Validez de criterio de los hallazgos gammagráficos en manos para diagnóstico de osteoartritis en población adulta

La osteoartritis (OA, Por sus siglas en inglés), es uno de los trastornos articulares más debilitantes del mundo, y afecta hasta al 10% de los hombres y al 13% de las mujeres (1). En las sociedades occidentales, se espera que la prevalencia de la OA aumente debido al envejecimiento de la población (...

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Autores:: Díaz Contreras, Indira Eliana

Tipo de recurso:

Fecha de publicación:: 2023

Institución:: Universidad Autónoma de Bucaramanga - UNAB

Repositorio:: Repositorio UNAB

Idioma:: spa

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network_acronym_str	UNAB2
network_name_str	Repositorio UNAB
repository_id_str
dc.title.spa.fl_str_mv	Validez de criterio de los hallazgos gammagráficos en manos para diagnóstico de osteoartritis en población adulta
dc.title.translated.spa.fl_str_mv	Criterion validity of scintigraphic findings in hands for diagnosis of osteoarthritis in the adult population
title	Validez de criterio de los hallazgos gammagráficos en manos para diagnóstico de osteoartritis en población adulta
spellingShingle	Validez de criterio de los hallazgos gammagráficos en manos para diagnóstico de osteoartritis en población adulta Medical sciences Health sciences Nuclear medicine Radiation Physiological effect Arthritis hand function test Rheumatoid arthritis Nuclear magnetic resonance Technetium 99m Methylene Diphosphonate Trapezio-metacarpal joint Proximal interphalangeal Distal interphalangeal Bone scintigraphy Osteoarthritis Hand osteoarthritis The clinical diagnosis based on ACR 1990 classification criteria Medical radiology Diagnostic imaging Radioactivity (Measurements) Non-invasive diagnosis Ciencias médicas Medicina nuclear Radiación Efectos fisiológicos Radiología médica Diagnóstico por imágenes Radioactividad (Mediciones) Diagnóstico no invasivo Criterios del Colegio Americano de Reumatología Artritis reumatoidea Gammagrafía ósea Resonancia magnética nuclear Osteoartritis Articulación trapecio-metacarpiano Interfalángicas proximales Interfalángicas distales Osteoartritis en manos 99mTc-MDP Tecnecio 99m metileno difosfonato
title_short	Validez de criterio de los hallazgos gammagráficos en manos para diagnóstico de osteoartritis en población adulta
title_full	Validez de criterio de los hallazgos gammagráficos en manos para diagnóstico de osteoartritis en población adulta
title_fullStr	Validez de criterio de los hallazgos gammagráficos en manos para diagnóstico de osteoartritis en población adulta
title_full_unstemmed	Validez de criterio de los hallazgos gammagráficos en manos para diagnóstico de osteoartritis en población adulta
title_sort	Validez de criterio de los hallazgos gammagráficos en manos para diagnóstico de osteoartritis en población adulta
dc.creator.fl_str_mv	Díaz Contreras, Indira Eliana
dc.contributor.advisor.none.fl_str_mv	Morales Avellaneda, Tatiana Saaibi Solano, Diego Luis Ochoa Vera, Miguel Enrique
dc.contributor.author.none.fl_str_mv	Díaz Contreras, Indira Eliana
dc.contributor.cvlac.spa.fl_str_mv	Morales Avellaneda, Tatiana [0000152758] Saaibi Solano, Diego Luis [0001362430] Ochoa Vera, Miguel Enrique [0000898465]
dc.contributor.orcid.spa.fl_str_mv	Morales Avellaneda, Tatiana [0000-0001-6250-8801] Saaibi Solano, Diego Luis [0000-0002-4880-7108]
dc.contributor.apolounab.spa.fl_str_mv	Morales Avellaneda, Tatiana [tatiana-morales-avellaneda] Saaibi Solano, Diego Luis [diego-luis-saaibi-solano] Ochoa Vera, Miguel Enrique [miguel-enrique-ochoa-vera]
dc.subject.keywords.spa.fl_str_mv	Medical sciences Health sciences Nuclear medicine Radiation Physiological effect Arthritis hand function test Rheumatoid arthritis Nuclear magnetic resonance Technetium 99m Methylene Diphosphonate Trapezio-metacarpal joint Proximal interphalangeal Distal interphalangeal Bone scintigraphy Osteoarthritis Hand osteoarthritis The clinical diagnosis based on ACR 1990 classification criteria Medical radiology Diagnostic imaging Radioactivity (Measurements) Non-invasive diagnosis
topic	Medical sciences Health sciences Nuclear medicine Radiation Physiological effect Arthritis hand function test Rheumatoid arthritis Nuclear magnetic resonance Technetium 99m Methylene Diphosphonate Trapezio-metacarpal joint Proximal interphalangeal Distal interphalangeal Bone scintigraphy Osteoarthritis Hand osteoarthritis The clinical diagnosis based on ACR 1990 classification criteria Medical radiology Diagnostic imaging Radioactivity (Measurements) Non-invasive diagnosis Ciencias médicas Medicina nuclear Radiación Efectos fisiológicos Radiología médica Diagnóstico por imágenes Radioactividad (Mediciones) Diagnóstico no invasivo Criterios del Colegio Americano de Reumatología Artritis reumatoidea Gammagrafía ósea Resonancia magnética nuclear Osteoartritis Articulación trapecio-metacarpiano Interfalángicas proximales Interfalángicas distales Osteoartritis en manos 99mTc-MDP Tecnecio 99m metileno difosfonato
dc.subject.lemb.spa.fl_str_mv	Ciencias médicas Medicina nuclear Radiación Efectos fisiológicos Radiología médica Diagnóstico por imágenes Radioactividad (Mediciones) Diagnóstico no invasivo
dc.subject.proposal.spa.fl_str_mv	Criterios del Colegio Americano de Reumatología Artritis reumatoidea Gammagrafía ósea Resonancia magnética nuclear Osteoartritis Articulación trapecio-metacarpiano Interfalángicas proximales Interfalángicas distales Osteoartritis en manos 99mTc-MDP Tecnecio 99m metileno difosfonato
description	La osteoartritis (OA, Por sus siglas en inglés), es uno de los trastornos articulares más debilitantes del mundo, y afecta hasta al 10% de los hombres y al 13% de las mujeres (1). En las sociedades occidentales, se espera que la prevalencia de la OA aumente debido al envejecimiento de la población (1). Es una enfermedad que genera dolor y discapacidad en los adultos con un importante impacto socioeconómico tanto dentro como fuera de nuestro país (2). Es una artropatía degenerativa, inflamatoria y crónica en la que influyen factores estresantes, factores de riesgo, hormonales, ambientales y genéticos, que pueden predisponer a un individuo a desarrollar OA en una articulación en particular. Afecta a los tejidos articulares incluyendo cartílago, hueso subcondral y la membrana sinovial. Este trastorno es consecuencia del catabolismo progresivo de los componentes de la matriz del cartílago articular, provocado por un desequilibrio entre la síntesis y la degradación bioquímica del cartílago articular en las articulaciones sinoviales; y cualquier articulación en el cuerpo puede verse afectada, sin embargo, la OA es más frecuente en las articulaciones que soportan peso, como las rodillas, las caderas, la columna vertebral y las manos. La artrosis de la mano y la muñeca cobra una mayor importancia dado que produce una discapacidad equivalente a la causada por enfermedades cardiacas, y mayor que cualquier otra patología en personas de avanzada edad. En la mano y la muñeca, el sitio más común de la OA, es la base del pulgar (Articulación trapecio-metacarpiano (TMC) o primera articulación carpo-metacarpiana (CMC I) (3). En el caso de las mujeres postmenopáusicas se presenta más comúnmente en las articulaciones interfalángicas distales y proximales (4). La radiografía ha sido un método sensible para la evaluación de la progresión digital de la OA evidenciando con cambios radiográficos indicativos como: (estrechamiento del espacio articular, osteofitos, formación de quistes, esclerosis) en hasta el 81% de la población anciana, sin embargo, no es capaz de detectar los cambios estructurales o bioquímicos de la OA, de forma frecuente los únicos hallazgos son los síntomas iniciales del paciente. La OA digital se asocia a brotes dolorosos ocasionales y durante varios años puede ser asintomática, que no se pueden predecir mediante la radiografía (5). Se ha sugerido que la Gammagrafía Ósea (GO) con Tecnecio 99m Metileno Difosfonato (99mTc–MDP) es un método sensible para detectar OA en una etapa temprana y la retención de isótopos alrededor de la mano o la rodilla se ha correlacionado con la progresión radiográfica posterior de OA (6,7). Es un estudio que no hace parte de la evaluación inicial de la enfermedad osteoarticular, pero su alta sensibilidad, permite detectar cambios estructurales previos, además es reproducible y tiene un valor predictivo negativo superior al 90%, permitiendo discriminar el origen del dolor si es proveniente de tejidos blandos u hueso. Esto es debido a que el radiofármaco alcanza el hueso a través de la circulación sanguínea y se une al cristal de hidroxiapatita con alta afinidad, permitiendo evaluar de manera indirecta la actividad osteoblástica (8). La gammagrafía ósea de las manos y las muñecas representa una importante técnica de imagen adjunta que complementa el examen radiográfico. El uso de la gammagrafía ósea trifásica proporciona información clínica no solo con respecto a la captación ósea, sino también el flujo sanguíneo y la distribución extravascular del radio trazador. En la literatura existen estudios antiguos y limitados, donde se correlaciona la gammagrafía ósea en pacientes con osteoartritis, sin embargo, no son reproducibles dado por el tamaño de la muestra, por el tiempo de observación y por no existir una correlación conjunta ni clínica ni imagenológica, sin embargo, durante muchos años, se ha enfatizado que la GO que utiliza compuestos de fosfonato de 99mTc tiene una alta sensibilidad, pero baja especificidad para la detección de enfermedades óseas y articulares, y se sugiere que es una herramienta que permite detectar cambios estructurales iniciales (6,7). Actualmente, hemos evidenciado que la detección accidental de cambios artríticos en una gammagrafía ósea es un hallazgo común que a menudo no se informa y se considera de poca importancia en el contexto clínico del estudio. Nuestra propuesta es realizar el primer estudio a nivel mundial evaluando los cambios tempranos de la OA, a partir de un estudio funcional y correlacionarlo con clínica e imágenes radiográficas, y de esta forma contribuir en el diagnóstico inicial para disminuir las limitaciones funcionales propias de la enfermedad y mejorar la calidad de vida relacionada con la salud.
