Prevalence and factors affecting rem and slow wave sleep rebound on cpap titration study in patients with obstructive sleep apnea

Background. In patients with obstructive sleep apnea syndrome (OSAS) treatment with CPAP results in an increase of REM sleep and slow wave sleep, but there is limited information about the prevalence of REM rebound in patients with OSAS and possible factors related to the rebound. Objective. REM reb...

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Autores:
Osuna Suárez, Édgar
Siddiqui, Fouzia
Vanegas, Marco A.
Walters, Arthur S.
Chokroverty, Sudhansu
Tipo de recurso:
Article of journal
Fecha de publicación:
2008
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/29927
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/29927
http://bdigital.unal.edu.co/20001/
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openAccess
License
Atribución-NoComercial 4.0 Internacional
id UNACIONAL2_03f2fafa1b89c7d1e83227e0ab390b2d
oai_identifier_str oai:repositorio.unal.edu.co:unal/29927
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Prevalence and factors affecting rem and slow wave sleep rebound on cpap titration study in patients with obstructive sleep apnea
title Prevalence and factors affecting rem and slow wave sleep rebound on cpap titration study in patients with obstructive sleep apnea
spellingShingle Prevalence and factors affecting rem and slow wave sleep rebound on cpap titration study in patients with obstructive sleep apnea
title_short Prevalence and factors affecting rem and slow wave sleep rebound on cpap titration study in patients with obstructive sleep apnea
title_full Prevalence and factors affecting rem and slow wave sleep rebound on cpap titration study in patients with obstructive sleep apnea
title_fullStr Prevalence and factors affecting rem and slow wave sleep rebound on cpap titration study in patients with obstructive sleep apnea
title_full_unstemmed Prevalence and factors affecting rem and slow wave sleep rebound on cpap titration study in patients with obstructive sleep apnea
title_sort Prevalence and factors affecting rem and slow wave sleep rebound on cpap titration study in patients with obstructive sleep apnea
dc.creator.fl_str_mv Osuna Suárez, Édgar
Siddiqui, Fouzia
Vanegas, Marco A.
Walters, Arthur S.
Chokroverty, Sudhansu
dc.contributor.author.spa.fl_str_mv Osuna Suárez, Édgar
Siddiqui, Fouzia
Vanegas, Marco A.
Walters, Arthur S.
Chokroverty, Sudhansu
description Background. In patients with obstructive sleep apnea syndrome (OSAS) treatment with CPAP results in an increase of REM sleep and slow wave sleep, but there is limited information about the prevalence of REM rebound in patients with OSAS and possible factors related to the rebound. Objective. REM rebound (RR) and slow wave sleep rebound (SWSR) has been described as a frequent phenomenon that occurs during CPAP titration, but the quantity that qualify for RR has not been mentioned in literature. The objective of our study was to determine the prevalence of REM rebound and slow wave sleep rebound in our sleep disorders center, to attempt to define RR and look for factors that may affect RR and SWSR on the first night of CPAP titration. Materials and methods. We included patients who had both baseline polysomnogram (bPSG) and CPAP polysomnogram (cPSG) studies done in the same laboratory. We included 179 patients and gt;18 years with Apnea hypopnea index (AHI) and gt;10/hr on the baseline study, with an adequate CPAP titration study. We compared the percentages of REM sleep and slow wave sleep during bPSG and cPSG. We analyzed the frequency of presentation and looked for the factors affecting RR and SWSR. Results. 179 patients were enrolled (M/F:118/61), with a mean age of 48.6±4 for men, and 51.6±12.9 for women. The mean interval between the bPSG and cPSG was 45 days. The mean REM percentage during the bPSG was 15.55 percent and during cPSG study it was 21.57 percent. We took 6 percent as our differential point as the results became statistically significant at this point (p:0001). We therefore present our data by dividing our patients population with RR6%. The mean SWS percentage during the bPSG was 8.11±9.68 and during the cPSG was 13.17±10, with a p:0.35 which is not statistically significant. The multiple regression model showed that the variables that contribute more to the REM change are: REM sleep during bPSG (-0.56), bAHI (0.24) and the body mass index (0.081). Conclusions. We suggest that an increase greater than 6% in REM sleep should be considered REM rebound, since 6.15 percent was the statistically significant difference between bPSG REM sleep and cPSG. The prevalence of RR in our group was 46 percent and the variables that contribute more to RR are REM sleep during bPSG, AHI at baseline and body mass index.
publishDate 2008
dc.date.issued.spa.fl_str_mv 2008
dc.date.accessioned.spa.fl_str_mv 2019-06-26T14:02:30Z
dc.date.available.spa.fl_str_mv 2019-06-26T14:02:30Z
dc.type.spa.fl_str_mv Artículo de revista
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url https://repositorio.unal.edu.co/handle/unal/29927
http://bdigital.unal.edu.co/20001/
dc.language.iso.spa.fl_str_mv spa
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dc.relation.spa.fl_str_mv http://revistas.unal.edu.co/index.php/revfacmed/article/view/16043
dc.relation.ispartof.spa.fl_str_mv Universidad Nacional de Colombia Revistas electrónicas UN Revista de la Facultad de Medicina
Revista de la Facultad de Medicina
dc.relation.ispartofseries.none.fl_str_mv Revista de la Facultad de Medicina; Vol. 56, núm. 1 (2008) 2357-3848 0120-0011
dc.relation.references.spa.fl_str_mv Osuna Suárez, Édgar and Siddiqui, Fouzia and Vanegas, Marco A. and Walters, Arthur S. and Chokroverty, Sudhansu (2008) Prevalence and factors affecting rem and slow wave sleep rebound on cpap titration study in patients with obstructive sleep apnea. Revista de la Facultad de Medicina; Vol. 56, núm. 1 (2008) 2357-3848 0120-0011 .
