Patrón en "Pinza de Cangrejo" asociado a ectasias corneales

Resumen: Objetivo General y Específicos: Determinar la sensibilidad y especificidad del patrón topográfico “Pinza de Cangrejo” para diferenciar los ojos con Degeneración Marginal Pelúcida (DMP) de los que tienen Queratocono. Material y Métodos: Se realizó un análisis retrospectivo de las topografías...

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Autores:
Ávalos González, Carlos
Tipo de recurso:
Fecha de publicación:
2016
Institución:
Universidad Autónoma de Bucaramanga - UNAB
Repositorio:
Repositorio UNAB
Idioma:
spa
OAI Identifier:
oai:repository.unab.edu.co:20.500.12749/1780
Acceso en línea:
http://hdl.handle.net/20.500.12749/1780
Palabra clave:
Cornea
Corneal diseases
Eye diseases
Medicine
Ophthalmology
Research
Corneal thinning
Pellucid marginal degeneration (PMD)
Keratoconus
Corneal ectasia
Corneal topography
Cornea
Enfermedades de la cornea
Enfermedades de los ojos
Medicina
Oftalmología
Investigaciones
Adelgazamiento corneal
Degeneración marginal pelúcida (DMP)
Queratocono
Ectasia corneal
Topografía corneal
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openAccess
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http://creativecommons.org/licenses/by-nc-nd/2.5/co/
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dc.title.spa.fl_str_mv Patrón en "Pinza de Cangrejo" asociado a ectasias corneales
dc.title.translated.eng.fl_str_mv "Crab Claw" pattern associated with corneal ectasias
title Patrón en "Pinza de Cangrejo" asociado a ectasias corneales
spellingShingle Patrón en "Pinza de Cangrejo" asociado a ectasias corneales
Cornea
Corneal diseases
Eye diseases
Medicine
Ophthalmology
Research
Corneal thinning
Pellucid marginal degeneration (PMD)
Keratoconus
Corneal ectasia
Corneal topography
Cornea
Enfermedades de la cornea
Enfermedades de los ojos
Medicina
Oftalmología
Investigaciones
Adelgazamiento corneal
Degeneración marginal pelúcida (DMP)
Queratocono
Ectasia corneal
Topografía corneal
title_short Patrón en "Pinza de Cangrejo" asociado a ectasias corneales
title_full Patrón en "Pinza de Cangrejo" asociado a ectasias corneales
title_fullStr Patrón en "Pinza de Cangrejo" asociado a ectasias corneales
title_full_unstemmed Patrón en "Pinza de Cangrejo" asociado a ectasias corneales
title_sort Patrón en "Pinza de Cangrejo" asociado a ectasias corneales
dc.creator.fl_str_mv Ávalos González, Carlos
dc.contributor.advisor.spa.fl_str_mv Galvis Ramírez, Virgilio
Tello Hernández, Alejandro
Barrera, Rodrigo
Corrales Martínez, María Isabel
Ochoa Vera, Miguel Enrique
dc.contributor.author.spa.fl_str_mv Ávalos González, Carlos
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https://orcid.org/0000-0001-5081-0720
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dc.contributor.researchgate.*.fl_str_mv https://www.researchgate.net/profile/Miguel_Ochoa7
https://www.researchgate.net/profile/Virgilio_Galvis
https://www.researchgate.net/profile/Alejandro_Tello2
dc.contributor.researchgroup.spa.fl_str_mv Grupo de Investigaciones Clínicas
dc.subject.keywords.eng.fl_str_mv Cornea
Corneal diseases
Eye diseases
Medicine
Ophthalmology
Research
Corneal thinning
Pellucid marginal degeneration (PMD)
Keratoconus
Corneal ectasia
Corneal topography
topic Cornea
Corneal diseases
Eye diseases
Medicine
Ophthalmology
Research
Corneal thinning
Pellucid marginal degeneration (PMD)
Keratoconus
Corneal ectasia
Corneal topography
Cornea
Enfermedades de la cornea
Enfermedades de los ojos
Medicina
Oftalmología
Investigaciones
Adelgazamiento corneal
Degeneración marginal pelúcida (DMP)
Queratocono
Ectasia corneal
Topografía corneal
dc.subject.lemb.spa.fl_str_mv Cornea
Enfermedades de la cornea
Enfermedades de los ojos
Medicina
Oftalmología
Investigaciones
dc.subject.proposal.none.fl_str_mv Adelgazamiento corneal
Degeneración marginal pelúcida (DMP)
Queratocono
Ectasia corneal
Topografía corneal
description Resumen: Objetivo General y Específicos: Determinar la sensibilidad y especificidad del patrón topográfico “Pinza de Cangrejo” para diferenciar los ojos con Degeneración Marginal Pelúcida (DMP) de los que tienen Queratocono. Material y Métodos: Se realizó un análisis retrospectivo de las topografías corneales incluidas dentro de los registros del equipo Orbscan II tomadas en el Centro Oftalmológico Virgilio Galvis tomadas desde el 15 de Febrero de 2009 hasta el 31 de Julio de 2015 para identificar ojos con patrón topográfico en “Pinza de Cangrejo”. En todos los casos, se analizaron los mapas de curvatura sagitales (queratométricos) y paquimétricos. Se incluyeron todos los ojos con patrón en pinza de cangrejo en el mapa sagital (o queratométrico) y además su ojo contralateral (sin importar si tuviese o no el patrón).