publishDate	2023
dc.date.issued.none.fl_str_mv	2023-12-12
dc.date.accessioned.none.fl_str_mv	2024-01-19T13:33:53Z
dc.date.available.none.fl_str_mv	2024-01-19T13:33:53Z
dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.local.spa.fl_str_mv	Tesis
dc.type.hasversion.none.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.redcol.none.fl_str_mv	http://purl.org/redcol/resource_type/TM
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/20.500.12749/23195
dc.identifier.instname.spa.fl_str_mv	instname:Universidad Autónoma de Bucaramanga - UNAB
dc.identifier.reponame.spa.fl_str_mv	reponame:Repositorio Institucional UNAB
dc.identifier.repourl.spa.fl_str_mv	repourl:https://repository.unab.edu.co
url	http://hdl.handle.net/20.500.12749/23195
identifier_str_mv	instname:Universidad Autónoma de Bucaramanga - UNAB reponame:Repositorio Institucional UNAB repourl:https://repository.unab.edu.co
dc.language.iso.spa.fl_str_mv	spa
language	spa
dc.relation.references.spa.fl_str_mv	Zhang Y, Jordan JM. Epidemiology of osteoarthritis. Vol. 26, Clinics in Geriatric Medicine. 2010. p. 355–69. Buckwalter JA, Saltzman C, Brown T. The impact of osteoarthritis: Implications for research. Clin Orthop Relat Res [Internet]. 2004 [cited 2022 Dec 6];427(SUPPL.). Available from: https://journals.lww.com/clinorthop/Fulltext/2004/10001/The_Impact_of_Osteoarthritis__Implications_for.4.aspx Kloppenburg M, Kwok WY. Hand osteoarthritisĝ€"a heterogeneous disorder. Vol. 8, Nature Reviews Rheumatology. 2012. p. 22–31. Johnson VL, Hunter DJ. The epidemiology of osteoarthritis. Vol. 28, Best Practice and Research: Clinical Rheumatology. Bailliere Tindall Ltd; 2014. p. 5–15. Felson DT. An update on the pathogenesis and epidemiology of osteoarthritis. Vol. 42, Radiologic Clinics of North America. W.B. Saunders; 2004. p. 1–9. Love C, Din AS, Tomas MB, Kalapparambath TP, Palestro CJ. Radionuclide Bone Imaging: An Illustrative Review. Vol. 23, Radiographics. Radiological Society of North America Inc.; 2003. p. 341–58. Balblanc JC, Mathieu P, Mathieut L, Tron AM, Conrozier T, Piperno M, et al. OSTEOARTHRITIS and CARTILAGE Progression of digital osteoarthritis: a sequential scintigraphic and radiographic study. Vol. 3, Osteoarthritis and Cartilage. 1995. O’Connor MK, Brown ML, Hung JC, Hayostek RJ. The Art of Bone Scintigraphy—Technical Aspects. Journal of Nuclear Medicine [Internet]. 1991 Dec 1 [cited 2022 Dec 6];32(12):2332–41. Available from: https://jnm.snmjournals.org/content/32/12/2332 A randomized, double-blind, placebo-controlled, parallel group, Phase II, 24-week study investigating the efficacy, safety and tolerability of AIN457 in patients with active overuse tendinopathy refractory to oral NSAIDs/acetaminophen, physiotherapy or corticosteroid injections. 2018. Zhang W, Doherty M, Leeb BF, Alekseeva L, Arden NK, Bijlsma JW, et al. EULAR evidence-based recommendations for the diagnosis of hand osteoarthritis: report of a task force of ESCISIT. Ann Rheum Dis [Internet]. 2009 Jan [cited 2022 Dec 7];68(1):8–17. Available from: https://pubmed.ncbi.nlm.nih.gov/18250111/ Guermazi A, Niu J, Hayashi D, Roemer FW, Englund M, Neogi T, et al. Prevalence of abnormalities in knees detected by MRI in adults without knee osteoarthritis: population based observational study (Framingham Osteoarthritis Study). BMJ [Internet]. 2012 Aug 29 [cited 2022 Dec 7];345(7874). Available from: https://www.bmj.com/content/345/bmj.e5339 Barr AJ, Dube B, Hensor EMA, Kingsbury SR, Peat G, Bowes MA, et al. The relationship between clinical characteristics, radiographic osteoarthritis and 3D bone area: Data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2014 Oct 1;22(10):1703–9. Kloppenburg M, Bøyesen P, Visser AW, Haugen IK, Boers M, Boonen A, et al. Report from the OMERACT Hand Osteoarthritis Working Group: Set of Core Domains and Preliminary Set of Instruments for Use in Clinical Trials and Observational Studies. J Rheumatol [Internet]. 2015 Nov 1 [cited 2022 Dec 7];42(11):2190–7. Available from: https://pubmed.ncbi.nlm.nih.gov/26136489/ Sodha S, Ring D, Zurakowski D, Jupiter JB. Prevalence of osteoarthrosis of the trapeziometacarpal joint. Journal of Bone and Joint Surgery [Internet]. 2005 [cited 2022 Dec 7];87(12 I):2614–8. Available from: https://journals.lww.com/jbjsjournal/Fulltext/2005/12000/Prevalence_of_Osteoarthrosis_of_the.3.aspx Kalichman L, Malkin I, Livshits G, Kobyliansky E. The association between morbidity and radiographic hand osteoarthritis: a population-based study. Joint Bone Spine. 2006 Jul 1;73(4):406–10. Ye L, Kalichman L, Spittle A, Dobson F, Bennell K. Effects of rehabilitative interventions on pain, function and physical impairments in people with hand osteoarthritis: A systematic review. Arthritis Res Ther. 2011 Feb 18;13(1). Zhang Y, Niu J, Kelly-Hayes M, Chaisson CE, Aliabadi P, Felson DT. Prevalence of symptomatic hand osteoarthritis and its impact on functional status among the elderly: The framingham study. Am J Epidemiol. 2002 Dec 1;156(11):1021–7. María M, Martín S. artrosis. etiopatogenia y tratamiento etiology and treatment. Ye L, Kalichman L, Spittle A, Dobson F, Bennell K. Effects of rehabilitative interventions on pain, function and physical impairments in people with hand osteoarthritis: A systematic review. Arthritis Res Ther. 2011 Feb 18;13(1). Visser AW, Ioan-Facsinay A, de Mutsert R, Widya RL, Loef M, de Roos A, et al. Adiposity and hand osteoarthritis: The Netherlands Epidemiology of Obesity study. Arthritis Res Ther. 2014 Jan 22;16(1). Visser AW, Bøyesen P, Haugen IK, Schoones JW, van der Heijde DM, Rosendaal FR, et al. Radiographic scoring methods in hand osteoarthritis - a systematic literature search and descriptive review. Osteoarthritis Cartilage [Internet]. 2014 Oct 1 [cited 2022 Dec 7];22(10):1710–23. Available from: http://www.oarsijournal.com/article/S106345841401108X/fulltext Chu CR, Williams AA, Coyle CH, Bowers ME. Early diagnosis to enable early treatment of pre-osteoarthritis. Arthritis Res Ther [Internet]. 2012 Jun 7 [cited 2022 Dec 7];14(3):1–10. Available from: https://arthritis-research.biomedcentral.com/articles/10.1186/ar3845 Mccrae F, Shouls J, Dieppe P, Watt I. Scintigraphic assessment of osteoarthritis of the knee joint. Vol. 51, Annals of the Rheumatic Diseases. 1992. Boegård T, Rudling O, Dahlström J, Dirksen H, Petersson IF, Jonsson K. Bone scintigraphy in chronic knee pain: comparison with magnetic resonance imaging. Nakamura N, Sugano N, Nishii T, Miki H, Haraguchi K, Hagio K, et al. Scintigraphic image patterns in dysplastic coxarthrosis: evaluation with reference to radiographic findings in 210 hips. Acta Orthop Scand [Internet]. 2003 Apr [cited 2022 Dec 7];74(2):159–64. Available from: https://pubmed.ncbi.nlm.nih.gov/12807322/ Perruccio A v., Power JD, Evans HMK, Mahomed SR, Gandhi R, Mahomed NN, et al. Multiple joint involvement in total knee replacement for osteoarthritis: Effects on patient-reported outcomes. Arthritis Care Res (Hoboken). 2012 Jun;64(6):838–46. Lawrence RC, Felson DT, Helmick CG, Arnold LM, Choi H, Deyo RA, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum [Internet]. 2008 Jan [cited 2022 Dec 7];58(1):26–35. Available from: https://pubmed.ncbi.nlm.nih.gov/18163497/ Haugen IK, Englund M, Aliabadi P, Niu J, Clancy M, Kvien TK, et al. Prevalence, incidence and progression of hand osteoarthritis in the general population: The Framingham Osteoarthritis Study. Ann Rheum Dis. 2011;70(9):1581–6. Carmona L, Ballina J, Gabriel R, Lavon A. The burden of musculoskeletal diseases in the general population of Spain: results from a national survey [Internet]. Vol. 60, Ann Rheum Dis. 2001. Available from: www.annrheumdis.com Kessler S, Stöve J, Puhl W, Stürmer T. First carpometacarpal and interphalangeal osteoarthritis of the hand in patients with advanced hip or knee OA. Are there differences in the aetiology? Clin Rheumatol. 2003 Dec;22(6):409–13. Carmona L, Ballina J, Gabriel R, Lavon A. The burden of musculoskeletal diseases in the general population of Spain: results from a national survey [Internet]. Vol. 60, Ann Rheum Dis. 2001. Available from: www.annrheumdis.com Dahaghin S, Bierma-Zeinstra SMA, Ginai AZ, Pols HAP, Hazes JMW, Koes BW. Prevalence and pattern of radiographic hand osteoarthritis and association with pain and disability (the Rotterdam study). Ann Rheum Dis. 2005 May;64(5):682–7. Kim E, Guilak F, Haider MA. The dynamic mechanical environment of the chondrocyte: A biphasic finite element model of cell-matrix interactions under cyclic compressive loading. J Biomech Eng. 2008 Dec;130(6). Zuscik MJ, Hilton MJ, Zhang X, Chen D, O’Keefe RJ. Regulation of chondrogenesis and chondrocyte differentiation by stress. Vol. 118, Journal of Clinical Investigation. 2008. p. 429–38. Aigner T, Sachse A, Gebhard PM, Roach HI. Osteoarthritis: pathobiology-targets and ways for therapeutic intervention. Adv Drug Deliv Rev [Internet]. 