Acciones de la terapia de reemplazo hormonal a través de la vía L-Arginina óxido nítirico en el sistema cardiovascular y nervioso de mujeres menopáusicas

La administración de estrógenos como terapia hormonal sustitutiva (THS) en mujeres menopáusicas mejora la función mental y el estado emocional, efectos que pueden ser dados por el acción favorable en la función endotelial que se manifiesta por aumento del flujo sanguíneo cerebral mediado por óxido n...

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Autores:
Pardo Palencia, Alberto
Díaz Martínez, Luis Alfonso
Casas Romero, Juan Pablo
García Rey, Rafael Eduardo
Cortés Yepes, Julián
Guillermo Barrera, Juan
Parra Zuluaga, Gustavo Adolfo
Jaimes Carvajal, Kermes
García Martínez, Rose Mary
Chaudhuri, Gautham
López Jaramillo, Patricio
Tipo de recurso:
Fecha de publicación:
2002
Institución:
Universidad Autónoma de Bucaramanga - UNAB
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Repositorio UNAB
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spa
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oai:repository.unab.edu.co:20.500.12749/18051
Acceso en línea:
http://hdl.handle.net/20.500.12749/18051
Palabra clave:
Medical sciences
Health sciences
Radiology
Diagnostic imaging
Menopause
Women
Hormone therapy
Nitrogen compounds
Estrogens (Therapeutic use)
Hormone therapy
Cardiovascular system
Ciencias médicas
Radiología
Diagnóstico para imágenes
Compuestos de nitrógeno
Estrogenos (Uso terapeútico)
Terapia hormonal
Sistema cardiovascular
Ciencias de la salud
Terapia hormonal
Menopausia
Mujeres
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id UNAB2_b9f1271b8282de07ca1ea1176c049677
oai_identifier_str oai:repository.unab.edu.co:20.500.12749/18051
network_acronym_str UNAB2
network_name_str Repositorio UNAB
repository_id_str
dc.title.spa.fl_str_mv Acciones de la terapia de reemplazo hormonal a través de la vía L-Arginina óxido nítirico en el sistema cardiovascular y nervioso de mujeres menopáusicas
dc.title.translated.spa.fl_str_mv Actions of hormone replacement therapy through the L-arginine nitiric oxide pathway on the cardiovascular and nervous systems of menopausal women
title Acciones de la terapia de reemplazo hormonal a través de la vía L-Arginina óxido nítirico en el sistema cardiovascular y nervioso de mujeres menopáusicas
spellingShingle Acciones de la terapia de reemplazo hormonal a través de la vía L-Arginina óxido nítirico en el sistema cardiovascular y nervioso de mujeres menopáusicas
Medical sciences
Health sciences
Radiology
Diagnostic imaging
Menopause
Women
Hormone therapy
Nitrogen compounds
Estrogens (Therapeutic use)
Hormone therapy
Cardiovascular system
Ciencias médicas
Radiología
Diagnóstico para imágenes
Compuestos de nitrógeno
Estrogenos (Uso terapeútico)
Terapia hormonal
Sistema cardiovascular
Ciencias de la salud
Terapia hormonal
Menopausia
Mujeres
title_short Acciones de la terapia de reemplazo hormonal a través de la vía L-Arginina óxido nítirico en el sistema cardiovascular y nervioso de mujeres menopáusicas
title_full Acciones de la terapia de reemplazo hormonal a través de la vía L-Arginina óxido nítirico en el sistema cardiovascular y nervioso de mujeres menopáusicas
title_fullStr Acciones de la terapia de reemplazo hormonal a través de la vía L-Arginina óxido nítirico en el sistema cardiovascular y nervioso de mujeres menopáusicas
title_full_unstemmed Acciones de la terapia de reemplazo hormonal a través de la vía L-Arginina óxido nítirico en el sistema cardiovascular y nervioso de mujeres menopáusicas