publishDate 2016
dc.date.issued.none.fl_str_mv 2016
dc.date.accessioned.none.fl_str_mv 2020-06-26T20:01:40Z
dc.date.available.none.fl_str_mv 2020-06-26T20:01:40Z
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.local.spa.fl_str_mv Tesis
dc.type.redcol.none.fl_str_mv http://purl.org/redcol/resource_type/TM
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12749/1780
dc.identifier.instname.spa.fl_str_mv instname:Universidad Autónoma de Bucaramanga - UNAB
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional UNAB
url http://hdl.handle.net/20.500.12749/1780
identifier_str_mv instname:Universidad Autónoma de Bucaramanga - UNAB
reponame:Repositorio Institucional UNAB
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.references.spa.fl_str_mv Ávalos González, Carlos (2016). Patrón en Pinza de Cangrejo asociado a ectasias corneales. Bucaramanga (Santander, Colombia) : Universidad Autónoma de Bucaramanga UNAB
1. Rabinowitz YS. Keratoconus. Surv Ophthalmol 1998; 42:297-319.
2. Gorskova EN, Sevostianov EN. [Epidemiology of keratoconus in the Urals]. Vestn Oftalmol. 1998;114:38-40.
3. Hashemi H, Khabazkhoob M, Yazdani N, Ostadimoghaddam H, Norouzirad R, Amanzadeh K et al. The prevalence of keratoconus in a young population in Mashhad, Iran. Ophthalmic Physiol Opt. 2014;34:519-527.
4. Kennedy R, Bourne W, Dyer J. A 48-year clinical and epidemiologic study of keratoconus. Am J Ophthalmol. 1986;101:267-273.
5. Galvis V, Tello A, Jaramillo JA, Gutierrez AJ, Rodriguez L, Quintero MP. Prevalence of keratoconus patients who consulted with a desire refractive surgery in ophthalmology center reference Bucaramanga, Colombia. Rev Soc Colomb Oftal. 2011;44:129-134.
6. Li X, Rabinowitz YS, Rasheed K, Yang H. Longitudinal study of the normal eyes in unilateral keratoconus patientes. Ophthalmology. 2004;111:440-446.
7. Georgiou T, Funnell CL, Cassels-Brown A, O'Conor R. Influence of ethnic origin on the incidence of keratoconus and associated atopic disease in Asians and white patients. Eye (lond). 2004;18:379-383.
8. Pearson AR, Soneji B, Sarvananthan N, Sandford-Smith JH. Does ethnic influence the incidence or severity of keratoconus? Eye (Lond). 2000;14:625-628.
9. Edwards M, McGhee CN, Dean S. The genetics of keratoconus. Clin Experiment Ophthalmol. 2001;29:345-351.
10. Woodward EG, Morris MT. Joint hypermobility in keratoconus. Ophthalmic Physiol Opt. 1990;10:360-362.
11. Nielsen K, Hjortdal J, Pihlmann M, Corydon TJ. Update on the keratoconus genetics. Acta Ophthalmol. 2013;91:106-113.
12. Burdon KP, Coster DJ, Charlesworth JC, Mills RA, Laurie KJ, Giunta C et al. Apparent autosomal dominant keratoconus in a large Australian pedigree accounted for by digenic inheritance of two novel loci. Hum Genet. 2008;124:379-836.
13. Rabinowitz YS. The genetics of keratoconus. Ophthalmol Clin North Am. 2003;16:607-620.
14. Gordon-Shaag A, Millodot M, Essa M, Garth J, Ghara M, Shneor E. Is consanguinity a risk factor for keratoconus? Optom Vis Sci. 2013;90:448-454.
15. Davidson AE, Hayes S, Hardcastle AJ, Tuft SJ. The pathogenesis of keratoconus. Eye (Lond). 2014;28:189-195.
16. Czugala M, Karolak JA, Nowak DM, Polakowski P, Pitarque J, Molinari A et al. Novel mutation and three other sequence variants segregating with phenotype at keratoconus 13q32 susceptibility locus. Eur J Hum Genet. 2012; 20:389-397.
17. Gajecka M, Radhakrishna U, Winters D, Nath SK, Rydzanicz M, Ratnamala U et al. Localization of a gene for keratoconus to a 5.6-Mb interval on 13q32. Invest Ophthalmol Vis Sci. 2009;50:1531-1539.
18. Wheeler J, Hauser MA, Afshari NA, Allingham RR, Liu Y. The genetics of keratoconus: a review. Reprod Syst Sex Disord. 2012; (Suppl 6). pii: 001.
19. Galvis V, Sherwin T, Tello A, Merayo J, Barrera R, Acera A. Keratoconus: an inflammatory disorder?. Eye (Lond). 2015;29(7):843-859.
20. Cheung IM, McGhee CN, Sherwin T. A new perspective on the pathobiology of keratoconus: interplay of stromal wound healing and reactive species-associated processes. Clin Exp Optom. 2013;96:188-196.
21. Pouliquen Y, Bureau J, Mirshahi M, Mirshahi SS, Assouline M, Lorens G. Keratoconus and inflammatory processes. Bull Soc Belge Ophtalmol. 1996;262:25-28.