2006 May 20 [cited 2022 Dec 7];58(2):128–49. Available from: https://pubmed.ncbi.nlm.nih.gov/16616393/ Iscru DF, Anghelina M, Agarwal S, Agarwal G. Changes in surface topologies of chondrocytes subjected to mechanical forces: an AFM analysis. Gadher SJ, Eyre DR, Wotton SF, Schmid TM, Woolley DE. Degradation of cartilage collagens type II, IX, X and XI by enzymes derived from human articular chondrocytes. Matrix [Internet]. 1990 [cited 2022 Dec 7];10(3):154–63. Available from: https://pubmed.ncbi.nlm.nih.gov/2170828/ Benito MJ, Veale DJ, FitzGerald O, van den Berg WB, Bresnihan B. Synovial tissue inflammation in early and late osteoarthritis. Ann Rheum Dis. 2005 Sep;64(9):1263–7. Davis Aileen M, M HG. Assessment of the patient with osteoarthritis and measurement of outcomes. Silman A, Smolen J, Weinblatt M, Weisman M, Hochberg M, Ellen G, editors. Rheumatology. 2018;2. Bellamy Nicholas, Carsolio Pacheco Rosario. Atlas de reumatología clínica /. Editorial Científica PLM,; 1985. Racz B, Reglodi D, Fodor B, Gasz B, Lubics A, Gallyas F, et al. Hyperosmotic stress-induced apoptotic signaling pathways in chondrocytes. Bone [Internet]. 2007 Jun [cited 2022 Dec 7];40(6):1536–43. Available from: https://pubmed.ncbi.nlm.nih.gov/17392049/ Roman-Blas JA, Stokes DG, Jimenez SA. Osteoarthritis Cartilage. Vol. 15. 2007. Felson DT, Lawrence RC, Dieppe PA, Hirsch R, Helmick CG, Jordan JM, et al. Osteoarthritis: new insights. Part 1: the disease and its risk factors. Ann Intern Med [Internet]. 2000 [cited 2022 Dec 7];133(8):635–46. Available from: https://pubmed.ncbi.nlm.nih.gov/11033593/ Cirillo DJ, Wallace RB, Wu L, Yood RA. Effect of hormone therapy on risk of hip and knee joint replacement in the Women’s Health Initiative. Arthritis Rheum [Internet]. 2006 Oct [cited 2022 Dec 7];54(10):3194–204. Available from: https://pubmed.ncbi.nlm.nih.gov/17009251/ de Klerk BM, Schiphof D, Groeneveld FPMJ, Koes BW, van Osch GJVM, van Meurs JBJ, et al. No clear association between female hormonal aspects and osteoarthritis of the hand, hip and knee: a systematic review. Rheumatology (Oxford) [Internet]. 2009 Sep [cited 2022 Dec 7];48(9):1160–5. Available from: https://pubmed.ncbi.nlm.nih.gov/19608726/ The effect of estrogen plus progestin on knee symptoms and related disability in postmenopausal women: The Heart and Estrogen/Progestin Replacement Study, a randomized, double-blind, placebo-controlled trial - PubMed [Internet]. [cited 2022 Dec 7]. Available from: https://pubmed.ncbi.nlm.nih.gov/11315920/ Hochberg MC, Lethbridge-Cejku M, Tobin JD. Bone mineral density and osteoarthritis: Data from the Baltimore Longitudinal Study of Aging. Osteoarthritis Cartilage [Internet]. 2004 [cited 2022 Dec 7];12(SUPLL.):45–8. Available from: https://pubmed.ncbi.nlm.nih.gov/14698641/ Spector TD, MacGregor AJ. Risk factors for osteoarthritis: Genetics. Osteoarthritis Cartilage [Internet]. 2004 [cited 2022 Dec 7];12(SUPLL.):39–44. Available from: https://pubmed.ncbi.nlm.nih.gov/14698640/ Evidence for a Mendelian gene in a segregation analysis of generalized radiographic osteoarthritis: the Framingham Study - PubMed [Internet]. [cited 2022 Dec 7]. Available from: https://pubmed.ncbi.nlm.nih.gov/9627016/ Kerkhof HJM, Lories RJ, Meulenbelt I, Jonsdottir I, Valdes AM, Arp P, et al. A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Arthritis Rheum [Internet]. 2010 Feb [cited 2022 Dec 7];62(2):499–510. Available from: https://pubmed.ncbi.nlm.nih.gov/20112360/ Chen HC, Shah SH, Li YJ, Stabler T v., Jordan JM, Kraus VB. Inverse Association of General Joint Hypermobility With Hand and Knee Osteoarthritis and Serum Cartilage Oligomeric Matrix Protein Levels. Arthritis Rheum [Internet]. 2008 Dec [cited 2022 Dec 7];58(12):3854. Available from: /pmc/articles/PMC3698615/ The relationship of joint hypermobility, bone mineral density, and osteoarthritis in the general population: the Chingford Study - PubMed [Internet]. [cited 2022 Dec 7]. Available from: https://pubmed.ncbi.nlm.nih.gov/12672202/ Hu PF, Bao JP, Wu LD. The emerging role of adipokines in osteoarthritis: a narrative review. Mol Biol Rep [Internet]. 2011 Feb [cited 2022 Dec 7];38(2):873–8. Available from: https://pubmed.ncbi.nlm.nih.gov/20480243/ Magliano M. Obesity and arthritis. Menopause Int [Internet]. 2008 [cited 2022 Dec 7];14(4):149–54. Available from: https://pubmed.ncbi.nlm.nih.gov/19037063/ Carman WJ, Sowers M, Hawthorne VM, Weissfeld LA. Obesity as a risk factor for osteoarthritis of the hand and wrist: a prospective study. Am J Epidemiol [Internet]. 1994 Jan 15 [cited 2022 Dec 7];139(2):119–29. Available from: https://pubmed.ncbi.nlm.nih.gov/8296779/ Kalichman L, Kobyliansky E, Seibel MJ, Livshits G. Repeated measurement study of hand osteoarthritis in an apparently healthy Caucasian population. Am J Hum Biol [Internet]. 2005 Sep [cited 2022 Dec 7];17(5):611–21. Available from: https://pubmed.ncbi.nlm.nih.gov/16136535/ Kalichman L, Li L, Batsevich V, Malkin I, Kobyliansky E. Prevalence, pattern and determinants of radiographic hand osteoarthritis in five Russian community-based samples. Osteoarthritis Cartilage [Internet]. 2010 Jun [cited 2022 Dec 7];18(6):803–9. Available from: https://pubmed.ncbi.nlm.nih.gov/20172037/ Comparison of the prevalence of knee osteoarthritis between the elderly Chinese population in Beijing and whites in the United States: The Beijing Osteoarthritis Study - PubMed [Internet]. [cited 2022 Dec 7]. Available from: https://pubmed.ncbi.nlm.nih.gov/11592368/ Zhang Y, Terkeltaub R, Nevitt M, Xu L, Neogi T, Aliabadi P, et al. Lower prevalence of chondrocalcinosis in Chinese subjects in Beijing than in white subjects in the United States: The Beijing osteoarthritis study. Arthritis Rheum. 2006 Nov;54(11):3508–12. Toba N, Sakai A, Aoyagi K, Yoshida S, Honda S, Nakamura T. Prevalence and involvement patterns of radiographic hand osteoarthritis in Japanese women: the Hizen-Oshima Study. J Bone Miner Metab [Internet]. 2006 Jul [cited 2022 Dec 7];24(4):344–8. Available from: https://pubmed.ncbi.nlm.nih.gov/16816930/ Zeng QY, Chen R, Darmawan J, Xiao ZY, Chen SB, Wigley R, et al. Rheumatic diseases in China. Arthritis Res Ther. 2008 Jan 31;10(1). Epidemiology of osteoarthritis of the hand and wrist.OA Musculoskeletal Medicine [Internet]. [cited 2022 Dec 7]. Available from: https://www.oapublishinglondon.com/article/872 Neogi T, Zhang Y. Epidemiology of osteoarthritis. Rheum Dis Clin North Am [Internet]. 2013 Feb [cited 2022 Dec 7];39(1):1–19. Available from: https://pubmed.ncbi.nlm.nih.gov/23312408/ Moreno-Reyes R, Egrise D, Nève J, Pasteels JL, Schoutens A. Selenium deficiency-induced growth retardation is associated with an impaired bone metabolism and osteopenia. Journal of Bone and Mineral Research. 2001;16(8):1556–63. Lohmander LS, de Verdier MG, Rollof J, Nilsson PM, Engström G. Incidence of severe knee and hip osteoarthritis in relation to different measures of body mass: a population-based prospective cohort study. Ann Rheum Dis [Internet]. 2009 Apr [cited 2022 Dec 7];68(4):490–6. Available from: https://pubmed.ncbi.nlm.nih.gov/18467514/ Forward DP, Davis TRC, Sithole JS. Do young patients with malunited fractures of the distal radius inevitably develop symptomatic post-traumatic osteoarthritis? J Bone Joint Surg Br [Internet]. 2008 May [cited 2022 Dec 7];90(5):629–37. Available from: https://pubmed.ncbi.nlm.nih.gov/18450631/ LIVESLEY PJ. The conservative management of Bennett’s fracture-dislocation: a 26-year follow-up. J Hand Surg Br [Internet]. 1990 Jun [cited 2022 Dec 7];15(3):291–4. Available from: https://pubmed.ncbi.nlm.nih.gov/2230493/ Kirk JA, Ansell BM, Bywaters EG. The hypermobility syndrome. Musculoskeletal complaints associated with generalized joint hypermobility. Ann Rheum Dis [Internet]. 1967 [cited 2022 Dec 7];26(5):419. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1031347/ Meyer-Scholten C, Valeva A, Zorn K, Meurer A, Fassbender HG. [Significance of clinically latent bacterial arthritis]. Z Rheumatol [Internet]. 2008 Feb [cited 2022 Dec 7];67(1):41–6. Available from: https://pubmed.ncbi.nlm.nih.gov/18214500/ Sinha M, Jain S, Woods DA. Septic arthritis of the small joints of the hand. J Hand Surg Br [Internet]. 2006 Dec [cited 2022 Dec 7];31(6):665–72. Available from: https://pubmed.ncbi.nlm.nih.gov/17046120/ Sammer DM, Shin AY. Comparison of arthroscopic and open treatment of septic arthritis of the wrist. J Bone Joint Surg Am [Internet]. 2009 Jun 1 [cited 2022 Dec 7];91(6):1387–93. Available from: https://pubmed.ncbi.nlm.nih.gov/19487516/ Sperry MM, Ita ME, Kartha S, Zhang S, Yu YH, Winkelstein B. The Interface of Mechanics and Nociception in Joint Pathophysiology: Insights From the Facet and Temporomandibular Joints. J Biomech Eng [Internet]. 