Terapia transfusional y técnicas de ahorro sanguíneo intraoperatorio en pacientes sometidos a cirugía no cardiaca. Recomendaciones basadas en síntesis de la evidencia

A nivel mundial, muchas cirugías mayores requieren transfusiones, lo que conlleva riesgos de reacciones adversas e infecciones. A pesar de las técnicas disponibles para reducir la necesidad de transfusiones, muchas guías clínicas están desactualizadas y no cubren todas las poblaciones de pacientes n...

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Autores:
Serrano Vásquez, Rafael Enrique
Tipo de recurso:
Fecha de publicación:
2024
Institución:
Universidad Autónoma de Bucaramanga - UNAB
Repositorio:
Repositorio UNAB
Idioma:
spa
OAI Identifier:
oai:repository.unab.edu.co:20.500.12749/24651
Acceso en línea:
http://hdl.handle.net/20.500.12749/24651
Palabra clave:
Medical sciences
Health sciences
Non-cardiac surgery
Blood-saving techniques
Plasma exchange
Blood (Transfusion)
Blood cells
Literature review
Information storage and retrieval systems
Ciencias médicas
Intercambio plasmático
Transfusión de sangre
Células sanguíneas
Revisión de literatura
Sistemas de almacenamiento y recuperación de información
Ciencias de la salud
Transfusión
Cirugía no cardiaca
Técnicas de ahorro sanguíneo
GRADE
Rights
License
http://creativecommons.org/licenses/by-nc-nd/2.5/co/
id UNAB2_8c494a351f37a6376a33e7be1c772957
oai_identifier_str oai:repository.unab.edu.co:20.500.12749/24651
network_acronym_str UNAB2
network_name_str Repositorio UNAB
repository_id_str
dc.title.spa.fl_str_mv Terapia transfusional y técnicas de ahorro sanguíneo intraoperatorio en pacientes sometidos a cirugía no cardiaca. Recomendaciones basadas en síntesis de la evidencia
dc.title.translated.spa.fl_str_mv Transfusion Therapy and Intraoperative Blood Conservation Techniques in Patients Undergoing Non-Cardiac Surgery. Evidence-Based Recommendations
title Terapia transfusional y técnicas de ahorro sanguíneo intraoperatorio en pacientes sometidos a cirugía no cardiaca. Recomendaciones basadas en síntesis de la evidencia
spellingShingle Terapia transfusional y técnicas de ahorro sanguíneo intraoperatorio en pacientes sometidos a cirugía no cardiaca. Recomendaciones basadas en síntesis de la evidencia
Medical sciences
Health sciences
Non-cardiac surgery
Blood-saving techniques
Plasma exchange
Blood (Transfusion)
Blood cells
Literature review
Information storage and retrieval systems
Ciencias médicas
Intercambio plasmático
Transfusión de sangre
Células sanguíneas
Revisión de literatura
Sistemas de almacenamiento y recuperación de información
Ciencias de la salud
Transfusión
Cirugía no cardiaca
Técnicas de ahorro sanguíneo
GRADE
title_short Terapia transfusional y técnicas de ahorro sanguíneo intraoperatorio en pacientes sometidos a cirugía no cardiaca. Recomendaciones basadas en síntesis de la evidencia
title_full Terapia transfusional y técnicas de ahorro sanguíneo intraoperatorio en pacientes sometidos a cirugía no cardiaca. Recomendaciones basadas en síntesis de la evidencia
title_fullStr Terapia transfusional y técnicas de ahorro sanguíneo intraoperatorio en pacientes sometidos a cirugía no cardiaca. Recomendaciones basadas en síntesis de la evidencia
title_full_unstemmed Terapia transfusional y técnicas de ahorro sanguíneo intraoperatorio en pacientes sometidos a cirugía no cardiaca. Recomendaciones basadas en síntesis de la evidencia
title_sort Terapia transfusional y técnicas de ahorro sanguíneo intraoperatorio en pacientes sometidos a cirugía no cardiaca. Recomendaciones basadas en síntesis de la evidencia
dc.creator.fl_str_mv Serrano Vásquez, Rafael Enrique
dc.contributor.advisor.none.fl_str_mv Vásquez Hernández, Skarlet Marcell
Álvarez Robles, Saul
dc.contributor.author.none.fl_str_mv Serrano Vásquez, Rafael Enrique
dc.contributor.cvlac.spa.fl_str_mv Vásquez Hernández, Skarlet Marcell [0001349039]
Álvarez Robles, Saul [0000833797]
dc.contributor.orcid.spa.fl_str_mv Vásquez Hernández, Skarlet Marcell [0000-0003-2552-9819]
Álvarez Robles, Saul [0000-0002-3676-0058]
dc.contributor.apolounab.spa.fl_str_mv Vásquez Hernández, Skarlet Marcell [skarlet-m-vásquez]
dc.subject.keywords.spa.fl_str_mv Medical sciences
Health sciences
Non-cardiac surgery
Blood-saving techniques
Plasma exchange
Blood (Transfusion)
Blood cells
Literature review
Information storage and retrieval systems
topic Medical sciences
Health sciences
Non-cardiac surgery
Blood-saving techniques
Plasma exchange
Blood (Transfusion)
Blood cells
Literature review
Information storage and retrieval systems
Ciencias médicas
Intercambio plasmático
Transfusión de sangre
Células sanguíneas
Revisión de literatura
Sistemas de almacenamiento y recuperación de información
Ciencias de la salud
Transfusión
Cirugía no cardiaca
Técnicas de ahorro sanguíneo
GRADE
dc.subject.lemb.spa.fl_str_mv Ciencias médicas
Intercambio plasmático
Transfusión de sangre
Células sanguíneas
Revisión de literatura
Sistemas de almacenamiento y recuperación de información
dc.subject.proposal.spa.fl_str_mv Ciencias de la salud
Transfusión
Cirugía no cardiaca
Técnicas de ahorro sanguíneo
GRADE
description A nivel mundial, muchas cirugías mayores requieren transfusiones, lo que conlleva riesgos de reacciones adversas e infecciones. A pesar de las técnicas disponibles para reducir la necesidad de transfusiones, muchas guías clínicas están desactualizadas y no cubren todas las poblaciones de pacientes no cardíacos. Este estudio tiene como objetivo desarrollar recomendaciones para la terapia transfusional y las técnicas de ahorro sanguíneo en cirugías no cardíacas, utilizando la metodología GRADE. Se formularon cinco preguntas PICO tras una búsqueda sistemática y revisión de la literatura, priorizando revisiones sistemáticas y ensayos clínicos aleatorizados. Se evaluó el riesgo de sesgo y la certeza de la evidencia con herramientas AMSTAR II y Rob-2. Las recomendaciones finales se basan en seis estudios clave y un marco EtD, destacando la necesidad de ensayos clínicos más robustos y mejor diseñados.
publishDate 2024
dc.date.accessioned.none.fl_str_mv 2024-05-20T16:44:38Z
dc.date.available.none.fl_str_mv 2024-05-20T16:44:38Z
dc.date.issued.none.fl_str_mv 2024-04-22
dc.type.eng.fl_str_mv Thesis
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.local.spa.fl_str_mv Tesis
dc.type.hasversion.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12749/24651
dc.identifier.instname.spa.fl_str_mv instname:Universidad Autónoma de Bucaramanga - UNAB
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional UNAB
dc.identifier.repourl.spa.fl_str_mv repourl:https://repository.unab.edu.co
url http://hdl.handle.net/20.500.12749/24651
identifier_str_mv instname:Universidad Autónoma de Bucaramanga - UNAB
reponame:Repositorio Institucional UNAB
repourl:https://repository.unab.edu.co
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.references.spa.fl_str_mv 1. Mannucci PM, Levi M. Prevention and treatment of major blood loss. N Engl J Med. 2007 May 31;356(22):2301-11. doi: 10.1056/NEJMra067742. PMID: 17538089.
2. Instituto Nacional de Salud. Informe de la red nacional bancos de sangre de Colombia, 2021. 2022; 1-82. Disponible en: http://www.ins.gov.co/bibliotecadigital/informe-anualbancos-de-sangre-2021.pdf
3. Kleinman S, Kor DJ. Transfusion-related acute lung injury (TRALI). UpToDate. https://www.uptodate.com/contents/transfusion-related-acute-lung-injurytrali?csi=52bef3c4-1896-48cc-b746-6c70fb82e465&source=contentShare
4. FDA. Fatalities reported to FDA following blood collection and transfusion. Annual Summary for Fiscal Year. 2015. 2017; Silver Spring: 3-11.
