Manejo práctico de los nuevos anticoagulantes orales en fibrilación auricular no valvular
Introducción. La fibrilación auricular es la arritmia más frecuente en la prácticaclínica, cuya incidencia viene en ascenso alcanzando el 8 % en edades que superanlos 80 años, con un impacto importante en la morbimortalidad relacionado conlas complicaciones cerebrovasculares. El objetivo es identifi...
- Autores:
-
Laguado, Marlon
Ardila Acuña, Laura Yesenia
Mayorga Quintero, Jairo Alberto
Rangel Vera, Jully Andrea
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2019
- Institución:
- Universidad Autónoma de Bucaramanga - UNAB
- Repositorio:
- Repositorio UNAB
- Idioma:
- spa
- OAI Identifier:
- oai:repository.unab.edu.co:20.500.12749/9936
- Palabra clave:
- anticoagulantes
Fibrilación auricular
Dabigatran
Rivaroxaban
Accidente cerebrovascular
anticoagulants
Atrial fibrillation
Dabigatran
Rivaroxaban
Cerebrovascular accident
- Rights
- License
- http://creativecommons.org/licenses/by-nc-nd/2.5/co/
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dc.title.none.fl_str_mv |
Manejo práctico de los nuevos anticoagulantes orales en fibrilación auricular no valvular |
dc.title.translated.none.fl_str_mv |
Practical use of new oral anticoagulants in non-valvular atrial fibrillation |
title |
Manejo práctico de los nuevos anticoagulantes orales en fibrilación auricular no valvular |
spellingShingle |
Manejo práctico de los nuevos anticoagulantes orales en fibrilación auricular no valvular anticoagulantes Fibrilación auricular Dabigatran Rivaroxaban Accidente cerebrovascular anticoagulants Atrial fibrillation Dabigatran Rivaroxaban Cerebrovascular accident |
title_short |
Manejo práctico de los nuevos anticoagulantes orales en fibrilación auricular no valvular |
title_full |
Manejo práctico de los nuevos anticoagulantes orales en fibrilación auricular no valvular |
title_fullStr |
Manejo práctico de los nuevos anticoagulantes orales en fibrilación auricular no valvular |
title_full_unstemmed |
Manejo práctico de los nuevos anticoagulantes orales en fibrilación auricular no valvular |
title_sort |
Manejo práctico de los nuevos anticoagulantes orales en fibrilación auricular no valvular |
dc.creator.fl_str_mv |
Laguado, Marlon Ardila Acuña, Laura Yesenia Mayorga Quintero, Jairo Alberto Rangel Vera, Jully Andrea |
dc.contributor.author.spa.fl_str_mv |
Laguado, Marlon Ardila Acuña, Laura Yesenia Mayorga Quintero, Jairo Alberto Rangel Vera, Jully Andrea |
dc.subject.none.fl_str_mv |
anticoagulantes Fibrilación auricular Dabigatran Rivaroxaban Accidente cerebrovascular |
topic |
anticoagulantes Fibrilación auricular Dabigatran Rivaroxaban Accidente cerebrovascular anticoagulants Atrial fibrillation Dabigatran Rivaroxaban Cerebrovascular accident |
dc.subject.keywords.eng.fl_str_mv |
anticoagulants Atrial fibrillation Dabigatran Rivaroxaban Cerebrovascular accident |
description |
Introducción. La fibrilación auricular es la arritmia más frecuente en la prácticaclínica, cuya incidencia viene en ascenso alcanzando el 8 % en edades que superanlos 80 años, con un impacto importante en la morbimortalidad relacionado conlas complicaciones cerebrovasculares. El objetivo es identificar los aspectosfarmacológicos y de manejo práctico de los nuevos anticoagulantes orales enpaciente con fibrilación auricular no valvular. División de los temas tratados. Se realizó una revisión bibliográfica no sistemáticaen bases de datos y bibliotecas electrónicas (PubMed, Cochrane, Lilacs) incluyendoartículos desde 2008 hasta 2019, en idioma inglés y español que contuvieran lostópicos de interés. Se realizó una descripción detallada de las generalidades de losanticoagulantes orales en fibrilación auricular, incluyendo dabigatrán, rivaroxabán,apixabán y edoxabán; monitorización de la actividad anticoagulante; descripcióndel manejo perioperatorio de los nuevos anticoagulantes orales y reversión de laanticoagulación para los nuevos anticoagulantes orales.Conclusiones. El uso de nuevos anticoagulantes orales en paciente con fibrilaciónauricular no valvular es una buena alternativa, con facilidad de administración oral,sin aumento significativo del riesgo de sangrado, comparado con warfarina, con laventaja de no requerir monitoría continua con paraclínicos. |
publishDate |
2019 |
dc.date.issued.none.fl_str_mv |
2019-07-30 |
dc.date.accessioned.none.fl_str_mv |
2020-10-27T14:19:21Z |
dc.date.available.none.fl_str_mv |
2020-10-27T14:19:21Z |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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http://purl.org/coar/resource_type/c_6501 |
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2382-4603 0123-7047 |
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http://hdl.handle.net/20.500.12749/9936 |
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instname:Universidad Autónoma de Bucaramanga UNAB |
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repourl:https://repository.unab.edu.co |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.29375/01237047.2823 |
identifier_str_mv |
2382-4603 0123-7047 instname:Universidad Autónoma de Bucaramanga UNAB repourl:https://repository.unab.edu.co |
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http://hdl.handle.net/20.500.12749/9936 https://doi.org/10.29375/01237047.2823 |
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https://revistas.unab.edu.co/index.php/medunab/article/view/2823/3072 Https://revistas.unab.edu.co/index.php/medunab/article/view/2823/3084 /*ref*/Deshpande S, Catanzaro J , Wann S. Atrial fibrillation prevalence and scope of the problem. Cardiac Electrophysiology Clinics. 2014; 6 (1):1 - 4. doi: 10.1016/j. ccep.2013.10.006 2. Renoux C, Patenaude V , Suissa S. Incidence, mortality, and sex differences of non-valvular atrial fibrillation: A population-based study. Journal of the American Heart Association. 2014; 3 (6):1 - 8. doi: 10.1161/ JAHA.114.001402 3. Mulpuru S, Rabinstein A, Asirvatham S. Atrial fibrillation and stroke a neurologic perspective. Cardiac Electrophysiology Clinics 2014; 6(1):31 - 41. doi: 10.1016/j.ccep.2013.11.001 4. Castellano JM, Chinitz J, Willner J, Fuster V. Mechanisms of stroke in atrial fibrillation. Cardiac Electrophysiology Clinics. 2014; 6(1):5 - 15. doi: 10.1016/j. ccep.2013.10.007. 5. January CT, Wann LS, Alpert JS, Calkins H, Cigarroa JE, Cleveland JC, et al. 2014 AHA/ACC/HRS Guideline for the management of patients with atrial fibrillation: A report of the American College of cardiology/American heart association task force on practice guidelines and the heart rhythm society. Circulation. 2014; 130(23)201 -267. doi: 10.1161/ CIR.0000000000000041 6. Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B, et al. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. European Heart Journal. 2016; 37(38):2893 - 2962. doi: 10.1093/eurheartj/ehw210 7. Harter K, Levine M, Henderson S. O. Anticoagulation drug therapy: a review. The Western Journal of Emergency Medicine. 