Implicaciones funcionales de los linfocitos B en el desarrollo de la artritis reumatoide

Los linfocitos B tienen un papel importante en la regulación del sistema inmune, pues además de producir anticuerpos, son células presentadoras de antígenos que interactúan con otras células mo-nonucleares y contribuyen directamente en las vías inflamatorias. Existe evidencia acerca de una disrupció...

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Autores:: Páez Leal, María Carolina
Gómez, Luis Miguel
Anaya, Juan Manuel

Tipo de recurso:: Article of journal

Fecha de publicación:: 2006

Institución:: Universidad Autónoma de Bucaramanga - UNAB

Repositorio:: Repositorio UNAB

Idioma:: spa

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network_acronym_str	UNAB2
network_name_str	Repositorio UNAB
repository_id_str
dc.title.none.fl_str_mv	Implicaciones funcionales de los linfocitos B en el desarrollo de la artritis reumatoide
title	Implicaciones funcionales de los linfocitos B en el desarrollo de la artritis reumatoide
spellingShingle	Implicaciones funcionales de los linfocitos B en el desarrollo de la artritis reumatoide Ciencias médicas Innovaciones en salud Investigaciones Health Sciences Medicine Medical Sciences Biomedical Sciences Life Sciences Innovations in health Research B cells Rheumatoid arthritis Rheumatoid factor Anti-cyclic citrullinated peptide antibodies (Anti-CCP) BAFF Anti-CD20 Ciencias de la salud Medicina Ciencias biomédicas Ciencias de la vida Linfocitos B Artritis reumatoide Factor reumatoide Anticuerpos anti-péptidos cíclicos citrulinados (Anti-CCP) BAFF Anticuerpos anti-CD20
title_short	Implicaciones funcionales de los linfocitos B en el desarrollo de la artritis reumatoide
title_full	Implicaciones funcionales de los linfocitos B en el desarrollo de la artritis reumatoide
title_fullStr	Implicaciones funcionales de los linfocitos B en el desarrollo de la artritis reumatoide
title_full_unstemmed	Implicaciones funcionales de los linfocitos B en el desarrollo de la artritis reumatoide
title_sort	Implicaciones funcionales de los linfocitos B en el desarrollo de la artritis reumatoide
dc.creator.fl_str_mv	Páez Leal, María Carolina Gómez, Luis Miguel Anaya, Juan Manuel
dc.contributor.author.spa.fl_str_mv	Páez Leal, María Carolina Gómez, Luis Miguel Anaya, Juan Manuel
dc.contributor.cvlac.none.fl_str_mv	Páez Leal, María Carolina [0000066656]
dc.contributor.googlescholar.none.fl_str_mv	Páez Leal, María Carolina [BAPR3-cAAAAJ]
dc.contributor.orcid.none.fl_str_mv	Páez Leal, María Carolina [0000-0002-0310-0125]
dc.contributor.scopus.none.fl_str_mv	Páez Leal, María Carolina [12243485600]
dc.contributor.researchgate.none.fl_str_mv	Páez Leal, María Carolina [profile/Maria_Paez-Leal] Páez Leal, María Carolina [profile/Maria_Paez-Leal]
dc.contributor.researchgroup.spa.fl_str_mv	Grupo de Estudio Genético de Enfermedades Complejas Grupo de Investigaciones Clínicas
dc.subject.none.fl_str_mv	Ciencias médicas Innovaciones en salud Investigaciones
topic	Ciencias médicas Innovaciones en salud Investigaciones Health Sciences Medicine Medical Sciences Biomedical Sciences Life Sciences Innovations in health Research B cells Rheumatoid arthritis Rheumatoid factor Anti-cyclic citrullinated peptide antibodies (Anti-CCP) BAFF Anti-CD20 Ciencias de la salud Medicina Ciencias biomédicas Ciencias de la vida Linfocitos B Artritis reumatoide Factor reumatoide Anticuerpos anti-péptidos cíclicos citrulinados (Anti-CCP) BAFF Anticuerpos anti-CD20
dc.subject.keywords.eng.fl_str_mv	Health Sciences Medicine Medical Sciences Biomedical Sciences Life Sciences Innovations in health Research
dc.subject.keywords.none.fl_str_mv	B cells Rheumatoid arthritis Rheumatoid factor Anti-cyclic citrullinated peptide antibodies (Anti-CCP) BAFF Anti-CD20
