Simulación de la evolución de la estructura espacial y organización celular de agregados celulares en diversas geometrías sencillas, mediante un método monte carlo cinético aplicado a un modelo reticular

ilustraciones, graficas

Autores:
Sanchez Rodriguez, Diego Alejandro
Tipo de recurso:
Fecha de publicación:
2021
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
eng
OAI Identifier:
oai:repositorio.unal.edu.co:unal/82216
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/82216
https://repositorio.unal.edu.co/
Palabra clave:
570 - Biología::573 - Sistemas fisiológicos específicos en animales, histología regional y fisiología en los animales
Cell aggregates
Morphogenesis model
Tissue engineering
Cell aggregates
Cell rearrangement
Self-learning KMC
Morphogenesis
Bioprinting simulation
Bioconvergence
Agregados celulares
Modelo de morfogenesis
Ingenieria de tejidos
Morfogenesis
Bioconvergencia
Rights
openAccess
License
Reconocimiento 4.0 Internacional
id UNACIONAL2_0643fd7c6438cd0fd880ed8e1f0f2064
oai_identifier_str oai:repositorio.unal.edu.co:unal/82216
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.eng.fl_str_mv Simulación de la evolución de la estructura espacial y organización celular de agregados celulares en diversas geometrías sencillas, mediante un método monte carlo cinético aplicado a un modelo reticular
dc.title.translated.spa.fl_str_mv Simulation of the spatial structure and cellular organization evolution of cell aggregates arranged in various simple geometries, using a kinetic monte carlo method applied to a lattice model
title Simulación de la evolución de la estructura espacial y organización celular de agregados celulares en diversas geometrías sencillas, mediante un método monte carlo cinético aplicado a un modelo reticular
spellingShingle Simulación de la evolución de la estructura espacial y organización celular de agregados celulares en diversas geometrías sencillas, mediante un método monte carlo cinético aplicado a un modelo reticular
570 - Biología::573 - Sistemas fisiológicos específicos en animales, histología regional y fisiología en los animales
Cell aggregates
Morphogenesis model
Tissue engineering
Cell aggregates
Cell rearrangement
Self-learning KMC
Morphogenesis
Bioprinting simulation
Bioconvergence
Agregados celulares
Modelo de morfogenesis
Ingenieria de tejidos
Morfogenesis
Bioconvergencia
title_short Simulación de la evolución de la estructura espacial y organización celular de agregados celulares en diversas geometrías sencillas, mediante un método monte carlo cinético aplicado a un modelo reticular
title_full Simulación de la evolución de la estructura espacial y organización celular de agregados celulares en diversas geometrías sencillas, mediante un método monte carlo cinético aplicado a un modelo reticular
title_fullStr Simulación de la evolución de la estructura espacial y organización celular de agregados celulares en diversas geometrías sencillas, mediante un método monte carlo cinético aplicado a un modelo reticular
title_full_unstemmed Simulación de la evolución de la estructura espacial y organización celular de agregados celulares en diversas geometrías sencillas, mediante un método monte carlo cinético aplicado a un modelo reticular
title_sort Simulación de la evolución de la estructura espacial y organización celular de agregados celulares en diversas geometrías sencillas, mediante un método monte carlo cinético aplicado a un modelo reticular
dc.creator.fl_str_mv Sanchez Rodriguez, Diego Alejandro
dc.contributor.advisor.none.fl_str_mv Godoy Silva, Ruben Dario
dc.contributor.author.none.fl_str_mv Sanchez Rodriguez, Diego Alejandro
dc.contributor.editor.none.fl_str_mv Ramos Murillo Ana Isabel
dc.contributor.researchgroup.spa.fl_str_mv Grupo de Investigación en Procesos Químicos y Bioquímicos
dc.subject.ddc.spa.fl_str_mv 570 - Biología::573 - Sistemas fisiológicos específicos en animales, histología regional y fisiología en los animales
topic 570 - Biología::573 - Sistemas fisiológicos específicos en animales, histología regional y fisiología en los animales
Cell aggregates
Morphogenesis model
Tissue engineering
Cell aggregates
Cell rearrangement
Self-learning KMC
Morphogenesis
Bioprinting simulation
Bioconvergence
Agregados celulares
Modelo de morfogenesis
Ingenieria de tejidos
Morfogenesis
Bioconvergencia
dc.subject.proposal.eng.fl_str_mv Cell aggregates
Morphogenesis model
Tissue engineering
Cell aggregates
Cell rearrangement
Self-learning KMC
Morphogenesis
Bioprinting simulation
Bioconvergence
dc.subject.proposal.spa.fl_str_mv Agregados celulares
Modelo de morfogenesis
Ingenieria de tejidos
Morfogenesis
Bioconvergencia
description ilustraciones, graficas
publishDate 2021
dc.date.issued.none.fl_str_mv 2021
dc.date.accessioned.none.fl_str_mv 2022-08-31T16:12:48Z
dc.date.available.none.fl_str_mv 2022-08-31T16:12:48Z
dc.type.spa.fl_str_mv Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv DataPaper
Image
Model
Software
Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/82216