2015; 16(1):11 - 7. doi: 10.5811/ westjem.2014.12.22933 8. Tatjana S, Gregory Y. Novel oral anticoagulants in non-valvular atrial fibrillation. Cardiovascular. Hematological Agents in Medicinal Chemistry. 2014 ; 26 (2) :115 - 129. doi: 10.1016/j.beha.2013.07.008 9. Cove C, Hylek E. An updated review of target-specific oral anticoagulants used in stroke prevention in atrial fibrillation, venous thromboembolic disease, and acute coronary syndromes. Journal of the American Heart Association. 2013; 2(5):115 - 219. doi: 10.1161/ JAHA.113.000136 10. Connolly S, Ezekowitz M, Yusuf S, Eikelboom J, Oldgren J, Parekh A, et al. Dabigatran versus warfarin in patients with atrial fibrillation. The New England Journal of Medicine. 2009; 361(12):1139 - 1151. doi: 10.1056/NEJMoa0905561 11. Hinojar R, Jiménez-Natcher J, Fernández-Golfín C, Zamorano J. New oral anticoagulants: a practical guide for physicians. European Heart Journal - Cardiovascular Pharmacotherapy. 2015; 1(2):134 - 145. doi: 10.1093/ehjcvp/pvv002 12. Ferns S, Naccarelli G. New Oral Anticoagulants. Their Role in Stroke Prevention in High-Risk Patients with Atrial Fibrillation. Medical Clinics of North America. 2015; 99(4):759 - 80. doi: 10.1016/j. mcna.2015.02.006 13. Shafeeq H , Tran T. New oral anticoagulants for atrial fibrillation: are they worth the risk? P&T : A Peer-Reviewed Journal for Formulary Management. [Internet]. 2014.[citado el 03 de Junio del 2019]; 39(1):54 - 64. Recuperado a partir de: https://www.ncbi.nlm. nih.gov/pmc/articles/PMC3956385/ 14. Patel MR, Mahaffey KW, Garg J, Pan G, Singer DE, Hacke W, et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. The New England Journal of Medicine. 2011; 365(10):883-91. doi: 10.1056/NEJMoa1009638 15. López-Sendón J, Merino J. Resultados e implicaciones del estudio ROCKET. Revista Española de Cardiología Suplementos. 2013; 13(C):42 - 46. doi: 10.1016/S1131-3587(13)70058-X 16. Mekaj Y, Mekaj A, Duci S, Miftari E. New oral anticoagulants: Their advantages and disadvantages compared with vitamin K antagonists in the prevention and treatment of patients with thromboembolic events. Therapeutics and Clinical Risk Management. 2015(11):967 - 977. doi: 10.2147/TCRM.S84210 17. Shamoun F, Obeid H, Ramakrishna H. Novel anticoagulants in atrial fibrillation: Monitoring, reversal and perioperative management. BioMed Research International. 2015; 424031. doi: 10.1155/2015/424031 18. Steinberg B, Piccini, J. Anticoagulation in atrial fibrillation. British Medical Journal. 2014; 14(348) 2116. doi: 10.1136/bmj.g2116 19. Martínez-Rubio A, Martínez-Torrecilla R. Evidencias actuales de los nuevos anticoagulantes orales en el tratamiento de la fibrilación auricular no valvular: comparación de subestudios. Revista Espanola de Cardiologia. 2015; 68(3):185 - 189. doi: 10.1016/j. recesp.2014.07.017 20. Mateo J. Nuevos anticoagulantes orales y su papel en la práctica clínica. Revista Española de Cardiología Suplementos. 2013; 13(1 SUPPL.3) 33 - 41. doi: 10.1016/S1131-3587(13)70057-8 21. Hanley C, Kowey P. Are the novel anticoagulants better than warfarin for patients with atrial fibrillation?. Journal of Thoracic Disease. 2015; 7(2):165 - 171. doi: 10.3978/j.issn.2072-1439.2015.01.23 22. Heidbuchel H, Verhamme P, Alings M, Antz M, Hacke W, Oldgren J, et al. Updated European Heart Rhythm Association Practical Guide on the use of non-Vitamin K antagonist anticoagulants in patients with non-valvular atrial fibrillation. Europace. 