Lesion Scoring Systems: a Comparative Review. J Comp Pathol. 154(2–3):125–134. doi:10.1016/j.jcpa.2015.11.003. Goecke NB, Kobberø M, Kusk TK, Hjulsager CK, Pedersen KS, Kristensen CS, Larsen LE. 2020. Objective pathogen monitoring in nursery and finisher pigs by monthly laboratory diagnostic testing. Porcine Health Manag. 6(1):23. doi:10.1186/s40813-020-00161-3. Hansen M. S., Pors SE, Jensen HE, Bille-Hansen V, Bisgaard M, Flachs EM, Nielsen OL. 2010. An investigation of the pathology and pathogens associated with porcine respiratory disease complex in Denmark. J Comp Pathol. 143(2–3):120–131. doi:10.1016/j.jcpa.2010.01.012. Hansen M.S., Pors SE, Jensen HE, Bille-Hansen V, Bisgaard M, Flachs EM, Nielsen OL. 2010. An Investigation of the Pathology and Pathogens Associated with Porcine Respiratory Disease Complex in Denmark. J Comp Pathol. 143(2–3):120–131. doi:10.1016/j.jcpa.2010.01.012. Harms PA, Halbur PG, Sorden SD. 2002. Three cases of porcine respiratory disease complex associated with porcine circovirus type 2 infection. Journal of Swine Health and Production. 10(1):27–30. Hernandez-Garcia J, Robben N, Magnée D, Eley T, Dennis I, Kayes SM, Thomson JR, Tucker AW. 2017. The use of oral fluids to monitor key pathogens in porcine respiratory disease complex. Porcine Health Manag. 3(1):7. doi:10.1186/s40813-017-0055-4. Janke BH. 2014. Influenza A Virus Infections in Swine. Vet Pathol. 51(2):410–426. doi:10.1177/0300985813513043. Kekarainen T, Segalés J. 2015. Porcine circovirus 2 immunology and viral evolution. Porcine Health Manag. 1(1):17. doi:10.1186/s40813-015-0012-z. Kim J, Chung H-K, Chae C. 2003. Association of porcine circovirus 2 with porcine respiratory disease complex. The Veterinary Journal. 166(3):251–256. doi:10.1016/S1090-0233(02)00257-5. Krimmling T, Schwegmann-Weßels C. 2017. Comparison of mono- and co-infection by swine influenza A viruses and porcine respiratory coronavirus in porcine precision-cut lung slices. Res Vet Sci. 115:470–477. doi:10.1016/j.rvsc.2017.07.016. Leal Zimmer FMA, Paes JA, Zaha A, Ferreira HB. 2020. Pathogenicity & virulence of Mycoplasma hyopneumoniae. Virulence. 11(1):1600–1622. doi:10.1080/21505594.2020.1842659. Lopez A, Shannon M. 2022. Respiratory System, Thoracic Cavities, Mediastinum, and Pleurae. In: Zachary JF, editor. Pathologic Basis of Veterinary Disease. Seventh. Elsevier. p. 547–642. Maes D, Sibila M, Kuhnert P, Segalés J, Haesebrouck F, Pieters M. 2018. Update on Mycoplasma hyopneumoniae infections in pigs: Knowledge gaps for improved disease control. Transbound Emerg Dis. 65:110–124. doi:10.1111/tbed.12677. Maes D, Sibila M, Pieters M, Haesebrouck F, Segalés J, de Oliveira LG. 2023. Review on the methodology to assess respiratory tract lesions in pigs and their production impact. Vet Res. 54(1):8. doi:10.1186/s13567-023-01136-2. Maity H, Samanta K, Deb R, Gupta V. 2023. Revisiting Porcine Circovirus Infection: Recent Insights and Its Significance in the Piggery Sector. Vaccines (Basel). 11(8):1308. doi:10.3390/vaccines11081308. Meng F, Wu NH, Nerlich A, Herrler G, Valentin-Weigand P, Seitz M. 2015. Dynamic Virus-Bacterium Interactions in a Porcine Precision-Cut Lung Slice Coinfection Model: Swine Influenza Virus Paves the Way for Streptococcus suis Infection in a Two-Step Process. Infect Immun. 