Production of bioabsorbible nanoparticles of polycaprolactone by using a tubular recirculating system
Encapsulation and controlled release of substances using polymeric nanoparticles require that these have a high reproducibility, homogeneity, and control over their properties, especially when they are to be used in medical, pharmaceutical or nutritional applications among others. This work shows a...
- Autores:
-
Colmenares-Roldan, Gabriel Jaime
Agudelo-Gomez, Liliana Maria
Pinal, Rodolfo
Hoyos Palacio, Lina Marcela
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2018
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/68542
- Acceso en línea:
- https://repositorio.unal.edu.co/handle/unal/68542
http://bdigital.unal.edu.co/69575/
- Palabra clave:
- 62 Ingeniería y operaciones afines / Engineering
nanoparticles
polycaprolactone
nanoprecipitation
encapsulation
delivery
nanopartículas
policaprolactona
nanoprecipitación
encapsulación
liberación
- Rights
- openAccess
- License
- Atribución-NoComercial 4.0 Internacional
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Production of bioabsorbible nanoparticles of polycaprolactone by using a tubular recirculating system |
| title |
Production of bioabsorbible nanoparticles of polycaprolactone by using a tubular recirculating system |
| spellingShingle |
Production of bioabsorbible nanoparticles of polycaprolactone by using a tubular recirculating system 62 Ingeniería y operaciones afines / Engineering nanoparticles polycaprolactone nanoprecipitation encapsulation delivery nanopartículas policaprolactona nanoprecipitación encapsulación liberación |
| title_short |
Production of bioabsorbible nanoparticles of polycaprolactone by using a tubular recirculating system |
| title_full |
Production of bioabsorbible nanoparticles of polycaprolactone by using a tubular recirculating system |
| title_fullStr |
Production of bioabsorbible nanoparticles of polycaprolactone by using a tubular recirculating system |
| title_full_unstemmed |
Production of bioabsorbible nanoparticles of polycaprolactone by using a tubular recirculating system |
| title_sort |
Production of bioabsorbible nanoparticles of polycaprolactone by using a tubular recirculating system |
| dc.creator.fl_str_mv |
Colmenares-Roldan, Gabriel Jaime Agudelo-Gomez, Liliana Maria Pinal, Rodolfo Hoyos Palacio, Lina Marcela |
| dc.contributor.author.spa.fl_str_mv |
Colmenares-Roldan, Gabriel Jaime Agudelo-Gomez, Liliana Maria Pinal, Rodolfo Hoyos Palacio, Lina Marcela |
| dc.subject.ddc.spa.fl_str_mv |
62 Ingeniería y operaciones afines / Engineering |
| topic |
62 Ingeniería y operaciones afines / Engineering nanoparticles polycaprolactone nanoprecipitation encapsulation delivery nanopartículas policaprolactona nanoprecipitación encapsulación liberación |
| dc.subject.proposal.spa.fl_str_mv |
nanoparticles polycaprolactone nanoprecipitation encapsulation delivery nanopartículas policaprolactona nanoprecipitación encapsulación liberación |
| description |
Encapsulation and controlled release of substances using polymeric nanoparticles require that these have a high reproducibility, homogeneity, and control over their properties, especially when they are to be used in medical, pharmaceutical or nutritional applications among others. This work shows a high productivity system to synthesize nanoparticles in an easy, fast and controlled way. This study shows the effect of molecular weight of the polymer, the type of surfactant and the relationship between the volumes of the aqueous and the organic phases. It was found that the first two variables have a statistically significant effect on the diameter of the nanoparticles while the relationship between the volume of the aqueous phase and the organic phase does not significantly affect the diameter of the nanoparticles. Additionally, it was found that none of the three variables significantly affects the polydispersity index (PI) of the nanoparticles. |
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2018 |
| dc.date.issued.spa.fl_str_mv |
2018-01-01 |
| dc.date.accessioned.spa.fl_str_mv |
2019-07-03T07:04:45Z |
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2019-07-03T07:04:45Z |
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Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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info:eu-repo/semantics/article |
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http://purl.org/coar/resource_type/c_6501 |
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Text |
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http://purl.org/redcol/resource_type/ART |
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publishedVersion |
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ISSN: 2346-2183 |
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https://repositorio.unal.edu.co/handle/unal/68542 |
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http://bdigital.unal.edu.co/69575/ |
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ISSN: 2346-2183 |
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spa |
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spa |