2015; 15(5):625 - 651. doi: 10.1093/europace/euv309 23. Bounameaux H, Camm AJ. Edoxaban: An update on the new oral direct factor Xa inhibitor. Drugs. 2014; 74(11):1209-1231. doi: http://dx.doi.org/10.1007/ s40265-014-0261-1 24. Hapgood G, Butler J, Malan E, Chunilal S, Tran H. The effect of dabigatran on the activated partial thromboplastin time and thrombin time as determined by the hemoclot thrombin inhibitor assay in patient plasma samples. Thrombosis and Haemostasis. 2013 ; 110(2):308 - 315. doi: 10.1160/TH13-04-0301 25. Rechenmacher S, Fang, J. Bridging Anticoagulation Primum Non Nocere. Journal of the American College of Cardiology. 2015; 66(12):1392-13403. doi: 10.1016/j.jacc.2015.08.002 26. Díaz J, Duque M, Duque L, Uribe W, Medina E, Marín J. Tratamiento perioperatorio del paciente con antiagregación o anticoagulación. Revista Colombiana de Cardiología. 2012; 19(5): 252 - 259. doi: 10.1016/ S0120-5633(12)70141-9 27. Lai A, Davidson N, Galloway S, Thachil J. Perioperative management of patients on new oral anticoagulants. The British journal of surgery. 2014; 101(7): 742 - 9. doi: 10.1002/bjs.9485 28. Skaistis J, Tagami T. Risk of fatal bleeding in episodes of major bleeding with new oral anticoagulants and Vitamin K antagonists: A systematic review and me ta-Analysis. PLoS ONE. 2015; 10(9): e0137444. doi: 10.1371/journal.pone.0137444 29. Ansell J. Reversal Agents for the Direct Oral Anticoagulants. Hematology/Oncology Clinics of North America. 2016; 30(5): 1085-1098. doi: 10.1016/j. hoc.2016.05.006 30. Siegal DM, Curnutte JT, Connolly SJ, Lu G, Conley PB, Wiens BL, et al. Andexanet Alfa for the Reversal of Factor Xa Inhibitor Activity. N Engl J Med. 2015; 373(25):2413-2424. doi: 10.1056/NEJMoa1510991 31. Pollack CV, Reilly PA, Eikelboom J, Glund S, Verhamme P, Bernstein RA, et al. Idarucizumab for Dabigatran Reversal. NEnglJMed. 2015; 373(6):511 - 520. doi: 10.1056/NEJMoa1502000 32. Ansell JE, Bakhru SH, Laulicht BE, Steiner SS, Grosso M, Brown K, et al. Use of PER977 to Reverse the Anticoagulant Effect of Edoxaban. New England Journal of Medicine. 2014; 371(22):2141 - 2142. doi: 10.1056/NEJMc1411800 33. Connolly SJ, Crowther M, Eikelboom JW, Gibson CM, Curnutte JT, Lawrence JH, et al. Full Study Report of Andexanet Alfa for Bleeding Associated with Factor Xa Inhibitors. N Engl J Med. 2019; 380(14):1326 - 1335. doi: 10.1056/NEJMoa1814051. |
dc.relation.uri.none.fl_str_mv |
https://revistas.unab.edu.co/index.php/medunab/issue/view/249 |
dc.relation.references.none.fl_str_mv |
Deshpande S, Catanzaro J , Wann S. Atrial fibrillation prevalence and scope of the problem. Cardiac Electro-physiology Clinics. 2014; 6 (1):1 - 4. doi: 10.1016/j.ccep.2013.10.006 Renoux C, Patenaude V , Suissa S. Incidence, mortal-ity, and sex differences of non-valvular atrial fibrilla-tion: A population-based study. Journal of the Ameri-can Heart Association. 2014; 3 (6):1 - 8. doi: 10.1161/JAHA.114.001402 Mulpuru S, Rabinstein A, Asirvatham S. Atrial fibril-lation and stroke a neurologic perspective. Cardiac Electrophysiology Clinics 2014; 6(1):31 - 41. doi: 10.1016/j.ccep.2013.11.001 Castellano JM, Chinitz J, Willner J, Fuster V. Mecha-nisms of stroke in atrial fibrillation. Cardiac Electro-physiology Clinics. 2014; 6(1):5 - 15. doi: 10.1016/j.ccep.2013.10.007. January CT, Wann LS, Alpert JS, Calkins H, Cigar-roa JE, Cleveland JC, et al. 2014 AHA/ACC/HRS Guideline for the management of patients with atri-al fibrillation: A report of the American College of cardiology/American heart association task force on practice guidelines and the heart rhythm society. Circulation. 