83(7):2806–2815. doi:10.1128/IAI.00171-15. Meyns T, Dewulf J, de Kruif A, Calus D, Haesebrouck F, Maes D. 2006. Comparison of transmission of Mycoplasma hyopneumoniae in vaccinated and non-vaccinated populations. Vaccine. 24(49–50):7081–7086. doi:10.1016/j.vaccine.2006.07.004. Morrison RB, Hilley HD, Leman AD. 1985. Comparison of methods for assessing the prevalence and extent of pneumonia in market weight Swine. Can Vet J. 26(12):381–4. Opriessnig T, Giménez-Lirola LG, Halbur PG. 2011. Polymicrobial respiratory disease in pigs. Anim Health Res Rev. 12(2):133–148. doi:10.1017/S1466252311000120 Opriessnig T, Halbur PG. 2012. Concurrent infections are important for expression of porcine circovirus associated disease. Virus Res. 164(1–2):20–32. doi:10.1016/j.virusres.2011.09.014. Opriessnig T, Karuppannan AK, Castro AMMG, Xiao C-T. 2020. Porcine circoviruses: current status, knowledge gaps and challenges. Virus Res. 286:198044. doi:10.1016/j.virusres.2020.198044. Opriessnig T, Meng X-J, Halbur PG. 2007. Porcine Circovirus Type 2–Associated Disease: Update on Current Terminology, Clinical Manifestations, Pathogenesis, Diagnosis, and Intervention Strategies. Journal of Veterinary Diagnostic Investigation. 19(6):591–615. doi:10.1177/104063870701900601. Opriessnig T, Thacker EL, Yu S, Fenaux M, Meng X-J, Halbur PG. 2004. Experimental Reproduction of Postweaning Multisystemic Wasting Syndrome in Pigs by Dual Infection with Mycoplasma hyopneumoniae and Porcine Circovirus Type 2. Vet Pathol. 41(6):624–640. doi:10.1354/vp.41-6-624. Ouyang T, Zhang X, Liu X, Ren L. 2019. Co-Infection of Swine with Porcine Circovirus Type 2 and Other Swine Viruses. Viruses. 11(2):185. doi:10.3390/v11020185. Paladino ES, Gabardo M de P, Lunardi PN, Morés N, Guedes RMC. 2017a. Anatomopathological pneumonic aspects associated with highly pathogenic Pasteurella multocida in finishing pigs. Pesquisa Veterinaria Brasileira. 37(10):1091–1100. doi:10.1590/S0100-736X2017001000009. Pallarés F, Añón J, Rodríguez-Gómez I, Gómez-Laguna J, Fabré R, Sánchez-Carvajal J, Ruedas-Torres I, Carrasco L. 2021. Prevalence of mycoplasma-like lung lesions in pigs from commercial farms from Spain and Portugal. Porcine Health Manag. 7(1):26. doi:10.1186/s40813-021-00204-3. Palzer A, Ritzmann M, Wolf G, Heinritzi K. 2008. Associations between pathogens in healthy pigs and pigs with pneumonia. Veterinary Record. 162(9):267–271. doi:10.1136/vr.162.9.267. Pan J, Zeng M, Zhao M, Huang L. 2023. Research Progress on the detection methods of porcine reproductive and respiratory syndrome virus. Front Microbiol. 14. doi:10.3389/fmicb.2023.1097905. Park S-J, Seo HW, Park C, Chae C. 2014. Interaction between single-dose Mycoplasma hyopneumoniae and porcine reproductive and respiratory syndrome virus vaccines on dually infected pigs. Res Vet Sci. 96(3):516–522. doi:10.1016/j.rvsc.2014.03.009. Paz-Sánchez Y, Herráez P, Quesada-Canales Ó, Poveda CG, Díaz-Delgado J, Quintana-Montesdeoca M del P, Plamenova Stefanova E, Andrada M. 2021. Assessment of Lung Disease in Finishing Pigs at Slaughter: Pulmonary Lesions and Implications on Productivity Parameters. Animals. 11(12):3604. doi:10.3390/ani11123604. Petri FAM, Ferreira GC, Arruda LP, Malcher CS, Storino GY, Almeida HM de S, Sonalio K, Silva DG da, Oliveira LG de. 2023. Associations between Pleurisy and the Main Bacterial Pathogens of the Porcine Respiratory Diseases Complex (PRDC). Animals. 