Factores asociados a remisión imagenológica funcional completa en pacientes con carcinoma diferenciado de tiroides tratados con yodo radiactivo para manejo de metástasis pulmonares

Introducción: el carcinoma diferenciado de tiroides (CDT) es uno de los tipos de cáncer endocrino más comúnmente observados. En general, el pronóstico del CDT es favorable; sin embargo, los pacientes que presentan metástasis a distancia tienen peor pronóstico. La localización a distancia más frecuen...

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Autores:: Torres Agredo, Liliana Patricia

Tipo de recurso:

Fecha de publicación:: 2021

Institución:: Universidad Autónoma de Bucaramanga - UNAB

Repositorio:: Repositorio UNAB

Idioma:: spa

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oai_identifier_str	oai:repository.unab.edu.co:20.500.12749/14233
network_acronym_str	UNAB2
network_name_str	Repositorio UNAB
repository_id_str
dc.title.spa.fl_str_mv	Factores asociados a remisión imagenológica funcional completa en pacientes con carcinoma diferenciado de tiroides tratados con yodo radiactivo para manejo de metástasis pulmonares
dc.title.translated.spa.fl_str_mv	Factors associated with complete functional imaging remission in patients with differentiated thyroid carcinoma treated with radioactive iodine for the management of lung metastases
title	Factores asociados a remisión imagenológica funcional completa en pacientes con carcinoma diferenciado de tiroides tratados con yodo radiactivo para manejo de metástasis pulmonares
spellingShingle	Factores asociados a remisión imagenológica funcional completa en pacientes con carcinoma diferenciado de tiroides tratados con yodo radiactivo para manejo de metástasis pulmonares Medical sciences Health sciences Nuclear medicine Radiation Physiological effect Thyroid cancer Lung metastasis Radioactive iodine therapy Whole body scan Endocrine glands Thyroid diseases Carcinomas Ciencias médicas Medicina nuclear Radiación Efectos fisiológicos Glándulas endocrinas Enfermedades de las tiroides Carcinomas Ciencias de la salud Cáncer de tiroides Metástasis pulmonar Terapia yodo radioactivo Rastreo corporal total
title_short	Factores asociados a remisión imagenológica funcional completa en pacientes con carcinoma diferenciado de tiroides tratados con yodo radiactivo para manejo de metástasis pulmonares
title_full	Factores asociados a remisión imagenológica funcional completa en pacientes con carcinoma diferenciado de tiroides tratados con yodo radiactivo para manejo de metástasis pulmonares
title_fullStr	Factores asociados a remisión imagenológica funcional completa en pacientes con carcinoma diferenciado de tiroides tratados con yodo radiactivo para manejo de metástasis pulmonares
title_full_unstemmed	Factores asociados a remisión imagenológica funcional completa en pacientes con carcinoma diferenciado de tiroides tratados con yodo radiactivo para manejo de metástasis pulmonares
title_sort	Factores asociados a remisión imagenológica funcional completa en pacientes con carcinoma diferenciado de tiroides tratados con yodo radiactivo para manejo de metástasis pulmonares
dc.creator.fl_str_mv	Torres Agredo, Liliana Patricia
dc.contributor.advisor.none.fl_str_mv	Wandurraga Sánchez, Edwin Antonio Morales Avellaneda, Tatiana Camacho López, Paul Anthony
dc.contributor.author.none.fl_str_mv	Torres Agredo, Liliana Patricia
dc.contributor.cvlac.spa.fl_str_mv	Wandurraga Sánchez, Edwin Antonio [0001475567]
dc.contributor.cvlac.none.fl_str_mv	Camacho López, Paul Anthony [0000323578] Camacho López, Paul Anthony [0000323578]
dc.contributor.googlescholar.none.fl_str_mv	Camacho López, Paul Anthony [es&oi=ao] Camacho López, Paul Anthony [OvqUoOAAAAAJ]
dc.contributor.orcid.spa.fl_str_mv	Wandurraga Sánchez, Edwin Antonio [0000-0002-0529-2343]
dc.contributor.orcid.none.fl_str_mv	Camacho López, Paul Anthony [0000-0002-6233-9582] Camacho López, Paul Anthony [0000-0002-6233-9582]
dc.contributor.scopus.none.fl_str_mv	Camacho López, Paul Anthony [16047325700]
