Análisis de supervivencia a 5 años de pacientes con Sarcoma de Kaposi del área metropolitana de Bucaramanga entre los años 2000-2015
El sarcoma de Kaposi es un tumor angioproliferativo poco frecuente etiológicamente vinculado al virus herpes humano tipo 8 y asociado a inmunosupresión. Clínicamente se reconocen 4 subtipos, en los cuales observamos que pueden presentar compromiso a nivel cutáneo y/o visceral. Algunos de ellos puede...
- Autores:
-
Díaz Bueno, Pedro Antonio
- Tipo de recurso:
- Fecha de publicación:
- 2021
- Institución:
- Universidad Autónoma de Bucaramanga - UNAB
- Repositorio:
- Repositorio UNAB
- Idioma:
- spa
- OAI Identifier:
- oai:repository.unab.edu.co:20.500.12749/13926
- Acceso en línea:
- http://hdl.handle.net/20.500.12749/13926
- Palabra clave:
- Dermatology
Medical sciences
Health sciences
Kaposi's sarcoma
Angioproliferative tumor
Neoplasms
Biometrics
Dermatología
Ciencias médicas
Medicina
Neoplasmas
Biometría
Ciencias de la salud
Sarcoma de kaposi
Tumor angioproliferativo
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-nd/2.5/co/
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|
dc.title.spa.fl_str_mv |
Análisis de supervivencia a 5 años de pacientes con Sarcoma de Kaposi del área metropolitana de Bucaramanga entre los años 2000-2015 |
dc.title.translated.spa.fl_str_mv |
5-year survival analysis of patients with kaposi sarcoma in the metropolitan area of Bucaramanga between the years 2000-2015 |
title |
Análisis de supervivencia a 5 años de pacientes con Sarcoma de Kaposi del área metropolitana de Bucaramanga entre los años 2000-2015 |
spellingShingle |
Análisis de supervivencia a 5 años de pacientes con Sarcoma de Kaposi del área metropolitana de Bucaramanga entre los años 2000-2015 Dermatology Medical sciences Health sciences Kaposi's sarcoma Angioproliferative tumor Neoplasms Biometrics Dermatología Ciencias médicas Medicina Neoplasmas Biometría Ciencias de la salud Sarcoma de kaposi Tumor angioproliferativo |
title_short |
Análisis de supervivencia a 5 años de pacientes con Sarcoma de Kaposi del área metropolitana de Bucaramanga entre los años 2000-2015 |
title_full |
Análisis de supervivencia a 5 años de pacientes con Sarcoma de Kaposi del área metropolitana de Bucaramanga entre los años 2000-2015 |
title_fullStr |
Análisis de supervivencia a 5 años de pacientes con Sarcoma de Kaposi del área metropolitana de Bucaramanga entre los años 2000-2015 |
title_full_unstemmed |
Análisis de supervivencia a 5 años de pacientes con Sarcoma de Kaposi del área metropolitana de Bucaramanga entre los años 2000-2015 |
title_sort |
Análisis de supervivencia a 5 años de pacientes con Sarcoma de Kaposi del área metropolitana de Bucaramanga entre los años 2000-2015 |
dc.creator.fl_str_mv |
Díaz Bueno, Pedro Antonio |
dc.contributor.advisor.none.fl_str_mv |
Uribe Pérez, Claudia Janeth Serrano Gómez, Sergio Eduardo |
dc.contributor.author.none.fl_str_mv |
Díaz Bueno, Pedro Antonio |
dc.contributor.cvlac.spa.fl_str_mv |
Uribe Pérez, Claudia Janeth [0000267848] Serrano Gómez, Sergio Eduardo [0001521095] |
dc.contributor.orcid.spa.fl_str_mv |
Serrano Gómez, Sergio Eduardo [0000-0001-6418-7116] |
dc.contributor.researchgate.spa.fl_str_mv |
Uribe Pérez, Claudia Janeth [Claudia-Janeth-Uribe-Perez-2157369946] |
dc.subject.keywords.spa.fl_str_mv |
Dermatology Medical sciences Health sciences Kaposi's sarcoma Angioproliferative tumor Neoplasms Biometrics |
topic |
Dermatology Medical sciences Health sciences Kaposi's sarcoma Angioproliferative tumor Neoplasms Biometrics Dermatología Ciencias médicas Medicina Neoplasmas Biometría Ciencias de la salud Sarcoma de kaposi Tumor angioproliferativo |
dc.subject.lemb.spa.fl_str_mv |
Dermatología Ciencias médicas Medicina Neoplasmas Biometría |
dc.subject.proposal.spa.fl_str_mv |
