Virus chikungunya: etiología, patogenia y diagnóstico

La fiebre del chikungnya es una enfermedad que afecta a muchos países a nivel mundial. Su agente etiológico es el alfavirus Virus del chikungnuya, perteneciente a la familia Togaviridae, conformado por un ARN monocatenario, del cual se han aislado tres genotipos diferentes según el análisis filogené...

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Autores:
Mancera Galindo, Nataly
Páez Leal, María Carolina
Becerra Bayona, Silvia Milena
Tipo de recurso:
http://purl.org/coar/resource_type/c_f744
Fecha de publicación:
2017
Institución:
Universidad Autónoma de Bucaramanga - UNAB
Repositorio:
Repositorio UNAB
Idioma:
spa
OAI Identifier:
oai:repository.unab.edu.co:20.500.12749/17084
Acceso en línea:
http://hdl.handle.net/20.500.12749/17084
Palabra clave:
CHIKV
Aedes aegypt
Persistent arthralgia
Health sciences
Research proposal
Hotbeds of research
UNAB
Event memories
Ciencias de la salud
Propuesta de investigación
Semilleros de investigación
UNAB
Memorias de evento
CHIKV
Aedes aegypt
Artralgia persistente
Rights
License
http://creativecommons.org/licenses/by-nc-nd/2.5/co/
id UNAB2_347f0628a5321bbf59a37f6b98ee5aed
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network_acronym_str UNAB2
network_name_str Repositorio UNAB
repository_id_str
dc.title.spa.fl_str_mv Virus chikungunya: etiología, patogenia y diagnóstico
dc.title.translated.spa.fl_str_mv Chikungunya virus: etiology, pathogenesis and diagnosis
title Virus chikungunya: etiología, patogenia y diagnóstico
spellingShingle Virus chikungunya: etiología, patogenia y diagnóstico
CHIKV
Aedes aegypt
Persistent arthralgia
Health sciences
Research proposal
Hotbeds of research
UNAB
Event memories
Ciencias de la salud
Propuesta de investigación
Semilleros de investigación
UNAB
Memorias de evento
CHIKV
Aedes aegypt
Artralgia persistente
title_short Virus chikungunya: etiología, patogenia y diagnóstico
title_full Virus chikungunya: etiología, patogenia y diagnóstico
title_fullStr Virus chikungunya: etiología, patogenia y diagnóstico
title_full_unstemmed Virus chikungunya: etiología, patogenia y diagnóstico
title_sort Virus chikungunya: etiología, patogenia y diagnóstico
dc.creator.fl_str_mv Mancera Galindo, Nataly
Páez Leal, María Carolina
Becerra Bayona, Silvia Milena
dc.contributor.author.none.fl_str_mv Mancera Galindo, Nataly
Páez Leal, María Carolina
Becerra Bayona, Silvia Milena
dc.contributor.cvlac.spa.fl_str_mv Mancera Galindo, Nataly [0001906070]
Páez Leal, María Carolina [0000066656]
Becerra Bayona, Silvia Milena [0001568861]
dc.contributor.googlescholar.spa.fl_str_mv Páez Leal, María Carolina [BAPR3-cAAAAJ]
Becerra Bayona, Silvia Milena [5wr21EQAAAAJ]
dc.contributor.orcid.spa.fl_str_mv Becerra Bayona, Silvia Milena [0000-0002-4499-5885]
dc.contributor.scopus.spa.fl_str_mv Páez Leal, María Carolina [12243485600]
Becerra Bayona, Silvia Milena [36522328100]
dc.contributor.researchgate.spa.fl_str_mv Mancera Galindo, Nataly [Nataly-Mancera-Galindo]
Becerra Bayona, Silvia Milena [Silvia-Becerra-Bayona]
dc.contributor.researchgroup.spa.fl_str_mv Grupo de Estudio Genético de Enfermedades Complejas
Grupo de Investigaciones Clínicas
dc.contributor.apolounab.none.fl_str_mv Becerra Bayona, Silvia Milena [silvia-milena-becerra-bayona]