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/82216
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.indexed.spa.fl_str_mv RedCol
LaReferencia
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dc.publisher.branch.spa.fl_str_mv Universidad Nacional de Colombia - Sede Bogotá
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spelling Reconocimiento 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Godoy Silva, Ruben Dario8866744983709005103dd37b112eec3aSanchez Rodriguez, Diego Alejandroe8edc325173e06bffcc7140bbcf1fa18600Ramos Murillo Ana IsabelGrupo de Investigación en Procesos Químicos y Bioquímicos2022-08-31T16:12:48Z2022-08-31T16:12:48Z2021https://repositorio.unal.edu.co/handle/unal/82216Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, graficasEsta tesis trata los modelos de morfogénesis, en particular los modelos de evolución guiada por contacto que son coherentes con la hipótesis de la adhesión diferencial. Se presenta una revisión de algunos modelos, sus principios biológicos subyacentes, la relevancia y aplicaciones en el marco de la bioimpresión, la ingeniería de tejidos y la bioconvergencia. Luego, se presentan los detalles de los modelos basados en métodos de Monte Carlo para profundizar más adelante en el modelo basados en algoritmos Kinetic Monte Carlo (KMC) , más específicamente, se describe en detalle un modelo KMC de autoaprendizaje (SL-KMC). Se presenta y explica la estructura algorítmica del código implementado, se evalúa el rendimiento del modelo y se compara con un modelo KMC tradicional. Finalmente, se realizan los procesos de calibración y validación, se observó que el modelo es capaz de replicar la evolución del sistema multicelular cuando las condiciones de energía interfacial del sistema simulado son similares a las del sistema de calibraciones. (Texto tomado de la fuente)This thesis treats the models for morphogenesis, in particular the contact-guided evolution models that are coherent with the differential adhesion hypothesis. A review of some models, their biological underpinning principles, the relevance and applications in the framework of bioprinting, tissue engineering and bioconvergence are presented. Then the details for the Monte Carlo methods-based models are presented to later deep dive into the Kinetic Monte Carlo (KMC) based model, and more specifically a Self-Learning KMC (SL-KMC) model is described to detail. The algorithmic structure of the implemented code is presented and explained, the model performance is assessed and compared with a traditional KMC model. Finally, the calibration and validation processes have been carried out, it was observed that the model is able to replicate the multicellular system evolution when the interfacial energy conditions of the simulated system are similar to those of the calibrations system.MaestríaMagíster en Ingeniería - Ingeniería Química227 páginasapplication/pdfengUniversidad Nacional de ColombiaBogotá - Ingeniería - Maestría en Ingeniería - Ingeniería QuímicaDepartamento de Ingeniería Química y AmbientalFacultad de IngenieríaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá570 - Biología::573 - Sistemas fisiológicos específicos en animales, histología regional y fisiología en los animalesCell aggregatesMorphogenesis modelTissue engineeringCell aggregatesCell rearrangementSelf-learning KMCMorphogenesisBioprinting simulationBioconvergenceAgregados celularesModelo de morfogenesisIngenieria de tejidosMorfogenesisBioconvergenciaSimulación de la evolución de la estructura espacial y organización celular de agregados celulares en diversas geometrías sencillas, mediante un método monte carlo cinético aplicado a un modelo reticularSimulation of the spatial structure and cellular organization evolution of cell aggregates arranged in various simple geometries, using a kinetic monte carlo method applied to a lattice modelTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionDataPaperImageModelSoftwareTexthttp://purl.org/redcol/resource_type/TMRedColLaReferenciaSánchez Rodríguez, D.A., A.I. 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Applied microbiology and biotechnology, 2017. 101(22): p. 8101-8113.EstudiantesInvestigadoresMaestrosPúblico generalLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unal.edu.co/bitstream/unal/82216/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINAL1013662187.2022.pdf1013662187.2022.pdfTesis de Maestría en Ingeniería - Ingeniería Químicaapplication/pdf6429024https://repositorio.unal.edu.co/bitstream/unal/82216/3/1013662187.2022.pdf6c100c60a5389b2461a262ffe303ae0dMD53THUMBNAIL1013662187.2022.pdf.jpg1013662187.2022.pdf.jpgGenerated Thumbnailimage/jpeg5658https://repositorio.unal.edu.co/bitstream/unal/82216/4/1013662187.2022.pdf.jpgf9c6eb0085f1523a48c09eb9da337d55MD54unal/82216oai:repositorio.unal.edu.co:unal/822162023-08-08 23:04:10.265Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.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