22.Balasubramanian SA, Mohan S, Pye DC, Willcox MD. Proteases, proteolysis and inflammatory molecules in the tears of people with keratoconus. Acta Ophthalmol. 2012;90:e303-e309.
23. Lema I, Durán JA. Inflammatory molecules in the tears of patients with keratoconus. Ophthalmology. 2005;112:654-659.
24. Jun AS, Cope L, Speck C, Feng X, Lee S, Meng H et al. Subnormal cytokine profile in the tear fluid of keratoconus patients. PLoS One. 2011;6:1-8.
25. Kim WJ, Rabinowitz YS, Meisler DM, Wilson SE. Keratocyte apoptosis associated with keratoconus. Exp Eye Res. 1999;69:475-481.
26. Balasubramanian SA, Pye DC, Willcox MD. Are proteinases the reason for keratoconus? Curr Eye Res. 2010;35:185-191.
27. Pannebaker C, Chandler HL, Nichols JJ. Tear proteomics in keratoconus. Mol vis. 2010;16:1949-1957.
28. Wojcik KA, Kaminska A, Blasiak J, Szaflik J, Szaflik JP. Oxidative stress in the pathogenesis of keratoconus and Fuchs endothelial corneal dystrophy. Int J Mol Sci. 2013;14:19294-19308.
29. Ben Mkaddem S, Rossato E, Heming N, Monteiro RC. Anti-inflammatory role of the IgA Fc receptor (CD89): from autoimmunity to therapeutic perspectives. Autoimmun Rev. 2013;12:666-669.
30. Balasubramanian SA, Pye DC, Willcox MD. Levels of lactoferrin, secretory IgA and serum albumin in the tear film of people with keratoconus. Exp Eye Res. 2012; 96:132-137.
31. Balasubramanian SA, Wasinger VC, Pye DC, Willcox MD. Preliminary identification of differentially expressed tear proteins in keratoconus. Mol Vis. 2013;19:2124-2134.
32. Chwa M, Atilano SR, Hertzog D, Zheng H, Langberg J, Kim DW et al. Hypersensitive response to oxidative stress in keratoconus corneal fibroblasts. Invest Ophthalmol Vis Sci. 2008;49:4361-4370.
33. Buddi R, Lin B, Atilano SR, Zorapapel NC, Kenney MC, Brown DJ. Evidence of oxidative stress in human corneal diseases. J Histochem Cytochem. 2002;50:341-351.
34. Brown DJ, Lin B, Chwa M, Atilano SR, Kim DW, Kenney MC. Elements of the nitric oxide pathway can degrade TIMP-1 and increase gelatinase activity. Mol Vis. 2004;10:281-288.
35. Rabinowitz YS. Keratoconus. Surv Ophthalmol. 1998;42(4):297-319.
36. Romero-Jiménez M, Santodomingo-Rubido J, Wolffsohn JS. Keratoconus: a review. Cont Lens Anterior Eye. 2010;33(4):157-166.
37. Vazirani J, Basu S. Keratoconus: current perspectives. Clin Ophthalmol. 2013;7:2019-2030.
38. Ertan A, Muftuoglu O. Keratoconus clinical findings according to different age and gender groups. Cornea. 2008;27(10):1109-1113.
39. Naderan M, Shoar S, Kamaleddin MA, Rajabi MT, Naderan M, Khodadadi M. Keratoconus Clinical Findings According to Different Classifications. Cornea. 2015;34(9):1005-1011.
40. Brautaset RL, Nilsson M, Miller WL, Leach NE, Tukler JH, Bergmanson JP. Central and peripheral corneal thinning in keratoconus. Cornea. 2013;32(3):257-261.
41. Rao SN, Raviv T, Majmudar PA, Epstein RJ. Role of Orbscan II in screening keratoconus suspects before refractive corneal surgery. S Ophthalmology. 2002;109(9):1642-1646.
42. Ahmadi Hosseini SM, Abolbashari F, Niyazmand H, Sedaghat MR. Efficacy of corneal tomography parameters and biomechanical characteristic in keratoconus detection. Cont Lens Anterior Eye. 2014;37(1):26-30.
43. Jaramillo S, Galvis V, Tello A, Rivera A, Chaparro T, Lonngi M, et al; Sensibilidad y especificidad de índices topográficos para la detección de queratocono utilizando topografía con discos de placido, topografía de elevación y topografía Scheimpflug; Rev. Sociedad Colombiana de Oftalmología. 2011;44(3):191-290.
44. Rabinowitz YS, Rasheed K. KISA% index: a quantitative videokeratography algorithm embodying minimal topographic criteria for diagnosing keratoconus. J Cataract Refract Surg. 1999;25(10):1327-1335.
45. Downie LE, Lindsay RG. Contact lens management of keratoconus. Clin Exp Optom. 2015;98(4):299-311.
46. Alhayek A, Lu PR. Corneal collagen crosslinking in keratoconus and other eye disease. Int J Ophthalmol. 201518;8(2):407-418.
47. Avni-Zauberman N, Rootman DS. Cross-linking and intracorneal ring segments--review of the literature. Eye Contact Lens. 2014;40(6):365-370.