13(9):1493. doi:10.3390/ani13091493. Rahe MC, Michael A, Piñeyro PE, Groeltz-Thrush J, Derscheid RJ. 2023. Porcine Astrovirus 4 Detection in Lesions of Epitheliotropic Viral Infection in the Porcine Respiratory Tract. Transbound Emerg Dis. 2023:1–4. doi:10.1155/2023/9113355. Ross FR. 1999. Mycoplasma Disease. In: Brabara E. Straw, Sylvie D’Allaire, William L Ruggeri J, Salogni C, Giovannini S, Vitale N, Boniotti MB, Corradi A, Pozzi P, Pasquali P, Alborali GL. 2020. Association Between Infectious Agents and Lesions in Post-Weaned Piglets and Fattening Heavy Pigs With Porcine Respiratory Disease Complex (PRDC). Front Vet Sci. 7. doi:10.3389/fvets.2020.00636. Saade G, Deblanc C, Bougon J, Marois-Créhan C, Fablet C, Auray G, Belloc C, Leblanc-Maridor M, Gagnon CA, Zhu J, et al. 2020. Coinfections and their molecular consequences in the porcine respiratory tract. Vet Res. 51(1):80. doi:10.1186/s13567-020-00807-8. Sarli G, D’annunzio G, Gobbo F, Benazzi C, Ostanello F. 2021. The role of pathology in the diagnosis of swine respiratory disease. Vet Sci. 8(11). doi:10.3390/vetsci8110256. Sibila M, Pieters M, Molitor T, Maes D, Haesebrouck F, Segalés J. 2009. Current perspectives on the diagnosis and epidemiology of Mycoplasma hyopneumoniae infection. The Veterinary Journal. 181(3):221–231. doi:10.1016/j.tvjl.2008.02.020. Silva APSP, Almeida M, Michael A, Rahe MC, Siepker C, Magstadt DR, Piñeyro P, Arruda BL, Macedo NR, Sahin O, et al. 2023. Detection and disease diagnosis trends (2017–2022) for Streptococcus suis, Glaesserella parasuis, Mycoplasma hyorhinis, Actinobacillus suis and Mycoplasma hyosynoviae at Iowa State University Veterinary Diagnostic Laboratory. BMC Vet Res. 19(1):268. doi:10.1186/s12917-023-03807-w. Sinha A, Shen HG, Schalk S, Beach NM, Huang YW, Meng XJ, Halbur PG, Opriessnig T. 2011. Porcine reproductive and respiratory syndrome virus (PRRSV) influences infection dynamics of porcine circovirus type 2 (PCV2) subtypes PCV2a and PCV2b by prolonging PCV2 viremia and shedding. Vet Microbiol. 152(3–4):235–246. doi:10.1016/j.vetmic.2011.05.005. Sun Q, Yu X, He D, Ku X, Hong B, Zeng W, Zhang H, He Q. 2022. Investigation and analysis of etiology associated with porcine respiratory disease complex in China from 2017 to 2021. Front Vet Sci. 9. doi:10.3389/fvets.2022.960033. SUNAGA F, TSUCHIAKA S, KISHIMOTO M, AOKI H, KAKINOKI M, KURE K, OKUMURA H, OKUMURA M, OKUMURA A, NAGAI M, et al. 2020. Development of a one-run real-time PCR detection system for pathogens associated with porcine respiratory diseases. Journal of Veterinary Medical Science. 82(2):217–223. doi:10.1292/jvms.19-0063. Thacker EL, Halbur PG, Ross RF, Thanawongnuwech R, Thacker BJ. 1999. Mycoplasma hyopneumoniae Potentiation of Porcine Reproductive and Respiratory Syndrome Virus-Induced Pneumonia. J Clin Microbiol. 37(3):620–627. doi:10.1128/JCM.37.3.620-627.1999. Thacker EL. 2001. Immunology of the Porcine Respiratory Disease Complex. Veterinary Clinics of North America: Food Animal Practice. 17(3):551–565. doi:10.1016/S0749-0720(15)30006-2. Thacker EL. 2004. Diagnosis of Mycoplasma hyopneumoniae. Anim Health Res Rev. 5(2):317–320. doi:10.1079/AHR200491. Vangroenweghe Frédéric A. C. J., Thas O. 2021. Seasonal Variation in Prevalence of Mycoplasma hyopneumoniae and Other Respiratory Pathogens in Peri-Weaned, Post-Weaned, and Fattening Pigs with Clinical Signs of Respiratory Diseases in Belgian and Dutch Pig Herds, Using a Tracheobronchial Swab Sampling Technique, and Their Associations with Local Weather Conditions. Pathogens. 10(9):1202. doi:10.3390/pathogens10091202. Zimmerman, Jeffrey J., Locke A. Karriker, Alejandro Ramirez, Kent J. Schwartz, Gregory W. Stevenson, y Jianqiang Zhang. 2019. Diseases Of Swine. John Wiley & Sons. |
