Hernia diafragmática congénita posterolateral derecha sin herniación hepática: presentación de caso con tratamiento exitoso

La hernia diafragmática congénita es un defecto en la formación del diafragma con una alta mortalidad y morbilidad para el recién nacido. La ubicación en el lado derecho corresponde a solo el 10% de todos los casos y se asocia con una menor supervivencia, especialmente cuando hay una herniación hepá...

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Autores:
Rubio Duarte, Andrés Felipe
Angarita, Daniel Ricardo
Zarate Suárez, Luis Augusto
Tipo de recurso:
Article of investigation
Fecha de publicación:
2021
Institución:
Universidad Autónoma de Bucaramanga - UNAB
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Repositorio UNAB
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spa
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oai:repository.unab.edu.co:20.500.12749/15890
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http://hdl.handle.net/20.500.12749/15890
Palabra clave:
Diaphragmatic hernia
Congenital anomalies
Medicine
Newborn
Medicina
Ciencias de la salud
Hernia diafragmática
Anomalías congénitas
Recién nacido
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network_acronym_str UNAB2
network_name_str Repositorio UNAB
repository_id_str
dc.title.spa.fl_str_mv Hernia diafragmática congénita posterolateral derecha sin herniación hepática: presentación de caso con tratamiento exitoso
dc.title.translated.spa.fl_str_mv Right posterolateral congenital diaphragmatic hernia without hepatic herniation: case report with successful treatment
title Hernia diafragmática congénita posterolateral derecha sin herniación hepática: presentación de caso con tratamiento exitoso
spellingShingle Hernia diafragmática congénita posterolateral derecha sin herniación hepática: presentación de caso con tratamiento exitoso
Diaphragmatic hernia
Congenital anomalies
Medicine
Newborn
Medicina
Ciencias de la salud
Hernia diafragmática
Anomalías congénitas
Recién nacido
title_short Hernia diafragmática congénita posterolateral derecha sin herniación hepática: presentación de caso con tratamiento exitoso
title_full Hernia diafragmática congénita posterolateral derecha sin herniación hepática: presentación de caso con tratamiento exitoso
title_fullStr Hernia diafragmática congénita posterolateral derecha sin herniación hepática: presentación de caso con tratamiento exitoso
title_full_unstemmed Hernia diafragmática congénita posterolateral derecha sin herniación hepática: presentación de caso con tratamiento exitoso
title_sort Hernia diafragmática congénita posterolateral derecha sin herniación hepática: presentación de caso con tratamiento exitoso
dc.creator.fl_str_mv Rubio Duarte, Andrés Felipe
Angarita, Daniel Ricardo
Zarate Suárez, Luis Augusto
dc.contributor.author.none.fl_str_mv Rubio Duarte, Andrés Felipe
Angarita, Daniel Ricardo
Zarate Suárez, Luis Augusto
dc.subject.keywords.spa.fl_str_mv Diaphragmatic hernia
Congenital anomalies
Medicine
Newborn
topic Diaphragmatic hernia
Congenital anomalies
Medicine
Newborn
Medicina
Ciencias de la salud
Hernia diafragmática
Anomalías congénitas
Recién nacido
dc.subject.lemb.spa.fl_str_mv Medicina
Ciencias de la salud
dc.subject.proposal.spa.fl_str_mv Hernia diafragmática
Anomalías congénitas
Recién nacido
description La hernia diafragmática congénita es un defecto en la formación del diafragma con una alta mortalidad y morbilidad para el recién nacido. La ubicación en el lado derecho corresponde a solo el 10% de todos los casos y se asocia con una menor supervivencia, especialmente cuando hay una herniación hepática. No se conoce con precisión el porcentaje de casos de hernia diafragmática congénita derecha que no implican una herniación hepática. Aun no hay certeza del tiempo estimado para obtener el mayor beneficio de la corrección quirúrgica, en nuestro caso realizado con éxito a los 2 días de vida, logrando previamente una adecuada estabilidad hemodinámica y ventilatoria. El manejo perioperatorio en unidad de cuidado intensivo neonatal, es fundamental para reducir la morbimortalidad asociada. Se presenta un caso de hernia diafragmática congénita derecha tratado con éxito y se exponen los aspectos más relevantes del manejo médicoquirúrgico de esta patología
publishDate 2021
dc.date.issued.none.fl_str_mv 2021
dc.date.accessioned.none.fl_str_mv 2022-03-11T20:35:12Z
dc.date.available.none.fl_str_mv 2022-03-11T20:35:12Z
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dc.relation.references.spa.fl_str_mv Chandrasekharan PK, Rawat M, Madappa R, Rothstein DH, Lakshminrusimha S. Congenital diaphragmatic hernia: A review. Matern Health Neonatol Perinatol. 2017; 3(6): 532-40.
