Asociacion entre la presencia de acrocordones y pólipos del colon un estudio de corte transversal

Los acrocordones son tumores fibroepiteliales comunes en la dermis y están asociados con factores como la predisposición genética, diabetes mellitus, acromegalia, obesidad y síndrome metabólico. La posible relación entre los acrocordones y los pólipos del colon (PC) ha generado controversia, destacá...

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Autores:
Del Castillo Pinto, Alejandra María
Tipo de recurso:
Fecha de publicación:
2024
Institución:
Universidad Autónoma de Bucaramanga - UNAB
Repositorio:
Repositorio UNAB
Idioma:
spa
OAI Identifier:
oai:repository.unab.edu.co:20.500.12749/25316
Acceso en línea:
http://hdl.handle.net/20.500.12749/25316
Palabra clave:
Medical sciences
Skin Tags
Colon polyps
Dermatology
Medical sciences
Medicine
Polyps (Pathology)
Colon (Anatomy Cancer)
Neurocutaneous disorders
Dermatología
Ciencias médicas
Medicina
Pólipos (Patología)
Colon (Anatomía Cáncer)
Trastornos neurocutáneos
Acrocordones
Pólipos del colon
Rights
License
http://creativecommons.org/licenses/by-nc-nd/2.5/co/
id UNAB2_5143cdd8fb7ab0976f1069f385143e08
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network_acronym_str UNAB2
network_name_str Repositorio UNAB
repository_id_str
dc.title.spa.fl_str_mv Asociacion entre la presencia de acrocordones y pólipos del colon un estudio de corte transversal
dc.title.translated.spa.fl_str_mv Association between the presence of skin tags and colon polyps: a cross-sectional study
title Asociacion entre la presencia de acrocordones y pólipos del colon un estudio de corte transversal
spellingShingle Asociacion entre la presencia de acrocordones y pólipos del colon un estudio de corte transversal
Medical sciences
Skin Tags
Colon polyps
Dermatology
Medical sciences
Medicine
Polyps (Pathology)
Colon (Anatomy Cancer)
Neurocutaneous disorders
Dermatología
Ciencias médicas
Medicina
Pólipos (Patología)
Colon (Anatomía Cáncer)
Trastornos neurocutáneos
Acrocordones
Pólipos del colon
title_short Asociacion entre la presencia de acrocordones y pólipos del colon un estudio de corte transversal
title_full Asociacion entre la presencia de acrocordones y pólipos del colon un estudio de corte transversal
title_fullStr Asociacion entre la presencia de acrocordones y pólipos del colon un estudio de corte transversal
title_full_unstemmed Asociacion entre la presencia de acrocordones y pólipos del colon un estudio de corte transversal
title_sort Asociacion entre la presencia de acrocordones y pólipos del colon un estudio de corte transversal
dc.creator.fl_str_mv Del Castillo Pinto, Alejandra María
dc.contributor.advisor.none.fl_str_mv Wandurraga Sánchez, Edwin Antonio
Vergara Rueda, Jessica Inés
Serrano, Sergio
Tovar Fierro, Germán
Amaya Muñoz, María Camila
Logreira Castillo, Alejandra
dc.contributor.author.none.fl_str_mv Del Castillo Pinto, Alejandra María
dc.contributor.cvlac.spa.fl_str_mv Wandurraga Sánchez, Edwin Antonio [0001475567]
dc.contributor.googlescholar.spa.fl_str_mv Wandurraga Sánchez, Edwin Antonio [es&oi=ao]
dc.contributor.orcid.spa.fl_str_mv Wandurraga Sánchez, Edwin Antonio [000-0002-0529-2343]
Del Castillo Pinto, Alejandra María [0000-0002-0292-9329]
dc.contributor.apolounab.spa.fl_str_mv Wandurraga Sánchez, Edwin Antonio [edwin-antonio-wandurraga-sánchez]
dc.subject.keywords.spa.fl_str_mv Medical sciences
Skin Tags
Colon polyps
Dermatology
Medical sciences
Medicine
Polyps (Pathology)
Colon (Anatomy Cancer)
Neurocutaneous disorders
topic Medical sciences
Skin Tags
Colon polyps
Dermatology
Medical sciences
Medicine
Polyps (Pathology)
Colon (Anatomy Cancer)
Neurocutaneous disorders
Dermatología
Ciencias médicas
Medicina
Pólipos (Patología)
Colon (Anatomía Cáncer)
Trastornos neurocutáneos
Acrocordones
Pólipos del colon
dc.subject.lemb.spa.fl_str_mv Dermatología
Ciencias médicas
Medicina
Pólipos (Patología)
Colon (Anatomía Cáncer)
Trastornos neurocutáneos
dc.subject.proposal.spa.fl_str_mv Acrocordones
Pólipos del colon
description Los acrocordones son tumores fibroepiteliales comunes en la dermis y están asociados con factores como la predisposición genética, diabetes mellitus, acromegalia, obesidad y síndrome metabólico. La posible relación entre los acrocordones y los pólipos del colon (PC) ha generado controversia, destacándose la sobreexpresión del IGF-1 y polimorfismos del gen IGF-1 como posibles vínculos fisiopatológicos. Realizamos un estudio transversal en la Fundación oftalmológica de Santander – Fosunab, evaluando 210 sujetos, encontrando una prevalencia de acrocordones del 49% y de pólipos del colon del 16.7%. Aunque la asociacion no fue estadisticamente significativa entre los pólipos del colon y los acrocordones, se observó una relación entre los acrocordones y obesidad abdominal, antecedentes de enfermedad cardiovascular, sugiriendo la resistencia a la insulina como un denominador común. El estudio resalta la necesidad de investigaciones futuras sobre la conexión y relevancia clínica de estas condiciones.