5. Liu JV. Medicina Transfusional Perioperatoria. Segunda edición. España. Editorial ELSEVIER. 2019
6. Yepes AM. Auditoría y Evaluación del Proceso de Transfusión Sanguínea. 2013. Medellín. Disponible en: https://repository.ces.edu.co/bitstream/handle/10946/1223/Auditoria_transfusion_san guinea.pdf?sequence=2
7. Informe de reacciones adversas a la transfusión 2019. Instituto Nacional de Salud. https://www.ins.gov.co/BibliotecaDigital/informe-rat-2019.pdf
7. Informe de reacciones adversas a la transfusión 2019. Instituto Nacional de Salud. https://www.ins.gov.co/BibliotecaDigital/informe-rat-2019.pdf
8. Carson JL, Duff A, Poses RM, et al. Effect of anaemia and cardiovascular disease on surgical mortality and morbidity. Lancet. 1996;348(9034):1055-1060. doi:10.1016/S01406736(96)04330-9
9. Oliveros-Rodríguez HO, Beltrán Linares Édgar. Preoperative Hemoglobin Levels and Outcomes in Cardiovascular Surgical Patients; systematic review and meta-analysis. Colomb. J. Anesthesiol. [Internet]. 2012 Jan. 1 [cited 2024 Apr. 12];40(1):27-33. Available from: https://www.revcolanest.com.co/index.php/rca/article/view/861.
10. McFarland JG. Perioperative blood transfusions: indications and options. Chest. 1999 May;115(5 Suppl):113S-121S. doi: 10.1378/chest.115.suppl_2.113s. PMID: 10331343.
11. Vascular Events in Noncardiac Surgery Patients Cohort Evaluation (VISION) Study Investigators; Spence J, LeManach Y, Chan MTV, Wang CY, Sigamani A, Xavier D, Pearse R, Alonso-Coello P, Garutti I, Srinathan SK, Duceppe E, Walsh M, Borges FK, Malaga G, Abraham V, Faruqui A, Berwanger O, Biccard BM, Villar JC, Sessler DI, Kurz A, Chow CK, Polanczyk CA, Szczeklik W, Ackland G, X GA, Jacka M, Guyatt GH, Sapsford RJ, Williams C, 76 Cortes OL, Coriat P, Patel A, Tiboni M, Belley-Côté EP, Yang S, Heels-Ansdell D, McGillion M, Parlow S, Patel M, Pettit S, Yusuf S, Devereaux PJ. Association between complications and death within 30 days after noncardiac surgery. CMAJ. 2019 Jul 29;191(30):E830-E837. doi: 10.1503/cmaj.190221. PMID: 31358597; PMCID: PMC6663503.
12. Park J, Kwon JH, Lee SH, Lee JH, Min JJ, Kim J, Oh AR, Seo W, Hyeon CW, Yang K, Choi JH, Lee SC, Kim K, Ahn J, Gwon HC. Intraoperative blood loss may be associated with myocardial injury after non-cardiac surgery. PLoS One. 2021 Feb 24;16(2):e0241114. doi: 10.1371/journal.pone.0241114. PMID: 33626048; PMCID: PMC7904206.
13. Listyo S, Forrest E, Graf L, Korte W. The Need for Red Cell Support During Non-Cardiac Surgery Is Associated to Pre-Transfusion Levels of FXIII and the Platelet Count. J Clin Med. 2020 Jul 31;9(8):2456. doi: 10.3390/jcm9082456. PMID: 32751988; PMCID: PMC7465630.
14. Houston BL, Uminski K, Mutter T, Rimmer E, Houston DS, Menard CE, Garland A, Ariano R, Tinmouth A, Abou-Setta AM, Rabbani R, Neilson C, Rochwerg B, Turgeon AF, Falk J, Breau RH, Fergusson DA, Zarychanski R. Efficacy and Safety of Tranexamic Acid in Major Non-Cardiac Surgeries at High Risk for Transfusion: A Systematic Review and MetaAnalysis. Transfus Med Rev. 2020 Jan;34(1):51-62. doi: 10.1016/j.tmrv.2019.10.001. Epub 2019 Oct 23. PMID: 31982293.
15. Wedel C, Møller CM, Budtz-Lilly J, Eldrup N. Red blood cell transfusion associated with increased morbidity and mortality in patients undergoing elective open abdominal aortic aneurysm repair. PLoS One. 2019 Jul 11;14(7):e0219263. 10.1371/journal.pone.0219263. PMID: 31295273; PMCID: PMC6623955.
16. Al-Refaie WB, Parsons HM, Markin A, Abrams J, Habermann EB. Blood transfusion and cancer surgery outcomes: a continued reason for concern. Surgery. 2012 Sep;152(3):34454. doi: 10.1016/j.surg.2012.06.008. PMID: 22938895.
17. Bernard AC, Davenport DL, Chang PK, Vaughan TB, Zwischenberger JB. Intraoperative transfusion of 1 U to 2 U packed red blood cells is associated with increased 30-day mortality, surgical-site infection, pneumonia, and sepsis in general surgery patients. J Am Coll Surg. 2009 May;208(5):931-7, 937.e1-2; discussion 10.1016/j.jamcollsurg.2008.11.019. Epub 2009 Mar 26. PMID: 19476865.
18. Lim AR, Kim JH, Hyun MH, Chang WJ, Lee S, Kim YH, Park KH, Park JH. Blood transfusion has an adverse impact on the prognosis of patients receiving chemotherapy for advanced colorectal cancer: experience from a single institution with a patient blood management program. Support Care Cancer. 2022 Jun;30(6):5289-5297. doi: 10.1007/s00520-02206949-z. Epub 2022 Mar 11. PMID: 35277757.
19. FDA: Fatalities reported to FDA following blood collection and transfusion: Annual Summary for Fiscal Year 2018. Silver Spring, MD, US Food and Drug Administration, 2018. Fatalities Reported to FDA Following Blood Collection and Transfusion Annual Summary for FY2020
20. Lier H, Böttiger BW, Hinkelbein J, Krep H, Bernhard M. Coagulation management in multiple trauma: a systematic review. Intensive Care Med. 2011 Apr;37(4):572-82. doi: 10.1007/s00134-011-2139-y. Epub 2011 Feb 12. PMID: 21318436.
21. Haas T, Fries D, Tanaka KA, Asmis L, Curry NS, Schöchl H. Usefulness of standard plasma coagulation tests in the management of perioperative coagulopathic bleeding: is there any evidence? Br J Anaesth. 2015 Feb;114(2):217-24. doi: 10.1093/bja/aeu303. Epub 2014 Sep 8. PMID: 25204698.
22. Solomon C, Sørensen B, Hochleitner G, Kashuk J, Ranucci M, Schöchl H. Comparison of whole blood fibrin-based clot tests in thrombelastography and thromboelastometry. Anesth Analg. 2012 Apr;114(4):721-30. doi: 10.1213/ANE.0b013e31824724c8. Epub 2012 Feb 7. PMID: 22314689.
23. Whiting P, Al M, Westwood M, Ramos IC, Ryder S, Armstrong N, Misso K, Ross J, Severens J, Kleijnen J. Viscoelastic point-of-care testing to assist with the diagnosis, management and monitoring of haemostasis: a systematic review and cost-effectiveness analysis. Health Technol Assess. 2015 Jul;19(58):1-228, v-vi. doi: 10.3310/hta19580. PMID: 26215747; PMCID: PMC4781169.
24. Ministerio de Salud y Protección Social. Colombia. Guía de Práctica Clínica basada en la evidencia para el uso de componentes sanguíneos (Adopción), guía N° 62 guía completa, GPC en Internet. Edición 1°. Bogotá D.C: El Ministerio; 2016 (consultada 08 09 2022). Disponible en gpc.minsalud.gov.co.
25. Kozek-Langenecker, Sibylle A.; Ahmed, Aamer B.; Afshari, Arash; Albaladejo, Pierre. Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology. European Journal of Anaesthesiology: June 2017 - Volume 34 - Issue 6 - p 332-395. doi: 10.1097/EJA.0000000000000630
26. Patel PA, Wyrobek JA, Butwick AJ, Pivalizza EG, Hare GMT, Mazer CD, Goobie SM. Update on Applications and Limitations of Perioperative Tranexamic Acid. Anesth Analg. 2022 Sep 1;135(3):460-473. doi: 10.1213/ANE.0000000000006039. Epub 2022 Aug 17. PMID: 35977357.
27. Ramirez RJ, Spinella PC, Bochicchio GV. Tranexamic Acid Update in Trauma. Crit Care Clin. 2017 Jan;33(1):85-99. doi: 10.1016/j.ccc.2016.08.004. PMID: 27894501
28. Gerstein NS, Brierley JK, Windsor J, Panikkath PV, Ram H, Gelfenbeyn KM, Jinkins LJ, Nguyen LC, Gerstein WH. Antifibrinolytic Agents in Cardiac and Noncardiac Surgery: A 78 Comprehensive Overview and Update. J Cardiothorac Vasc Anesth. 2017 Dec;31(6):21832205. doi: 10.1053/j.jvca.2017.02.029. Epub 2017 Feb 5. PMID: 28457777.