McGivern MR, Best KE, Rankin J, Wellesley D, Greenlees R, Addor MC, et al. Epidemiology of congenital diaphragmatic hernia in Europe: A register-based study. Arch Dis Child Fetal Neonatal Ed. 2015; 100(2): F137-44.
Woodbury JM, Bojanić K, Grizelj R, Cavalcante AN, Donempudi VK, Weingarten TN, et al. Incidence of congenital diaphragmatic hernia in Olmsted County, Minnesota: a population-based study. J Matern Neonatal Med. 2019; 32(5): 742-8.
Larsen UL, Jepsen S, Strøm T, Qvist N, Toft P. Congenital diaphragmatic hernia presenting with symptoms within the first day of life; outcomes from a non-ECMO centre in Denmark. BMC Pediatr. 2020; 20(1): 196.
Brownlee EM, Howatson AG, Davis CF, Sabharwal AJ. The hidden mortality of congenital diaphragmatic hernia: a 20-year review. J Pediatr Surg. 2009; 44(2): 317-20.
Mantilla JC, Melo MA, Vargas LM. Hernia diagfragmática congénita derecha en el Hospital Universitario de Santander. Salud UIS [Internet]. 2010; 42(2): 133-8. Disponible en: http:// www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0121- 08072010000200007&lng=en
Lally KP, Lasky RE, Lally PA, Bagolan P, Davis CF, Frenckner BP, et al. Standardized reporting for congenital diaphragmatic hernia - An international consensus. J Pediatr Surg. 2013; 48(12): 2408-15.
Antonoff MB, Hustead VA, Groth SS, Schmeling DJ. Protocolized management of infants with congenital diaphragmatic hernia: Effect on survival. J Pediatr Surg. 2011; 46(1): 39-46.
Holcomb G, Murphy JP, St Peter S. Ashcraft’s Pediatric Surgery. 7th ed. Elsevier; 2019 Abr 14.
Kadir D, Lilja HE. Risk factors for postoperative mortality in congenital diaphragmatic hernia: a single-centre observational study. Pediatr Surg Int. 2017; 33(3): 317-23.
Bojanić K, Woodbury JM, Cavalcante AN, Grizelj R, Asay GF, Colby CE, et al. Congenital diaphragmatic hernia: outcomes of neonates treated at Mayo Clinic with and without extracorporeal membrane oxygenation. Paediatr Anaesth. 2017; 27(3): 314-21.
Malekzadegan A, Sargazi A. Congenital Diaphragmatic Hernia with Delayed Presentation. Case Rep Surg. 2016 Oct 30; 2016(2016): 1-4.
Gallot D, Coste K, Francannet C, Laurichesse H, Boda C, Ughetto S, et al. Antenatal detection and impact on outcome of congenital diaphragmatic hernia: a 12-year experience in Auvergne, France. Eur J Obstet Gynecol Reprod Biol. 2006; 125(2): 202-5.
Kotecha S, Barbato A, Bush A, Claus F, Davenport M, Delacourt C, et al. Congenital diaphragmatic hernia. Eur Respir J. 2012; 39(4): 820-9.
Tovar JA. Congenital Diaphragmatic Hernia. Orphanet J Rare Dis. 2012 En 3; 7(1): 1-15.
Mullins ME, Stein J, Saini SS, Mueller PR. Prevalence of Incidental Bochdalek’s Hernia in a Large Adult Population. AJR Am J Roentgenol. 2001; 177(2): 363-6.