dc.contributor.linkedin.none.fl_str_mv Becerra Bayona, Silvia Milena [silvia-becerra-3174455a]
dc.subject.keywords.spa.fl_str_mv CHIKV
Aedes aegypt
Persistent arthralgia
Health sciences
Research proposal
Hotbeds of research
UNAB
Event memories
topic CHIKV
Aedes aegypt
Persistent arthralgia
Health sciences
Research proposal
Hotbeds of research
UNAB
Event memories
Ciencias de la salud
Propuesta de investigación
Semilleros de investigación
UNAB
Memorias de evento
CHIKV
Aedes aegypt
Artralgia persistente
dc.subject.lemb.spa.fl_str_mv Ciencias de la salud
Propuesta de investigación
Semilleros de investigación
UNAB
Memorias de evento
dc.subject.proposal.spa.fl_str_mv CHIKV
Aedes aegypt
Artralgia persistente
description La fiebre del chikungnya es una enfermedad que afecta a muchos países a nivel mundial. Su agente etiológico es el alfavirus Virus del chikungnuya, perteneciente a la familia Togaviridae, conformado por un ARN monocatenario, del cual se han aislado tres genotipos diferentes según el análisis filogenético: el asiático, el africano este-central-sur (ECSA) y el africano occidental. La principal vía de transmisión es la vectorial a través de los mosquitos del género Aedes. En cuanto a la patogenia, se ha asociado una mayor carga viral y niveles elevados de IL6 durante la fase aguda con el desarrollo de artralgia persistente como secuela. Finalmente, el diagnóstico se hace con base en la clínica y es confirmado mediante pruebas moleculares como ELISA, RTPCR o cultivo viral
publishDate 2017
dc.date.issued.none.fl_str_mv 2017-11
dc.date.accessioned.none.fl_str_mv 2022-07-26T00:21:53Z
dc.date.available.none.fl_str_mv 2022-07-26T00:21:53Z
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dc.identifier.instname.spa.fl_str_mv instname:Universidad Autónoma de Bucaramanga - UNAB
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional UNAB
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instname:Universidad Autónoma de Bucaramanga - UNAB
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dc.language.iso.spa.fl_str_mv spa
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dc.relation.ispartofseries.spa.fl_str_mv Generación Creativa : Encuentro de Semilleros de Investigación UNAB
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dc.relation.references.spa.fl_str_mv Bowman, M., Debray, S. K., and Peterson, L. L. 1993. Reasoning about naming systems. ACM Trans. Program. Lang. Syst. 15, 5 (Nov. 1993), 795-825. DOI= http://doi.acm.org/10.1145/161468.16147.
Ding, W. and Marchionini, G. 1997. A Study on Video Browsing Strategies. Technical Report. University of Maryland at College Park.
Fröhlich, B. and Plate, J. 2000. The cubic mouse: a new device for three-dimensional input. In Proceedings of the SIGCHI Conference on Human Factors in Computing Systems (The Hague, The Netherlands, April 01 - 06, 2000). CHI '00. ACM, New York, NY, 526-531. DOI= http://doi.acm.org/10.1145/332040.332491.
Tavel, P. 2007. Modeling and Simulation Design. AK Peters Ltd., Natick, MA.
Sannella, M. J. 1994. Constraint Satisfaction and Debugging for Interactive User Interfaces. Doctoral Thesis. UMI Order Number: UMI Order No. GAX95- 09398., University of Washington.
Forman, G. 2003. An extensive empirical study of feature selection metrics for text classification. J. Mach. Learn. Res. 3 (Mar. 2003), 1289-1305.
