Niveles de TSLP y control de la enfermedad en el paciente con diagnóstico de asma, revisión sistemática y metaanálisis

ilustraciones, graficas

Autores:
Ramírez Camacho, Oscar Javier
Tipo de recurso:
Fecha de publicación:
2021
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/81421
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/81421
https://repositorio.unal.edu.co/
Palabra clave:
610 - Medicina y salud::616 - Enfermedades
Citocinas
Cytokines
Asthma
Asma
TSLP: Lifopoyetina del estroma Timico
CLI: Células linfoides innatas
VEF1/CVF Volumen espiratorio forzado en el primer segundo / capacidad vital funcional
Th2: Linfocitos T helper Tipo 2
TSLP: Thymic stromal lipopoietin
ILC: Innate lymphoid cells
FEV1/FVC Forced expiratory volume in 1 second / functional vital capacity
Th2: Type 2 helper T lymphocytes
Rights
openAccess
License
Reconocimiento 4.0 Internacional
id UNACIONAL2_0a0115a4760481ac66cb7bbe9a256928
oai_identifier_str oai:repositorio.unal.edu.co:unal/81421
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Niveles de TSLP y control de la enfermedad en el paciente con diagnóstico de asma, revisión sistemática y metaanálisis
dc.title.translated.eng.fl_str_mv TSLP levels and disease control in patients diagnosed with asthma. Systematic review and meta-analysis
dc.title.translated.none.fl_str_mv TSLP levels and disease control in patients diagnosed with asthma, systematic review and meta-analysis
title Niveles de TSLP y control de la enfermedad en el paciente con diagnóstico de asma, revisión sistemática y metaanálisis
spellingShingle Niveles de TSLP y control de la enfermedad en el paciente con diagnóstico de asma, revisión sistemática y metaanálisis
610 - Medicina y salud::616 - Enfermedades
Citocinas
Cytokines
Asthma
Asma
TSLP: Lifopoyetina del estroma Timico
CLI: Células linfoides innatas
VEF1/CVF Volumen espiratorio forzado en el primer segundo / capacidad vital funcional
Th2: Linfocitos T helper Tipo 2
TSLP: Thymic stromal lipopoietin
ILC: Innate lymphoid cells
FEV1/FVC Forced expiratory volume in 1 second / functional vital capacity
Th2: Type 2 helper T lymphocytes
title_short Niveles de TSLP y control de la enfermedad en el paciente con diagnóstico de asma, revisión sistemática y metaanálisis
title_full Niveles de TSLP y control de la enfermedad en el paciente con diagnóstico de asma, revisión sistemática y metaanálisis
title_fullStr Niveles de TSLP y control de la enfermedad en el paciente con diagnóstico de asma, revisión sistemática y metaanálisis
title_full_unstemmed Niveles de TSLP y control de la enfermedad en el paciente con diagnóstico de asma, revisión sistemática y metaanálisis
title_sort Niveles de TSLP y control de la enfermedad en el paciente con diagnóstico de asma, revisión sistemática y metaanálisis
dc.creator.fl_str_mv Ramírez Camacho, Oscar Javier
dc.contributor.advisor.none.fl_str_mv Montilla Velásquez, Maria del Pilar
Henao, Sandra Patricia
dc.contributor.author.none.fl_str_mv Ramírez Camacho, Oscar Javier
dc.subject.ddc.spa.fl_str_mv 610 - Medicina y salud::616 - Enfermedades
topic 610 - Medicina y salud::616 - Enfermedades
Citocinas
Cytokines
Asthma
Asma
TSLP: Lifopoyetina del estroma Timico
CLI: Células linfoides innatas
VEF1/CVF Volumen espiratorio forzado en el primer segundo / capacidad vital funcional
Th2: Linfocitos T helper Tipo 2
TSLP: Thymic stromal lipopoietin
ILC: Innate lymphoid cells
FEV1/FVC Forced expiratory volume in 1 second / functional vital capacity
Th2: Type 2 helper T lymphocytes
dc.subject.other.sp.fl_str_mv Citocinas
dc.subject.other.eng.fl_str_mv Cytokines
Asthma
dc.subject.other.spa.fl_str_mv Asma
dc.subject.proposal.spa.fl_str_mv TSLP: Lifopoyetina del estroma Timico
CLI: Células linfoides innatas
VEF1/CVF Volumen espiratorio forzado en el primer segundo / capacidad vital funcional
Th2: Linfocitos T helper Tipo 2
dc.subject.proposal.eng.fl_str_mv TSLP: Thymic stromal lipopoietin
ILC: Innate lymphoid cells