Hartnett KS. Congenital diaphragmatic hernia: Advanced physiology and care concepts. Adv Neonatal Care. 2008; 8(2): 107-15.
Stoll C, Alembik Y, Dott B, Roth MP. Associated malformations in patients with esophageal atresia. Eur J Med Genet. 2009; 52(5): 287-90.
Harting MT. Congenital diaphragmatic hernia-associated pulmonary hypertension. Semin Pediatr Surg. 2017; 26(3): 147-53.
Montalva L, Antounians L, Zani A. Pulmonary hypertension secondary to congenital diaphragmatic hernia: factors and pathways involved in pulmonary vascular remodeling. Pediatr Res. 2019; 85(6): 754-68.
Tennant PW, Pearce MS, Bythell M, Rankin J. 20-year survival of children born with congenital anomalies: a population-based study. Lancet. 2010; 375(9715): 649-56.
McGivern MR, Best KE, Rankin J, Wellesley D, Greenlees R, Addor MC, et al. Epidemiology of congenital diaphragmatic hernia in Europe: A register-based study. Arch Dis Child Fetal Neonatal Ed. 2015; 100(2): F137-44.
Mullassery D, Ba’Ath ME, Jesudason EC, Losty PD. Value of liver herniation in prediction of outcome in fetal congenital diaphragmatic hernia: A systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2010; 35(5): 609-14.
Metkus AP, Filly RA, Stringer MD, Harrison MR, Adzick NS. Sonographic predictors of survival in fetal diaphragmatic hernia. J Pediatr Surg. 1996; 31(1): 148-52.
Chatziioannidis I, Mouravas V, Babatseva E. When is the appropriate timing of surgical repair for congenital diaphragmatic hernia? Hippokratia. 2014; 18(4): 381.
Datin-Dorriere V, Walter-Nicolet E, Rousseau V, Taupin P, Benachi A, Parat S, et al. Experience in the management of eighty-two newborns with congenital diaphragmatic hernia treated with high-frequency oscillatory ventilation and delayed surgery without the use of extracorporeal membrane oxygenation. J Intensive Care Med. 2008; 23(2): 128-35.
Migliazza L, Bellan C, Alberti D, Auriemma A, Burgio G, Colombo L, et al. A Retrospective study of 111 cases of congenital diaphragmatic hernia treated with early high-frequency oscillatory ventilation and presurgical stabilization. J Pediatr Surg. 2007; 42(9): 1526-32.
McHoney M, Hammond P. Role of ECMO in congenital diaphragmatic hernia. Arch Dis Child Fetal Neonatal Ed. 2018; 103(2): F178-81.
Danzer E. Kim SS. Neurodevelopmental outcome in congenital diaphragmatic hernia: Evaluation, predictors and outcome. World J Clin Pediatr. 2014; 3(3): 30-6.
Zani A, Zani-Ruttenstock E, Pierro A. Advances in the surgical approach to congenital diaphragmatic hernia. Semin Fetal Neonatal Med. 2014; 19(6): 364-9.
Rozmiarek AJ, Qureshi FG, Cassidy L, Ford HR, Hackam DJ. Factors influencing survival in newborns with congenital diaphragmatic hernia: The relative role of timing of surgery. J Pediatr Surg. 2004; 39(6): 821-4.
Puligandla PS, Skarsgard ED, Offringa M, Adatia I, Baird R, Bailey JAM, et al. Diagnosis and management of congenital diaphragmatic hernia: a clinical practice guideline. CMAJ. 2018; 190(4): E103-12.
Putnam LR, Harting MT, Tsao K, Morini F, Yoder BA, Luco M, et al. Congenital diaphragmatic hernia defect size and infant morbidity at discharge. Pediatrics. 2016; 138(5).
Peetsold MG, Heij HA, Kneepkens CMF, Nagelkerke AF, Huisman J, Gemke R. The long-term follow-up of patients with a congenital diaphragmatic hernia: A broad spectrum of morbidity. Pediatr Surg Int. 2009; 25(1): 1-17.
Morini F, Valfrè L, Bagolan P. Long-term morbidity of congenital diaphragmatic hernia: A plea for standardization. Semin Pediatr Surg. 2017; 26(5): 301-10.
