Novel furocarbazole a lkaloids and antibacterial activity of ethanol extract from zanthoxylum fagara (l.) sargent

From ethanol-soluble extract of the bark from Zanthoxylum fagara (L.) Sargent. were isolated two novel furocarbazole alkaloids, 4-methoxy-10H-furo[3,2-a]carbazole ( ) and 10H-furo[3,2-a]carbazole ( ), whose structures were elucidated on the basis of IR, MS and NMR (including 1D and 2D) techniques. I...

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Autores:
Macías, Víctor
Coy, Ericcson
Cuca, Luis Enrique
Tipo de recurso:
Article of journal
Fecha de publicación:
2010
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/33367
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/33367
http://bdigital.unal.edu.co/23447/
http://bdigital.unal.edu.co/23447/2/
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openAccess
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Atribución-NoComercial 4.0 Internacional
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spelling Atribución-NoComercial 4.0 InternacionalDerechos reservados - Universidad Nacional de Colombiahttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Macías, Víctor40442055-5ac5-4703-9e97-68dfb257089a300Coy, Ericcson57b2209e-ec20-48ae-9990-839e0c861583300Cuca, Luis Enrique07d547a1-1db9-4ea7-973f-48bc4d91e3f53002019-06-27T22:56:20Z2019-06-27T22:56:20Z2010https://repositorio.unal.edu.co/handle/unal/33367http://bdigital.unal.edu.co/23447/http://bdigital.unal.edu.co/23447/2/From ethanol-soluble extract of the bark from Zanthoxylum fagara (L.) Sargent. were isolated two novel furocarbazole alkaloids, 4-methoxy-10H-furo[3,2-a]carbazole ( ) and 10H-furo[3,2-a]carbazole ( ), whose structures were elucidated on the basis of IR, MS and NMR (including 1D and 2D) techniques. In addition, the antibacterial effect of the ethanol extract of bark was evaluated against Gram-negative bacteria Escherichia coli, Salmonella typhi, Shigella boydii, Vibrio cholerae El Tor, and Vibrio cholerae clinical lysate; and Gram-positive bacteria Bacillus subtilis and Staphylococcus epidermidis, using the Agar-well diffusion method. In above-mentioned assay was found that the ethanol extract of bark exhibited inhibition against strains B. subtilis (17mm), V. cholerae El Tor (11mm), V. cholerae clinical lysate (10mm), and S. epidermidis (9mm).application/pdfspaUniversidad Nacional de Colombiahttp://revistas.unal.edu.co/index.php/rcolquim/article/view/20355Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de QuímicaRevista Colombiana de QuímicaRevista Colombiana de Química; Vol. 39, núm. 3 (2010); 333-341 0120-2804Macías, Víctor and Coy, Ericcson and Cuca, Luis Enrique (2010) Novel furocarbazole a lkaloids and antibacterial activity of ethanol extract from zanthoxylum fagara (l.) sargent. Revista Colombiana de Química; Vol. 39, núm. 3 (2010); 333-341 0120-2804 .Novel furocarbazole a lkaloids and antibacterial activity of ethanol extract from zanthoxylum fagara (l.) sargentArtículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/ARTORIGINAL20355-68646-1-PB.pdfapplication/pdf310066https://repositorio.unal.edu.co/bitstream/unal/33367/1/20355-68646-1-PB.pdfa98e8324d5e3a72f88841b1ad7ef0135MD51THUMBNAIL20355-68646-1-PB.pdf.jpg20355-68646-1-PB.pdf.jpgGenerated Thumbnailimage/jpeg6732https://repositorio.unal.edu.co/bitstream/unal/33367/2/20355-68646-1-PB.pdf.jpg07bca95c1563c15a240f59c0c8224e29MD52unal/33367oai:repositorio.unal.edu.co:unal/333672022-12-25 23:03:49.314Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.co
dc.title.spa.fl_str_mv Novel furocarbazole a lkaloids and antibacterial activity of ethanol extract from zanthoxylum fagara (l.) sargent
title Novel furocarbazole a lkaloids and antibacterial activity of ethanol extract from zanthoxylum fagara (l.) sargent
spellingShingle Novel furocarbazole a lkaloids and antibacterial activity of ethanol extract from zanthoxylum fagara (l.) sargent
title_short Novel furocarbazole a lkaloids and antibacterial activity of ethanol extract from zanthoxylum fagara (l.) sargent
title_full Novel furocarbazole a lkaloids and antibacterial activity of ethanol extract from zanthoxylum fagara (l.) sargent
title_fullStr Novel furocarbazole a lkaloids and antibacterial activity of ethanol extract from zanthoxylum fagara (l.) sargent
title_full_unstemmed Novel furocarbazole a lkaloids and antibacterial activity of ethanol extract from zanthoxylum fagara (l.) sargent
title_sort Novel furocarbazole a lkaloids and antibacterial activity of ethanol extract from zanthoxylum fagara (l.) sargent
dc.creator.fl_str_mv Macías, Víctor
Coy, Ericcson
Cuca, Luis Enrique
dc.contributor.author.spa.fl_str_mv Macías, Víctor
Coy, Ericcson
Cuca, Luis Enrique
description From ethanol-soluble extract of the bark from Zanthoxylum fagara (L.) Sargent. were isolated two novel furocarbazole alkaloids, 4-methoxy-10H-furo[3,2-a]carbazole ( ) and 10H-furo[3,2-a]carbazole ( ), whose structures were elucidated on the basis of IR, MS and NMR (including 1D and 2D) techniques. In addition, the antibacterial effect of the ethanol extract of bark was evaluated against Gram-negative bacteria Escherichia coli, Salmonella typhi, Shigella boydii, Vibrio cholerae El Tor, and Vibrio cholerae clinical lysate; and Gram-positive bacteria Bacillus subtilis and Staphylococcus epidermidis, using the Agar-well diffusion method. In above-mentioned assay was found that the ethanol extract of bark exhibited inhibition against strains B. subtilis (17mm), V. cholerae El Tor (11mm), V. cholerae clinical lysate (10mm), and S. epidermidis (9mm).
publishDate 2010
dc.date.issued.spa.fl_str_mv 2010
dc.date.accessioned.spa.fl_str_mv 2019-06-27T22:56:20Z
dc.date.available.spa.fl_str_mv 2019-06-27T22:56:20Z
dc.type.spa.fl_str_mv Artículo de revista
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url https://repositorio.unal.edu.co/handle/unal/33367
http://bdigital.unal.edu.co/23447/
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dc.relation.ispartof.spa.fl_str_mv Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de Química
Revista Colombiana de Química
dc.relation.ispartofseries.none.fl_str_mv Revista Colombiana de Química; Vol. 39, núm. 3 (2010); 333-341 0120-2804
dc.relation.references.spa.fl_str_mv Macías, Víctor and Coy, Ericcson and Cuca, Luis Enrique (2010) Novel furocarbazole a lkaloids and antibacterial activity of ethanol extract from zanthoxylum fagara (l.) sargent. Revista Colombiana de Química; Vol. 39, núm. 3 (2010); 333-341 0120-2804 .
dc.rights.spa.fl_str_mv Derechos reservados - Universidad Nacional de Colombia
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dc.rights.license.spa.fl_str_mv Atribución-NoComercial 4.0 Internacional
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dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv Atribución-NoComercial 4.0 Internacional
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dc.publisher.spa.fl_str_mv Universidad Nacional de Colombia
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