publishDate 2024
dc.date.accessioned.none.fl_str_mv 2024-07-04T19:41:13Z
dc.date.available.none.fl_str_mv 2024-07-04T19:41:13Z
dc.date.issued.none.fl_str_mv 2024-06-27
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.local.spa.fl_str_mv Tesis
dc.type.hasversion.none.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.redcol.none.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12749/25316
dc.identifier.instname.spa.fl_str_mv instname:Universidad Autónoma de Bucaramanga - UNAB
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional UNAB
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url http://hdl.handle.net/20.500.12749/25316
identifier_str_mv instname:Universidad Autónoma de Bucaramanga - UNAB
reponame:Repositorio Institucional UNAB
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dc.language.iso.spa.fl_str_mv spa
language spa
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44. Jowkar F, Fallahi A, Namazi M. Is there any relation between serum insulin and insulin-like growth factor-I in non-diabetic patients with skin tag? Journal of the European Academy of Dermatology and Venereology. 2010 Jan;24(1):73–4.
45. Oran M, Erfan G, Mete R, Yanik ME, Yildirim O, Aydin M, et al. Association of colon adenomas and skin tags: coincidence or coexistence? Eur Rev Med Pharmacol Sci. 2014;18(7):1073–7.
46. Foltyn W, Kos-Kudla B, Strzelczyk J, Matyja V, Karpe J, Rudnik A, et al. Is there any relation between hyperinsulinemia, insulin resistance and colorectal lesions in patients with acromegaly? Neuro Endocrinol Lett. 2008 Feb;29(1):107–12.
47. Nishii T, Kono S, Abe H, Eguchi H, Shimazaki K, Hatano B, et al. Glucose Intolerance, Plasma Insulin Levels, and Colon Adenomas in Japanese Men. Japanese Journal of Cancer Research. 2001 Aug;92(8):836–40.
48. McKeown-Eyssen G. Epidemiology of colorectal cancer revisited: are serum triglycerides and/or plasma glucose associated with risk? Cancer Epidemiol Biomarkers Prev. 1994 Dec;3(8):687–95.
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50. Beitler M, Eng A, Kilgour M, Lebwohl M. Association between acrochordons and colonic polyps. J Am Acad Dermatol. 1986 Jun;14(6):1042–4.
51. Gould BE, Ellison RC, Greene HL, Bernhard JD. Lack of association between skin tags and colon polyps in a primary care setting. Arch Intern Med. 1988 Aug;148(8):1799–800.
52. Varma JR. Skin tags--a marker for colon polyps? J Am Board Fam Pract. 1990;3(3):175–80.
53. Radack K, Park S. Is there a valid association between skin tags and colonic polyps. J Gen Intern Med. 1993 Aug;8(8):413–21.
54. Jowkar F, Fallahi A, Namazi MR. Is there any relation between serum insulin and insulin-like growth factor-I in non-diabetic patients with skin tag? J Eur Acad Dermatol Venereol. 2010 Jan;24(1):73–4.
55. Agarwal P, Rai P, Jain M, Mishra S, Singh U, Gupta S. Prevalence of colonic polyp and its
56. Köseoğlu HG, Bozca BC, Başsorgun Cİ, Sarı R, Akbaş SH, Karakaş AA. The role of insulin-like growth factor in Acrochordon Etiopathology. BMC Dermatol. 2020 Dec 3;20(1):14.