dc.rights.spa.fl_str_mv Derechos reservados - Universidad Nacional de Colombia
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.license.spa.fl_str_mv Atribución-NoComercial 4.0 Internacional
dc.rights.uri.spa.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv Atribución-NoComercial 4.0 Internacional
Derechos reservados - Universidad Nacional de Colombia
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eu_rights_str_mv openAccess
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Facultad de Medicina. Universidad Nacional de Colombia. Sede Bogotá
institution Universidad Nacional de Colombia
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spelling Atribución-NoComercial 4.0 InternacionalDerechos reservados - Universidad Nacional de Colombiahttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Osuna Suárez, Édgar63649a31-91ed-4393-9566-4c65bdda1bee300Siddiqui, Fouzia807d1456-3b2e-4feb-ba1f-f890d55b00a3300Vanegas, Marco A.3bc6ebea-cdb5-4ff8-9308-2bf69a6c8aa6300Walters, Arthur S.7d702fbc-da16-499e-a9e2-30184ca70719300Chokroverty, Sudhansu47d09edf-c0b2-485b-8135-86c12a7b4a033002019-06-26T14:02:30Z2019-06-26T14:02:30Z2008https://repositorio.unal.edu.co/handle/unal/29927http://bdigital.unal.edu.co/20001/Background. In patients with obstructive sleep apnea syndrome (OSAS) treatment with CPAP results in an increase of REM sleep and slow wave sleep, but there is limited information about the prevalence of REM rebound in patients with OSAS and possible factors related to the rebound. Objective. REM rebound (RR) and slow wave sleep rebound (SWSR) has been described as a frequent phenomenon that occurs during CPAP titration, but the quantity that qualify for RR has not been mentioned in literature. The objective of our study was to determine the prevalence of REM rebound and slow wave sleep rebound in our sleep disorders center, to attempt to define RR and look for factors that may affect RR and SWSR on the first night of CPAP titration. Materials and methods. We included patients who had both baseline polysomnogram (bPSG) and CPAP polysomnogram (cPSG) studies done in the same laboratory. We included 179 patients and gt;18 years with Apnea hypopnea index (AHI) and gt;10/hr on the baseline study, with an adequate CPAP titration study. We compared the percentages of REM sleep and slow wave sleep during bPSG and cPSG. We analyzed the frequency of presentation and looked for the factors affecting RR and SWSR. Results. 179 patients were enrolled (M/F:118/61), with a mean age of 48.6±4 for men, and 51.6±12.9 for women. The mean interval between the bPSG and cPSG was 45 days. The mean REM percentage during the bPSG was 15.55 percent and during cPSG study it was 21.57 percent. We took 6 percent as our differential point as the results became statistically significant at this point (p:0001). We therefore present our data by dividing our patients population with RR6%. The mean SWS percentage during the bPSG was 8.11±9.68 and during the cPSG was 13.17±10, with a p:0.35 which is not statistically significant. The multiple regression model showed that the variables that contribute more to the REM change are: REM sleep during bPSG (-0.56), bAHI (0.24) and the body mass index (0.081). Conclusions. We suggest that an increase greater than 6% in REM sleep should be considered REM rebound, since 6.15 percent was the statistically significant difference between bPSG REM sleep and cPSG. The prevalence of RR in our group was 46 percent and the variables that contribute more to RR are REM sleep during bPSG, AHI at baseline and body mass index.application/pdfspaFacultad de Medicina. Universidad Nacional de Colombia. Sede Bogotáhttp://revistas.unal.edu.co/index.php/revfacmed/article/view/16043Universidad Nacional de Colombia Revistas electrónicas UN Revista de la Facultad de MedicinaRevista de la Facultad de MedicinaRevista de la Facultad de Medicina; Vol. 56, núm. 1 (2008) 2357-3848 0120-0011Osuna Suárez, Édgar and Siddiqui, Fouzia and Vanegas, Marco A. and Walters, Arthur S. and Chokroverty, Sudhansu (2008) Prevalence and factors affecting rem and slow wave sleep rebound on cpap titration study in patients with obstructive sleep apnea. Revista de la Facultad de Medicina; Vol. 56, núm. 1 (2008) 2357-3848 0120-0011 .Prevalence and factors affecting rem and slow wave sleep rebound on cpap titration study in patients with obstructive sleep apneaArtículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/ARTORIGINAL16043-49582-1-PB.pdfapplication/pdf3866015https://repositorio.unal.edu.co/bitstream/unal/29927/1/16043-49582-1-PB.pdf973f543889663a5a0a4c21f982e355eeMD51THUMBNAIL16043-49582-1-PB.pdf.jpg16043-49582-1-PB.pdf.jpgGenerated Thumbnailimage/jpeg8915https://repositorio.unal.edu.co/bitstream/unal/29927/2/16043-49582-1-PB.pdf.jpg63a3555c554ae700027a000dccb6c13fMD52unal/29927oai:repositorio.unal.edu.co:unal/299272022-11-23 23:05:27.728Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.co