Ciencias de la salud Sarcoma de kaposi Tumor angioproliferativo |
description |
El sarcoma de Kaposi es un tumor angioproliferativo poco frecuente etiológicamente vinculado al virus herpes humano tipo 8 y asociado a inmunosupresión. Clínicamente se reconocen 4 subtipos, en los cuales observamos que pueden presentar compromiso a nivel cutáneo y/o visceral. Algunos de ellos pueden tener un crecimiento lento, localizado o indolente, pero pueden llegar a diseminarse y/o crecer rápidamente y causar morbilidad y mortalidad significativa. Desde su primer reporte en 1872, observamos que el sarcoma de Kaposi presentó un aumento las tasas de incidencia asociado a la epidemia del VIH hacia los años 80´s, con posterior descenso con el advenimiento de la terapia antirretroviral(1,2). Actualmente se reconocen tasas de supervivencia a 5 años que van desde el 38% al 72% de acuerdo a si el compromiso es extenso o localizado, respectivamente(2). Sin embargo, en Colombia, y específicamente en Santander, no se ha encontrado hasta la fecha ningún estudio que aporte datos locales sobre el comportamiento de este tumor en nuestra población. Por lo anterior, teniendo en cuenta la importancia de esta patología, la falta de estudios a nivel nacional que caractericen o demuestren una asociación entre las variables clínicas con la sobrevida y el impacto de la obtención de estos datos y su aplicabilidad en los modelos de atención, promoción y prevención de tumores malignos, se decide realizar este estudio retrospectivo tomando los datos del registro poblacional de cáncer del área metropolitana de Bucaramanga de los años, con el objetivo de determinar las variables sociodemográficas que impactan en la sobrevida del paciente, obteniendo datos importantes como la incidencia del sarcoma de Kaposi en el área metropolitana, la tasa de sobrevida de esta población, el grado de asociación con las diferentes variables entre otros. |
publishDate |
2021 |
dc.date.accessioned.none.fl_str_mv |
2021-08-19T22:07:23Z |
dc.date.available.none.fl_str_mv |
2021-08-19T22:07:23Z |
dc.date.issued.none.fl_str_mv |
2021 |
dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/masterThesis |
dc.type.local.spa.fl_str_mv |
Tesis |
dc.type.redcol.none.fl_str_mv |
http://purl.org/redcol/resource_type/TM |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12749/13926 |
dc.identifier.instname.spa.fl_str_mv |
instname:Universidad Autónoma de Bucaramanga - UNAB |
dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional UNAB |
dc.identifier.repourl.spa.fl_str_mv |
repourl:https://repository.unab.edu.co |
url |
http://hdl.handle.net/20.500.12749/13926 |
identifier_str_mv |
instname:Universidad Autónoma de Bucaramanga - UNAB reponame:Repositorio Institucional UNAB repourl:https://repository.unab.edu.co |
dc.language.iso.spa.fl_str_mv |
spa |
language |
spa |
dc.relation.references.spa.fl_str_mv |
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Elsevier Espa8#241;a, S.L.U.; 2016. 1868–1873 p. Available from: http://dx.doi.org/10.1016/B978-84-9022-917-0/00143-8 6. Cattani P, Cerimele F, Porta D, Graffeo R, Ranno S, Marchetti S, et al. Agespecific seroprevalence of human herpesvirus 8 in Mediterranean regions. Clin Microbiol Infect [Internet]. 2003 Apr 1 [cited 2020 Jul 7];9(4):274–9. Available from: https://pubmed.ncbi.nlm.nih.gov/12667236/ 7. Angeloni A, Heston L, Uccini S, Sirianni MC, Cottoni F, Masala MV, et al. High Prevalence of Antibodies to Human Herpesvirus 8 in Relatives of Patients with Classic Kaposi’s Sarcoma from Sardinia. J Infect Dis [Internet]. 1998 Jun [cited 2020 Jul 7];177(6):1715–8. Available from: https://pubmed.ncbi.nlm.nih.gov/9607855/ 8. Mohanna S, Ferrufino JC, Sanchez J, Bravo F, Gotuzzo E. Epidemiological and clinical characteristics of classic Kaposi’s sarcoma in Peru. J Am Acad Dermatol [Internet]. 