2017 Feb 1 [cited 2022 Dec 7];139(2):0210031. Available from: /pmc/articles/PMC5253677/ Hochberg MC, Altman RD, April KT, Benkhalti M, Guyatt G, McGowan J, et al. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res (Hoboken) [Internet]. 2012 Apr [cited 2022 Dec 7];64(4):465–74. Available from: https://pubmed.ncbi.nlm.nih.gov/22563589/ Stecher RM. HEBERDEN’S NODES: THE CLINICAL CHARACTERISTIC OF OSTEO-ARTHRITIS OF THE FINGERS. Sofat N, Jeyabaladevan S, Sofat N, Jeyabaladevan S. Hand Osteoarthritis — Clinical Presentation, Phenotypes and Management. Osteoarthritis - Progress in Basic Research and Treatment [Internet]. 2015 Jul 1 [cited 2022 Dec 7]; Available from: https://www.intechopen.com/state.item.id Sandell LJ, Aigner T. Articular cartilage and changes in arthritis. An introduction: cell biology of osteoarthritis. Arthritis Res [Internet]. 2001 [cited 2022 Dec 7];3(2):107–13. Available from: https://pubmed.ncbi.nlm.nih.gov/11178118/ Jensen JC, Sherson D. Work-related bilateral osteoarthritis of the first carpometacarpal joints. Occup Med (Lond) [Internet]. 2007 Sep [cited 2022 Dec 7];57(6):456–60. Available from: https://pubmed.ncbi.nlm.nih.gov/17698839/ Sofat N, Jeyabaladevan S, Sofat N, Jeyabaladevan S. Hand Osteoarthritis — Clinical Presentation, Phenotypes and Management. Osteoarthritis - Progress in Basic Research and Treatment [Internet]. 2015 Jul 1 [cited 2022 Dec 7]; Available from: https://www.intechopen.com/state.item.id Pol EN. Evaluación del paciente y medida de resultados. Aten Primaria [Internet]. 2014 Jan [cited 2022 Dec 7];46(Supl.1):32–8. Available from: https://medes.com/publication/86758 Poole JL. Measures of hand function: Arthritis Hand Function Test (AHFT), Australian Canadian Osteoarthritis Hand Index (AUSCAN), Cochin Hand Function Scale, Functional Index for Hand Osteoarthritis (FIHOA), Grip Ability Test (GAT), Jebsen Hand Function Test (JHFT), and Michigan Hand Outcomes Questionnaire (MHQ). Arthritis Care Res (Hoboken) [Internet]. 2011 Nov [cited 2022 Dec 7];63 Suppl 11(SUPPL. 11). Available from: https://pubmed.ncbi.nlm.nih.gov/22588744/ CHMP. Osteoarthritis Guideline - DRAFT [Internet]. Available from: http://www.emea.europa.eu Marshall M, Dziedzic KS, van der Windt DA, Hay EM. A systematic search and narrative review of radiographic definitions of hand osteoarthritis in population-based studies. Osteoarthritis Cartilage [Internet]. 2008 Feb [cited 2022 Dec 7];16(2):219–26. Available from: https://pubmed.ncbi.nlm.nih.gov/17646114/ Buckland‐Wright JC, Macfarlane DG, Lynch JA, Clark B. Quantitative microfocal radiographic assessment of progression in osteoarthritis of the hand. Arthritis Rheum [Internet]. 1990 [cited 2022 Dec 7];33(1):57–65. Available from: https://pubmed.ncbi.nlm.nih.gov/2302268/ Haugen IK, Bøyesen P. Imaging modalities in hand osteoarthritis - status and perspectives of conventional radiography, magnetic resonance imaging, and ultrasonography. Arthritis Res Ther [Internet]. 2011 Dec 13 [cited 2022 Dec 7];13(6):248. Available from: /pmc/articles/PMC3334630/ Verbruggen G, Veys EM. Numerical scoring systems for the anatomic evolution of osteoarthritis of the finger joints. Arthritis Rheum [Internet]. 1996 Feb [cited 2022 Dec 7];39(2):308–20. Available from: https://pubmed.ncbi.nlm.nih.gov/8849385/ Buckland-Wright C. Subchondral bone changes in hand and knee osteoarthritis detected by radiography. Osteoarthritis Cartilage [Internet]. 2004 [cited 2022 Dec 7];12(SUPLL.):10–9. Available from: https://pubmed.ncbi.nlm.nih.gov/14698636/ Kohn MD, Sassoon AA, Fernando ND. Classifications in Brief: Kellgren-Lawrence Classification of Osteoarthritis. Clin Orthop Relat Res [Internet]. 2016 Aug 1 [cited 2022 Dec 7];474(8):1886. Available from: /pmc/articles/PMC4925407/ Spector TD, Cooper C. Radiographic assessment of osteoarthritis in population studies: whither Kellgren and Lawrence? Osteoarthritis Cartilage [Internet]. 1993 [cited 2022 Dec 7];1(4):203–6. Available from: https://pubmed.ncbi.nlm.nih.gov/15449506/ Verbruggen G, Veys EM. Numerical scoring systems for the anatomic evolution of osteoarthritis of the finger joints. Arthritis Rheum [Internet]. 1996 Feb [cited 2022 Dec 7];39(2):308–20. Available from: https://pubmed.ncbi.nlm.nih.gov/8849385/ Haugen IK. The Reliability and Validity of Magnetic Resonance Imaging in Patients with Hand Osteoarthritis. Feydy A, Pluot E, Guerini H, Drapé JL. Osteoarthritis of the wrist and hand, and spine. Radiol Clin North Am [Internet]. 2009 Jul [cited 2022 Dec 7];47(4):723–59. Available from: https://pubmed.ncbi.nlm.nih.gov/19631079/ Dahaghin S, Bierma-Zeinstra SMA, Ginai AZ, Pols HAP, Hazes JMW, Koes BW. Prevalence and pattern of radiographic hand osteoarthritis and association with pain and disability (the Rotterdam study). Ann Rheum Dis. 2005 May;64(5):682–7. Spector TD, Nandra D, Hart DJ, Doyle D V. Is hormone replacement therapy protective for hand and knee osteoarthritis in women?: The Chingford Study. Ann Rheum Dis. 1997;56(7):432–4. Wilder F V., Barrett JP, Farina EJ. Joint-specific prevalence of osteoarthritis of the hand. Osteoarthritis Cartilage [Internet]. 2006 Sep [cited 2023 Oct 21];14(9):953–7. Available from: https://pubmed.ncbi.nlm.nih.gov/16759885/ Mathiessen A, Haugen IK, Slatkowsky-Christensen B, Bøyesen P, Kvien TK, Hammer HB. Ultrasonographic assessment of osteophytes in 127 patients with hand osteoarthritis: exploring reliability and associations with MRI, radiographs and clinical joint findings. Ann Rheum Dis [Internet]. 2013 Jan 1 [cited 2023 Oct 21];72(1):51–6. Available from: https://ard.bmj.com/content/72/1/51 Jones AG, Francis MD, Davis MA. Bone scanning: radionuclidic reaction mechanisms. Semin Nucl Med [Internet]. 1976 [cited 2023 Oct 21];6(1):3–18. Available from: https://pubmed.ncbi.nlm.nih.gov/174228/
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spelling	Morales Avellaneda, Tatianafeffb104-96aa-4759-8d63-1bbe91f5b894Saaibi Solano, Diego Luis50b17398-ffd0-46c0-bff2-7937bd6ff75eOchoa Vera, Miguel Enriqueb2f66b1f-7691-4abf-a110-466c07955478Díaz Contreras, Indira Eliana7951dba8-ddc9-4b63-b4a9-84893839c45bMorales Avellaneda, Tatiana [0000152758]Saaibi Solano, Diego Luis [0001362430]Ochoa Vera, Miguel Enrique [0000898465]Morales Avellaneda, Tatiana [0000-0001-6250-8801]Saaibi Solano, Diego Luis [0000-0002-4880-7108]Morales Avellaneda, Tatiana [tatiana-morales-avellaneda]Saaibi Solano, Diego Luis [diego-luis-saaibi-solano]Ochoa Vera, Miguel Enrique [miguel-enrique-ochoa-vera]ColombiaUNAB Campus Bucaramanga2024-01-19T13:33:53Z2024-01-19T13:33:53Z2023-12-12http://hdl.handle.net/20.500.12749/23195instname:Universidad Autónoma de Bucaramanga - UNABreponame:Repositorio Institucional UNABrepourl:https://repository.unab.edu.coLa osteoartritis (OA, Por sus siglas en inglés), es uno de los trastornos articulares más debilitantes del mundo, y afecta hasta al 10% de los hombres y al 13% de las mujeres (1). En las sociedades occidentales, se espera que la prevalencia de la OA aumente debido al envejecimiento de la población (1). Es una enfermedad que genera dolor y discapacidad en los adultos con un importante impacto socioeconómico tanto dentro como fuera de nuestro país (2). Es una artropatía degenerativa, inflamatoria y crónica en la que influyen factores estresantes, factores de riesgo, hormonales, ambientales y genéticos, que pueden predisponer a un individuo a desarrollar OA en una articulación en particular. Afecta a los tejidos articulares incluyendo cartílago, hueso subcondral y la membrana sinovial. Este trastorno es consecuencia del catabolismo progresivo de los componentes de la matriz del cartílago articular, provocado por un desequilibrio entre la síntesis y la degradación bioquímica del cartílago articular en las articulaciones sinoviales; y cualquier articulación en el cuerpo puede verse afectada, sin embargo, la OA es más frecuente en las articulaciones que soportan peso, como las rodillas, las caderas, la columna vertebral y las manos. La artrosis de la mano y la muñeca cobra una mayor importancia dado que produce una discapacidad equivalente a la causada por enfermedades cardiacas, y mayor que cualquier otra patología en personas de avanzada edad. En la mano y la muñeca, el sitio más común de la OA, es la base del pulgar (Articulación trapecio-metacarpiano (TMC) o primera articulación carpo-metacarpiana (CMC I) (3). En el caso de las mujeres postmenopáusicas se presenta más comúnmente en las articulaciones interfalángicas distales y proximales (4). La radiografía ha sido un método sensible para la evaluación de la progresión digital de la OA evidenciando con cambios radiográficos indicativos como: (estrechamiento del espacio articular, osteofitos, formación de quistes, esclerosis) en hasta el 81% de la población anciana, sin embargo, no es