dc.subject.lemb.none.fl_str_mv	Ciencias de la salud Medicina Ciencias biomédicas Ciencias de la vida
dc.subject.proposal.none.fl_str_mv	Linfocitos B Artritis reumatoide Factor reumatoide Anticuerpos anti-péptidos cíclicos citrulinados (Anti-CCP) BAFF Anticuerpos anti-CD20
description	Los linfocitos B tienen un papel importante en la regulación del sistema inmune, pues además de producir anticuerpos, son células presentadoras de antígenos que interactúan con otras células mo-nonucleares y contribuyen directamente en las vías inflamatorias. Existe evidencia acerca de una disrupción en la regulación de estos procesos en la patogénesis de las enfermedades autoin-munes, tales como la artritis reumatoide (AR). Esta enfermedad se caracteriza por una inflamación crónica de las articulaciones afectadas en las que es característico el desarrollo de centros germinales ectópicos en la membrana sinovial. Este microambiente facilita la diferenciación y activación de las células B, las cuales, al transformarse en células plasmáticas, secretan directamente en la membrana sinovial anticuerpos de alta afinidad. En consecuencia, la formación de complejos inmunes con la posterior activación de la cascada del complemento y el estímulo de macrófagos, contribuyen en la destrucción de la articulación. Las células B también tienen un papel relevante en la activación de las células T sinoviales y en la inducción de la síntesis de citoquinas. Finalmente, la eficacia terapéutica obtenida con la depleción de linfocitos B por medio del uso de anticuerpos monoclonales contra CD20, enfatiza su importancia en la patogénesis de la AR [Páez M-C, Gómez LM, Anaya J-M. Functional implications of B lymphocytes in the development of reumatoide arthritis. MedUNAB 2006; 9:34-44]
publishDate	2006
dc.date.issued.none.fl_str_mv	2006-04-02
dc.date.accessioned.none.fl_str_mv	2020-10-27T14:21:34Z
dc.date.available.none.fl_str_mv	2020-10-27T14:21:34Z
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dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/article
dc.type.local.spa.fl_str_mv	Artículo
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dc.type.redcol.none.fl_str_mv	http://purl.org/redcol/resource_type/ART
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dc.identifier.issn.none.fl_str_mv	2382-4603 0123-7047
dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/20.500.12749/10402
dc.identifier.instname.spa.fl_str_mv	instname:Universidad Autónoma de Bucaramanga UNAB
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url	http://hdl.handle.net/20.500.12749/10402
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dc.relation.none.fl_str_mv	https://revistas.unab.edu.co/index.php/medunab/article/view/167/152
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Targeting B cells for the treatment of rheumatoid arthritis Arthritis Res Ther 2003; 5(Suppl 4):S7-S11 Pierce SK. Lipid rafts and B cell activation. Nat Rev Immunol 2002; 2:96-105 Martín-Belmonte F, Millán J. Estructura y función de las balsas lipídicas (“rafts”), dominios de membrana ricos en esfingolípidos y colesterol. Inmunología 2001; 20:216-24 Cherukuri A, Cheng PC, Sohn HW, Pierce SK. The CD19/CD21 complex functions to prolong B cell antigen receptor signaling from lipid rafts. Immunity 2001; 14:169-79 Aman MJ, Tosello-Trampont AC, Ravichandran K. Fc_RIIB1/SHIP-mediated inhibitory signalling in B cells involves lipid rafts. J Biol Chem 2001; 276:46371-8 Rajewsky K. Clonal selection and learning in the antibody sys-tem. Nature 1996; 381:751-8 Gay D, Saunders T, Camper S, Weigert M. Receptor editing: an approach by autoreactive B cells to escape tolerance. J Exp Med 1993; 177:999-108 Tiegs SL, Russel