2005 [cited 2020 Jul 7];53(3):435–41. Available from: https://pubmed.ncbi.nlm.nih.gov/16112349/ 9. 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Available from: http://dx.doi.org/10.1016/B978-84-9113-365-0/00080-2 14. Sternbach G, Varon J. Moritz Kaposi: Idiopathic pigmented sarcoma of the skin. J Emerg Med [Internet]. 1995 [cited 2020 Jul 8];13(5):671–4. Available from: https://pubmed.ncbi.nlm.nih.gov/8530789/ 15. North PE. Neoplasias y proliferaciones seudoneoplásicas vasculares [Internet]. Cuarta edi. Bolognia J, Schaffer J, Cerroni L, editors. Dermatología. Madrid: Elsevier Espa8#241;a, S.L.U.; 2018. 2020–2049 p. Available from: http://dx.doi.org/10.1016/B978-84-9113-365-0/00114-5 16. Antman K, Chang Y. Kaposi ’s Sarcoma. N Engl J Med. 2000;342(14):1027– 38 17. Cai Q, Verma SC, Lu J, Robertson ES. Molecular Biology of Kaposi’s Sarcoma-associated Herpesvirus and Related Oncogenesis [Internet]. 1st ed. Vol. 78, Advances in Virus Research. Elsevier Inc.; 2010. 87–142 p. Available from: http://dx.doi.org/10.1016/B978-0-12-385032-4.00003-3 18. Vangipuram R, Tyring SK. Epidemiology of Kaposi sarcoma: review and description of the nonepidemic variant. Int J Dermatol. 2019;58(5):538–42 19. Grulich AE, Vajdic CM. The epidemiology of cancers in human immunodeficiency virus infection and after organ transplantation [Internet]. Vol. 42, Seminars in Oncology. W.B. Saunders; 2015 [cited 2020 Jul 12]. p. 247–57. Available from: https://pubmed.ncbi.nlm.nih.gov/25843729/ 20. Corey C. Virology, epidemiology, and transmission of human herpesvirus 8 infection - UpToDate [Internet]. Uptodate. [cited 2020 Jul 12]. Available from: https://www-uptodate-com.aure.unab.edu.co/contents/virology-epidemiologyand-transmission-of-human-herpesvirus-8-infection?search=sarcoma de kaposi&topicRef=7726&source=see_link 21. Krown S, Chadha J. Classic Kaposi sarcoma: Epidemiology, risk factors, pathology, and molecular pathogenesis - UpToDate [Internet]. Uptodate. 2019 [cited 2020 Jul 12]. 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Vol. 10, Surgical Pathology Clinics. W.B. Saunders; 2017 [cited 2020 Aug 18]. p. 345–66. Available from: https://pubmed.ncbi.nlm.nih.gov/28477885 36. Butler LM, Dorsey G, Hladik W, Rosenthal PJ, Brander C, Neilands TB, et al. Kaposi sarcoma-associated herpesvirus (KSHV) seroprevalence in population-based samples of african children: Evidence for at least 2 patterns of KSHV transmission. J Infect Dis [Internet]. 2009 Aug 1 [cited 2020 Aug 18];200(3):430–8. Available from: /pmc/articles/PMC3975590/?report=abstract 37. Moosa MR. Kaposi’s sarcoma in kidney transplant recipients: A 23-year experience. QJM - Mon J Assoc Physicians [Internet]. 2005 Mar [cited 2020 Aug 18];98(3):205–14. Available from: https://pubmed.ncbi.nlm.nih.gov/15728402 38. Bower M, Weir J, Francis N, Newsom-Davis T, Powles S, Crook T, et al. The effect of HAART in 254 consecutive patients with AIDS-related Kaposi’s sarcoma. AIDS [Internet]. 2009 Aug 24 [cited 2020 Aug 18];23(13):1701–6. Available from: https://pubmed.ncbi.nlm.nih.gov/19550283 39. Cianfrocca M, Lee S, Von Roenn J, Tulpule A, Dezube BJ, Aboulafia DM, et al. Randomized trial of paclitaxel versus pegylated liposomal doxorubicin for advanced human immunodeficiency virus-associated Kaposi sarcoma: Evidence of symptom palliation from chemotherapy. Cancer [Internet]. 2010 Aug 15 [cited 2020 Aug 18];116(16):3969–77. Available from: https://pubmed.ncbi.nlm.nih.gov/20564162 40. Delyon J, Bizot A, Battistella M, Madelaine I, Vercellino L, Lebbé C. PD-1 blockade with nivolumab in endemic Kaposi sarcoma [Internet]. Vol. 29, Annals of Oncology. Oxford University Press; 2018 [cited 2020 Aug 18]. p. 1067–9. Available from: https://pubmed.ncbi.nlm.nih.gov/29324995 41. Lundgren JD, Melbye M, Pedersen C, Rosenberg PS, Gerstoft J. Changing patterns of kaposi’s sarcoma in danish acquired immunodeficiency syndrome patients with complete follow-up. Am J Epidemiol [Internet]. 