capaz de detectar los cambios estructurales o bioquímicos de la OA, de forma frecuente los únicos hallazgos son los síntomas iniciales del paciente. La OA digital se asocia a brotes dolorosos ocasionales y durante varios años puede ser asintomática, que no se pueden predecir mediante la radiografía (5). Se ha sugerido que la Gammagrafía Ósea (GO) con Tecnecio 99m Metileno Difosfonato (99mTc–MDP) es un método sensible para detectar OA en una etapa temprana y la retención de isótopos alrededor de la mano o la rodilla se ha correlacionado con la progresión radiográfica posterior de OA (6,7). Es un estudio que no hace parte de la evaluación inicial de la enfermedad osteoarticular, pero su alta sensibilidad, permite detectar cambios estructurales previos, además es reproducible y tiene un valor predictivo negativo superior al 90%, permitiendo discriminar el origen del dolor si es proveniente de tejidos blandos u hueso. Esto es debido a que el radiofármaco alcanza el hueso a través de la circulación sanguínea y se une al cristal de hidroxiapatita con alta afinidad, permitiendo evaluar de manera indirecta la actividad osteoblástica (8). La gammagrafía ósea de las manos y las muñecas representa una importante técnica de imagen adjunta que complementa el examen radiográfico. El uso de la gammagrafía ósea trifásica proporciona información clínica no solo con respecto a la captación ósea, sino también el flujo sanguíneo y la distribución extravascular del radio trazador. En la literatura existen estudios antiguos y limitados, donde se correlaciona la gammagrafía ósea en pacientes con osteoartritis, sin embargo, no son reproducibles dado por el tamaño de la muestra, por el tiempo de observación y por no existir una correlación conjunta ni clínica ni imagenológica, sin embargo, durante muchos años, se ha enfatizado que la GO que utiliza compuestos de fosfonato de 99mTc tiene una alta sensibilidad, pero baja especificidad para la detección de enfermedades óseas y articulares, y se sugiere que es una herramienta que permite detectar cambios estructurales iniciales (6,7). Actualmente, hemos evidenciado que la detección accidental de cambios artríticos en una gammagrafía ósea es un hallazgo común que a menudo no se informa y se considera de poca importancia en el contexto clínico del estudio. Nuestra propuesta es realizar el primer estudio a nivel mundial evaluando los cambios tempranos de la OA, a partir de un estudio funcional y correlacionarlo con clínica e imágenes radiográficas, y de esta forma contribuir en el diagnóstico inicial para disminuir las limitaciones funcionales propias de la enfermedad y mejorar la calidad de vida relacionada con la salud.PLANTEAMIENTO DEL PROBLEMA ................................................................. 8 JUSTIFICACIÓN .................................................................................................. 10 MARCO TEORICO Y ESTADO DEL ARTE .......................................................... 14 Epidemiología de la OA .................................................................................... 14 Fisiopatología ..................................................................................................... 15 Etiología .............................................................................................................. 19 Clasificación ....................................................................................................... 19 Factores de riesgo para el desarrollo de OA en manos .............................. 20 Diagnostico ........................................................................................................ 26 Fenotipos clínicos de la mano OA .................................................................. 26 Perspectiva histórica de los nodos de Heberden ........................................ 28 Primera articulación carpometacarpiana en OA ......................................... 30 Medidas de la función de la mano ................................................................ 32 Imágenes .......................................................................................................... 34 Radiografía ....................................................................................................... 34 Sistema de puntuación ................................................................................... 36 PREGUNTA DE INVESTIGACIÓN ..................................................................... 38 OBJETIVOS GENERALES ................................................................................... 38 OBJETIVOS ESPECIFICOS ................................................................................. 38 METODOLOGÍA ................................................................................................ 39 Tipo de estudio ................................................................................................ 39 Población .......................................................................................................... 39 Criterios de inclusión ...................................................................................... 39 Criterios de exclusión ..................................................................................... 39 Cálculo del tamaño de muestra .................................................................... 39 Recolección de la información ...................................................................... 40 Plan de análisis ................................................................................................ 40 Limitaciones del estudio ................................................................................ 41 Aspectos éticos ............................................................................................... 41 RESULTADOS ................................................................................................... 43 DISCUSIÓN ....................................................................................................... 54 CONCLUSIONES ............................................................................................... 58 CRONOGRAMA ................................................................................................. 60 PRESUPUESTO .................................................................................................. 61 BIBLIOGRAFÍA ................................................................................................... 62 ANEXOS ............................................................................................................. 69 Variables ........................................................................................................... 69 Consentimiento informado ........................................................................... 79 Datos de medicina nuclear ........................................................................... 84 Datos de reumatología .................................................................................. 86EspecializaciónOsteoarthritis (OA) is one of the most debilitating joint disorders in the world, affecting up to 10% of men and 13% of women (1). In Western societies, the prevalence of OA is expected to increase due to population aging (1). It is a disease that generates pain and disability in adults with a significant socioeconomic impact both inside and outside our country (2). It is a degenerative, inflammatory and chronic arthropathy influenced by stress factors, risk factors, hormonal, environmental and genetic, which can predispose an individual to develop OA in a particular joint. It affects joint tissues including cartilage, subchondral bone and the synovial membrane. This disorder is a consequence of the progressive catabolism of the components of the articular cartilage matrix, caused by an imbalance between the synthesis and biochemical degradation of articular cartilage in the synovial joints; and any joint in the body can be affected, however, OA is most common in weight-bearing joints such as the knees, hips, spine, and hands. Osteoarthritis of the hand and wrist takes on greater importance since it produces a disability equivalent to that caused by heart disease, and greater than any other pathology in elderly people. In the hand and wrist, the most common site of OA is the base of the thumb (trapezio-metacarpal joint (TMC) or first carpo-metacarpal joint (CMC I) (3). In the case of postmenopausal women, It most commonly occurs in the distal and proximal interphalangeal joints (4). Radiography has been a sensitive method for the evaluation of the digital progression of OA, showing indicative radiographic changes such as: (narrowing of the joint space, osteophytes, cyst formation, sclerosis) in up to 81% of the