48. Parker JS, van Dijk K, Melles GR. Treatment options for advanced keratoconus: A review. Surv Ophthalmol. 2015;60(5):459-480.
49. Krachmer JH. Pellucid marginal corneal degeneration. Arch Ophthalmol. 1978; 96:1217-1221.
50. Jinabhai A, Radhakrishnan H, O'Donnell C. Pellucid corneal marginal degeneration: A review. Cont Lens Anterior Eye. 2011;34(2):56-63.
51. Sridhar MS, Mahesh S, Bansal AK, Nutheti R, Rao GN. Pellucid marginal corneal degeneration. Ophthalmology. 2004;111(6):1102-1107.
52. Santo R, Beehara SJ, Kara-Jose N. Corneal topography in asymptomatic family members of a patient with pellucid marginal degeneration. Am J Ophthalmol. 1999;127:205-207.
53. Nagy M, Vigvary L. Beitrage zur atiologie der degeneratio marginalis pellucida cornea. Klin Monatsbl Augenh. 1972;161:604-611.
54. Krachmer JH, Feder RS, BelinMW. Keratoconus and related non inflammatory corneal thinning disorders. Surv Ophthalmol. 1984;28:293-322.
55. Rodrigues MM, Newsome DA, Krachmer JH, Eiferman RA. Pellucid marginal corneal degeneration: a clinicopathologic study of two cases. Exp Eye Res. 1981;33:277-288.
56. Zucchini G. Su di un caso di degenerazione marginale della cornea – varieta inferiore pellucida – studio clinico ed istologico. Ann Ottalmol Clin Oculist. 1962;88:47-56.
57. Francois J, Hanssens M, Stockmans L. Degenerescence marginale pellucide de la cornee. Ophthalmologica. 1968;155:337-356.
58. Sridhar MS, Mahesh S, Bansal AK, Rao GN. Superior pellucid marginal corneal degeneration. Eye (Lond). 2004;18(4):393-399.
59. Taglia DP, Sugar J. Superior pellucid marginal corneal degeneration with hydrops. Arch Ophthalmol. 1997;115:274-275.
60. Gharebaghi D, Fallahi B, Javadzadeh A, Amiraslanzadeh G. Spontaneous Corneal Hydrops and Perforation in Pellucid Marginal Degeneration; A Case Report. J Ophthalmic Vis Res. 2009 Jul; 4(3): 174–176. PMCID: PMC3498565
61. Maguire LJ, Klyce SD, McDonald MB, Kaufman HE. Corneal topography of pellucid marginal degeneration. Ophthalmology. 1987;94(5):519-524.
62. Fuchihata M, Maeda N, Toda R, Koh S, Fujikado T, Nishida K. Characteristics of corneal topographic and pachymetric patterns in patients with pellucid marginal corneal degeneration. Jpn J Ophthalmol. 2014;58(2):131-138.
63. Karabatsas CH, Cook SD. Topographic analysis in pellucid marginal corneal degeneration and keratoglobus. Eye (Lond). 1996;10( Pt 4):451-455.
64. Kompella VB, Aasuri MK, Rao GN. Management of pellucid marginal corneal degeneration with rigid gas permeable contact lenses. CLAO J. 2002;28(3):140-145.
65. Bayraktar S, Cebeci Z, Oray M, Alparslan N. Corneal Collagen Cross-Linking in Pellucid Marginal Degeneration: 2 Patients, 4 Eyes. Case Rep Ophthalmol Med. 2015;2015:840687.
66. Moshirfar M, Edmonds JN, Behunin NL, Christiansen SM. Current options in the management of pellucid marginal degeneration. J Refract Surg. 2014;30(7):474-485.
67. Robin JB, Schanzlin DJ, Verity SM, Barron BA, Arffa RC, Suarez E, Kaufman HE. Peripheral corneal disorders. Surv Ophthalmol. 1986;31:1-36.
68. Belin MW, Asota IM, Ambrosio R Jr, Khachikian SS. What's in a name: keratoconus, pellucid marginal degeneration, and related thinning disorders. Am J Ophthalmol. 2011;152(2):157-162.e1.
69. Lee BW, Jurkunas UV, Harissi-Dagher M, Poothullil AM, Tobaigy FM, Azar DT. Ectatic disorders associated with a claw-shaped pattern on corneal topography. Am J Ophthalmol. 2007;144:154-156.
70. Randleman JB. Re: Ectatic disorders associated with a claw-shaped pattern on corneal topography. Am J Ophthalmol. 2007;144(6):977-978.
71. Sinjab MM, Youssef LN. Pellucid-like keratoconus. F1000Res. 2012;15;1:48.
72. Tummanapalli SS, Maseedupally V, Mandathara P, Rathi VM, Sangwan VS. Evaluation of corneal elevation and thickness indices in pellucid marginal degeneration and keratoconus. J Cataract Refract Surg. 2013;39(1):56-65.
73. Tang M, Shekhar R, Miranda D, Huang D. Characteristics of keratoconus and pellucid marginal degeneration in mean curvature maps. Am J Ophthalmol. 2005;140(6):993-1001.