2014; 130(23)201 -267. doi: 10.1161/CIR.0000000000000041 Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B, et al. 2016 ESC Guidelines for the management of atrial fibrillation developed in collab-oration with EACTS. European Heart Journal. 2016; 37(38):2893 - 2962. doi: 10.1093/eurheartj/ehw210 Harter K, Levine M, Henderson S. O. Anticoagulation drug therapy: a review. The Western Journal of Emer-gency Medicine. 2015; 16(1):11 - 7. doi: 10.5811/westjem.2014.12.22933 Tatjana S, Gregory Y. Novel oral anticoagulants in non-valvular atrial fibrillation. Cardiovascular. He-matological Agents in Medicinal Chemistry. 2014 ; 26 (2) :115 - 129. doi: 10.1016/j.beha.2013.07.008 Cove C, Hylek E. An updated review of target-specif-ic oral anticoagulants used in stroke prevention in atri-al fibrillation, venous thromboembolic disease, and acute coronary syndromes. Journal of the American Heart Association. 2013; 2(5):115 - 219. doi: 10.1161/JAHA.113.000136 Connolly S, Ezekowitz M, Yusuf S, Eikelboom J, Oldgren J, Parekh A, et al. Dabigatran versus warfarin in patients with atrial fibrillation. The New England Journal of Medicine. 2009; 361(12):1139 - 1151. doi: 10.1056/NEJMoa0905561 |
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Atribución-NoComercial-SinDerivadas 2.5 Colombia |
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MedUNAB; Vol. 22 Núm. 1 (2019): abril - julio 2019: Cáncer Colorrectal, Sensation Seeking, Anticoagulantes; 38-50 |
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Laguado, Marlon2581715f-678c-4c35-bdcf-aca8f8cb111cArdila Acuña, Laura Yesenia26dcfd66-bd4f-44ae-927c-67e796cfaad2Mayorga Quintero, Jairo Alberto1aba977c-935f-4edb-a57f-d2b1046f31e3Rangel Vera, Jully Andrea71bb47ba-0f2b-4bfe-ad79-f88d98b4eb112020-10-27T14:19:21Z2020-10-27T14:19:21Z2019-07-302382-46030123-7047http://hdl.handle.net/20.500.12749/9936instname:Universidad Autónoma de Bucaramanga UNABrepourl:https://repository.unab.edu.cohttps://doi.org/10.29375/01237047.2823Introducción. La fibrilación auricular es la arritmia más frecuente en la prácticaclínica, cuya incidencia viene en ascenso alcanzando el 8 % en edades que superanlos 80 años, con un impacto importante en la morbimortalidad relacionado conlas complicaciones cerebrovasculares. El objetivo es identificar los aspectosfarmacológicos y de manejo práctico de los nuevos anticoagulantes orales enpaciente con fibrilación auricular no valvular. División de los temas tratados. Se realizó una revisión bibliográfica no sistemáticaen bases de datos y bibliotecas electrónicas (PubMed, Cochrane, Lilacs) incluyendoartículos desde 2008 hasta 2019, en idioma inglés y español que contuvieran lostópicos de interés. Se realizó una descripción detallada de las generalidades de losanticoagulantes orales en fibrilación auricular, incluyendo dabigatrán, rivaroxabán,apixabán y edoxabán; monitorización de la actividad anticoagulante; descripcióndel manejo perioperatorio de los nuevos anticoagulantes orales y reversión de laanticoagulación para los nuevos anticoagulantes orales.Conclusiones. El uso de nuevos anticoagulantes orales en paciente con fibrilaciónauricular no valvular es una buena alternativa, con facilidad de administración oral,sin aumento significativo del riesgo de sangrado, comparado con warfarina, con laventaja de no requerir monitoría continua con