29. Roberts I, Shakur H, Coats T, et al. The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients. Southampton (UK): NIHR Journals Library; 2013 Mar. (Health Technology Assessment, No. 17.10.) Available from: https://www.ncbi.nlm.nih.gov/books/NBK260390/ doi: 10.3310/hta17100
30. Lin Z, Xiaoyi Z. Tranexamic acid-associated seizures: A meta-analysis. Seizure. 2016 Mar;36:70-73. doi: 10.1016/j.seizure.2016.02.011. Epub 2016 Feb 26. PMID: 26967164.
30. Lin Z, Xiaoyi Z. Tranexamic acid-associated seizures: A meta-analysis. Seizure. 2016 Mar;36:70-73. doi: 10.1016/j.seizure.2016.02.011. Epub 2016 Feb 26. PMID: 26967164.
31. Llau JV, Acosta FJ, Escolar G, et al. Multidisciplinary consensus document on the management of massive haemorrhage (HEMOMAS document). Med Intensiva. 2015;39(8):483-504. doi:10.1016/j.medin.2015.05.002
32. Rossaint R, Bouillon B, Cerny V, Coats TJ, Duranteau J, Fernández-Mondéjar E, Filipescu D, Hunt BJ, Komadina R, Nardi G, Neugebauer EA, Ozier Y, Riddez L, Schultz A, Vincent JL, Spahn DR. The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition. Crit Care. 2016 Apr 12;20:100. doi: 10.1186/s13054016-1265-x. PMID: 27072503; PMCID: PMC4828865.
33. Spahn DR, Bouillon B, Cerny V, Duranteau J, Filipescu D, Hunt BJ, Komadina R, Maegele M, Nardi G, Riddez L, Samama CM, Vincent JL, Rossaint R. The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition. Crit Care. 2019 Mar 27;23(1):98. doi: 10.1186/s13054-019-2347-3. PMID: 30917843; PMCID: PMC6436241.
34. Ghadimi K, Levy JH, Welsby IJ. Prothrombin Complex Concentrates for Bleeding in the Perioperative Setting. Anesth Analg. doi:10.1213/ANE.0000000000001188 2016;122(5):1287-1300.
35. Garcia DA, Crowther MA. Reversal of warfarin: case-based practice recommendations. Circulation.2012;125(23):2944-2947.doi:10.1161/CIRCULATIONAHA.111.081489
36. Innerhofer P, Fries D, Mittermayr M, et al. Reversal of trauma-induced coagulopathy using first-line coagulation factor concentrates or fresh frozen plasma (RETIC): a singlecentre, parallel-group, open-label, randomised trial [published correction appears in Lancet Haematol. 2017 Jun;4(6):e257]. Lancet Haematol. 2017;4(6):e258-e271. doi:10.1016/S2352-3026(17)30077-7
37. Lindner G, Exadaktylos AK. How Noninvasive Haemoglobin Measurement with Pulse COOximetry Can Change Your Practice: An Expert Review. Emerg Med Int. 2013;2013:701529. doi:10.1155/2013/701529
38. Khalafallah AA, Chilvers CR, Thomas M, Chilvers CM, Sexton M, Vialle M, Robertson IK. Usefulness of non-invasive spectrophotometric haemoglobin estimation for detecting low haemoglobin levels when compared with a standard laboratory assay for preoperative assessment. Br J Anaesth. 2015 Apr;114(4):669-76. doi: 10.1093/bja/aeu403. Epub 2014 Dec 13. PMID: 25501721.
40. Kim, Sang-Hyun MD, PhD*; Lilot, Marc MD*; Murphy, Linda Suk-Ling MLIS†; Sidhu, Kulraj S. MD*; Yu, Zhaoxia PhD‡; Rinehart, Joseph MD*; Cannesson, Maxime MD, PhD. Accuracy of Continuous Noninvasive Hemoglobin Monitoring: A Systematic Review and MetaAnalysis. Anesthesia & Analgesia: August 2014 - Volume 119 - Issue 2 - p 332-346. doi: 10.1213/ANE.0000000000000272.
41. Lee, JH., Park, YH. & Kim, JT. Current Use of Noninvasive Hemoglobin Monitoring in Anesthesia. Curr Anesthesiol Rep 4, 233–241 (2014). https://doi.org/10.1007/s40140014-0070-9
42. Colquhoun, D.A., Forkin, K.T., Durieux, M.E. et al. Ability of the Masimo pulse COOximeter to detect changes in hemoglobin. J Clin Monit Comput 26, 69–73 (2012). https://doi.org/10.1007/s10877-012-9335-3
43. National blood Authority Australia. Patient blood management guidelines. (2011) https://www.blood.gov.au/pbm-guidelines.
44. American Society of Anesthesiologists Task Force on Perioperative Blood Management. Practice guidelines for perioperative blood management: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Management. Anesthesiology. 2015 Feb;122(2):241-75. doi: 10.1097/ALN.0000000000000463. PMID: 25545654.
45. Rayyan AI. Plataforma de gestión de revisiones sistemáticas. Disponible en: https://new.rayyan.ai
46. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hróbjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, Moher D. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021 Mar 29;372:n71. doi: 10.1136/bmj.n71. PMID: 33782057; PMCID: PMC8005924.
47. Evidence Synthesis Hackathon. PRISMA2020 R package and ShinyApp for making PRISMA2020 flow diagrams. Disponible https://www.eshackathon.org/software/PRISMA2020.html
39. Joseph B, Haider A, Rhee P. Non-invasive hemoglobin monitoring. Int J Surg. 2016;33(Pt B):254-257. doi:10.1016/j.ijsu.2015.11.048
48. Shea BJ, Reeves BC, Wells G, Thuku M, Hamel C, Moran J, Moher D, Tugwell P, Welch V, Kristjansson E, Henry DA. AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ. 2017 Sep 21;358:j4008. doi: 10.1136/bmj.j4008. PMID: 28935701; PMCID: PMC5833365
49. Cochrane. Risk of Bias 2 (RoB https://methods.cochrane.org/risk-bias-2 2) tool. 2017. Disponible en:
50. AGREE Next Steps Consortium. Instrumento AGREE II Versión electrónica. 2019. Disponible en: https://portal.guiasalud.es/wp-content/uploads/2019/01/spanish-agreeii.pdf
51. McMaster University. GRADEpro. [Accedido en Marzo de 2023]. Disponible en: https://www.gradepro.org/
52. GRADEpro GDT/ Cochrane GRADEing [Accedido en Marzo de 2024]. Disponible en: GRADEpro GDT | Cochrane GRADEing
53. RevMan Web (cochrane.org). [Accedido enero 2024]. Disponible en: RevMan Web (cochrane.org)
54. Akdag S, Zengin SU, Cakmak G, Umuroglu T, Aykac ZZ, Saracoglu A. Targeted Bleeding Management Guided by Non-Invasive Haemoglobin Measurement in Surgical Patients. J Coll Physicians Surg Pak. 2022 Oct;32(10):1242-1248. doi: 10.29271/jcpsp.2022.10.1242. PMID: 36205265.
54. Akdag S, Zengin SU, Cakmak G, Umuroglu T, Aykac ZZ, Saracoglu A. Targeted Bleeding Management Guided by Non-Invasive Haemoglobin Measurement in Surgical Patients. J Coll Physicians Surg Pak. 2022 Oct;32(10):1242-1248. doi: 10.29271/jcpsp.2022.10.1242. PMID: 36205265.
56. Tang B, Yu X, Xu L, Zhu A, Zhang Y, Huang Y. Continuous noninvasive hemoglobin monitoring estimates timing for detecting anemia better than clinicians: a randomized controlled trial. BMC Anesthesiol. 2019 May 17;19(1):80. doi: 10.1186/s12871-019-07551. PMID: 31101083; PMCID: PMC6525351.
57. Bugaev N, Como JJ, Golani G, Freeman JJ, Sawhney JS, Vatsaas CJ, Yorkgitis BK, Kreiner LA, Garcia NM, Aziz HA, Pappas PA, Mahoney EJ, Brown ZW, Kasotakis G. Thromboelastography and rotational thromboelastometry in bleeding patients with coagulopathy: Practice management guideline from the Eastern Association for the Surgery of Trauma. J Trauma Acute Care Surg. 2020 Dec;89(6):999-1017. doi: 10.1097/TA.0000000000002944. Erratum in: J Trauma Acute Care Surg. 2021 Apr 1;90(4):766-767. PMID: 32941349.
58. Sampaio AM, Guimarães GMN, Medeiros GP, Damasceno GMM, Silva RMA, Nunes RR, Rocha HAL, Nascimento JCR. Eficácia e segurança de antifibrinolíticos em cirurgia 81 oncológica: uma revisão sistemática e metanálise [Efficacy and safety of antifibrinolytics in oncological surgery: a systematic review and meta-analysis]. Braz J Anesthesiol. 2019 Sep-Oct;69(5):484-492. doi: 10.1016/j.bjan.2019.06.005. Epub 2019 Oct 19. PMID: 31640900; PMCID: PMC9391867.
59. Longo MA, Cavalheiro BT, de Oliveira Filho GR. Systematic review and meta-analyses of tranexamic acid use for bleeding reduction in prostate surgery. J Clin Anesth. 2018 Aug;48:32-38. doi: 10.1016/j.jclinane.2018.04.014. Epub 2018 May 1. PMID: 29727761.