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dc.publisher.faculty.spa.fl_str_mv Facultad Ciencias de la Salud
dc.source.spa.fl_str_mv Médicas UIS. Vol. 34 Núm. 3 (2021). Páginas 72-77
institution Universidad Autónoma de Bucaramanga - UNAB
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spelling Rubio Duarte, Andrés Felipe7dc5f2c3-96fb-4a91-a1c4-155026f20463Angarita, Daniel Ricardo57103509-5172-4ead-9e25-deb80f0e12e2Zarate Suárez, Luis Augusto12b38df9-d897-4b80-9c72-dfe340668b932022-03-11T20:35:12Z2022-03-11T20:35:12Z2021http://hdl.handle.net/20.500.12749/15890instname:Universidad Autónoma de Bucaramanga - UNABreponame:Repositorio Institucional UNABrepourl:https://repository.unab.edu.coLa hernia diafragmática congénita es un defecto en la formación del diafragma con una alta mortalidad y morbilidad para el recién nacido. La ubicación en el lado derecho corresponde a solo el 10% de todos los casos y se asocia con una menor supervivencia, especialmente cuando hay una herniación hepática. No se conoce con precisión el porcentaje de casos de hernia diafragmática congénita derecha que no implican una herniación hepática. Aun no hay certeza del tiempo estimado para obtener el mayor beneficio de la corrección quirúrgica, en nuestro caso realizado con éxito a los 2 días de vida, logrando previamente una adecuada estabilidad hemodinámica y ventilatoria. El manejo perioperatorio en unidad de cuidado intensivo neonatal, es fundamental para reducir la morbimortalidad asociada. Se presenta un caso de hernia diafragmática congénita derecha tratado con éxito y se exponen los aspectos más relevantes del manejo médicoquirúrgico de esta patologíaCongenital diaphragmatic hernia is a defect in the formation of the diaphragm with high mortality and morbidity for the newborn. Right-sided location corresponds to only 10% of all cases and is associated with lower survival, especially when there is liver herniation. The percentage of cases of right congenital diaphragmatic hernia that do not involve liver herniation is not precisely known. There is still no certainty of the estimated time to obtain the greatest benefit from surgical correction, in our case successfully performed at 2 days of life, previously achieving adequate hemodynamic and ventilatory stability. Perioperative management in the neonatal intensive care unit is essential to reduce associated morbidity and mortality. A case of successfully treated right congenital diaphragmatic hernia is presented and the most relevant aspects of the medical-surgical management of this pathology are exposed.application/pdfspahttps://revistas.uis.edu.co/index.php/revistamedicasuis/article/view/12916Chandrasekharan PK, Rawat M, Madappa R, Rothstein DH, Lakshminrusimha S. Congenital diaphragmatic hernia: A review. Matern Health Neonatol Perinatol. 2017; 3(6): 532-40.McGivern MR, Best KE, Rankin J, Wellesley D, Greenlees R, Addor MC, et al. Epidemiology of congenital diaphragmatic hernia in Europe: A register-based study. Arch Dis Child Fetal Neonatal Ed. 2015; 100(2): F137-44.Woodbury JM, Bojanić K, Grizelj R, Cavalcante AN, Donempudi VK, Weingarten TN, et al. Incidence of congenital diaphragmatic hernia in Olmsted County, Minnesota: a population-based study. J Matern Neonatal Med. 2019; 32(5): 742-8.Larsen UL, Jepsen S, Strøm T, Qvist N, Toft P. Congenital diaphragmatic hernia presenting with symptoms within the first day of life; outcomes from a non-ECMO centre in Denmark. BMC Pediatr. 