Brown, L. D., Hua, H., and Gao, C. 2003. A widget framework for augmented interaction in SCAPE. In Proceedings of the 16th Annual ACM Symposium on User Interface Software and Technology (Vancouver, Canada, November 02 - 05, 2003). UIST '03. ACM, New York, NY, 1-10. DOI= http://doi.acm.org/10.1145/964696.964697.
Yu, Y. T. and Lau, M. F. 2006. A comparison of MC/DC, MUMCUT and several other coverage criteria for logical decisions. J. Syst. Softw. 79, 5 (May. 2006), 577-590. DOI= http://dx.doi.org/10.1016/j.jss.2005.05.030.
Gasque, P., Couderc, T., Lecuit, M., Roques, P. and F.P, L. 2015. Chikungunya Virus Pathogenesis and Immunity. VECTOR-BORNE AND ZOONOTIC DISEASES Volume 15, Number 4, 2015. DOI= 10.1089/vbz.2014.1710
Chow, A., Her, Z., Ong, E., Chen, J., et al. 2010. Persistent Arthralgia Induced by Chikungunya Virus Infection is Associated with Interleukin-6 and Granulocyte Macrophage Colony-Stimulating Factor. The Journal of Infectious Diseases 2011;203:149–157. DOI= 10.1093/infdis/jiq042
Krutikov, M. and Manson, J. 2016. Chikungunya Virus Infection: An Update on Joint Manifestations and Management. Rambam Maimonides Med J | www.rmmj.org.il, Volume 7, Issue 4 e0033. DOI= :10.5041/RMMJ.10260.
Rodríguez, A., Calvache, C., Giraldo, J., et. al. 2015. Postchikungunya chronic arthralgia: Results from a retrospective follow-up study of 131 cases in Tolima, Colombia. Travel Medicine and Infectious Disease (2016) 14, 58-59. DOI= http://dx.doi.org/10.1016/j.tmaid.2015.09.001
Rodríguez, A., Villamil, W., Merlano, M. and Simone, L. 2015. Post-chikungunya chronic arthralgia: a first retrospective follow-up study of 39 cases in Colombia. Clin Rheumatol DOI= 10.1007/s10067-015-3041-8
Rodríguez, A., Restrepo, A., Ramírez, V., et. al. 2016. Post-chikungunya chronic inflammatory rheumatism: results from a retrospective follow-up study of 283 adult and child cases in La Virginia, Risaralda, Colombia [version 2; referees: 3 approved]. F1000Research 2016, 5:360 (DOI= 10.12688/f1000research.8235.2).
Carletti, F., Bordi, L., Chiapinni, R., et al. 2007. Short Report: Rapid Detection and Quantification of Chikungunya Virus by a One-Step Reverse Transcription–Polymerase Chain Reaction Real-Time Assay. Am. J. Trop. Med. Hyg., 77(3), 2007, pp. 521–524.
Pongsiri, P., Praianantathavorn, K., Theamboonlers, A., Payungporn, S and Poovorawan, Y. 2012. Multiplex realtime RT-PCR for detecting chikungunya virus and dengue virus. Asian Pacific Journal of Tropical Medicine.
Laurent, P., Le Roux, K., Grivard, P., et al. 2007. Development of a Sensitive Real-Time Reverse Transcriptase PCR Assay with an Internal Control to Detect and Quantify Chikungunya Virus. Clinical Chemistry 53:8 1408 –1414 (2007). DOI= 10.1373/clinchem.2007.086595
Sam, C., Ku¨mmerer, B., Chan, Y., et al. 2015. Updates on Chikungunya Epidemiology, Clinical Disease, and Diagnostics. VECTOR-BORNE AND ZOONOTIC DISEASES Volume 15, Number 4, 2015. DOI= 10.1089/vbz.2014.1680.