57. Alagaratnam S, Loizidou M, Yang S yu, Fuller B, Ramesh B. Increased expression of IGF-1Ec with increasing colonic polyp dysplasia and colorectal cancer. J Cancer Res Clin Oncol. 2020 Nov 8;146(11):2861–70.
58. Fang CEH, Crowe C, Murphy A, O’Donnell M, Finucane FM. Cross-sectional study of the association between skin tags and vascular risk factors in a bariatric clinic-based cohort of Irish adults with morbid obesity. BMC Res Notes. 2020 Dec 16;13(1):156.
59. Plascencia Gómez A, Vega Memije ME, Torres Tamayo M, Rodríguez Carreón AA. Dermatosis en pacientes con sobrepeso y obesidad y su relación con la insulina. Actas Dermosifiliogr. 2014 Mar;105(2):178–85.
60. Cano D, Otero W, Gómez M, Marulanda H. [Comparative prevalence of adenomatous polyps in people aged 45 to 49 years and in people over 50 years of age in a Colombian population: a case-control study]. Rev Gastroenterol Peru. 2021;41(3):150–5.
61. Restrepo C, Correa P, Duque E, Cuello C. Polyps in a low-risk colonic cancer population in Colombia, South America. Dis Colon Rectum. 1981;24(1):29–36.
62. Mella JM, González R, Fischer C, Panigadi GN, Pereyra L, Luna P, et al. Tu1545 Risk of Colorectal Polyps in Patients With Skin Lesions, a Prospective Case-Control Pilot Study. Gastrointest Endosc. 2011 Apr;73(4):AB443.
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dc.coverage.temporal.spa.fl_str_mv Junio - diciembre 2023
dc.coverage.campus.spa.fl_str_mv UNAB Campus Bucaramanga
dc.publisher.grantor.spa.fl_str_mv Universidad Autónoma de Bucaramanga UNAB
dc.publisher.faculty.spa.fl_str_mv Facultad Ciencias de la Salud
dc.publisher.program.spa.fl_str_mv Especialización en Dermatología
institution Universidad Autónoma de Bucaramanga - UNAB
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spelling Wandurraga Sánchez, Edwin Antonio5fa2192c-e67b-4220-8462-a44b20361ed6Vergara Rueda, Jessica Inés7557d239-9352-4396-88dd-5790dfd2b3f9Serrano, Sergio5a740149-27f0-45f1-af5f-efc06abd80f5Tovar Fierro, Germán3e179882-8bc9-4a11-a496-83321f8f0079Amaya Muñoz, María Camila68fb21ee-4986-44f3-9878-5b8ff40ce773Logreira Castillo, Alejandra75ac63e0-020e-4130-b018-2ea43722e9d5Del Castillo Pinto, Alejandra Maríaddcff2b0-6c07-43f6-9784-a42fc814ce60Wandurraga Sánchez, Edwin Antonio [0001475567]Wandurraga Sánchez, Edwin Antonio [es&oi=ao]Wandurraga Sánchez, Edwin Antonio [000-0002-0529-2343]Del Castillo Pinto, Alejandra María [0000-0002-0292-9329]Wandurraga Sánchez, Edwin Antonio [edwin-antonio-wandurraga-sánchez]Bucaramanga (Santander, Colombia)Junio - diciembre 2023UNAB Campus Bucaramanga2024-07-04T19:41:13Z2024-07-04T19:41:13Z2024-06-27http://hdl.handle.net/20.500.12749/25316instname:Universidad Autónoma de Bucaramanga - UNABreponame:Repositorio Institucional UNABrepourl:https://repository.unab.edu.coLos acrocordones son tumores fibroepiteliales comunes en la dermis y están asociados con factores como la predisposición genética, diabetes mellitus, acromegalia, obesidad y síndrome metabólico. La posible relación entre los acrocordones y los pólipos del colon (PC) ha generado controversia, destacándose la sobreexpresión del IGF-1 y polimorfismos del gen IGF-1 como posibles vínculos fisiopatológicos. Realizamos un estudio transversal en la Fundación oftalmológica de Santander – Fosunab, evaluando 210 sujetos, encontrando una prevalencia de acrocordones del 49% y de pólipos del colon del 16.7%. Aunque la asociacion no fue estadisticamente significativa entre los pólipos del colon y los acrocordones, se observó una relación entre los acrocordones y obesidad abdominal, antecedentes de enfermedad cardiovascular, sugiriendo la resistencia a la insulina como un denominador común. El estudio resalta la necesidad de investigaciones futuras sobre la conexión y relevancia clínica de estas condiciones.Portada 1 Pregunta de investigación 3 Resumen 4 Justificación 5 Marco teórico 7 Estado del arte 13 Objetivos 25 