1995 Apr 1 [cited 2020 Nov 18];142(7):652–8. 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Factors affecting progression-free survival in non-HIV-related Kaposi sarcoma. J Dermatolog Treat. 2016;27(3):275–7. 47. Royse KE, El Chaer F, Amirian ES, Hartman C, Krown SE, Uldrick TS, et al. Disparities in Kaposi sarcoma incidence and survival in the United States: 2000-2013. PLoS One. 2017;12(8):1–12 48. Vivek K, Parita S, Mohit G, Arsalan T, Abhinav B. Racial disparities in incidence & survival of Kaposi’s sarcoma in the United States Vivek. Indian J Med Res [Internet]. 2019;354–63. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23144490 49. Saldarriaga-Cantillo A, Bravo LE, Londoño Ó, García LS, Collazos P. Epidemiological surveillance of the HIV/AIDS complex through the analysis of trends in the incidence of Kaposi’s sarcoma in Cali, Colombia. Colomb Med. 2012;43(4):273–80 50. Levi F. Cancer incidence in five continents, vol. VI. Vol. 29, European Journal of Cancer. 1993. 2315–2319 p 51. Bravo LE, García LS, Collazos P, Carrascal E, Ramírez O, Collazos T, et al. Reliable information for cancer control in Cali, Colombia. Colomb Med [Internet]. 2018 [cited 2021 Jun 8];49(1):23–34. Available from: /pmc/articles/PMC6018818/ 52. Mohanna S, Maco V, Bravo F, Gotuzzo E. Epidemiology and clinical characteristics of classic Kaposi’s sarcoma, seroprevalence, and variants of human herpesvirus 8 in South America: A critical review of an old disease [Internet]. Vol. 9, International Journal of Infectious Diseases. Elsevier; 2005 [cited 2020 Jul 7]. p. 239–50. Available from: https://pubmed.ncbi.nlm.nih.gov/16095940 53. Hiatt KM, Nelson AM, Lichy JH, Fanburg-Smith JC. Classic Kaposi Sarcoma in the United States over the last two decades: A clinicopathologic and molecular study of 438 non-HIV-related Kaposi Sarcoma patients with comparison to HIV-related Kaposi Sarcoma. Mod Pathol. 2008;21(5):572–82 54. Oncologia C. Survival and Prognostic Factors of Kaposi ’ s Sarcoma Patients Treated at a High Complexity Oncology Care Center. 2020;66(3). 55. Klingenberg RE, Esser S, Brockmeyer NH, Michalik C, Skaletz-Rorowski A, Potthoff A. Profile of Kaposi sarcoma patients in the competence network HIV/AIDS. Hautarzt. 2018;69(2):143–8. 56. Bower M, Dalla Pria A, Coyle C, Andrews E, Tittle V, Dhoot S, et al. Prospective stage-stratified approach to AIDS-related Kaposi’s sarcoma. J Clin Oncol. 2014;32(5):409–14 |
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Bucaramanga (Santander, Colombia) |
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2000-2015 |
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Universidad Autónoma de Bucaramanga UNAB |
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Facultad Ciencias de la Salud |
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Especialización en Dermatología |
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Uribe Pérez, Claudia Janethccc0f1cf-be6c-4b77-a985-d1713f5efc36-1Serrano Gómez, Sergio Eduardo9ea84e2c-e5e0-415b-9e16-308be15c2afc-1Díaz Bueno, Pedro Antonio28538fca-b0d0-4d65-b75a-f08c44f9c15f-1Uribe Pérez, Claudia Janeth [0000267848]Serrano Gómez, Sergio Eduardo [0001521095]Serrano Gómez, Sergio Eduardo [0000-0001-6418-7116]Uribe Pérez, Claudia Janeth [Claudia-Janeth-Uribe-Perez-2157369946]Bucaramanga (Santander, Colombia)2000-2015UNAB Campus Bucaramanga2021-08-19T22:07:23Z2021-08-19T22:07:23Z2021http://hdl.handle.net/20.500.12749/13926instname:Universidad Autónoma de Bucaramanga - UNABreponame:Repositorio Institucional UNABrepourl:https://repository.unab.edu.coEl sarcoma de Kaposi es un tumor angioproliferativo poco frecuente etiológicamente vinculado al virus herpes humano tipo 8 y asociado a