Parida, M., Santhosh, R., Dash, P., et al. 2007. Rapid and Real-Time Detection of Chikungunya Virus by Reverse Transcription Loop-Mediated Isothermal Amplification Assay. JOURNAL OF CLINICAL MICROBIOLOGY, Feb. 2007, p. 351–357 Vol. 45, No. 2 0095- 1137/07/$08.00 + 0 DOI=10.1128/JCM.01734-06
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dc.coverage.spatial.spa.fl_str_mv Bucaramanga (Santander, Colombia)
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dc.publisher.grantor.spa.fl_str_mv Universidad Autónoma de Bucaramanga UNAB
dc.publisher.faculty.none.fl_str_mv Facultad Ciencias de la Salud
dc.publisher.program.none.fl_str_mv Pregrado Medicina
dc.publisher.deparment.spa.fl_str_mv Sistema de Investigación SIUNAB
dc.source.spa.fl_str_mv Generación Creativa. Generación Creativa : Encuentro de Semilleros de Investigación UNAB ; Volumen 06, Número 06 (Noviembre 2017) ; páginas 85-88
institution Universidad Autónoma de Bucaramanga - UNAB
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spelling Mancera Galindo, Natalyf5b9e427-6f0f-4875-806b-a42207eb40daPáez Leal, María Carolina4c30d3de-095b-4497-b14c-f1501234ab69Becerra Bayona, Silvia Milena406421e2-8a7b-45c1-8f56-358ed51b3230Mancera Galindo, Nataly [0001906070]Páez Leal, María Carolina [0000066656]Becerra Bayona, Silvia Milena [0001568861]Páez Leal, María Carolina [BAPR3-cAAAAJ]Becerra Bayona, Silvia Milena [5wr21EQAAAAJ]Becerra Bayona, Silvia Milena [0000-0002-4499-5885]Páez Leal, María Carolina [12243485600]Becerra Bayona, Silvia Milena [36522328100]Mancera Galindo, Nataly [Nataly-Mancera-Galindo]Becerra Bayona, Silvia Milena [Silvia-Becerra-Bayona]Grupo de Estudio Genético de Enfermedades ComplejasGrupo de Investigaciones ClínicasBecerra Bayona, Silvia Milena [silvia-milena-becerra-bayona]Becerra Bayona, Silvia Milena [silvia-becerra-3174455a]Bucaramanga (Santander, Colombia)20172022-07-26T00:21:53Z2022-07-26T00:21:53Z2017-11ISSN 2344-7079http://hdl.handle.net/20.500.12749/17084instname:Universidad Autónoma de Bucaramanga - UNABreponame:Repositorio Institucional UNABrepourl:https://repository.unab.edu.coLa fiebre del chikungnya es una enfermedad que afecta a muchos países a nivel mundial. Su agente etiológico es el alfavirus Virus del chikungnuya, perteneciente a la familia Togaviridae, conformado por un ARN monocatenario, del cual se han aislado tres genotipos diferentes según el análisis filogenético: el asiático, el africano este-central-sur (ECSA) y el africano occidental. La principal vía de transmisión es la vectorial a través de los mosquitos del género Aedes. En cuanto a la patogenia, se ha asociado una mayor carga viral y niveles elevados de IL6 durante la fase aguda con el desarrollo de artralgia persistente como secuela. Finalmente, el diagnóstico se hace con base en la clínica y es confirmado mediante pruebas moleculares como ELISA, RTPCR o cultivo viralChikungnya fever is a disease that affects many countries worldwide. Its etiological agent is the alphavirus Chikungnuya virus, belonging to the Togaviridae family, made up of a single-stranded RNA, from which three different genotypes have been isolated according to phylogenetic analysis: Asian, East-Central-South African (ECSA) and West African. The main route of transmission is the vector through mosquitoes of