paraclínicos.Introduction. Atrial fibrillation is the most common arrhythmia in clinical practice. Itsincidence has been on the rise, reaching 8 % among those patients over the age of 80,with a significant impact on morbimortality related to cerebrovascular complications.The objective is to identify aspects of pharmacology and practical use of the new oralanticoagulants in patients with non-valvular atrial fibrillation.Division of topics covered. A non-systematic literature research was conducted indatabases and digital libraries (PubMed, Cochrane, Lilacs), including articles from2008 to 2019, both in English and in Spanish that included the topics of interest.A detailed description of the generalities of oral anticoagulants for atrial fibrillationwas made, including dabigatran, rivaroxaban, apixaban and edoxaban; monitoringanticoagulant activity; description of the perioperative use of new oral anticoagulantsand reversal of anticoagulation for the new oral anticoagulants.Conclusions. The use of new oral anticoagulants in patients with non-valvular atrialfibrillation is a good alternative, with easy oral administration, without significantincrease in the risk of bleeding, compared to warfarin, and with the advantage of notrequiring continuous paraclinical monitoring.application/pdfText/htmlspaUniversidad Autónoma de Bucaramanga UNABFacultad Ciencias de la Saludhttps://revistas.unab.edu.co/index.php/medunab/article/view/2823/3072Https://revistas.unab.edu.co/index.php/medunab/article/view/2823/3084/*ref*/Deshpande S, Catanzaro J , Wann S. Atrial fibrillation prevalence and scope of the problem. Cardiac Electrophysiology Clinics. 2014; 6 (1):1 - 4. doi: 10.1016/j. ccep.2013.10.006 2. Renoux C, Patenaude V , Suissa S. Incidence, mortality, and sex differences of non-valvular atrial fibrillation: A population-based study. Journal of the American Heart Association. 2014; 3 (6):1 - 8. doi: 10.1161/ JAHA.114.001402 3. Mulpuru S, Rabinstein A, Asirvatham S. Atrial fibrillation and stroke a neurologic perspective. Cardiac Electrophysiology Clinics 2014; 6(1):31 - 41. doi: 10.1016/j.ccep.2013.11.001 4. Castellano JM, Chinitz J, Willner J, Fuster V. Mechanisms of stroke in atrial fibrillation. Cardiac Electrophysiology Clinics. 2014; 6(1):5 - 15. doi: 10.1016/j. ccep.2013.10.007. 5. January CT, Wann LS, Alpert JS, Calkins H, Cigarroa JE, Cleveland JC, et al. 2014 AHA/ACC/HRS Guideline for the management of patients with atrial fibrillation: A report of the American College of cardiology/American heart association task force on practice guidelines and the heart rhythm society. Circulation. 2014; 130(23)201 -267. doi: 10.1161/ CIR.0000000000000041 6. Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B, et al. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. European Heart Journal. 2016; 37(38):2893 - 2962. doi: 10.1093/eurheartj/ehw210 7. Harter K, Levine M, Henderson S. O. Anticoagulation drug therapy: a review. The Western Journal of Emergency Medicine. 2015; 16(1):11 - 7. doi: 10.5811/ westjem.2014.12.22933 8. Tatjana S, Gregory Y. Novel oral anticoagulants in non-valvular atrial fibrillation. Cardiovascular. Hematological Agents in Medicinal Chemistry. 2014 ; 26 (2) :115 - 129. doi: 10.1016/j.beha.2013.07.008 9. Cove C, Hylek E. An updated review of target-specific oral anticoagulants used in stroke prevention in atrial fibrillation, venous thromboembolic disease, and acute coronary syndromes. Journal of the American Heart Association. 