Dosimetría en haces de radiación usados en la Radioterapia FLASH con haces de electrones de 7 MeV

ilustraciones, diagramas, fotografías, tablas

Autores:
Avilés León, Valentina
Tipo de recurso:
Fecha de publicación:
2024
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/86477
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/86477
https://repositorio.unal.edu.co/
Palabra clave:
530 - Física::539 - Física moderna
Radiometría
Radiometry
Radioterapia FLASH
radioterapia convencional
acelerador lineal de electrones
dosimetría
QA
PDD
PDD
output factors
FLASH Radiotherapy
conventional radiotherapy
electron linear accelerator
dosimetry
QA
output factors
Efectos de las radiaciones
Radiation effects
Rights
openAccess
License
Atribución-NoComercial 4.0 Internacional
id UNACIONAL2_0098909c784cb83f9874bdbd873c0cd7
oai_identifier_str oai:repositorio.unal.edu.co:unal/86477
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Dosimetría en haces de radiación usados en la Radioterapia FLASH con haces de electrones de 7 MeV
dc.title.translated.eng.fl_str_mv Dosimetry in Radiation Beams Used in FLASH Radiotherapy with 7 MeV Electron Beams
title Dosimetría en haces de radiación usados en la Radioterapia FLASH con haces de electrones de 7 MeV
spellingShingle Dosimetría en haces de radiación usados en la Radioterapia FLASH con haces de electrones de 7 MeV
530 - Física::539 - Física moderna
Radiometría
Radiometry
Radioterapia FLASH
radioterapia convencional
acelerador lineal de electrones
dosimetría
QA
PDD
PDD
output factors
FLASH Radiotherapy
conventional radiotherapy
electron linear accelerator
dosimetry
QA
output factors
Efectos de las radiaciones
Radiation effects
title_short Dosimetría en haces de radiación usados en la Radioterapia FLASH con haces de electrones de 7 MeV
title_full Dosimetría en haces de radiación usados en la Radioterapia FLASH con haces de electrones de 7 MeV
title_fullStr Dosimetría en haces de radiación usados en la Radioterapia FLASH con haces de electrones de 7 MeV
title_full_unstemmed Dosimetría en haces de radiación usados en la Radioterapia FLASH con haces de electrones de 7 MeV
title_sort Dosimetría en haces de radiación usados en la Radioterapia FLASH con haces de electrones de 7 MeV
dc.creator.fl_str_mv Avilés León, Valentina
dc.contributor.advisor.none.fl_str_mv Heinrich, Sophie
Plazas de Pinzón, María Cristina
dc.contributor.author.none.fl_str_mv Avilés León, Valentina
dc.contributor.researchgroup.spa.fl_str_mv Grupo Fisica Medica Unalb
dc.contributor.cvlac.spa.fl_str_mv Aviles, Valentina [https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000128868]
Aviles, Valentina [0000128868]
dc.subject.ddc.spa.fl_str_mv 530 - Física::539 - Física moderna
topic 530 - Física::539 - Física moderna
Radiometría
Radiometry
Radioterapia FLASH
radioterapia convencional
acelerador lineal de electrones
dosimetría
QA
PDD
PDD
output factors
FLASH Radiotherapy
conventional radiotherapy
electron linear accelerator
dosimetry
QA
output factors
Efectos de las radiaciones
Radiation effects
dc.subject.decs.spa.fl_str_mv Radiometría
dc.subject.decs.eng.fl_str_mv Radiometry
dc.subject.proposal.spa.fl_str_mv Radioterapia FLASH
radioterapia convencional
acelerador lineal de electrones
dosimetría
QA
PDD
PDD
output factors
dc.subject.proposal.eng.fl_str_mv FLASH Radiotherapy
conventional radiotherapy
electron linear accelerator
dosimetry
QA
output factors
dc.subject.unesco.spa.fl_str_mv Efectos de las radiaciones
dc.subject.unesco.eng.fl_str_mv Radiation effects
description ilustraciones, diagramas, fotografías, tablas
publishDate 2024
dc.date.accessioned.none.fl_str_mv 2024-07-16T19:51:58Z
dc.date.available.none.fl_str_mv 2024-07-16T19:51:58Z
dc.date.issued.none.fl_str_mv 2024-07-11
dc.type.spa.fl_str_mv Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/86477
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/86477
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
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Rossomme, S., Horn, J., Brons, S., Jäkel, O., Mairani, A., Ciocca, M., ... & Palmans, H. (2017). Ion recombination correction factor in scanned light-ion beams for absolute dose measurement using plane-parallel ionisation chambers. Physics in Medicine & Biology, 62(13), 5365.