the genus Aedes. Regarding the pathogenesis, a higher viral load and elevated levels of IL6 during the acute phase have been associated with the development of persistent arthralgia as a sequel. Finally, the diagnosis is made based on the clinic and is confirmed by molecular tests such as ELISA, RTPCR or viral cultureapplication/pdfspaGeneración Creativa : Encuentro de Semilleros de Investigación UNABhttp://hdl.handle.net/20.500.12749/14239Bowman, M., Debray, S. K., and Peterson, L. L. 1993. Reasoning about naming systems. ACM Trans. Program. Lang. Syst. 15, 5 (Nov. 1993), 795-825. DOI= http://doi.acm.org/10.1145/161468.16147.Ding, W. and Marchionini, G. 1997. A Study on Video Browsing Strategies. Technical Report. University of Maryland at College Park.Fröhlich, B. and Plate, J. 2000. The cubic mouse: a new device for three-dimensional input. In Proceedings of the SIGCHI Conference on Human Factors in Computing Systems (The Hague, The Netherlands, April 01 - 06, 2000). CHI '00. ACM, New York, NY, 526-531. DOI= http://doi.acm.org/10.1145/332040.332491.Tavel, P. 2007. Modeling and Simulation Design. AK Peters Ltd., Natick, MA.Sannella, M. J. 1994. Constraint Satisfaction and Debugging for Interactive User Interfaces. Doctoral Thesis. UMI Order Number: UMI Order No. GAX95- 09398., University of Washington.Forman, G. 2003. An extensive empirical study of feature selection metrics for text classification. J. Mach. Learn. Res. 3 (Mar. 2003), 1289-1305.Brown, L. D., Hua, H., and Gao, C. 2003. A widget framework for augmented interaction in SCAPE. In Proceedings of the 16th Annual ACM Symposium on User Interface Software and Technology (Vancouver, Canada, November 02 - 05, 2003). UIST '03. ACM, New York, NY, 1-10. DOI= http://doi.acm.org/10.1145/964696.964697.Yu, Y. T. and Lau, M. F. 2006. A comparison of MC/DC, MUMCUT and several other coverage criteria for logical decisions. J. Syst. Softw. 79, 5 (May. 2006), 577-590. DOI= http://dx.doi.org/10.1016/j.jss.2005.05.030.Gasque, P., Couderc, T., Lecuit, M., Roques, P. and F.P, L. 2015. Chikungunya Virus Pathogenesis and Immunity. VECTOR-BORNE AND ZOONOTIC DISEASES Volume 15, Number 4, 2015. DOI= 10.1089/vbz.2014.1710Chow, A., Her, Z., Ong, E., Chen, J., et al. 2010. Persistent Arthralgia Induced by Chikungunya Virus Infection is Associated with Interleukin-6 and Granulocyte Macrophage Colony-Stimulating Factor. The Journal of Infectious Diseases 2011;203:149–157. DOI= 10.1093/infdis/jiq042Krutikov, M. and Manson, J. 2016. Chikungunya Virus Infection: An Update on Joint Manifestations and Management. Rambam Maimonides Med J | www.rmmj.org.il, Volume 7, Issue 4 e0033. DOI= :10.5041/RMMJ.10260.Rodríguez, A., Calvache, C., Giraldo, J., et. al. 2015. Postchikungunya chronic arthralgia: Results from a retrospective follow-up study of 131 cases in Tolima, Colombia. Travel Medicine and Infectious Disease (2016) 14, 58-59. DOI= http://dx.doi.org/10.1016/j.tmaid.2015.09.001Rodríguez, A., Villamil, W., Merlano, M. and Simone, L. 2015. Post-chikungunya chronic arthralgia: a first retrospective follow-up study of 39 cases in Colombia. Clin Rheumatol DOI= 10.1007/s10067-015-3041-8Rodríguez, A., Restrepo, A., Ramírez, V., et. al. 2016. Post-chikungunya chronic inflammatory rheumatism: results from a retrospective