title_sort Acciones de la terapia de reemplazo hormonal a través de la vía L-Arginina óxido nítirico en el sistema cardiovascular y nervioso de mujeres menopáusicas
dc.creator.fl_str_mv Pardo Palencia, Alberto
Díaz Martínez, Luis Alfonso
Casas Romero, Juan Pablo
García Rey, Rafael Eduardo
Cortés Yepes, Julián
Guillermo Barrera, Juan
Parra Zuluaga, Gustavo Adolfo
Jaimes Carvajal, Kermes
García Martínez, Rose Mary
Chaudhuri, Gautham
López Jaramillo, Patricio
dc.contributor.author.none.fl_str_mv Pardo Palencia, Alberto
Díaz Martínez, Luis Alfonso
Casas Romero, Juan Pablo
García Rey, Rafael Eduardo
Cortés Yepes, Julián
Guillermo Barrera, Juan
Parra Zuluaga, Gustavo Adolfo
Jaimes Carvajal, Kermes
García Martínez, Rose Mary
Chaudhuri, Gautham
López Jaramillo, Patricio
dc.contributor.cvlac.spa.fl_str_mv Pardo Palencia, Alberto [0001338711]
Díaz Martínez, Luis Alfonso [0000066621]
Casas Romero, Juan Pablo [0000018562]
García Rey, Rafael Eduardo [0001337277]
Parra Zuluaga, Gustavo Adolfo [0000291064]
López Jaramillo, Patricio [0000043290]
dc.contributor.googlescholar.none.fl_str_mv Díaz Martínez, Luis Alfonso [es&oi=ao]
dc.contributor.googlescholar.spa.fl_str_mv López Jaramillo, Patricio [s&oi=ao]
dc.contributor.orcid.spa.fl_str_mv Pardo Palencia, Alberto [0000-0003-4011-4232]
Díaz Martínez, Luis Alfonso [0000-0002-4498-6639]
Parra Zuluaga, Gustavo Adolfo [0000-0003-1296-0853]
López Jaramillo, Patricio [0000-0002-9122-8742]
dc.subject.keywords.spa.fl_str_mv Medical sciences
Health sciences
Radiology
Diagnostic imaging
Menopause
Women
Hormone therapy
Nitrogen compounds
Estrogens (Therapeutic use)
Hormone therapy
Cardiovascular system
topic Medical sciences
Health sciences
Radiology
Diagnostic imaging
Menopause
Women
Hormone therapy
Nitrogen compounds
Estrogens (Therapeutic use)
Hormone therapy
Cardiovascular system
Ciencias médicas
Radiología
Diagnóstico para imágenes
Compuestos de nitrógeno
Estrogenos (Uso terapeútico)
Terapia hormonal
Sistema cardiovascular
Ciencias de la salud
Terapia hormonal
Menopausia
Mujeres
dc.subject.lemb.spa.fl_str_mv Ciencias médicas
Radiología
Diagnóstico para imágenes
Compuestos de nitrógeno
Estrogenos (Uso terapeútico)
Terapia hormonal
Sistema cardiovascular
dc.subject.proposal.spa.fl_str_mv Ciencias de la salud
Terapia hormonal
Menopausia
Mujeres
description La administración de estrógenos como terapia hormonal sustitutiva (THS) en mujeres menopáusicas mejora la función mental y el estado emocional, efectos que pueden ser dados por el acción favorable en la función endotelial que se manifiesta por aumento del flujo sanguíneo cerebral mediado por óxido nítrico (NO). Sin embargo, la inducción de la síntesis no se limita a las células endoteliales ya que otros tejidos también son estimulados, como el cerebro, así que la mejora observada con suplencia estrogénica de las funciones encefálicas superiores de la mujer menopáusica puede deberse a un doble efecto de la THS, uno por aumento del flujo sanguíneo y otro por incremento de No en el propio sistema nervioso central (SNC). La THS induce la síntesis de No en mujeres menopáusicas, lo que se refleja a nivel sistémico en aumento de los niveles plasmáticos de nitritos y nitratos. El incremento de los metabolitos estables probablemente refleja una mejor producción de No en endotelio vascular, que representa mejoría de la VMF. A nivel del SNC el efecto es selectivo y asimétrico.