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dc.publisher.spa.fl_str_mv Universidad Nacional de Colombia
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spelling Atribución-NoComercial 4.0 InternacionalDerechos reservados al autor, 2024http://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Heinrich, Sophie16a285428134284e03e12e83afdc5972Plazas de Pinzón, María Cristina2d91ad85f28aa72577a96576b0fa8084Avilés León, Valentina6b1b1d4dbcf3c65c601ae093487f716bGrupo Fisica Medica UnalbAviles, Valentina [https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000128868]Aviles, Valentina [0000128868]2024-07-16T19:51:58Z2024-07-16T19:51:58Z2024-07-11https://repositorio.unal.edu.co/handle/unal/86477Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramas, fotografías, tablasEl fenómeno radiobiológico conocido como efecto FLASH ha despertado considerable interés en la comunidad científica mundial. Estudios preclínicos han resaltado su notable capacidad para mitigar los efectos colaterales en tejidos sanos mientras mantiene la eficacia en tejidos tumorales. Este procedimiento juega un papel crucial en la expansión de las posibilidades terapéuticas y en mejorar la efectividad de la radioterapia al administrar dosis altas de radiación en intervalos de tiempo extremadamente corto, con tasas de dosis promedio excepcionalmente altas que superan los 40 Gy/s. Es importante destacar que la irradiación instantánea con dosis de energía ultra alta asociada con la Radioterapia FLASH presenta desafíos significativos en la medición y cuantificación de la dosis. La escasez de literatura, protocolos y orientación en este campo es uno de los desafíos que enfrenta esta área de investigación. A pesar de numerosos estudios sobre dosimetría en radioterapia FLASH, sigue existiendo una brecha considerable en el conocimiento de física médica. Además, considerar la relación entre parámetros temporales del haz de radiación, como la tasa de dosis, dosis por pulso y tasa de dosis promedio dentro del pulso, sigue siendo un desafío significativo. En este trabajo final de maestría, se llevarán a cabo mediciones dosimétricas de haces de electrones de 5 y 7 MeV, tanto en modalidades convencionales como FLASH. Este enfoque jugará un papel crucial en la comprensión de la dosimetría en la Radioterapia FLASH. Se anticipa que procedimientos como la determinación de curvas de PDD, controles de calidad diarios tanto para modalidades FLASH como convencionales, la evaluación de la dosis por pulso [Gy/pulso] en relación con la longitud real del pulso [µs], y la determinación de los output factors, entre otras medidas dosimétricos incorporados en este estudio, contribuirán significativamente a la caracterización precisa del haz de electrones para ambas energías. Este enriquecimiento se traducirá en una comprensión más profunda de la dosimetría para haces de electrones de ultra alta energía, fortaleciendo la base de conocimientos esencial para su aplicación en protocolos de aseguramiento de calidad de haces de radiación. (Texto tomado de la fuente)The radiobiological phenomenon known as the FLASH effect has sparked considerable interest in the global scientific community. Preclinical studies have highlighted its remarkable ability to mitigate adverse effects on healthy tissues while maintaining efficacy in tumor tissues. This procedure plays a crucial role in expanding therapeutic possibilities and improving the effectiveness of radiotherapy by delivering high-energy doses in brief time intervals, with exceptionally high average dose rates exceeding 40 Gy/s. It is noteworthy that instantaneous irradiation with ultra-high energy doses associated with FLASH Radiotherapy poses significant challenges in measuring and quantifying the dose. The scarcity of literature, protocols, and guidance in this field is one of the challenges facing this research area. Despite numerous studies on dosimetry in FLASH radiotherapy, there remains a considerable gap in medical physics knowledge. Additionally, considering the relationship betweentemporal parameters of the radiation beam, such as dose rate, dose per pulse, and average dose rate within the pulse, remains a significant challenge. In this final master’s thesis proposal, dosimetric measurements of 5 and 7 MeV electron beams will be conducted, both in conventional and FLASH modes. This approach will play a crucial role in understanding dosimetry in FLASH Radiotherapy. It is anticipated that procedures such as determining PDD curves, daily quality controls for both FLASH and conventional modalities, evaluating the dose per pulse [Gy/pulse] in relation to the actual pulse length [µs], and determining output factors, among other dosimetric tests incorporated in this study, will significantly contribute to the precise characterization of the electron beam for both energies. This enrichment will translate into a deeper understanding of dosimetry for ultra-high-energy electron beams, strengthening the essential knowledge base for their application in radiation beam quality assurance protocols.MaestríaMagíster en Física MédicaRadioterapia FLASHxv, 79 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ciencias - Maestría en Física MédicaFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá530 - Física::539 - Física modernaRadiometríaRadiometryRadioterapia FLASHradioterapia convencionalacelerador lineal de electronesdosimetríaQAPDDPDDoutput factorsFLASH Radiotherapyconventional radiotherapyelectron linear acceleratordosimetryQAoutput factorsEfectos de las radiacionesRadiation effectsDosimetría en haces de radiación usados en la Radioterapia FLASH con haces de electrones de 7 MeVDosimetry in Radiation Beams Used in FLASH Radiotherapy with 7 MeV Electron BeamsTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMBerry, R. 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Medical Physics, 49(3), 1902- 1910.EstudiantesInvestigadoresPadres y familiasPúblico generalLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/86477/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1075544942.2024.pdf1075544942.2024.pdfTesis de Maestría en Física Médicaapplication/pdf11296967https://repositorio.unal.edu.co/bitstream/unal/86477/2/1075544942.2024.pdf7373ab4ab6429e10c7013b31d23a3725MD52THUMBNAIL1075544942.2024.pdf.jpg1075544942.2024.pdf.jpgGenerated Thumbnailimage/jpeg5102https://repositorio.unal.edu.co/bitstream/unal/86477/3/1075544942.2024.pdf.jpgb246021c9313cb6d8c6ea5dc1b615a7fMD53unal/86477oai:repositorio.unal.edu.co:unal/864772024-08-26 23:10:55.963Repositorio Institucional Universidad Nacional de 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