Respuesta del cáncer al tratamiento mediante quimioterapia y terapia electroquímica utilizando modelado y simulación biocomputacional

ilustraciones,

Autores:
Vélez Salazar, Fabián Mauricio
Tipo de recurso:
Doctoral thesis
Fecha de publicación:
2022
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/83900
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/83900
https://repositorio.unal.edu.co/
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000 - Ciencias de la computación, información y obras generales::005 - Programación, programas, datos de computación
620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería
000 - Ciencias de la computación, información y obras generales::006 - Métodos especiales de computación
Electroporación - Modelos matemáticos
Cáncer
Modelos matemáticos
Simulación biocomputacional
Concentración extra-intracelular
Electroporación
Electroquimioterapia
Cancer
Mathematical models
Biocomputational simulation
Extra-intracellular concentration
Electroporation
Electrochemotherapy
Electroporación
Electroquimioterapia
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openAccess
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Reconocimiento 4.0 Internacional
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network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Respuesta del cáncer al tratamiento mediante quimioterapia y terapia electroquímica utilizando modelado y simulación biocomputacional
dc.title.translated.eng.fl_str_mv Response of cancer to treatment by chemotherapy and electrochemical therapy using biocomputational modeling and simulation
title Respuesta del cáncer al tratamiento mediante quimioterapia y terapia electroquímica utilizando modelado y simulación biocomputacional
spellingShingle Respuesta del cáncer al tratamiento mediante quimioterapia y terapia electroquímica utilizando modelado y simulación biocomputacional
000 - Ciencias de la computación, información y obras generales::005 - Programación, programas, datos de computación
620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería
000 - Ciencias de la computación, información y obras generales::006 - Métodos especiales de computación
Electroporación - Modelos matemáticos
Cáncer
Modelos matemáticos
Simulación biocomputacional
Concentración extra-intracelular
Electroporación
Electroquimioterapia
Cancer
Mathematical models
Biocomputational simulation
Extra-intracellular concentration
Electroporation
Electrochemotherapy
Electroporación
Electroquimioterapia
title_short Respuesta del cáncer al tratamiento mediante quimioterapia y terapia electroquímica utilizando modelado y simulación biocomputacional
title_full Respuesta del cáncer al tratamiento mediante quimioterapia y terapia electroquímica utilizando modelado y simulación biocomputacional
title_fullStr Respuesta del cáncer al tratamiento mediante quimioterapia y terapia electroquímica utilizando modelado y simulación biocomputacional
title_full_unstemmed Respuesta del cáncer al tratamiento mediante quimioterapia y terapia electroquímica utilizando modelado y simulación biocomputacional
title_sort Respuesta del cáncer al tratamiento mediante quimioterapia y terapia electroquímica utilizando modelado y simulación biocomputacional
dc.creator.fl_str_mv Vélez Salazar, Fabián Mauricio
dc.contributor.advisor.none.fl_str_mv Ruíz Villa, Carlos Alberto
Patiño Arcila, Iván David
dc.contributor.author.none.fl_str_mv Vélez Salazar, Fabián Mauricio
dc.contributor.orcid.spa.fl_str_mv Vélez Salazar, Fabián Mauricio [0000-0002-7299-5970]
dc.contributor.cvlac.spa.fl_str_mv https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001521879
dc.contributor.researchgate.spa.fl_str_mv https://www.researchgate.net/profile/Fabian-Velez-Salazar
dc.contributor.googlescholar.spa.fl_str_mv https://scholar.google.com/citations?user=56Sj_tYAAAAJ&hl=es
dc.subject.ddc.spa.fl_str_mv 000 - Ciencias de la computación, información y obras generales::005 - Programación, programas, datos de computación
620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería
000 - Ciencias de la computación, información y obras generales::006 - Métodos especiales de computación
topic 000 - Ciencias de la computación, información y obras generales::005 - Programación, programas, datos de computación
620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería
000 - Ciencias de la computación, información y obras generales::006 - Métodos especiales de computación
Electroporación - Modelos matemáticos
Cáncer
Modelos matemáticos
Simulación biocomputacional
Concentración extra-intracelular
Electroporación
Electroquimioterapia
Cancer
Mathematical models
Biocomputational simulation
Extra-intracellular concentration
Electroporation
Electrochemotherapy
Electroporación
Electroquimioterapia
dc.subject.lemb.none.fl_str_mv Electroporación - Modelos matemáticos
dc.subject.proposal.spa.fl_str_mv Cáncer
Modelos matemáticos
Simulación biocomputacional
Concentración extra-intracelular
Electroporación
Electroquimioterapia
dc.subject.proposal.eng.fl_str_mv Cancer
Mathematical models
Biocomputational simulation
Extra-intracellular concentration
Electroporation
Electrochemotherapy
dc.subject.wikidata.none.fl_str_mv Electroporación
Electroquimioterapia
description ilustraciones,
publishDate 2022
dc.date.issued.none.fl_str_mv 2022-07
dc.date.accessioned.none.fl_str_mv 2023-05-29T19:47:45Z
dc.date.available.none.fl_str_mv 2023-05-29T19:47:45Z
dc.type.spa.fl_str_mv Trabajo de grado - Doctorado
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/doctoralThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_db06
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TD
format http://purl.org/coar/resource_type/c_db06
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/83900
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/83900