dc.contributor.researchgate.spa.fl_str_mv	Wandurraga Sánchez, Edwin Antonio [Edwin-Antonio-Wandurraga-Sanchez-2168480303]
dc.contributor.researchgate.none.fl_str_mv	Camacho López, Paul Anthony [Paul_Camacho_Lopez]
dc.contributor.apolounab.none.fl_str_mv	Camacho López, Paul Anthony [paul-anthony-camacho-lópez]
dc.contributor.linkedin.none.fl_str_mv	Camacho López, Paul Anthony [paulcamachomdepi]
dc.subject.keywords.spa.fl_str_mv	Medical sciences Health sciences Nuclear medicine Radiation Physiological effect Thyroid cancer Lung metastasis Radioactive iodine therapy Whole body scan Endocrine glands Thyroid diseases Carcinomas
topic	Medical sciences Health sciences Nuclear medicine Radiation Physiological effect Thyroid cancer Lung metastasis Radioactive iodine therapy Whole body scan Endocrine glands Thyroid diseases Carcinomas Ciencias médicas Medicina nuclear Radiación Efectos fisiológicos Glándulas endocrinas Enfermedades de las tiroides Carcinomas Ciencias de la salud Cáncer de tiroides Metástasis pulmonar Terapia yodo radioactivo Rastreo corporal total
dc.subject.lemb.spa.fl_str_mv	Ciencias médicas Medicina nuclear Radiación Efectos fisiológicos Glándulas endocrinas Enfermedades de las tiroides Carcinomas
dc.subject.proposal.spa.fl_str_mv	Ciencias de la salud Cáncer de tiroides Metástasis pulmonar Terapia yodo radioactivo Rastreo corporal total
description	Introducción: el carcinoma diferenciado de tiroides (CDT) es uno de los tipos de cáncer endocrino más comúnmente observados. En general, el pronóstico del CDT es favorable; sin embargo, los pacientes que presentan metástasis a distancia tienen peor pronóstico. La localización a distancia más frecuente de las metástasis del CDT es a nivel pulmonar y la terapia con yodo radiactivo [131I]NaI es las más adecuada para aquellas metástasis pulmonares de CDT ávidas de [131I]NaI pero que no se pueden resecar quirúrgicamente y puede aliviar la afección parcialmente o eliminar la lesión de manera efectiva. Actualmente se ha convertido en la piedra angular del tratamiento de las metástasis pulmonares del CDT y hasta la fecha, algunas investigaciones previas han discutido la eficacia del yodo radioactivo y sus factores influyentes para los pacientes con CDT con metástasis pulmonares. Objetivo: Evaluar la eficacia de la terapia con el [131I]NaI para los pacientes con CDT con metástasis pulmonares, buscando explorar los factores asociados con la remisión imagenológica funcional completa. Materiales y métodos: Se realizó un estudio de cohorte retrospectivo, incluyendo a los pacientes atendidos en un centro de medicina nuclear entre el 1 enero de 2010 al 31 de diciembre de 2019 con diagnóstico de carcinoma diferenciado de tiroides. con metástasis pulmonares, a quienes se les realizó terapia ablativa con yodo radioactivo luego de la tiroidectomía total y posteriormente se analizó la remisión imagenológica completa, mediante los hallazgos del [131I]NaI -RCT posterior a los 24 meses de tratamiento con [131I]NaI. Se tomaron las variables sociodemográficas, histopatológicas, clínicas y quirúrgicas, para establecer los factores asociados con la remisión funcional pulmonar. Resultados: De los 10 años de seguimiento se identificaron 2640 pacientes con CDT el 3,18% presentaron metástasis a nivel pulmonar, y al aplicar los criterios de inclusión - exclusión se reclutaron 54 pacientes (2,05%). En el análisis bivariado, se encontró asociaciones entre la respuesta funcional pulmonar posterior a la terapia con yodo y el tamaño tumoral mayor a 3,5 cm RR 0.56, IC (95% 0.19-1.6) p = 0,28], la presencia de extensión extratiroidea (ETE) [RR 0.53, IC (95% 0.18-1.57) p = 0,24], y tener una dosis acumulada mayor a 370 mCi (13690 MBq) [RR 3.75, IC (95% 1.13-12.34) p = 0.16]. El 42 % de los pacientes presentaron remisión completa posterior a la tercera dosis de [131I] NaI; el tener mas sesiones de terapia con yodo-radioactivo presenta una probabilidad de 4,7 veces más de presentar remisión imagenológica que el realizar menos sesiones de terapia con [131I]NaI [RR 4.7, IC (95% 1.13-12.34) p = 0.03]. Al realizar el análisis multivariado, los factores asociados con la predicción de la eficacia en la terapia con [131I]Na para CDT con metástasis pulmonares fueron la presencia de ETE y la administración de yodo radiactivo en un número de dosis > de 3 veces. Conclusiones: Este estudio indicó que uno de cada cinco pacientes con CDT con metástasis pulmonares pueden obtener una remisión completa después de la terapia con [131I]NaI. La administración de yodo radiactivo en un número de dosis > de 3 veces, es un factor indicativo de buena respuesta.