inmunosupresión. Clínicamente se reconocen 4 subtipos, en los cuales observamos que pueden presentar compromiso a nivel cutáneo y/o visceral. Algunos de ellos pueden tener un crecimiento lento, localizado o indolente, pero pueden llegar a diseminarse y/o crecer rápidamente y causar morbilidad y mortalidad significativa. Desde su primer reporte en 1872, observamos que el sarcoma de Kaposi presentó un aumento las tasas de incidencia asociado a la epidemia del VIH hacia los años 80´s, con posterior descenso con el advenimiento de la terapia antirretroviral(1,2). Actualmente se reconocen tasas de supervivencia a 5 años que van desde el 38% al 72% de acuerdo a si el compromiso es extenso o localizado, respectivamente(2). Sin embargo, en Colombia, y específicamente en Santander, no se ha encontrado hasta la fecha ningún estudio que aporte datos locales sobre el comportamiento de este tumor en nuestra población. Por lo anterior, teniendo en cuenta la importancia de esta patología, la falta de estudios a nivel nacional que caractericen o demuestren una asociación entre las variables clínicas con la sobrevida y el impacto de la obtención de estos datos y su aplicabilidad en los modelos de atención, promoción y prevención de tumores malignos, se decide realizar este estudio retrospectivo tomando los datos del registro poblacional de cáncer del área metropolitana de Bucaramanga de los años, con el objetivo de determinar las variables sociodemográficas que impactan en la sobrevida del paciente, obteniendo datos importantes como la incidencia del sarcoma de Kaposi en el área metropolitana, la tasa de sobrevida de esta población, el grado de asociación con las diferentes variables entre otros.1. RESUMEN DEL PROYECTO: ......................................................................... 7 2. DESCRIPCIÓN DEL PROYECTO ...................................................................... 9 2.1 Planteamiento del problema y justificación .............................................. 9 2.2 Marco teórico.............................................................................................. 10 2.2.1 Definición ............................................................................................... 10 2.2.2 Epidemiología ........................................................................................ 10 2.2.3 Fisiopatogenia ....................................................................................... 13 2.2.4 Características clínicas .......................................................................... 14 2.2.5 Diagnóstico ............................................................................................ 16 2.2.6 Pronóstico y prevención ......................................................................... 17 2.2.7 Tratamiento ............................................................................................ 19 2.3 Estado del arte ........................................................................................... 20 2.4 Objetivos del estudio ................................................................................. 23 2.4.1 Objetivo general ..................................................................................... 23 2.4.2 Objetivos específicos ............................................................................. 23 2.5 Metodología ................................................................................................ 23 2.5.1. Criterios de inclusión ............................................................................. 23 2.5.2. Criterios de exclusión: ........................................................................... 23 2.5.3. Cálculo de tamaño de muestra y muestreo: ......................................... 23 2.5.4. Mecanismo de recolección de la información ....................................... 