publishDate 2002
dc.date.issued.none.fl_str_mv 2002
dc.date.accessioned.none.fl_str_mv 2022-10-12T14:12:27Z
dc.date.available.none.fl_str_mv 2022-10-12T14:12:27Z
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.local.spa.fl_str_mv Tesis
dc.type.hasversion.none.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.redcol.none.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12749/18051
dc.identifier.instname.spa.fl_str_mv instname:Universidad Autónoma de Bucaramanga - UNAB
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional UNAB
dc.identifier.repourl.spa.fl_str_mv repourl:https://repository.unab.edu.co
url http://hdl.handle.net/20.500.12749/18051
identifier_str_mv instname:Universidad Autónoma de Bucaramanga - UNAB
reponame:Repositorio Institucional UNAB
repourl:https://repository.unab.edu.co
dc.language.iso.spa.fl_str_mv spa
language spa
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spelling Pardo Palencia, Alberto2393ca5e-aa1a-4859-80b2-f3450064622bDíaz Martínez, Luis Alfonso482c441a-6518-41cb-a0fe-d7b4342ca0fbCasas Romero, Juan Pabloaf55f6fc-e060-47ec-9862-837a091bdb7aGarcía Rey, Rafael Eduardo1e013735-a318-4897-86b1-06bca394ec2bCortés Yepes, Juliána1cae5ae-94d9-45cc-bbd5-009a125801f7Guillermo Barrera, Juan9584b1c8-c3e9-4baf-97ce-eb0d86ac1441Parra Zuluaga, Gustavo Adolfo15a354f0-b168-4098-a991-687f85ec714aJaimes Carvajal, Kermes7b2b3fd6-18e7-4d9e-bab0-b1192f9b3f84García Martínez, Rose Maryf8278f03-4073-43c5-850d-f49a9d6f7a03Chaudhuri, Gautham5bf1b4b2-843f-47b4-a21f-5e504fd16658López Jaramillo, Patricioa2ae5539-6045-4a15-9c83-95cf618eb98ePardo Palencia, Alberto [0001338711]Díaz Martínez, Luis Alfonso [0000066621]Casas Romero, Juan Pablo [0000018562]García Rey, Rafael Eduardo [0001337277]Parra Zuluaga, Gustavo Adolfo [0000291064]López Jaramillo, Patricio [0000043290]Díaz Martínez, Luis Alfonso [es&oi=ao]López Jaramillo, Patricio [s&oi=ao]Pardo Palencia, Alberto [0000-0003-4011-4232]Díaz Martínez, Luis Alfonso [0000-0002-4498-6639]Parra Zuluaga, Gustavo Adolfo [0000-0003-1296-0853]López Jaramillo, Patricio [0000-0002-9122-8742]Bucaramanga (Santander, Colombia)20022022-10-12T14:12:27Z2022-10-12T14:12:27Z2002http://hdl.handle.net/20.500.12749/18051instname:Universidad Autónoma de Bucaramanga - UNABreponame:Repositorio Institucional UNABrepourl:https://repository.unab.edu.coLa administración de estrógenos como terapia hormonal sustitutiva (THS) en mujeres menopáusicas mejora la función mental y el estado emocional, efectos que pueden ser dados por el acción favorable en la función endotelial que se manifiesta por aumento del flujo sanguíneo cerebral mediado por óxido nítrico (NO). Sin embargo, la inducción de la síntesis no se limita a las células endoteliales ya que otros tejidos también son estimulados, como el cerebro, así que la mejora observada con suplencia estrogénica de las funciones encefálicas superiores de la mujer menopáusica puede deberse a un doble efecto de la THS, uno por aumento del flujo sanguíneo y otro por incremento de No en el propio sistema nervioso central (SNC). La THS induce la síntesis de No en mujeres menopáusicas, lo que se refleja a nivel sistémico en aumento de los niveles plasmáticos de nitritos y nitratos. El incremento de los metabolitos estables probablemente refleja una mejor producción de No en endotelio vascular, que representa mejoría de la VMF. A nivel del SNC el efecto es selectivo y asimétrico.1. OBJETIVO GENERAL 1 1.1 OBJETIVOS ESPECÍFICOS 1 2. PLANTEAMIENTO DEL PROBLEMA Y JUSTIFICACIÓN 3 3. IMPACTO 1 4. MARCO TEÓRICO 13 4.1 DEFINICIÓN DE TÉRMINOS 13 4.2 MENOPAUSIA Y SISTEMA CARDIOVASCULAR 14 4.3 ACCIONES DE LOS ESTRÓGENOS SOBRE EL SISTEMA CARDIOVASCULAR. 