FEV1/FVC Forced expiratory volume in 1 second / functional vital capacity
Th2: Type 2 helper T lymphocytes
description ilustraciones, graficas
publishDate 2021
dc.date.issued.none.fl_str_mv 2021-11-22
dc.date.accessioned.none.fl_str_mv 2022-03-30T21:47:33Z
dc.date.available.none.fl_str_mv 2022-03-30T21:47:33Z
dc.type.spa.fl_str_mv Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/81421
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/81421
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
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dc.publisher.faculty.spa.fl_str_mv Facultad de Medicina
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dc.publisher.branch.spa.fl_str_mv Universidad Nacional de Colombia - Sede Bogotá
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spelling Reconocimiento 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Montilla Velásquez, Maria del Pilar5846c236f70edd5990a85de30e5c2532Henao, Sandra Patricia3158fc409917768f4db6aaa898722c2bRamírez Camacho, Oscar Javier655d3ca1eb3ca2bc24c21f1d28554c6c2022-03-30T21:47:33Z2022-03-30T21:47:33Z2021-11-22https://repositorio.unal.edu.co/handle/unal/81421Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, graficasIntroducción: El asma es una enfermedad heterogénea, caracterizada por inflamación crónica de la vía aérea, con síntomas respiratorios variables relacionados con limitación al flujo aérea. En el asma con inflamación tipo 2, las células epiteliales estimulan a las células dendríticas y a otros grupos celulares como las células linfoides innatas (CLI), mediante unas citoquinas denominadas “alarminas”, que polarizan la respuesta inmune hacia este tipo de inflamación en el pulmón, una de estas citoquinas es la linfopoyetina del estroma timico (TSLP) por sus siglas en ingles, la cual esta implicada en la fisiopatología del asma, Se ha evidenciado en varios estudios que altos niveles de esta citoquina se relacionan con pobre control de la enfermedad. Objetivo: Evaluar los niveles de TSLP y control de la enfermedad en el paciente con diagnóstico de asma. Métodos de búsqueda: Se realizó una búsqueda con una fecha de corte para el 6 julio de 2020, en las bases de datos MEDLINE/Pubmed, EMBASE, CENTRAL, LILACS, Clinical trials.gov y open grey. Criterios de selección: Se incluyeron estudios observacionales analíticos de tipo casos y controles, prospectivos y retrospectivos y ensayos clínicos controlados aleatorizados. Se incluyeron estudios que compararan los niveles de TSLP en pacientes con asma y personas sanas, y entre los grupos de severidad de la enfermedad en cualquier muestra analizada. Recolección de datos y análisis: Dos revisores identificaron los criterios de inclusión de los estudios de manera independientemente, con revisión por título, resumen y texto completo. Se realizó la extracción de los datos, evaluación de riesgo de sesgo y metaanálisis a través del método de varianza inversa medias estandarizadas con pesos obtenidos a través del métodos de efectos aleatorios. Se realizó un gráfico de albatros para la correlación de los niveles de TSLP y volumen espiratorio forzado en el primer segundo (VEF1). Resultados principales: 31 estudios (2709 participantes) cumplieron los criterios de selección de los cuales 29 se incluyeron en el metaanálisis. Se analizaron los niveles de TSLP en pacientes asmáticos y controles según la muestra obtenida y la severidad de la enfermedad. Se encontró evidencia de mayores niveles de TSLP en pacientes con asma respecto a controles (2.76 SMD IC 95% 1.99-3.53), y mayores niveles en paciente con asma moderada-severa respecto a asma leve (0.81 SMD IC 95% 0.58-1.04). Se encontró correlación negativa entre los niveles de TSLP y el VEF1. Conclusión: Basados en lo hallazgos de los estudios incluidos en esta revisión, se considera que existe evidencia suficiente para afirmar que los niveles de TSLP son mayores en pacientes con asma y que estos se incrementan conforme la severidad de la enfermedad. Se encontró