23 2.5.6 Definición de variables ........................................................................... 24 2.6 Plan de análisis de datos: ......................................................................... 26 2.7 Consideraciones éticas: ............................................................................ 27 3. RESULTADOS ............................................................................................... 28 3.1 Descripción de la cohorte ......................................................................... 28 3.2 Desenlaces ................................................................................................. 31 3.3 Análisis de supervivencia ......................................................................... 32 4. DISCUSIÓN .................................................................................................... 39 5. CONCLUSIONES ........................................................................................... 41 6. BIBLIOGRAFÍA .............................................................................................. 42EspecializaciónKaposi's sarcoma is a rare angioproliferative tumor etiologically linked to human herpes virus type 8 and associated with immunosuppression. Clinically, 4 subtypes are recognized, in which we observe that they may present skin and / or visceral involvement. Some of them may be slow, localized or indolent growth, but they can spread and / or grow rapidly and cause significant morbidity and mortality. Since its first report in 1872, we observed that Kaposi's sarcoma presented an increase in the incidence rates associated with the HIV epidemic towards the 1980s, with a subsequent decrease with the advent of antiretroviral therapy (1,2). Currently, 5-year survival rates ranging from 38% to 72% are recognized according to whether the involvement is extensive or localized, respectively (2). However, in Colombia, and specifically in Santander, no study has been found to date that provides local data on the behavior of this tumor in our population. Therefore, taking into account the importance of this pathology, the lack of studies at the national level that characterize or demonstrate an association between clinical variables with survival and the impact of obtaining these data and their applicability in care models , promotion and prevention of malignant tumors, it was decided to carry out this retrospective study taking data from the population registry of cancer of the metropolitan area of Bucaramanga of the years, with the aim of determining the sociodemographic variables that impact on the survival of the patient, obtaining important data such as the incidence of Kaposi's sarcoma in the metropolitan area, the survival rate of this population, the degree of association with the different variables, among others.Modalidad Presencialapplication/pdfspahttp://creativecommons.org/licenses/by-nc-nd/2.5/co/Abierto (Texto Completo)info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial-SinDerivadas 2.5 ColombiaAnálisis de supervivencia a 5 años de pacientes con Sarcoma de Kaposi del área metropolitana de Bucaramanga entre los años 2000-20155-year survival analysis of patients with kaposi sarcoma in the metropolitan area of Bucaramanga between the years 2000-2015Especialista en DermatologíaUniversidad Autónoma de Bucaramanga UNABFacultad Ciencias de la SaludEspecialización en Dermatologíainfo:eu-repo/semantics/masterThesisTesishttp://purl.org/redcol/resource_type/TMDermatologyMedical sciencesHealth sciencesKaposi's sarcomaAngioproliferative tumorNeoplasmsBiometricsDermatologíaCiencias médicasMedicinaNeoplasmasBiometríaCiencias de la saludSarcoma de kaposiTumor angioproliferativo1. 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