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dc.coverage.spa.fl_str_mv Bucaramanga (Santander, Colombia)
dc.coverage.temporal.spa.fl_str_mv 2012-2016
dc.coverage.campus.spa.fl_str_mv UNAB Campus Bucaramanga
dc.publisher.grantor.spa.fl_str_mv Universidad Autónoma de Bucaramanga UNAB
dc.publisher.faculty.spa.fl_str_mv Facultad Ciencias de la Salud
dc.publisher.program.spa.fl_str_mv Especialización en Oftalmología
institution Universidad Autónoma de Bucaramanga - UNAB
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spelling Galvis Ramírez, Virgilio5395c80a-0da1-46ef-87b5-05e4bb4cc16dTello Hernández, Alejandro7ae428b7-0b9b-4aff-9bbf-6940dcfd7cb5Barrera, Rodrigo6ab33ea3-ead3-4180-8b67-9f37b5d6835fCorrales Martínez, María Isabel1a485dee-c89d-42c6-8532-d6e96fbf7327Ochoa Vera, Miguel Enriquebf83ca83-93c9-401e-91d3-b424889e868fÁvalos González, Carlos414abd88-3df6-4208-b11c-fd308414746ahttps://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000898465https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000552453https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001009125https://scholar.google.es/citations?hl=es&user=CZOaBDoAAAAJhttps://scholar.google.es/citations?hl=es&user=puxZHKYAAAAJhttps://orcid.org/0000-0002-4552-3388https://orcid.org/0000-0001-5081-0720https://www.scopus.com/authid/detail.uri?authorId=36987156500https://www.scopus.com/authid/detail.uri?authorId=55963715000https://www.scopus.com/authid/detail.uri?authorId=6603664598https://www.researchgate.net/profile/Miguel_Ochoa7https://www.researchgate.net/profile/Virgilio_Galvishttps://www.researchgate.net/profile/Alejandro_Tello2Grupo de Investigaciones Clínicas2012-2016Bucaramanga (Santander, Colombia)UNAB Campus Bucaramanga2020-06-26T20:01:40Z2020-06-26T20:01:40Z2016http://hdl.handle.net/20.500.12749/1780instname:Universidad Autónoma de Bucaramanga - UNABreponame:Repositorio Institucional UNABResumen: Objetivo General y Específicos: Determinar la sensibilidad y especificidad del patrón topográfico “Pinza de Cangrejo” para diferenciar los ojos con Degeneración Marginal Pelúcida (DMP) de los que tienen Queratocono. Material y Métodos: Se realizó un análisis retrospectivo de las topografías corneales incluidas dentro de los registros del equipo Orbscan II tomadas en el Centro Oftalmológico Virgilio Galvis tomadas desde el 15 de Febrero de 2009 hasta el 31 de Julio de 2015 para identificar ojos con patrón topográfico en “Pinza de Cangrejo”. En todos los casos, se analizaron los mapas de curvatura sagitales (queratométricos) y paquimétricos. Se incluyeron todos los ojos con patrón en pinza de cangrejo en el mapa sagital (o queratométrico) y además su ojo contralateral (sin importar si tuviese o no el patrón).EspecializaciónSummary: General and Specific Objective: To determine the sensitivity and specificity of the “Crab Claw” topographic pattern to differentiate eyes with Pellucid Marginal Degeneration (MPD) from those with Keratoconus. Material and methods: A retrospective analysis of the corneal topographies included within the records of the Orbscan II team taken at the Virgilio Galvis Ophthalmology Center was carried out from February 15, 2009 to July 31, 2015 to identify eyes with a topographic pattern in "Pinza de Crab". In all cases, sagittal (keratometric) and pachymetric curvature maps were analyzed. All eyes with a crab claw pattern were included in the sagittal (or keratometric) map, as well as their contralateral eye (regardless of whether it had the pattern or not).Modalidad Presencialapplication/pdfspahttp://creativecommons.org/licenses/by-nc-nd/2.5/co/Abierto (Texto Completo)info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial-SinDerivadas 2.5 ColombiaPatrón en "Pinza de Cangrejo" asociado a ectasias corneales"Crab Claw" pattern associated with corneal ectasiasEspecialista en OftalmologíaUniversidad Autónoma de Bucaramanga UNABFacultad Ciencias de la SaludEspecialización en Oftalmologíainfo:eu-repo/semantics/masterThesisTesishttp://purl.org/redcol/resource_type/TMCorneaCorneal diseasesEye diseasesMedicineOphthalmologyResearchCorneal thinningPellucid marginal degeneration (PMD)KeratoconusCorneal ectasiaCorneal topographyCorneaEnfermedades de la corneaEnfermedades de los ojosMedicinaOftalmologíaInvestigacionesAdelgazamiento cornealDegeneración marginal pelúcida (DMP)QueratoconoEctasia cornealTopografía cornealÁvalos González, Carlos (2016). Patrón en Pinza de Cangrejo asociado a ectasias corneales. Bucaramanga (Santander, Colombia) : Universidad Autónoma de Bucaramanga UNAB1. Rabinowitz YS. Keratoconus. Surv Ophthalmol 1998; 42:297-319.2. Gorskova EN, Sevostianov EN. [Epidemiology of keratoconus in the Urals]. Vestn Oftalmol. 