60. Clynch AL, Gillespie CS, Richardson GE, Mustafa MA, Islim AI, Keshwara SM, Bakhsh A, Kumar S, Zakaria R, Millward CP, Mills SJ, Brodbelt AR, Jenkinson MD. Tranexamic acid use in meningioma surgery - A systematic review and meta-analysis. J Clin Neurosci. 2023
61. Kietpeerakool C, Supoken A, Laopaiboon M, Lumbiganon P. Effectiveness of tranexamic acid in reducing blood loss during cytoreductive surgery for advanced ovarian cancer. Cochrane Database Syst Rev. 2016 Jan 23;2016(1):CD011732
62. Wijaya JH, July J, Quintero-Consuegra M, Chadid DP. A systematic review and metaanalysis of the effects of tranexamic acid in surgical procedure for intracranial meningioma. J Neurooncol. 2023 Jan;161(2):383-393. doi: 10.1007/s11060-023-04237-2. Epub 2023 Jan 12. PMID: 36633801.
63. Fowler H, Law J, Tham SM, Gunaravi SA, Houghton N, Clifford RE, Fok M, Barker JA, Vimalachandran D. Impact on blood loss and transfusion rates following administration of tranexamic acid in major oncological abdominal and pelvic surgery: A systematic review and meta-analysis. J Surg Oncol. 2022 Sep;126(3):609-621. doi: 10.1002/jso.26900. Epub 2022 Apr 26. PMID: 35471705.
64. Karanicolas PJ, Lin Y, Tarshis J, et al. Major liver resection, systemic fibrinolytic activity, and the impact of tranexamic acid. HPB (Oxford). 2016;18(12):991-999. doi:10.1016/j.hpb.2016.09.005
65. Jadad AR, Moore RA, Carroll D et al (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17:1–12. https:// doi. org/ 10. 1016/ 0197- 2456(95) 00134-4
66. Weber RS, Jabbour N, Martin RC 2nd. Anemia and transfusions in patients undergoing surgery for cancer. Ann Surg Oncol. 2008 Jan;15(1):34-45. doi: 10.1245/s10434-0079502-9. Epub 2007 Oct 18. PMID: 17943390; PMCID: PMC7101818.
67. Pang QY, An R, Liu HL. Perioperative transfusion and the prognosis of colorectal cancer surgery: a systematic review and meta-analysis. World J Surg Oncol. 2019 Jan 5;17(1):7. doi: 10.1186/s12957-018-1551-y. PMID: 30611274; PMCID: PMC6321702.
68. Myles PS, Smith JA, Forbes A, et al. Tranexamic Acid in Patients Undergoing CoronaryArtery Surgery [published correction appears in N Engl J Med. 2018 Feb 22;378(8):782]. N Engl J Med. 2017;376(2):136-148. doi:10.1056/NEJMoa1606424
69. Sukeik M, Alshryda S, Haddad FS, Mason JM. Systematic review and meta-analysis of the use of tranexamic acid in total hip replacement. J Bone Joint Surg Br. 2011 Jan 1;93B(1):39-46. https://doi.org/10.1302/0301-620X.93B1.24984
70. Abdol Razak NB, Jones G, Bhandari M, Berndt MC, Metharom P. Cancer-Associated Thrombosis: An Overview of Mechanisms, Risk Factors, and Treatment. Cancers (Basel). 2018 Oct 11;10(10):380. doi: 10.3390/cancers10100380. PMID: 30314362; PMCID: PMC6209883.
71. Khalil J, Bensaid B, Elkacemi H, et al. Venous thromboembolism in cancer patients: an underestimated major health problem. World J Surg Oncol. 2015;13:204. DOI: 10.1186/s12957-015-0592-8
72. Houston BL, Uminski K, Mutter T, Rimmer E, Houston DS, Menard CE, Garland A, Ariano R, Tinmouth A, Abou-Setta AM, Rabbani R, Neilson C, Rochwerg B, Turgeon AF, Falk J, Breau RH, Fergusson DA, Zarychanski R. Efficacy and Safety of Tranexamic Acid in Major Non-Cardiac Surgeries at High Risk for Transfusion: A Systematic Review and MetaAnalysis. Transfus Med Rev. 2020 Jan;34(1):51-62. doi: 10.1016/j.tmrv.2019.10.001. Epub 2019 Oct 23. PMID: 31982293.
73. McDaniel LM, Neal MD, Sperry JL, Alarcon LH, Forsythe RM, Triulzi D, Peitzman AB, Raval JS. Use of a massive transfusion protocol in nontrauma patients: activate away. J Am Coll Surg. 2013 Jun;216(6):1103-9. doi: 10.1016/j.jamcollsurg.2013.02.008. Epub 2013 Apr 6. PMID: 23571144.
74. Johansson PI, Stensballe J, Rosenberg I, Hilsløv TL, Jørgensen L, Secher NH. Proactive administration of platelets and plasma for patients with a ruptured abdominal aortic aneurysm: evaluating a change in transfusion practice. Transfusion. 2007 Apr;47(4):5938. doi: 10.1111/j.1537-2995.2007.01160.x. PMID: 17381616.
75. Martínez-Calle N, Hidalgo F, Alfonso A, Muñoz M, Hernández M, Lecumberri R, Páramo JA. Implementation of a management protocol for massive bleeding reduces mortality in non-trauma patients: Results from a single centre audit. Med Intensiva. 2016 Dec;40(9):550-559. English, Spanish. doi: 10.1016/j.medin.2016.05.003. Epub 2016 Jul 15. PMID: 27425576.
76. Dutta EH, Poole AT, Behnia F, Dunn HE, Clark SM, Pacheco LD, Saade GR, Hankins GDV. Hemostatic Resuscitation in Peripartum Hysterectomy Pre- and Postmassive Transfusion Protocol Initiation. Am J Perinatol. 2017 Jul;34(9):861-866. doi: 10.1055/s-0037-1599103. Epub 2017 Mar 6. PMID: 28264207.
77. RiskinDJ, Tsai TC, Riskin L,Hernandez-Boussard T, PurtillM,Maggio PM, Spain DA, Brundage SI. Massive transfusion protocols: the role of aggressive resuscitation versus product ratio in mortality reduction. J Am Coll Surg. 2009;209(2):198–205.
78. Cotton BA, Au BK, Nunez TC, Gunter OL, Robertson AM, Young PP. Predefined massive transfusion protocols are associated with a reduction in organ failure and postinjury complications. J Trauma. 2009;66(1):41–48; discussion 48–9.
79. ACS TQIP Best Practice Guidelines. Accessed 08-20-2018. Available from: https://www.facs.org/quality-programs/trauma/tqip/best-practice.
80. Sihler KC, Napolitano LM. Complications of massive transfusion. Chest. 2010 Jan;137(1):209-20. doi: 10.1378/chest.09-0252. Erratum in: Chest. 2010 Mar;137(3):744. PMID: 20051407.
81. Sommer N, Schnüriger B, Candinas D, Haltmeier T. Massive transfusion protocols in nontrauma patients: A systematic review and meta-analysis. J Trauma Acute Care Surg. 2019 Mar;86(3):493-504. doi: 10.1097/TA.0000000000002101. PMID: 30376535.
82. van den Brink DP, Wirtz MR, Neto AS, Schöchl H, Viersen V, Binnekade J, Juffermans NP. Effectiveness of prothrombin complex concentrate for the treatment of bleeding: A systematic review and meta-analysis. J Thromb Haemost. 2020 Oct;18(10):2457-2467. doi: 10.1111/jth.14991. Epub 2020 Aug 2. PMID: 32638483; PMCID: PMC7589201.
83. Kao TW, Lee YC, Chang HT. Prothrombin Complex Concentrate for Trauma Induced Coagulopathy: A Systematic Review and Meta-Analysis. J Acute Med. 2021 Sep 1;11(3):81-89. doi: 10.6705/j.jacme.202109_11(3).0001. PMID: 34595091; PMCID: PMC8440438.
84. Bouzat P, Charbit J, Abback PS, Huet-Garrigue D, Delhaye N, Leone M, Marcotte G, David JS, Levrat A, Asehnoune K, Pottecher J, Duranteau J, Courvalin E, Adolle A, Sourd D, Bosson JL, Riou B, Gauss T, Payen JF; PROCOAG Study Group. Efficacy and Safety of Early Administration of 4-Factor Prothrombin Complex Concentrate in Patients With Trauma at Risk of Massive Transfusion: The PROCOAG Randomized Clinical Trial. JAMA. 2023 Apr 25;329(16):1367-1375. doi: 10.1001/jama.2023.4080. PMID: 36942533; PMCID: PMC10031505.
85. Maegele M, Lefering R, Yucel N, et al. Early coagulopathy in multiple injury: an analysis from the German trauma registry on 8724 patients. Injury. 2007;38:298-304.