follow-up study of 283 adult and child cases in La Virginia, Risaralda, Colombia [version 2; referees: 3 approved]. F1000Research 2016, 5:360 (DOI= 10.12688/f1000research.8235.2).Carletti, F., Bordi, L., Chiapinni, R., et al. 2007. Short Report: Rapid Detection and Quantification of Chikungunya Virus by a One-Step Reverse Transcription–Polymerase Chain Reaction Real-Time Assay. Am. J. Trop. Med. Hyg., 77(3), 2007, pp. 521–524.Pongsiri, P., Praianantathavorn, K., Theamboonlers, A., Payungporn, S and Poovorawan, Y. 2012. Multiplex realtime RT-PCR for detecting chikungunya virus and dengue virus. Asian Pacific Journal of Tropical Medicine.Laurent, P., Le Roux, K., Grivard, P., et al. 2007. Development of a Sensitive Real-Time Reverse Transcriptase PCR Assay with an Internal Control to Detect and Quantify Chikungunya Virus. Clinical Chemistry 53:8 1408 –1414 (2007). DOI= 10.1373/clinchem.2007.086595Sam, C., Ku¨mmerer, B., Chan, Y., et al. 2015. Updates on Chikungunya Epidemiology, Clinical Disease, and Diagnostics. VECTOR-BORNE AND ZOONOTIC DISEASES Volume 15, Number 4, 2015. DOI= 10.1089/vbz.2014.1680.Parida, M., Santhosh, R., Dash, P., et al. 2007. Rapid and Real-Time Detection of Chikungunya Virus by Reverse Transcription Loop-Mediated Isothermal Amplification Assay. JOURNAL OF CLINICAL MICROBIOLOGY, Feb. 2007, p. 351–357 Vol. 45, No. 2 0095- 1137/07/$08.00 + 0 DOI=10.1128/JCM.01734-06http://creativecommons.org/licenses/by-nc-nd/2.5/co/Abierto (Texto Completo)Atribución-NoComercial-SinDerivadas 2.5 Colombiahttp://purl.org/coar/access_right/c_abf2Generación Creativa. Generación Creativa : Encuentro de Semilleros de Investigación UNAB ; Volumen 06, Número 06 (Noviembre 2017) ; páginas 85-88Virus chikungunya: etiología, patogenia y diagnósticoChikungunya virus: etiology, pathogenesis and diagnosisConferenceinfo:eu-repo/semantics/conferenceProceedingsMemoria de eventoshttp://purl.org/coar/resource_type/c_f744info:eu-repo/semantics/acceptedVersionhttp://purl.org/redcol/resource_type/EC_ACUniversidad Autónoma de Bucaramanga UNABFacultad Ciencias de la SaludPregrado MedicinaSistema de Investigación SIUNABCHIKVAedes aegyptPersistent arthralgiaHealth sciencesResearch proposalHotbeds of researchUNABEvent memoriesCiencias de la saludPropuesta de investigaciónSemilleros de investigaciónUNABMemorias de eventoCHIKVAedes aegyptArtralgia persistenteTHUMBNAILGeneración_creativa_2017-85-88.pdf.jpgGeneración_creativa_2017-85-88.pdf.jpgIM Thumbnailimage/jpeg9013https://repository.unab.edu.co/bitstream/20.500.12749/17084/3/Generaci%c3%b3n_creativa_2017-85-88.pdf.jpga07ecc8f6624575147c2b42471d2bfabMD53open accessORIGINALGeneración_creativa_2017-85-88.pdfGeneración_creativa_2017-85-88.pdfArtículoapplication/pdf424043https://repository.unab.edu.co/bitstream/20.500.12749/17084/1/Generaci%c3%b3n_creativa_2017-85-88.pdfab51f01ab20b01024a47a8eaa3adcbd0MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-8829https://repository.unab.edu.co/bitstream/20.500.12749/17084/2/license.txt3755c0cfdb77e29f2b9125d7a45dd316MD52open access20.500.12749/17084oai:repository.unab.edu.co:20.500.12749/170842024-01-18 17:51:22.978open accessRepositorio Institucional | Universidad Autónoma de Bucaramanga - UNABrepositorio@unab.edu.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