también que los niveles de TSLP se correlacionan de manera negativa con el VEF1. (Texto tomado de la fuente)Introduction: Asthma is a heterogeneous disease, characterized by chronic inflammation of the airway, with variable respiratory symptoms related to airflow limitation. In asthma with type 2 inflammation, epithelial cells stimulate dendritic cells and other cell groups such as innate lymphoid cells (ILC), through cytokines called "alarmins", which polarize the immune response towards this type of inflammation in the lung , one of these cytokines is thymic stromal lymphopoietin (TSLP), which is involved in the pathophysiology of asthma. Several studies have shown that high levels of this cytokine are related to poor disease control. Objective: To evaluate the levels of TSLP and disease control in patients diagnosed with asthma. Search methods: A search was conducted with a cut-off date of July 6, 2020, in the MEDLINE/Pubmed, EMBASE, CENTRAL, LILACS, Clinical trials.gov, and open gray databases. Selection criteria: Prospective and retrospective case-control analytical observational studies and controlled clinical trials were included, randomized. Studies were included that compared TSLP levels in patients with asthma and healthy people, and between disease severity groups in any sample analyzed. Data collection and analysis: Two reviewers independently identified study inclusion criteria, reviewing by title, abstract, and full text. Data extraction, risk of bias assessment, and meta-analysis were performed using the standardized mean inverse variance method with weights obtained using the random effects method. An albatross plot was made for the correlation of TSLP levels and forced expiratory volume in one second (FEV1). Main results: 31 studies (2709 participants) met the selection criteria of which 29 were included in the meta-analysis. TSLP levels were analyzed in asthmatic patients and controls according to the sample obtained and the severity of the disease. Evidence of higher levels of TSLP was found in patients with asthma compared to controls (2.76 SMD CI 95% 1.99-3.53), and higher levels in patients with moderate-severe asthma compared to mild asthma (0.81 SMD CI 95% 0.58-1.04). . A negative correlation was found between TSLP levels and FEV1. Conclusion: Based on the findings of the studies included in this review, it is considered that there is sufficient evidence to affirm that TSLP levels are higher in patients with asthma and that they increase with the severity of the disease. TSLP levels were also found to be negatively correlated with FEV1.MaestríaMagíster en Inmunología60 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Maestría en InmunologíaDepartamento de MicrobiologíaFacultad de MedicinaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud::616 - EnfermedadesCitocinasCytokinesAsthmaAsmaTSLP: Lifopoyetina del estroma TimicoCLI: Células linfoides innatasVEF1/CVF Volumen espiratorio forzado en el primer segundo / capacidad vital funcionalTh2: Linfocitos T helper Tipo 2TSLP: Thymic stromal lipopoietinILC: Innate lymphoid cellsFEV1/FVC Forced expiratory volume in 1 second / functional vital capacityTh2: Type 2 helper T lymphocytesNiveles de TSLP y control de la enfermedad en el paciente con diagnóstico de asma, revisión sistemática y metaanálisisTSLP levels and disease control in patients diagnosed with asthma. 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EVESURBIFBPUiBMQSBTRUNSRVRBUsONQSBHRU5FUkFMLiAqTEEgVEVTSVMgQSBQVUJMSUNBUiBERUJFIFNFUiBMQSBWRVJTScOTTiBGSU5BTCBBUFJPQkFEQS4gCgpBbCBoYWNlciBjbGljIGVuIGVsIHNpZ3VpZW50ZSBib3TDs24sIHVzdGVkIGluZGljYSBxdWUgZXN0w6EgZGUgYWN1ZXJkbyBjb24gZXN0b3MgdMOpcm1pbm9zLiBTaSB0aWVuZSBhbGd1bmEgZHVkYSBzb2JyZSBsYSBsaWNlbmNpYSwgcG9yIGZhdm9yLCBjb250YWN0ZSBjb24gZWwgYWRtaW5pc3RyYWRvciBkZWwgc2lzdGVtYS4KClVOSVZFUlNJREFEIE5BQ0lPTkFMIERFIENPTE9NQklBIC0gw5psdGltYSBtb2RpZmljYWNpw7NuIDE5LzEwLzIwMjEK

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