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Universidad Nacional de Colombia |
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Bogotá - Medicina Veterinaria y de Zootecnia - Especialidad en Anatomopatología Veterinaria |
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Facultad de Medicina Veterinaria y de Zootecnia |
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Bogotá, Colombia |
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Universidad Nacional de Colombia - Sede Bogotá |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Mogollon, Jose Darío40e8fdeedea1beaf8604ef9fcbffdea4Correa, Jairo Jaime03de747088c437a609cace9a0380dd69Ruiz Linares, Juan Sebastian0e914c9dcdd6b5a74e7e982803213a772024-10-25T15:47:25Z2024-10-25T15:47:25Z2024https://repositorio.unal.edu.co/handle/unal/87065Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/Ilustraciones, diagramas, fotografías, tablasEl complejo respiratorio porcino (CRP) es un síndrome clínico multietiológico, polilesional y multifactorial de difícil enfoque para su manejo, prevención y control en las etapas productivas de los cerdos, los cuales llevan a pérdidas económicas severas. El objetivo de este trabajo fue caracterizar las lesiones patológicas macroscópicas y su correlación con los patrones neumónicos observados en cerdos de precebo y ceba en una granja intensiva de tres sitios en el país. Se realizaron 50 necropsias, 25 cerdos de cada de las etapas de precebo-ceba respectivamente y toma de muestras de tejido pulmonar para histopatología. Se observó al menos un patrón neumónico evidente a la evaluación macroscópica en todos los cerdos. En precebo el patrón neumónico predominante fue la combinación de Bronconeumonía supurativa con Neumonía Intersticial. En ceba el patrón predominante fue la combinación de Neumonía intersticial con Neumonía Broncointersticial. Los hallazgos observados sugieren el comportamiento multietiológico, la variabilidad de posibles agentes inductores y la severidad de las coinfecciones virales y/o bacterianas presentes en un mismo cerdo. Estos hallazgos no son fácilmente observables y pueden confundirse entre sí a la evaluación macroscópica de los tejidos, por lo que la evaluación histopatológica es crucial para realizar la primera aproximación diagnóstica del CRP. Las lesiones encontradas pueden sugerir la participación de agentes como PRRSV, SIV, PCV2, Mycoplasma hyopneumoniae, y agentes bacterianos como Streptococcus suis, Glaeserella parasuis, Actinobacillus pleuropneumoniae. Esto refleja la necesidad de realizar pruebas complementarias como la detección de los agentes y su asociación con los hallazgos patológicos encontrados para precisar el diagnostico (Texto tomado de la fuente).The swine respiratory complex (PRC) refers to a multifactorial disease that arises from a combination of viral, bacterial agents, some management practices and environmental factors. The polymicrobial and polylesional features present a great challenge to diagnose infectious agents involved in a clinical problem which leads to a severe economic loses in Colombia and worldwide. The goal of this work was to characterize the macroscopic