2013; 2(5):115 - 219. doi: 10.1161/ JAHA.113.000136 10. Connolly S, Ezekowitz M, Yusuf S, Eikelboom J, Oldgren J, Parekh A, et al. Dabigatran versus warfarin in patients with atrial fibrillation. The New England Journal of Medicine. 2009; 361(12):1139 - 1151. doi: 10.1056/NEJMoa0905561 11. Hinojar R, Jiménez-Natcher J, Fernández-Golfín C, Zamorano J. New oral anticoagulants: a practical guide for physicians. European Heart Journal - Cardiovascular Pharmacotherapy. 2015; 1(2):134 - 145. doi: 10.1093/ehjcvp/pvv002 12. Ferns S, Naccarelli G. New Oral Anticoagulants. Their Role in Stroke Prevention in High-Risk Patients with Atrial Fibrillation. Medical Clinics of North America. 2015; 99(4):759 - 80. doi: 10.1016/j. mcna.2015.02.006 13. Shafeeq H , Tran T. New oral anticoagulants for atrial fibrillation: are they worth the risk? P&T : A Peer-Reviewed Journal for Formulary Management. [Internet]. 2014.[citado el 03 de Junio del 2019]; 39(1):54 - 64. Recuperado a partir de: https://www.ncbi.nlm. nih.gov/pmc/articles/PMC3956385/ 14. Patel MR, Mahaffey KW, Garg J, Pan G, Singer DE, Hacke W, et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. The New England Journal of Medicine. 2011; 365(10):883-91. doi: 10.1056/NEJMoa1009638 15. López-Sendón J, Merino J. Resultados e implicaciones del estudio ROCKET. 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The Western Journal of Emer-gency Medicine. 2015; 16(1):11 - 7. doi: 10.5811/westjem.2014.12.22933Tatjana S, Gregory Y. Novel oral anticoagulants in non-valvular atrial fibrillation. Cardiovascular. He-matological Agents in Medicinal Chemistry. 2014 ; 26 (2) :115 - 129. doi: 10.1016/j.beha.2013.07.008Cove C, Hylek E. An updated review of target-specif-ic oral anticoagulants used in stroke prevention in atri-al fibrillation, venous thromboembolic disease, and acute coronary syndromes. Journal of the American Heart Association. 2013; 2(5):115 - 219. doi: 10.1161/JAHA.113.000136Connolly S, Ezekowitz M, Yusuf S, Eikelboom J, Oldgren J, Parekh A, et al. Dabigatran versus warfarin in patients with atrial fibrillation. The New England Journal of Medicine. 2009; 361(12):1139 - 1151. doi: 10.1056/NEJMoa0905561http://creativecommons.org/licenses/by-nc-nd/2.5/co/Atribución-NoComercial-SinDerivadas 2.5 Colombiahttp://purl.org/coar/access_right/c_abf2MedUNAB; Vol. 22 Núm. 1 (2019): abril - julio 2019: Cáncer Colorrectal, Sensation Seeking, Anticoagulantes; 38-50anticoagulantesFibrilación auricularDabigatranRivaroxabanAccidente cerebrovascularanticoagulantsAtrial fibrillationDabigatranRivaroxabanCerebrovascular accidentManejo práctico de los nuevos anticoagulantes orales en fibrilación auricular no valvularPractical use of new oral anticoagulants in non-valvular atrial fibrillationinfo:eu-repo/semantics/articleArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85ORIGINAL2019_Manejo_práctico.pdf2019_Manejo_práctico.pdfArtículoapplication/pdf634814https://repository.unab.edu.co/bitstream/20.500.12749/9936/1/2019_Manejo_pr%c3%a1ctico.pdfdb8edff5b415e324ee7414f8f6f59410MD51open accessTHUMBNAIL2019_Manejo_práctico.pdf.jpg2019_Manejo_práctico.pdf.jpgIM Thumbnailimage/jpeg12515https://repository.unab.edu.co/bitstream/20.500.12749/9936/2/2019_Manejo_pr%c3%a1ctico.pdf.jpg930b5339e210fb5464005c0322e75b5eMD52open access20.500.12749/9936oai:repository.unab.edu.co:20.500.12749/99362024-06-05 22:02:51.231open accessRepositorio Institucional | Universidad Autónoma de Bucaramanga - UNABrepositorio@unab.edu.co |