publishDate	2021
dc.date.accessioned.none.fl_str_mv	2021-09-10T19:22:29Z
dc.date.available.none.fl_str_mv	2021-09-10T19:22:29Z
dc.date.issued.none.fl_str_mv	2021
dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.local.spa.fl_str_mv	Tesis
dc.type.redcol.none.fl_str_mv	http://purl.org/redcol/resource_type/TM
dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/20.500.12749/14233
dc.identifier.instname.spa.fl_str_mv	instname:Universidad Autónoma de Bucaramanga - UNAB
dc.identifier.reponame.spa.fl_str_mv	reponame:Repositorio Institucional UNAB
dc.identifier.repourl.spa.fl_str_mv	repourl:https://repository.unab.edu.co
url	http://hdl.handle.net/20.500.12749/14233
identifier_str_mv	instname:Universidad Autónoma de Bucaramanga - UNAB reponame:Repositorio Institucional UNAB repourl:https://repository.unab.edu.co
dc.language.iso.spa.fl_str_mv	spa
language	spa
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New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). European Journal Of Cancer, 45(2), 228-247. doi: 10.1016/j.ejca.2008.10.026 R. Shaha, A., P. Shah, J., & R. Loree, T. (1997). Differentiated thyroid cancer presenting initially with distant metastasis. The American Journal Of Surgery, 174(5), 474-476. doi: 10.1016/s0002-9610(97)00158- Cady B., Rossi R.(1988) An expanded view of risk-group definition in differentiated thyroid carcinoma. Surgery,104:947–953. doi: 10.1067/msy.1998.93106 . Cooper, D., Doherty, G., Haugen, B., Kloos, R., Lee, S., & Mandel, S. et al. (2009). Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid, 19(11), 1167-1214. doi: 10.1089/thy.2009.0110 Watkinson, J. (2004). The British Thyroid Association guidelines for the management of thyroid cancer in adults. Nuclear Medicine Communications, 25(9), 897-900. doi: 10.1097/00006231-200409000-00006 . Pacini, F., Schlumberger, M., Dralle, H., Elisei, R., Smit, J., Wiersinga, W.(2006). European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium. European Journal Of Endocrinology, 154(6), 787-803. doi: 10.1530/eje.1.02158 Riesco-Eizaguirre, G., Gutiérrez-Martínez, P., García-Cabezas, M., Nistal, M., & Santisteban, P. (2006). The oncogene BRAFV600E is associated with a high risk of recurrence and less differentiated papillary thyroid carcinoma due to the impairment of Na+/I− targeting to the membrane. Endocrine-Related Cancer, 13(1), 257-269. doi: 10.1677/erc.1.01119 Lin, J. (1999). Prognostic variables of papillary and follicular thyroid carcinoma patients with lymph node metastases and without distant metastases. Endocrine Related Cancer, 6(1), 109-115. doi: 10.1677/erc.0.0060109 R. Shaha, A., P. Shah, J., & R. Loree, T. (1997). 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Cancer, 53(4), 982-992. doi: 10.1002/1097-0142(19840215)53:4<982::aid-cncr2820530427>3.0.co;2-e Pitoia, F., Bueno, F., & Cross, G. (2014). Long-Term Survival and Low Effective Cumulative Radioiodine Doses to Achieve Remission in Patients With 131IodineAvid Lung Metastasis From Differentiated Thyroid Cancer. Clinical Nuclear Medicine, 39(9), 784-790. doi: 10.1097/rlu.0000000000000507 Mihailovic, J., Stefanovic, L., Malesevic, M., Erak, M., & Tesanovic, D. (2009). Metastatic differentiated thyroid carcinoma: clinical management and outcome of disease in patients with initial and late distant metastases. Nuclear Medicine Communications, 30(7), 558-564. doi: 10.1097/mnm.0b013e32832cc2ab Cho, S., Choi, H., Yeom, G., Lim, J., Moon, J., & Park, D. et al. (2014). Long-Term Prognosis of Differentiated Thyroid Cancer with Lung Metastasis