86. Bassin L, Stone M, Krol M, Reich DL. Risk factors for intraoperative coagulopathy in cardiac surgery. Heart Lung Circ. 2010;19:506.
87. Silvergleid AJ. Inmunologic transfusión reactions. UpToDate. Disponible en: https://www.uptodate.com/contents/immunologic-transfusion-reactions
88. Kleinman S, Kor DJ. Transfusion-related acute lung injury (TRALI). UpToDate. Disponible en: https://www.uptodate.com/contents/transfusion-related-acute-lung-injury-trali
89. Khan S, Davenport R, Raza I, et al. Damage control resuscitation using blood component therapy in standard doses has a limited effect on coagulopathy during trauma hemorrhage. Intensive Care Med. 2015;41:239-247.
90. Franchini M, Lippi G. Prothrombin complex concentrates: an update. Blood Transfus. 2010;8(3):149-154. doi:10.2450/2010.0149-09
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dc.publisher.faculty.spa.fl_str_mv Facultad Ciencias de la Salud
dc.publisher.program.spa.fl_str_mv Maestría en Métodos para la Producción y Aplicación de Conocimiento Científico en Salud
institution Universidad Autónoma de Bucaramanga - UNAB
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spelling Vásquez Hernández, Skarlet Marcell8b710a40-acd2-4858-9c46-b5c7dc2c38ddÁlvarez Robles, Saule8dec449-856f-4de4-a7ad-e055a8686981Serrano Vásquez, Rafael Enrique578252e0-d158-4f08-b84f-67ef985214acVásquez Hernández, Skarlet Marcell [0001349039]Álvarez Robles, Saul [0000833797]Vásquez Hernández, Skarlet Marcell [0000-0003-2552-9819]Álvarez Robles, Saul [0000-0002-3676-0058]Vásquez Hernández, Skarlet Marcell [skarlet-m-vásquez]Bucaramanga (Santander, Colombia)2022 - 2024UNAB Campus Bucaramanga2024-05-20T16:44:38Z2024-05-20T16:44:38Z2024-04-22http://hdl.handle.net/20.500.12749/24651instname:Universidad Autónoma de Bucaramanga - UNABreponame:Repositorio Institucional UNABrepourl:https://repository.unab.edu.coA nivel mundial, muchas cirugías mayores requieren transfusiones, lo que conlleva riesgos de reacciones adversas e infecciones. A pesar de las técnicas disponibles para reducir la necesidad de transfusiones, muchas guías clínicas están desactualizadas y no cubren todas las poblaciones de pacientes no cardíacos. Este estudio tiene como objetivo desarrollar recomendaciones para la terapia transfusional y las técnicas de ahorro sanguíneo en cirugías no cardíacas, utilizando la metodología GRADE. Se formularon cinco preguntas PICO tras una búsqueda sistemática y revisión de la literatura, priorizando revisiones sistemáticas y ensayos clínicos aleatorizados. Se evaluó el riesgo de sesgo y la certeza de la evidencia con herramientas AMSTAR II y Rob-2. Las recomendaciones finales se basan en seis estudios clave y un marco EtD, destacando la necesidad de ensayos clínicos más robustos y mejor diseñados.1. TITULO DEL PROYECTO 8 2. RESUMEN 8 3. DESCRIPCION DEL PROYECTO 12 3.1. PLANTEAMIENTO Y JUSTIFICACION DEL PROBLEMA 12 3.2. MARCO TEORICO 14 3.3. ESTADO DEL ARTE 18 3.4. OBJETIVOS 21 3.4.1. Objetivo General 23 3.4.2. Objetivos específicos 23 3.5. METODOLOGIA 23 3.5.1. Selección de las preguntas PICO 23 3.5.2. Estrategias de búsqueda de la literatura 26 3.5.3. Selección de los estudios 27 3.5.4. Evaluación de la calidad metodológica 28 3.5.5. Generación de recomendaciones basadas en la evidencia 28 3.5.6. Modificaciones al protocolo 29 4. RESULTADOS – DESARROLLO DE LAS PREGUNTAS 30 4.1. PREGUNTA PICO 1 30 4.1.1. Estudios de referencia y desenlaces extraídos 30 4.1.2. Juicios 33 4.1.3. Formulación de la recomendación pregunta PICO 1 36 4.2. PREGUNTA PICO 2 37 4.2.1. Estudios de referencia y desenlaces extraídos 37 4.2.2. Formulación de la recomendación pregunta PICO 2 43 4.3. PREGUNTA PICO 3 44 4.3.1. Estudios de referencia y desenlaces extraídos 44 4.3.2. Juicios 55 4.3.3. Formulación de la recomendación pregunta PICO 3 58 4.4. PREGUNTA PICO 4 58 4.4.1. Estudios de referencia y desenlaces extraídos 58 4.4.2. Juicios 62 4.4.3. Formulación de la recomendación pregunta PICO 4 64 4.5. PREGUNTA PICO 5 65 4.5.1. Estudios de referencia y desenlaces extraídos 65 4.5.2. Juicios 69 4.5.3. Formulación de la recomendación pregunta PICO 5 71 5. CONCLUSIONES 74 6. REFERENCIAS BIBLIOGRAFICAS 75 7. ANEXOSMaestríaGlobally, many major surgeries require transfusions, which carry risks of adverse reactions and infections. Despite the available techniques to reduce the need for transfusions, many clinical guidelines are outdated and do not cover all non-cardiac patient populations. This study aims to develop recommendations for transfusion therapy and blood conservation techniques in non-cardiac surgeries using the GRADE methodology. Five PICO questions were formulated after a systematic search and literature review, prioritizing systematic reviews and randomized clinical trials. The risk of bias and the certainty of evidence were assessed using AMSTAR II and Rob-2 tools. The final recommendations are based on six key studies and an EtD framework, highlighting the need for more robust and well-designed clinical trials.Modalidad Presencialapplication/pdfspahttp://creativecommons.org/licenses/by-nc-nd/2.5/co/Abierto (Texto Completo)Atribución-NoComercial-SinDerivadas 2.5 Colombiahttp://purl.org/coar/access_right/c_abf2Terapia transfusional y técnicas de ahorro sanguíneo intraoperatorio en pacientes sometidos a cirugía no cardiaca. Recomendaciones basadas en síntesis de la evidenciaTransfusion Therapy and Intraoperative Blood Conservation Techniques in Patients Undergoing Non-Cardiac Surgery. Evidence-Based RecommendationsThesisinfo:eu-repo/semantics/masterThesisTesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/redcol/resource_type/TMMagíster en Métodos para la Producción y Aplicación de Conocimiento Científico en SaludUniversidad Autónoma de Bucaramanga UNABFacultad Ciencias de la SaludMaestría en Métodos para la Producción y Aplicación de Conocimiento Científico en SaludMedical sciencesHealth sciencesNon-cardiac surgeryBlood-saving techniquesPlasma exchangeBlood (Transfusion)Blood cellsLiterature reviewInformation storage and retrieval systemsCiencias médicasIntercambio plasmáticoTransfusión de sangreCélulas sanguíneasRevisión de literaturaSistemas de almacenamiento y recuperación de informaciónCiencias de la saludTransfusiónCirugía no cardiacaTécnicas de ahorro sanguíneoGRADE1. Mannucci PM, Levi M. Prevention and treatment of major blood loss. N Engl J Med. 2007 May 31;356(22):2301-11. doi: 10.1056/NEJMra067742. PMID: 17538089.2. Instituto Nacional de Salud. Informe de la red nacional bancos de sangre de Colombia, 2021. 2022; 1-82. Disponible en: http://www.ins.gov.co/bibliotecadigital/informe-anualbancos-de-sangre-2021.pdf3. Kleinman S, Kor DJ. Transfusion-related acute lung injury (TRALI). UpToDate. https://www.uptodate.com/contents/transfusion-related-acute-lung-injurytrali?csi=52bef3c4-1896-48cc-b746-6c70fb82e465&source=contentShare4. FDA. Fatalities reported to FDA following blood collection and transfusion. Annual Summary for Fiscal Year. 2015. 2017; Silver Spring: 3-11.5. Liu JV. Medicina Transfusional Perioperatoria. Segunda edición. España. Editorial ELSEVIER. 20196. Yepes AM. Auditoría y Evaluación del Proceso de Transfusión Sanguínea. 