elderly population, however , is not capable of detecting the structural or biochemical changes of OA; frequently the only findings are the patient's initial symptoms. Digital OA is associated with occasional painful flares and for several years may be asymptomatic, which cannot be predicted by radiography (5). Technetium 99m Methylene Diphosphonate (99mTc–MDP) bone scintigraphy (GO) has been suggested to be a sensitive method for detecting OA at an early stage and isotope retention around the hand or knee has been correlated with subsequent radiographic progression of OA (6,7). It is a study that is not part of the initial evaluation of osteoarticular disease, but its high sensitivity allows for the detection of previous structural changes, it is also reproducible and has a negative predictive value greater than 90%, allowing the origin of pain to be discriminated if it is from of soft tissue or bone. This is because the radiopharmaceutical reaches the bone through blood circulation and binds to the hydroxyapatite crystal with high affinity, allowing osteoblastic activity to be indirectly evaluated (8). Bone scintigraphy of the hands and wrists represents an important adjunct imaging technique that complements radiographic examination. The use of triphasic bone scintigraphy provides clinical information not only regarding bone uptake, but also blood flow and extravascular distribution of the tracer radius. In the literature there are old and limited studies, where bone scintigraphy is correlated in patients with osteoarthritis, however, they are not reproducible given the size of the sample, the observation time and because there is no joint clinical or imaging correlation. However, for many years, it has been emphasized that GO using 99mTc-phosphonate compounds has high sensitivity, but low specificity for the detection of bone and joint diseases, and it is suggested that it is a tool that allows the detection of initial structural changes (6,7). Currently, we have shown that the accidental detection of arthritic changes in a bone scintigraphy is a common finding that is often not reported and considered of little importance in the clinical context of the study. Our proposal is to carry out the first study worldwide evaluating the early changes of OA, based on a functional study and correlating it with clinical and radiographic images, and in this way contribute to the initial diagnosis to reduce the functional limitations of the disease and improve health-related quality of life.Modalidad Presencialapplication/pdfspahttp://creativecommons.org/licenses/by-nc-nd/2.5/co/Abierto (Texto Completo)Atribución-NoComercial-SinDerivadas 2.5 Colombiahttp://purl.org/coar/access_right/c_abf2Validez de criterio de los hallazgos gammagráficos en manos para diagnóstico de osteoartritis en población adultaCriterion validity of scintigraphic findings in hands for diagnosis of osteoarthritis in the adult populationEspecialista en Medicina NuclearUniversidad Autónoma de Bucaramanga UNABFacultad Ciencias de la SaludEspecialización en Medicina Nuclearinfo:eu-repo/semantics/masterThesisTesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/redcol/resource_type/TMMedical sciencesHealth sciencesNuclear medicineRadiationPhysiological effectArthritis hand function testRheumatoid arthritisNuclear magnetic resonanceTechnetium 99m Methylene DiphosphonateTrapezio-metacarpal jointProximal interphalangealDistal interphalangealBone scintigraphyOsteoarthritisHand osteoarthritisThe clinical diagnosis based on ACR 1990 classification criteriaMedical radiologyDiagnostic imagingRadioactivity (Measurements)Non-invasive diagnosisCiencias médicasMedicina nuclearRadiaciónEfectos fisiológicosRadiología médicaDiagnóstico por imágenesRadioactividad (Mediciones)Diagnóstico no invasivoCriterios del Colegio Americano de ReumatologíaArtritis reumatoideaGammagrafía óseaResonancia magnética nuclearOsteoartritisArticulación trapecio-metacarpianoInterfalángicas proximalesInterfalángicas distalesOsteoartritis en manos99mTc-MDPTecnecio 99m metileno difosfonatoZhang Y, Jordan JM. Epidemiology of osteoarthritis. Vol. 26, Clinics in Geriatric Medicine. 2010. p. 355–69.Buckwalter JA, Saltzman C, Brown T. The impact of osteoarthritis: Implications for research. Clin Orthop Relat Res [Internet]. 2004 [cited 2022 Dec 6];427(SUPPL.). Available from: https://journals.lww.com/clinorthop/Fulltext/2004/10001/The_Impact_of_Osteoarthritis__Implications_for.4.aspxKloppenburg M, Kwok WY. Hand osteoarthritisĝ€"a heterogeneous disorder. Vol. 8, Nature Reviews Rheumatology. 2012. p. 22–31.Johnson VL, Hunter DJ. The epidemiology of osteoarthritis. Vol. 28, Best Practice and Research: Clinical Rheumatology. Bailliere Tindall Ltd; 2014. p. 5–15.Felson DT. An update on the pathogenesis and epidemiology of osteoarthritis. Vol. 42, Radiologic Clinics of North America. W.B. Saunders; 2004. p. 1–9.Love C, Din AS, Tomas MB, Kalapparambath TP, Palestro CJ. Radionuclide Bone Imaging: An Illustrative Review. Vol. 23, Radiographics. Radiological Society of North America Inc.; 2003. p. 341–58.Balblanc JC, Mathieu P, Mathieut L, Tron AM, Conrozier T, Piperno M, et al. OSTEOARTHRITIS and CARTILAGE Progression of digital osteoarthritis: a sequential scintigraphic and radiographic study. Vol. 3, Osteoarthritis and Cartilage. 1995.O’Connor MK, Brown ML, Hung JC, Hayostek RJ. The Art of Bone Scintigraphy—Technical Aspects. Journal of Nuclear Medicine [Internet]. 1991 Dec 1 [cited 2022 Dec 6];32(12):2332–41. Available from: https://jnm.snmjournals.org/content/32/12/2332A randomized, double-blind, placebo-controlled, parallel group, Phase II, 24-week study investigating the efficacy, safety and tolerability of AIN457 in patients with active overuse tendinopathy refractory to oral NSAIDs/acetaminophen, physiotherapy or corticosteroid injections. 2018.Zhang W, Doherty M, Leeb BF, Alekseeva L, Arden NK, Bijlsma JW, et al. EULAR evidence-based recommendations for the diagnosis of hand osteoarthritis: report of a task force of ESCISIT. Ann Rheum Dis [Internet]. 2009 Jan [cited 2022 Dec 7];68(1):8–17. Available from: https://pubmed.ncbi.nlm.nih.gov/18250111/Guermazi A, Niu J, Hayashi D, Roemer FW, Englund M, Neogi T, et al. Prevalence of abnormalities in knees detected by MRI in adults without knee osteoarthritis: population based observational study (Framingham Osteoarthritis Study). BMJ [Internet]. 2012 Aug 29 [cited 2022 Dec 7];345(7874). Available from: https://www.bmj.com/content/345/bmj.e5339Barr AJ, Dube B, Hensor EMA, Kingsbury SR, Peat G, Bowes MA, et al. The relationship between clinical characteristics, radiographic osteoarthritis and 3D bone area: Data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2014 Oct 1;22(10):1703–9.Kloppenburg M, Bøyesen P, Visser AW, Haugen IK, Boers M, Boonen A, et al. Report from the OMERACT Hand Osteoarthritis Working Group: Set of Core Domains and Preliminary Set of Instruments for Use in Clinical Trials and Observational Studies. J Rheumatol [Internet]. 2015 Nov 1 [cited 2022 Dec 7];42(11):2190–7. Available from: https://pubmed.ncbi.nlm.nih.gov/26136489/Sodha S, Ring D, Zurakowski D, Jupiter JB. Prevalence of osteoarthrosis of the trapeziometacarpal joint. Journal of Bone and Joint Surgery [Internet]. 2005 [cited 2022 Dec 7];87(12 I):2614–8. Available from: https://journals.lww.com/jbjsjournal/Fulltext/2005/12000/Prevalence_of_Osteoarthrosis_of_the.3.aspxKalichman L, Malkin I, Livshits G, Kobyliansky E. The association between morbidity and radiographic hand osteoarthritis: a population-based study. Joint Bone Spine. 2006 Jul 1;73(4):406–10.Ye L, Kalichman L, Spittle A, Dobson F, Bennell K. Effects of rehabilitative interventions on pain, function and physical impairments in people with hand osteoarthritis: A systematic review. Arthritis Res Ther. 2011 Feb 18;13(1).Zhang Y, Niu J, Kelly-Hayes M, Chaisson CE, Aliabadi P, Felson DT. Prevalence of symptomatic hand osteoarthritis and its impact on functional status among the elderly: The framingham study. Am J Epidemiol. 2002 Dec 1;156(11):1021–7.María M, Martín S. artrosis. etiopatogenia y tratamiento etiology and treatment.Ye L, Kalichman L, Spittle A, Dobson F, Bennell K. Effects of rehabilitative interventions on pain, function and physical impairments in people with hand osteoarthritis: A systematic review. Arthritis Res Ther. 2011 Feb 18;13(1).Visser AW, Ioan-Facsinay A, de Mutsert R, Widya RL, Loef M, de Roos A, et al. Adiposity and hand osteoarthritis: The Netherlands Epidemiology of Obesity study. Arthritis Res Ther. 2014 Jan 22;16(1).Visser AW, Bøyesen P, Haugen IK, Schoones JW, van der Heijde DM, Rosendaal FR, et al. Radiographic scoring methods in hand osteoarthritis - a systematic literature search and descriptive review. Osteoarthritis Cartilage [Internet]. 