DM, Nemazee D. Receptor editing in self-reactive bone marrow B cells. J Exp Med 1993; 177:1009-20 Radic MZ, Zouali M. Receptor editing, immune diversification and self-tolerance. Immunity 1996; 5:505-11 Oettinger MA, Schatz DG, Gorka C, Baltimore D. RAGl and RAG2, adjacent genes that synergistically activate V(D) recom-bination. Science 1990; 248:1517-23 Rycke LD, Nicholas AP, Cantaert T, Kruithof E, Echols JD, Vande-kerckhove B et al. Intracellular Citrullinated Proteins Colocalizing With Peptidyl Arginine Deiminase as Pathophysiologically Re-levant Antigenic Determinants of Rheumatoid Arthritis–Specific Humoral Autoimmunity. Arth Rheum 2005; 52:2323–30 Panayi GS, Hainsworth JD, Looney RJ, Keystone EC. Panel discussion on B cells and rituximab: mechanistic aspects, ef.cacy and safety in rheumatoid arthritis and non-Hodgkin’s lymphoma. Rheumatology 2005; 44(Suppl. 2):ii18–ii20 Goryman C, Leandro M, Isenberg DA. Does B cell depletion have a role to play in the treatment of systemic lupus erythematosus? Lupus 2004; 13:312-6 Looney RJ. B cells as a therapeutic target in autoimmune diseases other than rheumatoid arthritis Rheumatology 2005; 44(Suppl. 2):ii13–ii17
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dc.publisher.none.fl_str_mv	Universidad Autónoma de Bucaramanga UNAB
dc.publisher.faculty.none.fl_str_mv	Facultad Ciencias de la Salud
dc.publisher.program.none.fl_str_mv	Pregrado Medicina
publisher.none.fl_str_mv	Universidad Autónoma de Bucaramanga UNAB
dc.source.none.fl_str_mv	MedUNAB; Vol. 9 Núm. 1 (2006): Linfocitos B, Mortalidad Evitable, Trastornos del sueño; 34-44
institution	Universidad Autónoma de Bucaramanga - UNAB
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spelling	Páez Leal, María Carolina4c30d3de-095b-4497-b14c-f1501234ab69-1Gómez, Luis Miguel662b452c-49fa-4fed-90e2-5970788f74f6-1Anaya, Juan Manuelcb72a28e-6305-4920-b02c-650f95e962e4-1Páez Leal, María Carolina [0000066656]Páez Leal, María Carolina [BAPR3-cAAAAJ]Páez Leal, María Carolina [0000-0002-0310-0125]Páez Leal, María Carolina [12243485600]Páez Leal, María Carolina [profile/Maria_Paez-Leal]Páez Leal, María Carolina [profile/Maria_Paez-Leal]Grupo de Estudio Genético de Enfermedades ComplejasGrupo de Investigaciones Clínicas2020-10-27T14:21:34Z2020-10-27T14:21:34Z2006-04-022382-46030123-7047http://hdl.handle.net/20.500.12749/10402instname:Universidad Autónoma de Bucaramanga UNABrepourl:https://repository.unab.edu.coLos linfocitos B tienen un papel importante en la regulación del sistema inmune, pues además de producir anticuerpos, son células presentadoras de antígenos que interactúan con otras células mo-nonucleares y contribuyen directamente en las vías inflamatorias. Existe evidencia acerca de una disrupción en la regulación de estos procesos en la patogénesis de las enfermedades autoin-munes, tales como la artritis reumatoide (AR). Esta enfermedad se caracteriza por una inflamación crónica de las articulaciones afectadas en las que es característico el desarrollo de centros germinales ectópicos en la membrana sinovial. Este microambiente facilita la diferenciación y activación de las células B, las cuales, al transformarse en células plasmáticas, secretan directamente en la membrana sinovial anticuerpos de alta afinidad. En consecuencia, la formación de complejos inmunes con la posterior activación de la cascada del complemento y el estímulo de macrófagos, contribuyen en la destrucción de la articulación. Las células B también tienen un papel relevante en la activación de las células T sinoviales y en la inducción de la síntesis de citoquinas. Finalmente, la eficacia terapéutica obtenida con la depleción de linfocitos B por medio del uso de anticuerpos monoclonales contra CD20, enfatiza su importancia