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.indexed.spa.fl_str_mv LaReferencia
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spelling Reconocimiento 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Ruíz Villa, Carlos Alberto19826264d7b95033280a44a5d10f6336Patiño Arcila, Iván Davidbb268ea0b50c78030285624ac021191aVélez Salazar, Fabián Mauricio90b06d48a0201ee4a4467083db44a81dVélez Salazar, Fabián Mauricio [0000-0002-7299-5970]https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001521879https://www.researchgate.net/profile/Fabian-Velez-Salazarhttps://scholar.google.com/citations?user=56Sj_tYAAAAJ&hl=es2023-05-29T19:47:45Z2023-05-29T19:47:45Z2022-07https://repositorio.unal.edu.co/handle/unal/83900Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones,Los modelos de electroporación y electroquimioterapia son esquemas teóricos que describen procesos electrofisiológicos basados en formulaciones matemáticas que ayudan a comprender y predecir el comportamiento de fenómenos de transporte y dosificación de medicamentos mediante modelado y simulación computacional. En este trabajo se simuló el transporte de masa en tejidos electroporados usando técnicas sin malla mediante un estudio paramétrico de la influencia del voltaje y el espaciamiento entre pulsos en la eficiencia, agresividad y uniformidad del proceso de electroporación analizando el cambio de concentración de medicamentos entre los espacios extracelular e intracelular. Se utilizó el método de Funciones de Base Radial (RBF) para resolver el sistema de ecuaciones diferenciales del fenómeno y se simuló el transporte de fármacos quimioterapéuticos clásicos en tejidos electroporados a través del Método Global MAPS, estudiando la influencia de las dos variables sobre la magnitud y distribución del campo eléctrico, las concentraciones extracelulares e intracelulares y la eficiencia y agresividad del protocolo de electroporación. Los análisis se centran en la comparación de la respuesta de dos medicamentos quimioterapéuticos al cambio de los parámetros de electroporación y la influencia de esta respuesta en la eficiencia y agresividad del tratamiento. Se obtuvo que para ambos medicamentos la agresividad es inversamente proporcional al espaciamiento entre pulsos y directamente proporcional al voltaje. Para el protocolo menos agresivo de ambos medicamentos la eficacia es adecuada para la doxorrubicina y muy baja para el cisplatino. Como conclusión, la agresividad de un protocolo no es necesariamente proporcional a su eficacia; esta relación es determinada por el tipo de medicamento (texto tomado de la fuente)Electroporation and electrochemotherapy models are theoretical schemes that describe electrophysiological processes based on mathematical formulations that help to understand and predict the behavior of drug transport and dosing phenomena through modeling and computational simulation. In this work, mass transport in electroporated tissues was simulated using mesh-free techniques through a parametric study of the influence of voltage and pulse spacing on the efficiency, aggressiveness and uniformity of the electroporation process by analyzing the change in drug concentration between the extracellular and intracellular spaces. The Radial Basis Functions (RBF) method was used to solve the system of differential equations of the phenomenon and the transport of classical chemotherapeutic drugs in electroporated tissues was simulated through the Global MAPS Method, studying the influence of the two variables on the magnitude and distribution of the electric field, the extracellular and intracellular concentrations and the efficiency and aggressiveness of the electroporation protocol. The analyses focus on the comparison of the response of two chemotherapeutic drugs to the change of the electroporation parameters and the influence of this response on the efficiency and aggressiveness of the treatment. It was obtained that for both drugs aggressiveness is inversely proportional to pulse spacing and directly proportional to voltage. For the less aggressive protocol of both drugs the efficacy is adequate for doxorubicin and very low for cisplatin. As a conclusion, the aggressiveness of a protocol is not necessarily proportional to its efficacy; this relationship is determined by the type of drugDoctoradoDoctor en IngenieríaOrganizaciones, Gestión Tecnológica y Tic’sÁrea Curricular de Ingeniería Administrativa e Ingeniería Industrial206 páginasapplication/pdfspaUniversidad Nacional de ColombiaMedellín - Minas - Doctorado en Ingeniería - Industria y OrganizacionesFacultad de MinasMedellín, ColombiaUniversidad Nacional de Colombia - Sede Medellín000 - Ciencias de la computación, información y obras generales::005 - Programación, programas, datos de computación620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería000 - Ciencias de la computación, información y obras generales::006 - Métodos especiales de computaciónElectroporación - Modelos matemáticosCáncerModelos matemáticosSimulación biocomputacionalConcentración extra-intracelularElectroporaciónElectroquimioterapiaCancerMathematical modelsBiocomputational simulationExtra-intracellular concentrationElectroporationElectrochemotherapyElectroporaciónElectroquimioterapiaRespuesta del cáncer al tratamiento mediante quimioterapia y terapia electroquímica utilizando modelado y simulación biocomputacionalResponse of cancer to treatment by chemotherapy and electrochemical therapy using biocomputational modeling and simulationTrabajo de grado - Doctoradoinfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_db06Texthttp://purl.org/redcol/resource_type/TDLaReferenciaKeng-Cheng Ang, “Analysis of a tumour growth model with MATLAB,” Electron. 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