2014 Oct 1 [cited 2022 Dec 7];22(10):1710–23. Available from: http://www.oarsijournal.com/article/S106345841401108X/fulltextChu CR, Williams AA, Coyle CH, Bowers ME. Early diagnosis to enable early treatment of pre-osteoarthritis. Arthritis Res Ther [Internet]. 2012 Jun 7 [cited 2022 Dec 7];14(3):1–10. Available from: https://arthritis-research.biomedcentral.com/articles/10.1186/ar3845Mccrae F, Shouls J, Dieppe P, Watt I. Scintigraphic assessment of osteoarthritis of the knee joint. Vol. 51, Annals of the Rheumatic Diseases. 1992.Boegård T, Rudling O, Dahlström J, Dirksen H, Petersson IF, Jonsson K. Bone scintigraphy in chronic knee pain: comparison with magnetic resonance imaging.Nakamura N, Sugano N, Nishii T, Miki H, Haraguchi K, Hagio K, et al. Scintigraphic image patterns in dysplastic coxarthrosis: evaluation with reference to radiographic findings in 210 hips. Acta Orthop Scand [Internet]. 2003 Apr [cited 2022 Dec 7];74(2):159–64. Available from: https://pubmed.ncbi.nlm.nih.gov/12807322/Perruccio A v., Power JD, Evans HMK, Mahomed SR, Gandhi R, Mahomed NN, et al. Multiple joint involvement in total knee replacement for osteoarthritis: Effects on patient-reported outcomes. Arthritis Care Res (Hoboken). 2012 Jun;64(6):838–46.Lawrence RC, Felson DT, Helmick CG, Arnold LM, Choi H, Deyo RA, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum [Internet]. 2008 Jan [cited 2022 Dec 7];58(1):26–35. Available from: https://pubmed.ncbi.nlm.nih.gov/18163497/Haugen IK, Englund M, Aliabadi P, Niu J, Clancy M, Kvien TK, et al. Prevalence, incidence and progression of hand osteoarthritis in the general population: The Framingham Osteoarthritis Study. Ann Rheum Dis. 2011;70(9):1581–6.Carmona L, Ballina J, Gabriel R, Lavon A. The burden of musculoskeletal diseases in the general population of Spain: results from a national survey [Internet]. Vol. 60, Ann Rheum Dis. 2001. Available from: www.annrheumdis.comKessler S, Stöve J, Puhl W, Stürmer T. First carpometacarpal and interphalangeal osteoarthritis of the hand in patients with advanced hip or knee OA. Are there differences in the aetiology? Clin Rheumatol. 2003 Dec;22(6):409–13.Carmona L, Ballina J, Gabriel R, Lavon A. The burden of musculoskeletal diseases in the general population of Spain: results from a national survey [Internet]. Vol. 60, Ann Rheum Dis. 2001. Available from: www.annrheumdis.comDahaghin S, Bierma-Zeinstra SMA, Ginai AZ, Pols HAP, Hazes JMW, Koes BW. Prevalence and pattern of radiographic hand osteoarthritis and association with pain and disability (the Rotterdam study). Ann Rheum Dis. 2005 May;64(5):682–7.Kim E, Guilak F, Haider MA. The dynamic mechanical environment of the chondrocyte: A biphasic finite element model of cell-matrix interactions under cyclic compressive loading. J Biomech Eng. 2008 Dec;130(6).Zuscik MJ, Hilton MJ, Zhang X, Chen D, O’Keefe RJ. Regulation of chondrogenesis and chondrocyte differentiation by stress. Vol. 118, Journal of Clinical Investigation. 2008. p. 429–38.Aigner T, Sachse A, Gebhard PM, Roach HI. Osteoarthritis: pathobiology-targets and ways for therapeutic intervention. Adv Drug Deliv Rev [Internet]. 2006 May 20 [cited 2022 Dec 7];58(2):128–49. Available from: https://pubmed.ncbi.nlm.nih.gov/16616393/Iscru DF, Anghelina M, Agarwal S, Agarwal G. Changes in surface topologies of chondrocytes subjected to mechanical forces: an AFM analysis.Gadher SJ, Eyre DR, Wotton SF, Schmid TM, Woolley DE. Degradation of cartilage collagens type II, IX, X and XI by enzymes derived from human articular chondrocytes. Matrix [Internet]. 1990 [cited 2022 Dec 7];10(3):154–63. Available from: https://pubmed.ncbi.nlm.nih.gov/2170828/Benito MJ, Veale DJ, FitzGerald O, van den Berg WB, Bresnihan B. Synovial tissue inflammation in early and late osteoarthritis. Ann Rheum Dis. 2005 Sep;64(9):1263–7.Davis Aileen M, M HG. Assessment of the patient with osteoarthritis and measurement of outcomes. Silman A, Smolen J, Weinblatt M, Weisman M, Hochberg M, Ellen G, editors. Rheumatology. 2018;2.Bellamy Nicholas, Carsolio Pacheco Rosario. Atlas de reumatología clínica /. Editorial Científica PLM,; 1985.Racz B, Reglodi D, Fodor B, Gasz B, Lubics A, Gallyas F, et al. Hyperosmotic stress-induced apoptotic signaling pathways in chondrocytes. Bone [Internet]. 2007 Jun [cited 2022 Dec 7];40(6):1536–43. Available from: https://pubmed.ncbi.nlm.nih.gov/17392049/Roman-Blas JA, Stokes DG, Jimenez SA. Osteoarthritis Cartilage. Vol. 15. 2007.Felson DT, Lawrence RC, Dieppe PA, Hirsch R, Helmick CG, Jordan JM, et al. Osteoarthritis: new insights. Part 1: the disease and its risk factors. Ann Intern Med [Internet]. 2000 [cited 2022 Dec 7];133(8):635–46. Available from: https://pubmed.ncbi.nlm.nih.gov/11033593/Cirillo DJ, Wallace RB, Wu L, Yood RA. Effect of hormone therapy on risk of hip and knee joint replacement in the Women’s Health Initiative. Arthritis Rheum [Internet]. 2006 Oct [cited 2022 Dec 7];54(10):3194–204. Available from: https://pubmed.ncbi.nlm.nih.gov/17009251/de Klerk BM, Schiphof D, Groeneveld FPMJ, Koes BW, van Osch GJVM, van Meurs JBJ, et al. No clear association between female hormonal aspects and osteoarthritis of the hand, hip and knee: a systematic review. Rheumatology (Oxford) [Internet]. 2009 Sep [cited 2022 Dec 7];48(9):1160–5. Available from: https://pubmed.ncbi.nlm.nih.gov/19608726/The effect of estrogen plus progestin on knee symptoms and related disability in postmenopausal women: The Heart and Estrogen/Progestin Replacement Study, a randomized, double-blind, placebo-controlled trial - PubMed [Internet]. [cited 2022 Dec 7]. Available from: https://pubmed.ncbi.nlm.nih.gov/11315920/Hochberg MC, Lethbridge-Cejku M, Tobin JD. Bone mineral density and osteoarthritis: Data from the Baltimore Longitudinal Study of Aging. Osteoarthritis Cartilage [Internet]. 2004 [cited 2022 Dec 7];12(SUPLL.):45–8. Available from: https://pubmed.ncbi.nlm.nih.gov/14698641/Spector TD, MacGregor AJ. Risk factors for osteoarthritis: Genetics. Osteoarthritis Cartilage [Internet]. 2004 [cited 2022 Dec 7];12(SUPLL.):39–44. Available from: https://pubmed.ncbi.nlm.nih.gov/14698640/Evidence for a Mendelian gene in a segregation analysis of generalized radiographic osteoarthritis: the Framingham Study - PubMed [Internet]. [cited 2022 Dec 7]. Available from: https://pubmed.ncbi.nlm.nih.gov/9627016/Kerkhof HJM, Lories RJ, Meulenbelt I, Jonsdottir I, Valdes AM, Arp P, et al. A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Arthritis Rheum [Internet]. 2010 Feb [cited 2022 Dec 7];62(2):499–510. Available from: https://pubmed.ncbi.nlm.nih.gov/20112360/Chen HC, Shah SH, Li YJ, Stabler T v., Jordan JM, Kraus VB. Inverse Association of General Joint Hypermobility With Hand and Knee Osteoarthritis and Serum Cartilage Oligomeric Matrix Protein Levels. Arthritis Rheum [Internet]. 2008 Dec [cited 2022 Dec 7];58(12):3854. Available from: /pmc/articles/PMC3698615/The relationship of joint hypermobility, bone mineral density, and osteoarthritis in the general population: the Chingford Study - PubMed [Internet]. [cited 2022 Dec 7]. Available from: https://pubmed.ncbi.nlm.nih.gov/12672202/Hu PF, Bao JP, Wu LD. The emerging role of adipokines in osteoarthritis: a narrative review. Mol Biol Rep [Internet]. 2011 Feb [cited 2022 Dec 7];38(2):873–8. Available from: https://pubmed.ncbi.nlm.nih.gov/20480243/Magliano M. Obesity and arthritis. Menopause Int [Internet]. 2008 [cited 2022 Dec 7];14(4):149–54. Available from: https://pubmed.ncbi.nlm.nih.gov/19037063/Carman WJ, Sowers M, Hawthorne VM, Weissfeld LA. Obesity as a risk factor for osteoarthritis of the hand and wrist: a prospective study. Am J Epidemiol [Internet]. 1994 Jan 15 [cited 2022 Dec 7];139(2):119–29. Available from: https://pubmed.ncbi.nlm.nih.gov/8296779/Kalichman L, Kobyliansky E, Seibel MJ, Livshits G. Repeated measurement study of hand osteoarthritis in an apparently healthy Caucasian population. Am J Hum Biol [Internet]. 2005 Sep [cited 2022 Dec 7];17(5):611–21. Available from: https://pubmed.ncbi.nlm.nih.gov/16136535/Kalichman L, Li L, Batsevich V, Malkin I, Kobyliansky E. Prevalence, pattern and determinants of radiographic hand osteoarthritis in five Russian community-based samples. Osteoarthritis Cartilage [Internet]. 2010 Jun [cited 2022 Dec 7];18(6):803–9. Available from: https://pubmed.ncbi.nlm.nih.gov/20172037/Comparison of the prevalence of knee osteoarthritis between the elderly Chinese population in Beijing and whites in the United States: The Beijing Osteoarthritis Study - PubMed [Internet]. [cited 2022 Dec 7]. Available from: https://pubmed.ncbi.nlm.nih.gov/11592368/Zhang Y, Terkeltaub R, Nevitt M, Xu L, Neogi T, Aliabadi P, et al. Lower prevalence of chondrocalcinosis in Chinese subjects in Beijing than in white subjects in the United States: The Beijing osteoarthritis study. Arthritis Rheum. 