2013. Medellín. Disponible en: https://repository.ces.edu.co/bitstream/handle/10946/1223/Auditoria_transfusion_san guinea.pdf?sequence=27. Informe de reacciones adversas a la transfusión 2019. Instituto Nacional de Salud. https://www.ins.gov.co/BibliotecaDigital/informe-rat-2019.pdf7. Informe de reacciones adversas a la transfusión 2019. Instituto Nacional de Salud. https://www.ins.gov.co/BibliotecaDigital/informe-rat-2019.pdf8. Carson JL, Duff A, Poses RM, et al. Effect of anaemia and cardiovascular disease on surgical mortality and morbidity. Lancet. 1996;348(9034):1055-1060. doi:10.1016/S01406736(96)04330-99. Oliveros-Rodríguez HO, Beltrán Linares Édgar. Preoperative Hemoglobin Levels and Outcomes in Cardiovascular Surgical Patients; systematic review and meta-analysis. Colomb. J. Anesthesiol. [Internet]. 2012 Jan. 1 [cited 2024 Apr. 12];40(1):27-33. Available from: https://www.revcolanest.com.co/index.php/rca/article/view/861.10. McFarland JG. Perioperative blood transfusions: indications and options. Chest. 1999 May;115(5 Suppl):113S-121S. doi: 10.1378/chest.115.suppl_2.113s. PMID: 10331343.11. Vascular Events in Noncardiac Surgery Patients Cohort Evaluation (VISION) Study Investigators; Spence J, LeManach Y, Chan MTV, Wang CY, Sigamani A, Xavier D, Pearse R, Alonso-Coello P, Garutti I, Srinathan SK, Duceppe E, Walsh M, Borges FK, Malaga G, Abraham V, Faruqui A, Berwanger O, Biccard BM, Villar JC, Sessler DI, Kurz A, Chow CK, Polanczyk CA, Szczeklik W, Ackland G, X GA, Jacka M, Guyatt GH, Sapsford RJ, Williams C, 76 Cortes OL, Coriat P, Patel A, Tiboni M, Belley-Côté EP, Yang S, Heels-Ansdell D, McGillion M, Parlow S, Patel M, Pettit S, Yusuf S, Devereaux PJ. Association between complications and death within 30 days after noncardiac surgery. CMAJ. 2019 Jul 29;191(30):E830-E837. doi: 10.1503/cmaj.190221. PMID: 31358597; PMCID: PMC6663503.12. Park J, Kwon JH, Lee SH, Lee JH, Min JJ, Kim J, Oh AR, Seo W, Hyeon CW, Yang K, Choi JH, Lee SC, Kim K, Ahn J, Gwon HC. Intraoperative blood loss may be associated with myocardial injury after non-cardiac surgery. PLoS One. 2021 Feb 24;16(2):e0241114. doi: 10.1371/journal.pone.0241114. PMID: 33626048; PMCID: PMC7904206.13. Listyo S, Forrest E, Graf L, Korte W. The Need for Red Cell Support During Non-Cardiac Surgery Is Associated to Pre-Transfusion Levels of FXIII and the Platelet Count. J Clin Med. 2020 Jul 31;9(8):2456. doi: 10.3390/jcm9082456. PMID: 32751988; PMCID: PMC7465630.14. Houston BL, Uminski K, Mutter T, Rimmer E, Houston DS, Menard CE, Garland A, Ariano R, Tinmouth A, Abou-Setta AM, Rabbani R, Neilson C, Rochwerg B, Turgeon AF, Falk J, Breau RH, Fergusson DA, Zarychanski R. Efficacy and Safety of Tranexamic Acid in Major Non-Cardiac Surgeries at High Risk for Transfusion: A Systematic Review and MetaAnalysis. Transfus Med Rev. 2020 Jan;34(1):51-62. doi: 10.1016/j.tmrv.2019.10.001. Epub 2019 Oct 23. PMID: 31982293.15. Wedel C, Møller CM, Budtz-Lilly J, Eldrup N. Red blood cell transfusion associated with increased morbidity and mortality in patients undergoing elective open abdominal aortic aneurysm repair. PLoS One. 2019 Jul 11;14(7):e0219263. 10.1371/journal.pone.0219263. PMID: 31295273; PMCID: PMC6623955.16. Al-Refaie WB, Parsons HM, Markin A, Abrams J, Habermann EB. Blood transfusion and cancer surgery outcomes: a continued reason for concern. Surgery. 2012 Sep;152(3):34454. doi: 10.1016/j.surg.2012.06.008. PMID: 22938895.17. Bernard AC, Davenport DL, Chang PK, Vaughan TB, Zwischenberger JB. Intraoperative transfusion of 1 U to 2 U packed red blood cells is associated with increased 30-day mortality, surgical-site infection, pneumonia, and sepsis in general surgery patients. J Am Coll Surg. 2009 May;208(5):931-7, 937.e1-2; discussion 10.1016/j.jamcollsurg.2008.11.019. Epub 2009 Mar 26. PMID: 19476865.18. Lim AR, Kim JH, Hyun MH, Chang WJ, Lee S, Kim YH, Park KH, Park JH. Blood transfusion has an adverse impact on the prognosis of patients receiving chemotherapy for advanced colorectal cancer: experience from a single institution with a patient blood management program. Support Care Cancer. 2022 Jun;30(6):5289-5297. doi: 10.1007/s00520-02206949-z. Epub 2022 Mar 11. PMID: 35277757.19. FDA: Fatalities reported to FDA following blood collection and transfusion: Annual Summary for Fiscal Year 2018. Silver Spring, MD, US Food and Drug Administration, 2018. Fatalities Reported to FDA Following Blood Collection and Transfusion Annual Summary for FY202020. Lier H, Böttiger BW, Hinkelbein J, Krep H, Bernhard M. Coagulation management in multiple trauma: a systematic review. Intensive Care Med. 2011 Apr;37(4):572-82. doi: 10.1007/s00134-011-2139-y. Epub 2011 Feb 12. PMID: 21318436.21. Haas T, Fries D, Tanaka KA, Asmis L, Curry NS, Schöchl H. Usefulness of standard plasma coagulation tests in the management of perioperative coagulopathic bleeding: is there any evidence? Br J Anaesth. 2015 Feb;114(2):217-24. doi: 10.1093/bja/aeu303. Epub 2014 Sep 8. PMID: 25204698.22. Solomon C, Sørensen B, Hochleitner G, Kashuk J, Ranucci M, Schöchl H. Comparison of whole blood fibrin-based clot tests in thrombelastography and thromboelastometry. Anesth Analg. 2012 Apr;114(4):721-30. doi: 10.1213/ANE.0b013e31824724c8. Epub 2012 Feb 7. PMID: 22314689.23. Whiting P, Al M, Westwood M, Ramos IC, Ryder S, Armstrong N, Misso K, Ross J, Severens J, Kleijnen J. Viscoelastic point-of-care testing to assist with the diagnosis, management and monitoring of haemostasis: a systematic review and cost-effectiveness analysis. Health Technol Assess. 2015 Jul;19(58):1-228, v-vi. doi: 10.3310/hta19580. PMID: 26215747; PMCID: PMC4781169.24. Ministerio de Salud y Protección Social. Colombia. Guía de Práctica Clínica basada en la evidencia para el uso de componentes sanguíneos (Adopción), guía N° 62 guía completa, GPC en Internet. Edición 1°. Bogotá D.C: El Ministerio; 2016 (consultada 08 09 2022). Disponible en gpc.minsalud.gov.co.25. Kozek-Langenecker, Sibylle A.; Ahmed, Aamer B.; Afshari, Arash; Albaladejo, Pierre. Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology. European Journal of Anaesthesiology: June 2017 - Volume 34 - Issue 6 - p 332-395. doi: 10.1097/EJA.000000000000063026. Patel PA, Wyrobek JA, Butwick AJ, Pivalizza EG, Hare GMT, Mazer CD, Goobie SM. Update on Applications and Limitations of Perioperative Tranexamic Acid. Anesth Analg. 2022 Sep 1;135(3):460-473. doi: 10.1213/ANE.0000000000006039. Epub 2022 Aug 17. PMID: 35977357.27. Ramirez RJ, Spinella PC, Bochicchio GV. Tranexamic Acid Update in Trauma. Crit Care Clin. 2017 Jan;33(1):85-99. doi: 10.1016/j.ccc.2016.08.004. PMID: 2789450128. Gerstein NS, Brierley JK, Windsor J, Panikkath PV, Ram H, Gelfenbeyn KM, Jinkins LJ, Nguyen LC, Gerstein WH. Antifibrinolytic Agents in Cardiac and Noncardiac Surgery: A 78 Comprehensive Overview and Update. J Cardiothorac Vasc Anesth. 2017 Dec;31(6):21832205. doi: 10.1053/j.jvca.2017.02.029. Epub 2017 Feb 5. PMID: 28457777.29. Roberts I, Shakur H, Coats T, et al. The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients. Southampton (UK): NIHR Journals Library; 2013 Mar. (Health Technology Assessment, No. 17.10.) Available from: https://www.ncbi.nlm.nih.gov/books/NBK260390/ doi: 10.3310/hta1710030. Lin Z, Xiaoyi Z. Tranexamic acid-associated seizures: A meta-analysis. Seizure. 2016 Mar;36:70-73. doi: 10.1016/j.seizure.2016.02.011. Epub 2016 Feb 26. PMID: 26967164.30. Lin Z, Xiaoyi Z. Tranexamic acid-associated seizures: A meta-analysis. Seizure. 