2020; 20(1): 196.Brownlee EM, Howatson AG, Davis CF, Sabharwal AJ. The hidden mortality of congenital diaphragmatic hernia: a 20-year review. J Pediatr Surg. 2009; 44(2): 317-20.Mantilla JC, Melo MA, Vargas LM. Hernia diagfragmática congénita derecha en el Hospital Universitario de Santander. Salud UIS [Internet]. 2010; 42(2): 133-8. Disponible en: http:// www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0121- 08072010000200007&lng=enLally KP, Lasky RE, Lally PA, Bagolan P, Davis CF, Frenckner BP, et al. Standardized reporting for congenital diaphragmatic hernia - An international consensus. J Pediatr Surg. 2013; 48(12): 2408-15.Antonoff MB, Hustead VA, Groth SS, Schmeling DJ. Protocolized management of infants with congenital diaphragmatic hernia: Effect on survival. J Pediatr Surg. 2011; 46(1): 39-46.Holcomb G, Murphy JP, St Peter S. Ashcraft’s Pediatric Surgery. 7th ed. Elsevier; 2019 Abr 14.Kadir D, Lilja HE. Risk factors for postoperative mortality in congenital diaphragmatic hernia: a single-centre observational study. Pediatr Surg Int. 2017; 33(3): 317-23.Bojanić K, Woodbury JM, Cavalcante AN, Grizelj R, Asay GF, Colby CE, et al. Congenital diaphragmatic hernia: outcomes of neonates treated at Mayo Clinic with and without extracorporeal membrane oxygenation. Paediatr Anaesth. 2017; 27(3): 314-21.Malekzadegan A, Sargazi A. Congenital Diaphragmatic Hernia with Delayed Presentation. Case Rep Surg. 2016 Oct 30; 2016(2016): 1-4.Gallot D, Coste K, Francannet C, Laurichesse H, Boda C, Ughetto S, et al. Antenatal detection and impact on outcome of congenital diaphragmatic hernia: a 12-year experience in Auvergne, France. Eur J Obstet Gynecol Reprod Biol. 2006; 125(2): 202-5.Kotecha S, Barbato A, Bush A, Claus F, Davenport M, Delacourt C, et al. Congenital diaphragmatic hernia. Eur Respir J. 2012; 39(4): 820-9.Tovar JA. Congenital Diaphragmatic Hernia. Orphanet J Rare Dis. 2012 En 3; 7(1): 1-15.Mullins ME, Stein J, Saini SS, Mueller PR. Prevalence of Incidental Bochdalek’s Hernia in a Large Adult Population. AJR Am J Roentgenol. 2001; 177(2): 363-6.Hartnett KS. Congenital diaphragmatic hernia: Advanced physiology and care concepts. Adv Neonatal Care. 2008; 8(2): 107-15.Stoll C, Alembik Y, Dott B, Roth MP. Associated malformations in patients with esophageal atresia. Eur J Med Genet. 2009; 52(5): 287-90.Harting MT. Congenital diaphragmatic hernia-associated pulmonary hypertension. Semin Pediatr Surg. 2017; 26(3): 147-53.Montalva L, Antounians L, Zani A. Pulmonary hypertension secondary to congenital diaphragmatic hernia: factors and pathways involved in pulmonary vascular remodeling. Pediatr Res. 2019; 85(6): 754-68.Tennant PW, Pearce MS, Bythell M, Rankin J. 20-year survival of children born with congenital anomalies: a population-based study. Lancet. 2010; 375(9715): 649-56.McGivern MR, Best KE, Rankin J, Wellesley D, Greenlees R, Addor MC, et al. Epidemiology of congenital diaphragmatic hernia in Europe: A register-based study. Arch Dis Child Fetal Neonatal Ed. 2015; 100(2): F137-44.Mullassery D, Ba’Ath ME, Jesudason EC, Losty PD. Value of liver herniation in prediction of outcome in fetal congenital diaphragmatic hernia: A systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2010; 35(5): 609-14.Metkus AP, Filly RA, Stringer MD, Harrison MR, Adzick NS. Sonographic predictors of survival in fetal diaphragmatic hernia. J Pediatr Surg. 1996; 31(1): 148-52.Chatziioannidis I, Mouravas V, Babatseva E. When is the appropriate timing of surgical repair for congenital diaphragmatic hernia? Hippokratia. 