1998;114:38-40.3. Hashemi H, Khabazkhoob M, Yazdani N, Ostadimoghaddam H, Norouzirad R, Amanzadeh K et al. The prevalence of keratoconus in a young population in Mashhad, Iran. Ophthalmic Physiol Opt. 2014;34:519-527.4. Kennedy R, Bourne W, Dyer J. A 48-year clinical and epidemiologic study of keratoconus. Am J Ophthalmol. 1986;101:267-273.5. Galvis V, Tello A, Jaramillo JA, Gutierrez AJ, Rodriguez L, Quintero MP. Prevalence of keratoconus patients who consulted with a desire refractive surgery in ophthalmology center reference Bucaramanga, Colombia. Rev Soc Colomb Oftal. 2011;44:129-134.6. Li X, Rabinowitz YS, Rasheed K, Yang H. Longitudinal study of the normal eyes in unilateral keratoconus patientes. Ophthalmology. 2004;111:440-446.7. Georgiou T, Funnell CL, Cassels-Brown A, O'Conor R. Influence of ethnic origin on the incidence of keratoconus and associated atopic disease in Asians and white patients. Eye (lond). 2004;18:379-383.8. Pearson AR, Soneji B, Sarvananthan N, Sandford-Smith JH. Does ethnic influence the incidence or severity of keratoconus? Eye (Lond). 2000;14:625-628.9. Edwards M, McGhee CN, Dean S. The genetics of keratoconus. Clin Experiment Ophthalmol. 2001;29:345-351.10. Woodward EG, Morris MT. Joint hypermobility in keratoconus. Ophthalmic Physiol Opt. 1990;10:360-362.11. Nielsen K, Hjortdal J, Pihlmann M, Corydon TJ. Update on the keratoconus genetics. Acta Ophthalmol. 2013;91:106-113.12. Burdon KP, Coster DJ, Charlesworth JC, Mills RA, Laurie KJ, Giunta C et al. Apparent autosomal dominant keratoconus in a large Australian pedigree accounted for by digenic inheritance of two novel loci. Hum Genet. 2008;124:379-836.13. Rabinowitz YS. The genetics of keratoconus. Ophthalmol Clin North Am. 2003;16:607-620.14. Gordon-Shaag A, Millodot M, Essa M, Garth J, Ghara M, Shneor E. Is consanguinity a risk factor for keratoconus? Optom Vis Sci. 2013;90:448-454.15. Davidson AE, Hayes S, Hardcastle AJ, Tuft SJ. The pathogenesis of keratoconus. Eye (Lond). 2014;28:189-195.16. Czugala M, Karolak JA, Nowak DM, Polakowski P, Pitarque J, Molinari A et al. Novel mutation and three other sequence variants segregating with phenotype at keratoconus 13q32 susceptibility locus. Eur J Hum Genet. 2012; 20:389-397.17. Gajecka M, Radhakrishna U, Winters D, Nath SK, Rydzanicz M, Ratnamala U et al. Localization of a gene for keratoconus to a 5.6-Mb interval on 13q32. Invest Ophthalmol Vis Sci. 2009;50:1531-1539.18. Wheeler J, Hauser MA, Afshari NA, Allingham RR, Liu Y. The genetics of keratoconus: a review. Reprod Syst Sex Disord. 2012; (Suppl 6). pii: 001.19. Galvis V, Sherwin T, Tello A, Merayo J, Barrera R, Acera A. Keratoconus: an inflammatory disorder?. Eye (Lond). 2015;29(7):843-859.20. Cheung IM, McGhee CN, Sherwin T. A new perspective on the pathobiology of keratoconus: interplay of stromal wound healing and reactive species-associated processes. Clin Exp Optom. 2013;96:188-196.21. Pouliquen Y, Bureau J, Mirshahi M, Mirshahi SS, Assouline M, Lorens G. Keratoconus and inflammatory processes. Bull Soc Belge Ophtalmol. 1996;262:25-28.22.Balasubramanian SA, Mohan S, Pye DC, Willcox MD. Proteases, proteolysis and inflammatory molecules in the tears of people with keratoconus. Acta Ophthalmol. 2012;90:e303-e309.23. Lema I, Durán JA. Inflammatory molecules in the tears of patients with keratoconus. Ophthalmology. 