2016 Mar;36:70-73. doi: 10.1016/j.seizure.2016.02.011. Epub 2016 Feb 26. PMID: 26967164.31. Llau JV, Acosta FJ, Escolar G, et al. Multidisciplinary consensus document on the management of massive haemorrhage (HEMOMAS document). Med Intensiva. 2015;39(8):483-504. doi:10.1016/j.medin.2015.05.00232. Rossaint R, Bouillon B, Cerny V, Coats TJ, Duranteau J, Fernández-Mondéjar E, Filipescu D, Hunt BJ, Komadina R, Nardi G, Neugebauer EA, Ozier Y, Riddez L, Schultz A, Vincent JL, Spahn DR. The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition. Crit Care. 2016 Apr 12;20:100. doi: 10.1186/s13054016-1265-x. PMID: 27072503; PMCID: PMC4828865.33. Spahn DR, Bouillon B, Cerny V, Duranteau J, Filipescu D, Hunt BJ, Komadina R, Maegele M, Nardi G, Riddez L, Samama CM, Vincent JL, Rossaint R. The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition. Crit Care. 2019 Mar 27;23(1):98. doi: 10.1186/s13054-019-2347-3. PMID: 30917843; PMCID: PMC6436241.34. Ghadimi K, Levy JH, Welsby IJ. Prothrombin Complex Concentrates for Bleeding in the Perioperative Setting. Anesth Analg. doi:10.1213/ANE.0000000000001188 2016;122(5):1287-1300.35. Garcia DA, Crowther MA. Reversal of warfarin: case-based practice recommendations. Circulation.2012;125(23):2944-2947.doi:10.1161/CIRCULATIONAHA.111.08148936. Innerhofer P, Fries D, Mittermayr M, et al. Reversal of trauma-induced coagulopathy using first-line coagulation factor concentrates or fresh frozen plasma (RETIC): a singlecentre, parallel-group, open-label, randomised trial [published correction appears in Lancet Haematol. 2017 Jun;4(6):e257]. Lancet Haematol. 2017;4(6):e258-e271. doi:10.1016/S2352-3026(17)30077-737. Lindner G, Exadaktylos AK. How Noninvasive Haemoglobin Measurement with Pulse COOximetry Can Change Your Practice: An Expert Review. Emerg Med Int. 2013;2013:701529. doi:10.1155/2013/70152938. Khalafallah AA, Chilvers CR, Thomas M, Chilvers CM, Sexton M, Vialle M, Robertson IK. Usefulness of non-invasive spectrophotometric haemoglobin estimation for detecting low haemoglobin levels when compared with a standard laboratory assay for preoperative assessment. Br J Anaesth. 2015 Apr;114(4):669-76. doi: 10.1093/bja/aeu403. Epub 2014 Dec 13. PMID: 25501721.40. Kim, Sang-Hyun MD, PhD*; Lilot, Marc MD*; Murphy, Linda Suk-Ling MLIS†; Sidhu, Kulraj S. MD*; Yu, Zhaoxia PhD‡; Rinehart, Joseph MD*; Cannesson, Maxime MD, PhD. Accuracy of Continuous Noninvasive Hemoglobin Monitoring: A Systematic Review and MetaAnalysis. Anesthesia & Analgesia: August 2014 - Volume 119 - Issue 2 - p 332-346. doi: 10.1213/ANE.0000000000000272.41. Lee, JH., Park, YH. & Kim, JT. Current Use of Noninvasive Hemoglobin Monitoring in Anesthesia. Curr Anesthesiol Rep 4, 233–241 (2014). https://doi.org/10.1007/s40140014-0070-942. Colquhoun, D.A., Forkin, K.T., Durieux, M.E. et al. Ability of the Masimo pulse COOximeter to detect changes in hemoglobin. J Clin Monit Comput 26, 69–73 (2012). https://doi.org/10.1007/s10877-012-9335-343. National blood Authority Australia. Patient blood management guidelines. (2011) https://www.blood.gov.au/pbm-guidelines.44. American Society of Anesthesiologists Task Force on Perioperative Blood Management. Practice guidelines for perioperative blood management: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Management. Anesthesiology. 2015 Feb;122(2):241-75. doi: 10.1097/ALN.0000000000000463. PMID: 25545654.45. Rayyan AI. Plataforma de gestión de revisiones sistemáticas. Disponible en: https://new.rayyan.ai46. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hróbjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, Moher D. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021 Mar 29;372:n71. doi: 10.1136/bmj.n71. PMID: 33782057; PMCID: PMC8005924.47. Evidence Synthesis Hackathon. PRISMA2020 R package and ShinyApp for making PRISMA2020 flow diagrams. Disponible https://www.eshackathon.org/software/PRISMA2020.html39. Joseph B, Haider A, Rhee P. Non-invasive hemoglobin monitoring. Int J Surg. 2016;33(Pt B):254-257. doi:10.1016/j.ijsu.2015.11.04848. Shea BJ, Reeves BC, Wells G, Thuku M, Hamel C, Moran J, Moher D, Tugwell P, Welch V, Kristjansson E, Henry DA. AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ. 2017 Sep 21;358:j4008. doi: 10.1136/bmj.j4008. PMID: 28935701; PMCID: PMC583336549. Cochrane. Risk of Bias 2 (RoB https://methods.cochrane.org/risk-bias-2 2) tool. 2017. Disponible en:50. AGREE Next Steps Consortium. Instrumento AGREE II Versión electrónica. 2019. Disponible en: https://portal.guiasalud.es/wp-content/uploads/2019/01/spanish-agreeii.pdf51. McMaster University. GRADEpro. [Accedido en Marzo de 2023]. Disponible en: https://www.gradepro.org/52. GRADEpro GDT/ Cochrane GRADEing [Accedido en Marzo de 2024]. Disponible en: GRADEpro GDT | Cochrane GRADEing53. RevMan Web (cochrane.org). [Accedido enero 2024]. Disponible en: RevMan Web (cochrane.org)54. Akdag S, Zengin SU, Cakmak G, Umuroglu T, Aykac ZZ, Saracoglu A. Targeted Bleeding Management Guided by Non-Invasive Haemoglobin Measurement in Surgical Patients. J Coll Physicians Surg Pak. 2022 Oct;32(10):1242-1248. doi: 10.29271/jcpsp.2022.10.1242. PMID: 36205265.54. Akdag S, Zengin SU, Cakmak G, Umuroglu T, Aykac ZZ, Saracoglu A. Targeted Bleeding Management Guided by Non-Invasive Haemoglobin Measurement in Surgical Patients. J Coll Physicians Surg Pak. 2022 Oct;32(10):1242-1248. doi: 10.29271/jcpsp.2022.10.1242. PMID: 36205265.56. Tang B, Yu X, Xu L, Zhu A, Zhang Y, Huang Y. Continuous noninvasive hemoglobin monitoring estimates timing for detecting anemia better than clinicians: a randomized controlled trial. BMC Anesthesiol. 2019 May 17;19(1):80. doi: 10.1186/s12871-019-07551. PMID: 31101083; PMCID: PMC6525351.57. Bugaev N, Como JJ, Golani G, Freeman JJ, Sawhney JS, Vatsaas CJ, Yorkgitis BK, Kreiner LA, Garcia NM, Aziz HA, Pappas PA, Mahoney EJ, Brown ZW, Kasotakis G. Thromboelastography and rotational thromboelastometry in bleeding patients with coagulopathy: Practice management guideline from the Eastern Association for the Surgery of Trauma. J Trauma Acute Care Surg. 2020 Dec;89(6):999-1017. doi: 10.1097/TA.0000000000002944. Erratum in: J Trauma Acute Care Surg. 2021 Apr 1;90(4):766-767. PMID: 32941349.58. Sampaio AM, Guimarães GMN, Medeiros GP, Damasceno GMM, Silva RMA, Nunes RR, Rocha HAL, Nascimento JCR. Eficácia e segurança de antifibrinolíticos em cirurgia 81 oncológica: uma revisão sistemática e metanálise [Efficacy and safety of antifibrinolytics in oncological surgery: a systematic review and meta-analysis]. Braz J Anesthesiol. 2019 Sep-Oct;69(5):484-492. doi: 10.1016/j.bjan.2019.06.005. Epub 2019 Oct 19. PMID: 31640900; PMCID: PMC9391867.59. Longo MA, Cavalheiro BT, de Oliveira Filho GR. Systematic review and meta-analyses of tranexamic acid use for bleeding reduction in prostate surgery. J Clin Anesth. 2018 Aug;48:32-38. doi: 10.1016/j.jclinane.2018.04.014. Epub 2018 May 1. PMID: 29727761.60. Clynch AL, Gillespie CS, Richardson GE, Mustafa MA, Islim AI, Keshwara SM, Bakhsh A, Kumar S, Zakaria R, Millward CP, Mills SJ, Brodbelt AR, Jenkinson MD. Tranexamic acid use in meningioma surgery - A systematic review and meta-analysis. J Clin Neurosci. 