en la patogénesis de la AR [Páez M-C, Gómez LM, Anaya J-M. Functional implications of B lymphocytes in the development of reumatoide arthritis. MedUNAB 2006; 9:34-44]B cells play a key role in regulating the immune system by producing antibodies, acting as antigen-presenting cells, providing support to other mononuclear cells, and contributing directly to inflammatory pathways. Accumulating evidence indicates that there is a disruption of these regulated processes in the pathogenesis of autoimmune diseases, including rheumatoid arthritis (RA). In RA there is a chronic inflammation in the affected joints leading to the development of ectopic germinal centers. A micro-environment is established which supports B cell activation and differentiation. Plasma cells may develop which secrete autoantibodies of high affinity directly into the synovial tissue. As a result, antigen/antibody complex forma-tion, the activation of the complement cascade and the stimulation of macrophages may contribute to the destruction of joints. B cells also play a pivotal role in the activation of synovial T cells and the induction of cytokine secretion. Finally, the success of B cell deple-tion therapy by using monoclonal antibodies against CD20 further emphasized the importance of B cells in the pathogenesis of RA [Páez M-C, Gómez LM, Anaya J-M. Functional implications of B lymphocytes in the development of reumatoide arthritis. MedUNAB 2006; 9:34-44]application/pdfspaUniversidad Autónoma de Bucaramanga UNABFacultad Ciencias de la SaludPregrado Medicinahttps://revistas.unab.edu.co/index.php/medunab/article/view/167/152https://revistas.unab.edu.co/index.php/medunab/article/view/167Spindler A, Bellomio V, Berman A, Lucero E, Baigorria M, Paz Set al. 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B cells as a therapeutic target in autoimmune diseases other than rheumatoid arthritis Rheumatology 2005; 44(Suppl. 2):ii13–ii17MedUNAB; Vol. 9 Núm. 1 (2006): Linfocitos B, Mortalidad Evitable, Trastornos del sueño; 34-44Ciencias médicasInnovaciones en saludInvestigacionesHealth SciencesMedicineMedical SciencesBiomedical SciencesLife SciencesInnovations in healthResearchB cellsRheumatoid arthritisRheumatoid factorAnti-cyclic citrullinated peptide antibodies (Anti-CCP)BAFFAnti-CD20Ciencias de la saludMedicinaCiencias biomédicasCiencias de la vidaLinfocitos BArtritis reumatoideFactor reumatoideAnticuerpos anti-péptidos cíclicos citrulinados (Anti-CCP)BAFFAnticuerpos anti-CD20Implicaciones funcionales de los linfocitos B en el desarrollo de la artritis reumatoidehttp://creativecommons.org/licenses/by-nc-nd/2.5/co/Atribución-NoComercial-SinDerivadas 2.5 Colombiahttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/articleArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85ORIGINAL2006_Implicaciones_funcionale_de_los_linfocitos.pdf2006_Implicaciones_funcionale_de_los_linfocitos.pdfArticuloapplication/pdf1841193https://repository.unab.edu.co/bitstream/20.500.12749/10402/1/2006_Implicaciones_funcionale_de_los_linfocitos.pdff7398ae994c9ecac21a37d7bcb97bb26MD51open accessTHUMBNAIL2006_Implicaciones_funcionale_de_los_linfocitos.pdf.jpg2006_Implicaciones_funcionale_de_los_linfocitos.pdf.jpgIM Thumbnailimage/jpeg9307https://repository.unab.edu.co/bitstream/20.500.12749/10402/2/2006_Implicaciones_funcionale_de_los_linfocitos.pdf.jpga476ca420c212a536609227b1254f60dMD52open access20.500.12749/10402oai:repository.unab.edu.co:20.500.12749/104022024-01-19 14:09:18.478open accessRepositorio Institucional \| Universidad Autónoma de Bucaramanga - UNABrepositorio@unab.edu.co

Implicaciones funcionales de los linfocitos B en el desarrollo de la artritis reumatoide

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