2005;112:654-659.24. Jun AS, Cope L, Speck C, Feng X, Lee S, Meng H et al. Subnormal cytokine profile in the tear fluid of keratoconus patients. PLoS One. 2011;6:1-8.25. Kim WJ, Rabinowitz YS, Meisler DM, Wilson SE. Keratocyte apoptosis associated with keratoconus. Exp Eye Res. 1999;69:475-481.26. Balasubramanian SA, Pye DC, Willcox MD. Are proteinases the reason for keratoconus? Curr Eye Res. 2010;35:185-191.27. Pannebaker C, Chandler HL, Nichols JJ. Tear proteomics in keratoconus. Mol vis. 2010;16:1949-1957.28. Wojcik KA, Kaminska A, Blasiak J, Szaflik J, Szaflik JP. Oxidative stress in the pathogenesis of keratoconus and Fuchs endothelial corneal dystrophy. Int J Mol Sci. 2013;14:19294-19308.29. Ben Mkaddem S, Rossato E, Heming N, Monteiro RC. Anti-inflammatory role of the IgA Fc receptor (CD89): from autoimmunity to therapeutic perspectives. Autoimmun Rev. 2013;12:666-669.30. Balasubramanian SA, Pye DC, Willcox MD. Levels of lactoferrin, secretory IgA and serum albumin in the tear film of people with keratoconus. Exp Eye Res. 2012; 96:132-137.31. Balasubramanian SA, Wasinger VC, Pye DC, Willcox MD. Preliminary identification of differentially expressed tear proteins in keratoconus. Mol Vis. 2013;19:2124-2134.32. Chwa M, Atilano SR, Hertzog D, Zheng H, Langberg J, Kim DW et al. Hypersensitive response to oxidative stress in keratoconus corneal fibroblasts. Invest Ophthalmol Vis Sci. 2008;49:4361-4370.33. Buddi R, Lin B, Atilano SR, Zorapapel NC, Kenney MC, Brown DJ. Evidence of oxidative stress in human corneal diseases. J Histochem Cytochem. 2002;50:341-351.34. Brown DJ, Lin B, Chwa M, Atilano SR, Kim DW, Kenney MC. Elements of the nitric oxide pathway can degrade TIMP-1 and increase gelatinase activity. Mol Vis. 2004;10:281-288.35. Rabinowitz YS. Keratoconus. Surv Ophthalmol. 1998;42(4):297-319.36. Romero-Jiménez M, Santodomingo-Rubido J, Wolffsohn JS. Keratoconus: a review. Cont Lens Anterior Eye. 2010;33(4):157-166.37. Vazirani J, Basu S. Keratoconus: current perspectives. Clin Ophthalmol. 2013;7:2019-2030.38. Ertan A, Muftuoglu O. Keratoconus clinical findings according to different age and gender groups. Cornea. 2008;27(10):1109-1113.39. Naderan M, Shoar S, Kamaleddin MA, Rajabi MT, Naderan M, Khodadadi M. Keratoconus Clinical Findings According to Different Classifications. Cornea. 2015;34(9):1005-1011.40. Brautaset RL, Nilsson M, Miller WL, Leach NE, Tukler JH, Bergmanson JP. Central and peripheral corneal thinning in keratoconus. Cornea. 2013;32(3):257-261.41. Rao SN, Raviv T, Majmudar PA, Epstein RJ. Role of Orbscan II in screening keratoconus suspects before refractive corneal surgery. S Ophthalmology. 2002;109(9):1642-1646.42. Ahmadi Hosseini SM, Abolbashari F, Niyazmand H, Sedaghat MR. Efficacy of corneal tomography parameters and biomechanical characteristic in keratoconus detection. Cont Lens Anterior Eye. 2014;37(1):26-30.43. Jaramillo S, Galvis V, Tello A, Rivera A, Chaparro T, Lonngi M, et al; Sensibilidad y especificidad de índices topográficos para la detección de queratocono utilizando topografía con discos de placido, topografía de elevación y topografía Scheimpflug; Rev. Sociedad Colombiana de Oftalmología. 2011;44(3):191-290.44. Rabinowitz YS, Rasheed K. KISA% index: a quantitative videokeratography algorithm embodying minimal topographic criteria for diagnosing keratoconus. J Cataract Refract Surg. 1999;25(10):1327-1335.45. Downie LE, Lindsay RG. Contact lens management of keratoconus. Clin Exp Optom. 2015;98(4):299-311.46. Alhayek A, Lu PR. Corneal collagen crosslinking in keratoconus and other eye disease. Int J Ophthalmol. 201518;8(2):407-418.47. Avni-Zauberman N, Rootman DS. Cross-linking and intracorneal ring segments--review of the literature. Eye Contact Lens. 2014;40(6):365-370.48. Parker JS, van Dijk K, Melles GR. Treatment options for advanced keratoconus: A review. Surv Ophthalmol. 2015;60(5):459-480.49. Krachmer JH. Pellucid marginal corneal degeneration. Arch Ophthalmol. 1978; 96:1217-1221.50. Jinabhai A, Radhakrishnan H, O'Donnell C. Pellucid corneal marginal degeneration: A review. Cont Lens Anterior Eye. 2011;34(2):56-63.51. Sridhar MS, Mahesh S, Bansal AK, Nutheti R, Rao GN. Pellucid marginal corneal degeneration. Ophthalmology. 2004;111(6):1102-1107.52. Santo R, Beehara SJ, Kara-Jose N. Corneal topography in asymptomatic family members of a patient with pellucid marginal degeneration. Am J Ophthalmol. 1999;127:205-207.53. Nagy M, Vigvary L. Beitrage zur atiologie der degeneratio marginalis pellucida cornea. Klin Monatsbl Augenh. 1972;161:604-611.54. Krachmer JH, Feder RS, BelinMW. Keratoconus and related non inflammatory corneal thinning disorders. Surv Ophthalmol. 