202361. Kietpeerakool C, Supoken A, Laopaiboon M, Lumbiganon P. Effectiveness of tranexamic acid in reducing blood loss during cytoreductive surgery for advanced ovarian cancer. Cochrane Database Syst Rev. 2016 Jan 23;2016(1):CD01173262. Wijaya JH, July J, Quintero-Consuegra M, Chadid DP. A systematic review and metaanalysis of the effects of tranexamic acid in surgical procedure for intracranial meningioma. J Neurooncol. 2023 Jan;161(2):383-393. doi: 10.1007/s11060-023-04237-2. Epub 2023 Jan 12. PMID: 36633801.63. Fowler H, Law J, Tham SM, Gunaravi SA, Houghton N, Clifford RE, Fok M, Barker JA, Vimalachandran D. Impact on blood loss and transfusion rates following administration of tranexamic acid in major oncological abdominal and pelvic surgery: A systematic review and meta-analysis. J Surg Oncol. 2022 Sep;126(3):609-621. doi: 10.1002/jso.26900. Epub 2022 Apr 26. PMID: 35471705.64. Karanicolas PJ, Lin Y, Tarshis J, et al. Major liver resection, systemic fibrinolytic activity, and the impact of tranexamic acid. HPB (Oxford). 2016;18(12):991-999. doi:10.1016/j.hpb.2016.09.00565. Jadad AR, Moore RA, Carroll D et al (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17:1–12. https:// doi. org/ 10. 1016/ 0197- 2456(95) 00134-466. Weber RS, Jabbour N, Martin RC 2nd. Anemia and transfusions in patients undergoing surgery for cancer. Ann Surg Oncol. 2008 Jan;15(1):34-45. doi: 10.1245/s10434-0079502-9. Epub 2007 Oct 18. PMID: 17943390; PMCID: PMC7101818.67. Pang QY, An R, Liu HL. Perioperative transfusion and the prognosis of colorectal cancer surgery: a systematic review and meta-analysis. World J Surg Oncol. 2019 Jan 5;17(1):7. doi: 10.1186/s12957-018-1551-y. PMID: 30611274; PMCID: PMC6321702.68. Myles PS, Smith JA, Forbes A, et al. Tranexamic Acid in Patients Undergoing CoronaryArtery Surgery [published correction appears in N Engl J Med. 2018 Feb 22;378(8):782]. N Engl J Med. 2017;376(2):136-148. doi:10.1056/NEJMoa160642469. Sukeik M, Alshryda S, Haddad FS, Mason JM. Systematic review and meta-analysis of the use of tranexamic acid in total hip replacement. J Bone Joint Surg Br. 2011 Jan 1;93B(1):39-46. https://doi.org/10.1302/0301-620X.93B1.2498470. Abdol Razak NB, Jones G, Bhandari M, Berndt MC, Metharom P. Cancer-Associated Thrombosis: An Overview of Mechanisms, Risk Factors, and Treatment. Cancers (Basel). 2018 Oct 11;10(10):380. doi: 10.3390/cancers10100380. PMID: 30314362; PMCID: PMC6209883.71. Khalil J, Bensaid B, Elkacemi H, et al. Venous thromboembolism in cancer patients: an underestimated major health problem. World J Surg Oncol. 2015;13:204. DOI: 10.1186/s12957-015-0592-872. Houston BL, Uminski K, Mutter T, Rimmer E, Houston DS, Menard CE, Garland A, Ariano R, Tinmouth A, Abou-Setta AM, Rabbani R, Neilson C, Rochwerg B, Turgeon AF, Falk J, Breau RH, Fergusson DA, Zarychanski R. Efficacy and Safety of Tranexamic Acid in Major Non-Cardiac Surgeries at High Risk for Transfusion: A Systematic Review and MetaAnalysis. Transfus Med Rev. 2020 Jan;34(1):51-62. doi: 10.1016/j.tmrv.2019.10.001. Epub 2019 Oct 23. PMID: 31982293.73. McDaniel LM, Neal MD, Sperry JL, Alarcon LH, Forsythe RM, Triulzi D, Peitzman AB, Raval JS. Use of a massive transfusion protocol in nontrauma patients: activate away. J Am Coll Surg. 2013 Jun;216(6):1103-9. doi: 10.1016/j.jamcollsurg.2013.02.008. Epub 2013 Apr 6. PMID: 23571144.74. Johansson PI, Stensballe J, Rosenberg I, Hilsløv TL, Jørgensen L, Secher NH. Proactive administration of platelets and plasma for patients with a ruptured abdominal aortic aneurysm: evaluating a change in transfusion practice. Transfusion. 2007 Apr;47(4):5938. doi: 10.1111/j.1537-2995.2007.01160.x. PMID: 17381616.75. Martínez-Calle N, Hidalgo F, Alfonso A, Muñoz M, Hernández M, Lecumberri R, Páramo JA. Implementation of a management protocol for massive bleeding reduces mortality in non-trauma patients: Results from a single centre audit. Med Intensiva. 2016 Dec;40(9):550-559. English, Spanish. doi: 10.1016/j.medin.2016.05.003. Epub 2016 Jul 15. PMID: 27425576.76. Dutta EH, Poole AT, Behnia F, Dunn HE, Clark SM, Pacheco LD, Saade GR, Hankins GDV. Hemostatic Resuscitation in Peripartum Hysterectomy Pre- and Postmassive Transfusion Protocol Initiation. Am J Perinatol. 2017 Jul;34(9):861-866. doi: 10.1055/s-0037-1599103. Epub 2017 Mar 6. PMID: 28264207.77. RiskinDJ, Tsai TC, Riskin L,Hernandez-Boussard T, PurtillM,Maggio PM, Spain DA, Brundage SI. Massive transfusion protocols: the role of aggressive resuscitation versus product ratio in mortality reduction. J Am Coll Surg. 2009;209(2):198–205.78. Cotton BA, Au BK, Nunez TC, Gunter OL, Robertson AM, Young PP. Predefined massive transfusion protocols are associated with a reduction in organ failure and postinjury complications. J Trauma. 2009;66(1):41–48; discussion 48–9.79. ACS TQIP Best Practice Guidelines. Accessed 08-20-2018. Available from: https://www.facs.org/quality-programs/trauma/tqip/best-practice.80. Sihler KC, Napolitano LM. Complications of massive transfusion. Chest. 2010 Jan;137(1):209-20. doi: 10.1378/chest.09-0252. Erratum in: Chest. 2010 Mar;137(3):744. PMID: 20051407.81. Sommer N, Schnüriger B, Candinas D, Haltmeier T. Massive transfusion protocols in nontrauma patients: A systematic review and meta-analysis. J Trauma Acute Care Surg. 2019 Mar;86(3):493-504. doi: 10.1097/TA.0000000000002101. PMID: 30376535.82. van den Brink DP, Wirtz MR, Neto AS, Schöchl H, Viersen V, Binnekade J, Juffermans NP. Effectiveness of prothrombin complex concentrate for the treatment of bleeding: A systematic review and meta-analysis. J Thromb Haemost. 2020 Oct;18(10):2457-2467. doi: 10.1111/jth.14991. Epub 2020 Aug 2. PMID: 32638483; PMCID: PMC7589201.83. Kao TW, Lee YC, Chang HT. Prothrombin Complex Concentrate for Trauma Induced Coagulopathy: A Systematic Review and Meta-Analysis. J Acute Med. 2021 Sep 1;11(3):81-89. doi: 10.6705/j.jacme.202109_11(3).0001. PMID: 34595091; PMCID: PMC8440438.84. Bouzat P, Charbit J, Abback PS, Huet-Garrigue D, Delhaye N, Leone M, Marcotte G, David JS, Levrat A, Asehnoune K, Pottecher J, Duranteau J, Courvalin E, Adolle A, Sourd D, Bosson JL, Riou B, Gauss T, Payen JF; PROCOAG Study Group. Efficacy and Safety of Early Administration of 4-Factor Prothrombin Complex Concentrate in Patients With Trauma at Risk of Massive Transfusion: The PROCOAG Randomized Clinical Trial. JAMA. 2023 Apr 25;329(16):1367-1375. doi: 10.1001/jama.2023.4080. PMID: 36942533; PMCID: PMC10031505.85. Maegele M, Lefering R, Yucel N, et al. Early coagulopathy in multiple injury: an analysis from the German trauma registry on 8724 patients. Injury. 2007;38:298-304.86. Bassin L, Stone M, Krol M, Reich DL. Risk factors for intraoperative coagulopathy in cardiac surgery. Heart Lung Circ. 2010;19:506.87. Silvergleid AJ. Inmunologic transfusión reactions. UpToDate. Disponible en: https://www.uptodate.com/contents/immunologic-transfusion-reactions88. Kleinman S, Kor DJ. Transfusion-related acute lung injury (TRALI). UpToDate. Disponible en: https://www.uptodate.com/contents/transfusion-related-acute-lung-injury-trali89. Khan S, Davenport R, Raza I, et al. Damage control resuscitation using blood component therapy in standard doses has a limited effect on coagulopathy during trauma hemorrhage. Intensive Care Med. 2015;41:239-247.90. Franchini M, Lippi G. Prothrombin complex concentrates: an update. 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