2014; 18(4): 381.Datin-Dorriere V, Walter-Nicolet E, Rousseau V, Taupin P, Benachi A, Parat S, et al. Experience in the management of eighty-two newborns with congenital diaphragmatic hernia treated with high-frequency oscillatory ventilation and delayed surgery without the use of extracorporeal membrane oxygenation. J Intensive Care Med. 2008; 23(2): 128-35.Migliazza L, Bellan C, Alberti D, Auriemma A, Burgio G, Colombo L, et al. A Retrospective study of 111 cases of congenital diaphragmatic hernia treated with early high-frequency oscillatory ventilation and presurgical stabilization. J Pediatr Surg. 2007; 42(9): 1526-32.McHoney M, Hammond P. Role of ECMO in congenital diaphragmatic hernia. Arch Dis Child Fetal Neonatal Ed. 2018; 103(2): F178-81.Danzer E. Kim SS. Neurodevelopmental outcome in congenital diaphragmatic hernia: Evaluation, predictors and outcome. World J Clin Pediatr. 2014; 3(3): 30-6.Zani A, Zani-Ruttenstock E, Pierro A. Advances in the surgical approach to congenital diaphragmatic hernia. Semin Fetal Neonatal Med. 2014; 19(6): 364-9.Rozmiarek AJ, Qureshi FG, Cassidy L, Ford HR, Hackam DJ. Factors influencing survival in newborns with congenital diaphragmatic hernia: The relative role of timing of surgery. J Pediatr Surg. 2004; 39(6): 821-4.Puligandla PS, Skarsgard ED, Offringa M, Adatia I, Baird R, Bailey JAM, et al. Diagnosis and management of congenital diaphragmatic hernia: a clinical practice guideline. CMAJ. 2018; 190(4): E103-12.Putnam LR, Harting MT, Tsao K, Morini F, Yoder BA, Luco M, et al. Congenital diaphragmatic hernia defect size and infant morbidity at discharge. Pediatrics. 2016; 138(5).Peetsold MG, Heij HA, Kneepkens CMF, Nagelkerke AF, Huisman J, Gemke R. The long-term follow-up of patients with a congenital diaphragmatic hernia: A broad spectrum of morbidity. Pediatr Surg Int. 2009; 25(1): 1-17.Morini F, Valfrè L, Bagolan P. Long-term morbidity of congenital diaphragmatic hernia: A plea for standardization. Semin Pediatr Surg. 2017; 26(5): 301-10.http://creativecommons.org/licenses/by-nc-nd/2.5/co/Abierto (Texto Completo)Atribución-NoComercial-SinDerivadas 2.5 Colombiahttp://purl.org/coar/access_right/c_abf2Médicas UIS. Vol. 34 Núm. 3 (2021). Páginas 72-77Hernia diafragmática congénita posterolateral derecha sin herniación hepática: presentación de caso con tratamiento exitosoRight posterolateral congenital diaphragmatic hernia without hepatic herniation: case report with successful treatmentUniversidad Autónoma de Bucaramanga UNABFacultad Ciencias de la Saludinfo:eu-repo/semantics/articleArtículohttp://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/redcol/resource_type/ARTDiaphragmatic herniaCongenital anomaliesMedicineNewbornMedicinaCiencias de la saludHernia diafragmáticaAnomalías congénitasRecién nacidoORIGINAL2021-Artículo-Hernia_diafragmatica_congenita.pdf2021-Artículo-Hernia_diafragmatica_congenita.pdfArtículoapplication/pdf491379https://repository.unab.edu.co/bitstream/20.500.12749/15890/1/2021-Art%c3%adculo-Hernia_diafragmatica_congenita.pdf328ae064eee233ccfdf3b43f69f8c875MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-8829https://repository.unab.edu.co/bitstream/20.500.12749/15890/2/license.txt3755c0cfdb77e29f2b9125d7a45dd316MD52open accessTHUMBNAIL2021-Artículo-Hernia_diafragmatica_congenita.pdf.jpg2021-Artículo-Hernia_diafragmatica_congenita.pdf.jpgIM Thumbnailimage/jpeg11084https://repository.unab.edu.co/bitstream/20.500.12749/15890/3/2021-Art%c3%adculo-Hernia_diafragmatica_congenita.pdf.jpg573c5fac6c8c27b600e9476029074c6fMD53open access20.500.12749/15890oai:repository.unab.edu.co:20.500.12749/158902022-11-24 12:48:22.484open accessRepositorio Institucional | Universidad Autónoma de Bucaramanga - UNABrepositorio@unab.edu.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