2006 Nov;54(11):3508–12.Toba N, Sakai A, Aoyagi K, Yoshida S, Honda S, Nakamura T. Prevalence and involvement patterns of radiographic hand osteoarthritis in Japanese women: the Hizen-Oshima Study. J Bone Miner Metab [Internet]. 2006 Jul [cited 2022 Dec 7];24(4):344–8. Available from: https://pubmed.ncbi.nlm.nih.gov/16816930/Zeng QY, Chen R, Darmawan J, Xiao ZY, Chen SB, Wigley R, et al. Rheumatic diseases in China. Arthritis Res Ther. 2008 Jan 31;10(1).Epidemiology of osteoarthritis of the hand and wrist.OA Musculoskeletal Medicine [Internet]. [cited 2022 Dec 7]. Available from: https://www.oapublishinglondon.com/article/872Neogi T, Zhang Y. Epidemiology of osteoarthritis. Rheum Dis Clin North Am [Internet]. 2013 Feb [cited 2022 Dec 7];39(1):1–19. Available from: https://pubmed.ncbi.nlm.nih.gov/23312408/Moreno-Reyes R, Egrise D, Nève J, Pasteels JL, Schoutens A. Selenium deficiency-induced growth retardation is associated with an impaired bone metabolism and osteopenia. Journal of Bone and Mineral Research. 2001;16(8):1556–63.Lohmander LS, de Verdier MG, Rollof J, Nilsson PM, Engström G. Incidence of severe knee and hip osteoarthritis in relation to different measures of body mass: a population-based prospective cohort study. Ann Rheum Dis [Internet]. 2009 Apr [cited 2022 Dec 7];68(4):490–6. Available from: https://pubmed.ncbi.nlm.nih.gov/18467514/Forward DP, Davis TRC, Sithole JS. Do young patients with malunited fractures of the distal radius inevitably develop symptomatic post-traumatic osteoarthritis? J Bone Joint Surg Br [Internet]. 2008 May [cited 2022 Dec 7];90(5):629–37. Available from: https://pubmed.ncbi.nlm.nih.gov/18450631/LIVESLEY PJ. The conservative management of Bennett’s fracture-dislocation: a 26-year follow-up. J Hand Surg Br [Internet]. 1990 Jun [cited 2022 Dec 7];15(3):291–4. Available from: https://pubmed.ncbi.nlm.nih.gov/2230493/Kirk JA, Ansell BM, Bywaters EG. The hypermobility syndrome. Musculoskeletal complaints associated with generalized joint hypermobility. Ann Rheum Dis [Internet]. 1967 [cited 2022 Dec 7];26(5):419. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1031347/Meyer-Scholten C, Valeva A, Zorn K, Meurer A, Fassbender HG. [Significance of clinically latent bacterial arthritis]. Z Rheumatol [Internet]. 2008 Feb [cited 2022 Dec 7];67(1):41–6. Available from: https://pubmed.ncbi.nlm.nih.gov/18214500/Sinha M, Jain S, Woods DA. Septic arthritis of the small joints of the hand. J Hand Surg Br [Internet]. 2006 Dec [cited 2022 Dec 7];31(6):665–72. Available from: https://pubmed.ncbi.nlm.nih.gov/17046120/Sammer DM, Shin AY. Comparison of arthroscopic and open treatment of septic arthritis of the wrist. J Bone Joint Surg Am [Internet]. 2009 Jun 1 [cited 2022 Dec 7];91(6):1387–93. Available from: https://pubmed.ncbi.nlm.nih.gov/19487516/Sperry MM, Ita ME, Kartha S, Zhang S, Yu YH, Winkelstein B. The Interface of Mechanics and Nociception in Joint Pathophysiology: Insights From the Facet and Temporomandibular Joints. J Biomech Eng [Internet]. 2017 Feb 1 [cited 2022 Dec 7];139(2):0210031. Available from: /pmc/articles/PMC5253677/Hochberg MC, Altman RD, April KT, Benkhalti M, Guyatt G, McGowan J, et al. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res (Hoboken) [Internet]. 2012 Apr [cited 2022 Dec 7];64(4):465–74. Available from: https://pubmed.ncbi.nlm.nih.gov/22563589/Stecher RM. HEBERDEN’S NODES: THE CLINICAL CHARACTERISTIC OF OSTEO-ARTHRITIS OF THE FINGERS.Sofat N, Jeyabaladevan S, Sofat N, Jeyabaladevan S. Hand Osteoarthritis — Clinical Presentation, Phenotypes and Management. Osteoarthritis - Progress in Basic Research and Treatment [Internet]. 2015 Jul 1 [cited 2022 Dec 7]; Available from: https://www.intechopen.com/state.item.idSandell LJ, Aigner T. Articular cartilage and changes in arthritis. An introduction: cell biology of osteoarthritis. Arthritis Res [Internet]. 2001 [cited 2022 Dec 7];3(2):107–13. Available from: https://pubmed.ncbi.nlm.nih.gov/11178118/Jensen JC, Sherson D. Work-related bilateral osteoarthritis of the first carpometacarpal joints. Occup Med (Lond) [Internet]. 2007 Sep [cited 2022 Dec 7];57(6):456–60. Available from: https://pubmed.ncbi.nlm.nih.gov/17698839/Sofat N, Jeyabaladevan S, Sofat N, Jeyabaladevan S. Hand Osteoarthritis — Clinical Presentation, Phenotypes and Management. Osteoarthritis - Progress in Basic Research and Treatment [Internet]. 2015 Jul 1 [cited 2022 Dec 7]; Available from: https://www.intechopen.com/state.item.idPol EN. Evaluación del paciente y medida de resultados. Aten Primaria [Internet]. 2014 Jan [cited 2022 Dec 7];46(Supl.1):32–8. Available from: https://medes.com/publication/86758Poole JL. Measures of hand function: Arthritis Hand Function Test (AHFT), Australian Canadian Osteoarthritis Hand Index (AUSCAN), Cochin Hand Function Scale, Functional Index for Hand Osteoarthritis (FIHOA), Grip Ability Test (GAT), Jebsen Hand Function Test (JHFT), and Michigan Hand Outcomes Questionnaire (MHQ). Arthritis Care Res (Hoboken) [Internet]. 2011 Nov [cited 2022 Dec 7];63 Suppl 11(SUPPL. 11). Available from: https://pubmed.ncbi.nlm.nih.gov/22588744/CHMP. Osteoarthritis Guideline - DRAFT [Internet]. Available from: http://www.emea.europa.euMarshall M, Dziedzic KS, van der Windt DA, Hay EM. A systematic search and narrative review of radiographic definitions of hand osteoarthritis in population-based studies. Osteoarthritis Cartilage [Internet]. 2008 Feb [cited 2022 Dec 7];16(2):219–26. Available from: https://pubmed.ncbi.nlm.nih.gov/17646114/Buckland‐Wright JC, Macfarlane DG, Lynch JA, Clark B. Quantitative microfocal radiographic assessment of progression in osteoarthritis of the hand. Arthritis Rheum [Internet]. 1990 [cited 2022 Dec 7];33(1):57–65. Available from: https://pubmed.ncbi.nlm.nih.gov/2302268/Haugen IK, Bøyesen P. Imaging modalities in hand osteoarthritis - status and perspectives of conventional radiography, magnetic resonance imaging, and ultrasonography. Arthritis Res Ther [Internet]. 2011 Dec 13 [cited 2022 Dec 7];13(6):248. Available from: /pmc/articles/PMC3334630/Verbruggen G, Veys EM. Numerical scoring systems for the anatomic evolution of osteoarthritis of the finger joints. Arthritis Rheum [Internet]. 1996 Feb [cited 2022 Dec 7];39(2):308–20. Available from: https://pubmed.ncbi.nlm.nih.gov/8849385/Buckland-Wright C. Subchondral bone changes in hand and knee osteoarthritis detected by radiography. Osteoarthritis Cartilage [Internet]. 2004 [cited 2022 Dec 7];12(SUPLL.):10–9. Available from: https://pubmed.ncbi.nlm.nih.gov/14698636/Kohn MD, Sassoon AA, Fernando ND. Classifications in Brief: Kellgren-Lawrence Classification of Osteoarthritis. Clin Orthop Relat Res [Internet]. 2016 Aug 1 [cited 2022 Dec 7];474(8):1886. Available from: /pmc/articles/PMC4925407/Spector TD, Cooper C. Radiographic assessment of osteoarthritis in population studies: whither Kellgren and Lawrence? Osteoarthritis Cartilage [Internet]. 1993 [cited 2022 Dec 7];1(4):203–6. Available from: https://pubmed.ncbi.nlm.nih.gov/15449506/Verbruggen G, Veys EM. Numerical scoring systems for the anatomic evolution of osteoarthritis of the finger joints. Arthritis Rheum [Internet]. 1996 Feb [cited 2022 Dec 7];39(2):308–20. Available from: https://pubmed.ncbi.nlm.nih.gov/8849385/Haugen IK. The Reliability and Validity of Magnetic Resonance Imaging in Patients with Hand Osteoarthritis.Feydy A, Pluot E, Guerini H, Drapé JL. Osteoarthritis of the wrist and hand, and spine. Radiol Clin North Am [Internet]. 2009 Jul [cited 2022 Dec 7];47(4):723–59. Available from: https://pubmed.ncbi.nlm.nih.gov/19631079/Dahaghin S, Bierma-Zeinstra SMA, Ginai AZ, Pols HAP, Hazes JMW, Koes BW. Prevalence and pattern of radiographic hand osteoarthritis and association with pain and disability (the Rotterdam study). Ann Rheum Dis. 2005 May;64(5):682–7.Spector TD, Nandra D, Hart DJ, Doyle D V. Is hormone replacement therapy protective for hand and knee osteoarthritis in women?: The Chingford Study. Ann Rheum Dis. 1997;56(7):432–4.Wilder F V., Barrett JP, Farina EJ. Joint-specific prevalence of osteoarthritis of the hand. Osteoarthritis Cartilage [Internet]. 2006 Sep [cited 2023 Oct 21];14(9):953–7. Available from: https://pubmed.ncbi.nlm.nih.gov/16759885/Mathiessen A, Haugen IK, Slatkowsky-Christensen B, Bøyesen P, Kvien TK, Hammer HB. Ultrasonographic assessment of osteophytes in 127 patients with hand osteoarthritis: exploring reliability and associations with MRI, radiographs and clinical joint findings. Ann Rheum Dis [Internet]. 2013 Jan 1 [cited 2023 Oct 21];72(1):51–6. Available from: https://ard.bmj.com/content/72/1/51Jones AG, Francis MD, Davis MA. Bone scanning: radionuclidic reaction mechanisms. Semin Nucl Med [Internet]. 1976 [cited 2023 Oct 21];6(1):3–18. 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