Objetivo general 25 Objetivos específicos 25 Metodología 25 Tipo de estudio 25 Población 25 Criterios de inclusion y exclusion 25 Cálculo tamaño de muestra 26 Muestreo 27 Recolección de la información 27 Variables 28 Plan de análisis de datos 34 Consideraciones éticas 35 Resultados esperados 36 Impactos esperados 38 Resultados 39 Características sociodemográficas de la población de estudio 39 Características clínicas de la población de estudio 42 Análisis comparativo según la presencia de acrocordones: 49 Análisis comparativo según la presencia de pólipos 56 Análisis de asociación entre la presencia de acrocordones y pólipos en la población de estudio 63 Discusión 64 Conclusiones 68 Referencias bibliográficas 69 Anexos 72EspecializaciónSkin tags are common fibroepithelial tumors in the dermis and are associated with factors such as genetic predisposition, diabetes mellitus, acromegaly, obesity and metabolic syndrome. The possible relationship between skin tags and colon polyps (CP) has generated controversy, highlighting the overexpression of IGF-1 and polymorphisms of the IGF-1 gene as possible pathophysiological links. We carried out a cross-sectional study at the Santander Ophthalmology Foundation – Fosunab, evaluating 210 subjects, finding a prevalence of skin tags of 49% and colon polyps of 16.7%. Although the association was not statistically significant between colon polyps and skin tags, a relationship was observed between skin tags and abdominal obesity, history of cardiovascular disease, suggesting insulin resistance as a common denominator. The study highlights the need for future research into the connection and clinical relevance of these conditions.Modalidad Presencialapplication/pdfspahttp://creativecommons.org/licenses/by-nc-nd/2.5/co/Abierto (Texto Completo)Atribución-NoComercial-SinDerivadas 2.5 Colombiahttp://purl.org/coar/access_right/c_abf2Asociacion entre la presencia de acrocordones y pólipos del colon un estudio de corte transversalAssociation between the presence of skin tags and colon polyps: a cross-sectional studyEspecialista en DermatologíaUniversidad Autónoma de Bucaramanga UNABFacultad Ciencias de la SaludEspecialización en Dermatologíainfo:eu-repo/semantics/masterThesisTesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/redcol/resource_type/TMMedical sciencesSkin TagsColon polypsDermatologyMedical sciencesMedicinePolyps (Pathology)Colon (Anatomy Cancer)Neurocutaneous disordersDermatologíaCiencias médicasMedicinaPólipos (Patología)Colon (Anatomía Cáncer)Trastornos neurocutáneosAcrocordonesPólipos del colon1. 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Gastrointest Endosc. 2011 Apr;73(4):AB443.https://apolo.unab.edu.co/en/persons/edwin-antonio-wandurraga-s%C3%A1nchezORIGINALTesis.pdfTesis.pdfTesisapplication/pdf1776242https://repository.unab.edu.co/bitstream/20.500.12749/25316/1/Tesis.pdff1a95c7aa2bafd7e77152d2a7ce30718MD51open accessLicencia.pdfLicencia.pdfLicenciaapplication/pdf377579https://repository.unab.edu.co/bitstream/20.500.12749/25316/7/Licencia.pdf9a82ea108f8bd5de07ab451e2a2cd1aeMD57metadata only accessLICENSElicense.txtlicense.txttext/plain; charset=utf-8829https://repository.unab.edu.co/bitstream/20.500.12749/25316/6/license.txt3755c0cfdb77e29f2b9125d7a45dd316MD56open accessTHUMBNAILTesis.pdf.jpgTesis.pdf.jpgIM Thumbnailimage/jpeg7244https://repository.unab.edu.co/bitstream/20.500.12749/25316/8/Tesis.pdf.jpg0b84744164d9d44b8550a14188b0ed6bMD58open accessLicencia.pdf.jpgLicencia.pdf.jpgIM Thumbnailimage/jpeg12312https://repository.unab.edu.co/bitstream/20.500.12749/25316/9/Licencia.pdf.jpgb915b50371e06d7035efd61844a4ea3eMD59metadata only access20.500.12749/25316oai:repository.unab.edu.co:20.500.12749/253162024-07-04 22:01:44.958open accessRepositorio Institucional | Universidad Autónoma de Bucaramanga - UNABrepositorio@unab.edu.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