pathological lesions and their correlation with the pneumonic patterns observed in the nursery and fattening pigs in an intensive full-cycle farm in our country. Fifty pigs were selected and necropsied, 25 pigs belonged to each productive phase as mentioned above. Lung tissues were taken for histopathology. At least one pneumonic pattern was observed at macroscopic evaluation in all pigs studied. In nursery, the predominant pneumonic pattern was the combination of suppurative bronchopneumonia and interstitial pneumonia. In fattening, the predominant pattern was the combination of interstitial pneumonia and bronchointerstitial. The detected findings showed variability of possible inducing agents, and the severity of the co-infections. These findings are not easily observable and can be confusing at macroscopic evaluation of lungs. Thus, histopathological evaluation is crucial to apporach the first diagnostic approach of PRC. The lesions and their features found may suggest the involvement of agents such as PRRSV, SIV, PCV2, Mycoplasma hyopneumoniae, and bacterial agents such as Streptococcus suis, Glaeserella parasuis, Actinobacillus pleuropneumoniae. Finally, these findings indicate the need to perform molecular tests for the detection of agents involved and their correlation with lesions to establish a comprehensive final diagnosis.Especialidades MédicasEspecialista en Anatomopatología Veterinaria49 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina Veterinaria y de Zootecnia - Especialidad en Anatomopatología VeterinariaFacultad de Medicina Veterinaria y de ZootecniaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá630 - Agricultura y tecnologías relacionadas::636 - Producción animal590 - Animales::599 - MamíferosMICOLOGIA VETERINARIAHISTOLOGIA PATOLOGICAENFERMEDADES DE LOS PULMONESVeterinary mycologyHistology, pathologicalLung diseasesComplejo respiratorio porcino-CRPPatrones neumónicosDaño pulmonarEnfermedad multifactorialPorcine respiratory complex (PRDC)Pneumonic patternsLung damageMultifactorial diseaseCaracterización de las lesiones patológicas del complejo respiratorio porcino como una herramienta de diagnóstico en la línea de producción de granjas porcinasPathological characterization of swine respiratory complex lesions as a diagnostic tool in nursery and fattening pigs from an intensive swine farmTrabajo de grado - Especialidad Médicainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMBetlach AM, Valeris-Chacin R, Singer RS, Allerson M, Pieters M. 2020. 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John Wiley & Sons.InvestigadoresORIGINALTrabajo de grado Repositorio.pdfTrabajo de grado Repositorio.pdfTesis de Especialista en Anatomopatología Veterinariaapplication/pdf1144629https://repositorio.unal.edu.co/bitstream/unal/87065/2/Trabajo%20de%20grado%20Repositorio.pdfdbbf380e2926e6a5bd134167bf19b536MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/87065/3/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD53THUMBNAILTrabajo de grado Repositorio.pdf.jpgTrabajo de grado Repositorio.pdf.jpgGenerated Thumbnailimage/jpeg5716https://repositorio.unal.edu.co/bitstream/unal/87065/4/Trabajo%20de%20grado%20Repositorio.pdf.jpgd4ecf604f85e3413cedbb84acc54861fMD54unal/87065oai:repositorio.unal.edu.co:unal/870652024-10-25 23:25:23.093Repositorio Institucional Universidad Nacional de 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