1984;28:293-322.55. Rodrigues MM, Newsome DA, Krachmer JH, Eiferman RA. Pellucid marginal corneal degeneration: a clinicopathologic study of two cases. Exp Eye Res. 1981;33:277-288.56. Zucchini G. Su di un caso di degenerazione marginale della cornea – varieta inferiore pellucida – studio clinico ed istologico. Ann Ottalmol Clin Oculist. 1962;88:47-56.57. Francois J, Hanssens M, Stockmans L. Degenerescence marginale pellucide de la cornee. Ophthalmologica. 1968;155:337-356.58. Sridhar MS, Mahesh S, Bansal AK, Rao GN. Superior pellucid marginal corneal degeneration. Eye (Lond). 2004;18(4):393-399.59. Taglia DP, Sugar J. Superior pellucid marginal corneal degeneration with hydrops. Arch Ophthalmol. 1997;115:274-275.60. Gharebaghi D, Fallahi B, Javadzadeh A, Amiraslanzadeh G. Spontaneous Corneal Hydrops and Perforation in Pellucid Marginal Degeneration; A Case Report. J Ophthalmic Vis Res. 2009 Jul; 4(3): 174–176. PMCID: PMC349856561. Maguire LJ, Klyce SD, McDonald MB, Kaufman HE. Corneal topography of pellucid marginal degeneration. Ophthalmology. 1987;94(5):519-524.62. Fuchihata M, Maeda N, Toda R, Koh S, Fujikado T, Nishida K. Characteristics of corneal topographic and pachymetric patterns in patients with pellucid marginal corneal degeneration. Jpn J Ophthalmol. 2014;58(2):131-138.63. Karabatsas CH, Cook SD. Topographic analysis in pellucid marginal corneal degeneration and keratoglobus. Eye (Lond). 1996;10( Pt 4):451-455.64. Kompella VB, Aasuri MK, Rao GN. Management of pellucid marginal corneal degeneration with rigid gas permeable contact lenses. CLAO J. 2002;28(3):140-145.65. Bayraktar S, Cebeci Z, Oray M, Alparslan N. Corneal Collagen Cross-Linking in Pellucid Marginal Degeneration: 2 Patients, 4 Eyes. Case Rep Ophthalmol Med. 2015;2015:840687.66. Moshirfar M, Edmonds JN, Behunin NL, Christiansen SM. Current options in the management of pellucid marginal degeneration. J Refract Surg. 2014;30(7):474-485.67. Robin JB, Schanzlin DJ, Verity SM, Barron BA, Arffa RC, Suarez E, Kaufman HE. Peripheral corneal disorders. Surv Ophthalmol. 1986;31:1-36.68. Belin MW, Asota IM, Ambrosio R Jr, Khachikian SS. What's in a name: keratoconus, pellucid marginal degeneration, and related thinning disorders. Am J Ophthalmol. 2011;152(2):157-162.e1.69. Lee BW, Jurkunas UV, Harissi-Dagher M, Poothullil AM, Tobaigy FM, Azar DT. Ectatic disorders associated with a claw-shaped pattern on corneal topography. Am J Ophthalmol. 2007;144:154-156.70. Randleman JB. Re: Ectatic disorders associated with a claw-shaped pattern on corneal topography. Am J Ophthalmol. 2007;144(6):977-978.71. Sinjab MM, Youssef LN. Pellucid-like keratoconus. F1000Res. 2012;15;1:48.72. Tummanapalli SS, Maseedupally V, Mandathara P, Rathi VM, Sangwan VS. Evaluation of corneal elevation and thickness indices in pellucid marginal degeneration and keratoconus. J Cataract Refract Surg. 2013;39(1):56-65.73. Tang M, Shekhar R, Miranda D, Huang D. Characteristics of keratoconus and pellucid marginal degeneration in mean curvature maps. Am J Ophthalmol. 2005;140(6):993-1001.ORIGINAL2016_Tesis_Carlos_Avalos_Gonzalez.pdf2016_Tesis_Carlos_Avalos_Gonzalez.pdfTesisapplication/pdf583569https://repository.unab.edu.co/bitstream/20.500.12749/1780/1/2016_Tesis_Carlos_Avalos_Gonzalez.pdfbad247b91e7dfbc79a29992a24d457b8MD51open access2016_Licencia_Carlos_Avalos_Gonzalez.pdf2016_Licencia_Carlos_Avalos_Gonzalez.pdfLicenciaapplication/pdf779362https://repository.unab.edu.co/bitstream/20.500.12749/1780/2/2016_Licencia_Carlos_Avalos_Gonzalez.pdfe4f5838a87aa707a90ce71d50ded0fc2MD52metadata only accessTHUMBNAIL2016_Tesis_Carlos_Avalos_Gonzalez.pdf.jpg2016_Tesis_Carlos_Avalos_Gonzalez.pdf.jpgIM Thumbnailimage/jpeg7048https://repository.unab.edu.co/bitstream/20.500.12749/1780/3/2016_Tesis_Carlos_Avalos_Gonzalez.pdf.jpg7d9ca60226b591d5fa77140f37d56a9cMD53open access2016_Licencia_Carlos_Avalos_Gonzalez.pdf.jpg2016_Licencia_Carlos_Avalos_Gonzalez.pdf.jpgIM Thumbnailimage/jpeg11367https://repository.unab.edu.co/bitstream/20.500.12749/1780/4/2016_Licencia_Carlos_Avalos_Gonzalez.pdf.jpg87e0abd023572c5fde3a68feeaa0c90eMD54metadata only access20.500.12749/1780oai:repository.unab.edu.co:20.500.12749/17802024-01-21 10:18:38.353open accessRepositorio Institucional | Universidad Autónoma de Bucaramanga - UNABrepositorio@unab.edu.co