17 4.4 METODOLOGÍA DE LA VASOD1LATAC1ÓN MEDIADA POR FLUJO 20 4.4.1 Prueba 22 4.4.2 Factores de Control en el Momento de Selección de Pacientes 24 4.5 MENOPAUSIA Y SISTEMA NERVIOSO 25 4.5.1 Menopausia y Alteraciones del Estado de Ánimo 25 4.5.2 Menopausia y Alteraciones en la Memoria 26 4.5.3 Terapia Estrogénica, Producción de ON y Sistema Nervioso 27 4.5.4 Inventario de Depresión de Beck (IDB) 28 4.6 TOMOGRAFÍA CON EMISIÓN DE FOTÓN ÚNICO (SPECT) 29 4.6.1 Estudio de Perfusión Normal 29 4.6.2 SPECT con Neuroactivación 30 5. METODOLOGÍA 32 5.1 CARACTERÍSTICAS DEL ENSAYO CLÍNICO 32 5.2 PRUEBAS REALIZADAS 34 6. ANÁLISIS ESTADÍSTICO 37 7. RESULTADOS 39 7.2 SELECCIÓN DE PACIENTES 39 7.2 CARACTERÍSTICAS DE LAS PACIENTES INCLUIDAS 40 7.3 METABOLITOS DEL ÓXIDO NÍTRICO 44 7.4 PRUEBAS DE FLUJO VASCULAR 45 7.4.1 Vasodilatación Mediada por Flujo 45 7.4.2 Variadón de la Velocidad Pico 50 7.5 PRUEBAS DE NEUROPSICOLOGÍA 52 7.5.1 Inventario de Depresión de Beck 52 7.5.2 Prueba de Memoria Reciente 53 7.6 PRUEBAS DE ACTIVIDAD CEREBRAL POR SPECT 55 8. DISCUSIÓN 60EspecializaciónThe administration of estrogens as hormone replacement therapy (HRT) in menopausal women improves mental function and emotional state, effects that may be due to the favorable action on endothelial function that is manifested by an increase in cerebral blood flow mediated by nitric oxide ( NO). However, the induction of synthesis is not limited to endothelial cells as other tissues are also stimulated, such as the brain, so the improvement seen with estrogen supplementation in higher brain functions in menopausal women may be due to a dual effect. of HRT, one due to increased blood flow and the other due to an increase in No in the central nervous system (CNS) itself. HRT induces the synthesis of No in menopausal women, which is reflected at the systemic level in increased plasma levels of nitrites and nitrates. The increase in stable metabolites probably reflects a better production of No in the vascular endothelium, which represents an improvement in VMF. At the CNS level, the effect is selective and asymmetric.application/pdfspahttp://creativecommons.org/licenses/by-nc-nd/2.5/co/Abierto (Texto Completo)Atribución-NoComercial-SinDerivadas 2.5 Colombiahttp://purl.org/coar/access_right/c_abf2Acciones de la terapia de reemplazo hormonal a través de la vía L-Arginina óxido nítirico en el sistema cardiovascular y nervioso de mujeres menopáusicasActions of hormone replacement therapy through the L-arginine nitiric oxide pathway on the cardiovascular and nervous systems of menopausal womenEspecialistas en Radiología e Imágenes DiagnósticasUniversidad Autónoma de Bucaramanga UNABFacultad Ciencias de la SaludEspecialización en Radiología e Imágenes Diagnósticasinfo:eu-repo/semantics/masterThesisTesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/redcol/resource_type/TMMedical sciencesHealth sciencesRadiologyDiagnostic imagingMenopauseWomenHormone therapyNitrogen compoundsEstrogens (Therapeutic use)Hormone therapyCardiovascular systemCiencias médicasRadiologíaDiagnóstico para imágenesCompuestos de nitrógenoEstrogenos (Uso terapeútico)Terapia hormonalSistema cardiovascularCiencias de la saludTerapia hormonalMenopausiaMujeresStampfer Mj, Colditz GA, Willett WC, etal. 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JAMA 2002; 288:321-33.ORIGINAL2002_Tesis_Pardo_Palencia_Alberto.pdf2002_Tesis_Pardo_Palencia_Alberto.pdfTesisapplication/pdf21274494https://repository.unab.edu.co/bitstream/20.500.12749/18051/1/2002_Tesis_Pardo_Palencia_Alberto.pdf7c958f63b67d24607272dd6e323bb4e3MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-8829https://repository.unab.edu.co/bitstream/20.500.12749/18051/2/license.txt3755c0cfdb77e29f2b9125d7a45dd316MD52open accessTHUMBNAIL2002_Tesis_Pardo_Palencia_Alberto.pdf.jpg2002_Tesis_Pardo_Palencia_Alberto.pdf.jpgIM Thumbnailimage/jpeg5872https://repository.unab.edu.co/bitstream/20.500.12749/18051/3/2002_Tesis_Pardo_Palencia_Alberto.pdf.jpgc46415d685bb7d3b2362b9a90a501ae4MD53open access20.500.12749/18051oai:repository.unab.edu.co:20.500.12749/180512022-10-12 22:01:01.055open accessRepositorio Institucional | Universidad Autónoma de Bucaramanga - UNABrepositorio@unab.edu.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