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https://revistas.unal.edu.co/index.php/dyna/article/view/62292 |
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Universidad Nacional de Colombia Revistas electrónicas UN Dyna Dyna |
| dc.relation.references.spa.fl_str_mv |
Colmenares-Roldan, Gabriel Jaime and Agudelo-Gomez, Liliana Maria and Pinal, Rodolfo and Hoyos Palacio, Lina Marcela (2018) Production of bioabsorbible nanoparticles of polycaprolactone by using a tubular recirculating system. DYNA, 85 (204). pp. 277-282. ISSN 2346-2183 |
| dc.rights.spa.fl_str_mv |
Derechos reservados - Universidad Nacional de Colombia |
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http://purl.org/coar/access_right/c_abf2 |
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Atribución-NoComercial 4.0 Internacional |
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http://creativecommons.org/licenses/by-nc/4.0/ |
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info:eu-repo/semantics/openAccess |
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Atribución-NoComercial 4.0 Internacional Derechos reservados - Universidad Nacional de Colombia http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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Universidad Nacional de Colombia - Sede Medellín - Facultad de Minas |
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Atribución-NoComercial 4.0 InternacionalDerechos reservados - Universidad Nacional de Colombiahttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Colmenares-Roldan, Gabriel Jaime60cbf08e-b83f-4a49-99c8-9096d5495793300Agudelo-Gomez, Liliana Mariaf06a0cc2-b945-471e-8408-8021a9ac3ff8300Pinal, Rodolfo31264956-eead-4ae6-acce-b8533b4877ee300Hoyos Palacio, Lina Marcela17fbe07a-ce65-4931-85f1-974d6393cc263002019-07-03T07:04:45Z2019-07-03T07:04:45Z2018-01-01ISSN: 2346-2183https://repositorio.unal.edu.co/handle/unal/68542http://bdigital.unal.edu.co/69575/Encapsulation and controlled release of substances using polymeric nanoparticles require that these have a high reproducibility, homogeneity, and control over their properties, especially when they are to be used in medical, pharmaceutical or nutritional applications among others. This work shows a high productivity system to synthesize nanoparticles in an easy, fast and controlled way. This study shows the effect of molecular weight of the polymer, the type of surfactant and the relationship between the volumes of the aqueous and the organic phases. It was found that the first two variables have a statistically significant effect on the diameter of the nanoparticles while the relationship between the volume of the aqueous phase and the organic phase does not significantly affect the diameter of the nanoparticles. Additionally, it was found that none of the three variables significantly affects the polydispersity index (PI) of the nanoparticles.La encapsulación y la liberación controlada de sustancias que utilizan nanopartículas poliméricas requieren que estas tengan una alta reproducibilidad, homogeneidad y control sobre sus propiedades, especialmente cuando se van a utilizar en aplicaciones médicas, farmacéuticas o nutricionales entre otras. Este trabajo muestra un sistema de alta productividad para sintetizar nanopartículas poliméricas de una forma fácil, rápida y de manera controlada. Este estudio muestra el efecto del peso molecular del polímero, el tipo de tensioactivo y la relación entre los volúmenes de las fases acuosa y orgánica. Se encontró que las dos primeras variables tienen un efecto estadísticamente significativo sobre el diámetro de las nanopartículas, mientras que la relación entre el volumen de la fase acuosa y la fase orgánica no afecta significativamente el diámetro de las nanopartículas. Además, se encontró que ninguna de las tres variables afecta significativamente el índice de polidispersidad de las nanopartículas.application/pdfspaUniversidad Nacional de Colombia - Sede Medellín - Facultad de Minashttps://revistas.unal.edu.co/index.php/dyna/article/view/62292Universidad Nacional de Colombia Revistas electrónicas UN DynaDynaColmenares-Roldan, Gabriel Jaime and Agudelo-Gomez, Liliana Maria and Pinal, Rodolfo and Hoyos Palacio, Lina Marcela (2018) Production of bioabsorbible nanoparticles of polycaprolactone by using a tubular recirculating system. DYNA, 85 (204). pp. 277-282. ISSN 2346-218362 Ingeniería y operaciones afines / EngineeringnanoparticlespolycaprolactonenanoprecipitationencapsulationdeliverynanopartículaspolicaprolactonananoprecipitaciónencapsulaciónliberaciónProduction of bioabsorbible nanoparticles of polycaprolactone by using a tubular recirculating systemArtículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/ARTORIGINAL62292-376306-1-PB.pdfapplication/pdf635279https://repositorio.unal.edu.co/bitstream/unal/68542/1/62292-376306-1-PB.pdfc0fdf7e6be73d48dc176b016b241d0e9MD51THUMBNAIL62292-376306-1-PB.pdf.jpg62292-376306-1-PB.pdf.jpgGenerated Thumbnailimage/jpeg9778https://repositorio.unal.edu.co/bitstream/unal/68542/2/62292-376306-1-PB.pdf.jpg65b702c4c0654635920795f31a0fdb72MD52unal/68542oai:repositorio.unal.edu.co:unal/685422024-05-27 23:09:31.054Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.co |