in Korea and Its Prognostic Factors. Thyroid, 24(2), 277-286. doi: 10.1089/thy.2012.0654 Deandreis, D., Al Ghuzlan, A., Leboulleux, S., Lacroix, L., Garsi, J., & Talbot, M. et al. (2010). Do histological, immunohistochemical, and metabolic (radioiodine and fluorodeoxyglucose uptakes) patterns of metastatic thyroid cancer correlate with patient outcome?. Endocrine Related Cancer, 18(1), 159169. doi: 10.1677/erc-10-0233 Miyauchi, A., Kudo, T., Miya, A., Kobayashi, K., Ito, Y., & Takamura, Y. et al. (2011). Prognostic Impact of Serum Thyroglobulin Doubling-Time Under Thyrotropin Suppression in Patients with Papillary Thyroid Carcinoma Who Underwent Total Thyroidectomy. Thyroid, 21(7), 707-716. doi: 10.1089/thy.2010.0355 Lin JD, Chao TC, Chou SC, et al. Papillary thyroid carcinomas with lung metastases. Thyroid 2004;14:1091–6 Leite AK, Kulcsar MA, de Godoi Cavalheiro B, de Mello ES, Alves VA, Cernea CR, Matos LL. DEATH RELATED TO PULMONARY METASTASIS IN PATIENTS WITH DIFFERENTIATED THYROID CANCER. Endocr Pract. 2017 Jan;23(1):72-78 Boria, A.J., Perez-Torres, C.J. Minimal difference between fractionated and single-fraction exposure in a murine model of radiation necrosis. Radiat Oncol 14, 144 (2019). Zitvogel L, Kepp O, Senovilla L, Menger L, Chaput N, Kroemer G: Immunogenic tumor cell death for optimal anticancer therapy: the calreticulin exposure pathway. Clin Cancer Res 2010, 16: 3100-3104. 10.1158/1078-0432.CCR-09-2891 Rubner, Y., Muth, C., Strnad, A. et al. Fractionated radiotherapy is the main stimulus for the induction of cell death and of Hsp70 release of p53 mutated glioblastoma cell lines. Radiat Oncol 9, 89 (2014 Terashima, S., Hosokawa, Y., Tsuruga, E., Mariya, Y., & Nakamura, T. (2017). Impact of time interval and dose rate on cell survival following low-dose fractionated exposures. Journal of radiation research, 58(6), 782–790 Adamczewski, Z., Stasiołek, M., Karwowski, B., Dedecjus, M., OrszulakMichalak, D., Merecz, A., Śliwka, P. W., Puła, B., & Lewiński, A. (2015). The Effect of Diagnostic Absorbed Doses from 131I on Human Thyrocytes in Vitro. International journal of molecular sciences, 16(7), 14608–14622 Brassard M, Borget I, Edet-Sanson A, et al. Long-term follow-up of patients with papillary and follicular thyroid cancer: a prospective study on 715 patients. J Clin Endocrinol Metab 2011;96:1352–9 Heemstra KA, Liu YY, Stokkel M, et al. Serum thyroglobulin concentrations predict disease-free remission and death in differentiated thyroid carcinoma. Clin Endocrinol 2007;66:58–64 Nixon IJ, Whitcher MM, Palmer FL, et al. The impact of distant metastases at presentation on prognosis in patients with differentiated carcinoma of the thyroid gland. Thyroid 2012;22:884–9 Li YR, Chen ST, Hsueh C, Chao TC, Ho TY, Lin JD. Risk factors of distant metastasis in the follicular variant of papillary thyroid carcinoma. J Formos Med Assoc. 2016 Aug;115(8):665-71.
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dc.publisher.faculty.spa.fl_str_mv	Facultad Ciencias de la Salud
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spelling	Wandurraga Sánchez, Edwin Antonio5fa2192c-e67b-4220-8462-a44b20361ed6Morales Avellaneda, Tatianafeffb104-96aa-4759-8d63-1bbe91f5b894Camacho López, Paul Anthonye46d0c19-2faf-4964-80c2-bc6b94bb4127Torres Agredo, Liliana Patricia04e0d267-7863-4905-8b8b-1bae1f599c95Wandurraga Sánchez, Edwin Antonio [0001475567]Camacho López, Paul Anthony [0000323578]Camacho López, Paul Anthony [0000323578]Camacho López, Paul Anthony [es&oi=ao]Camacho López, Paul Anthony [OvqUoOAAAAAJ]Wandurraga Sánchez, Edwin Antonio [0000-0002-0529-2343]Camacho López, Paul Anthony [0000-0002-6233-9582]Camacho López, Paul Anthony [0000-0002-6233-9582]Camacho López, Paul Anthony [16047325700]Wandurraga Sánchez, Edwin Antonio [Edwin-Antonio-Wandurraga-Sanchez-2168480303]Camacho López, Paul Anthony [Paul_Camacho_Lopez]Camacho López, Paul Anthony [paul-anthony-camacho-lópez]Camacho López, Paul Anthony [paulcamachomdepi]Bucaramanga (Santander, Colombia)2010-2019UNAB Campus Bucaramanga2021-09-10T19:22:29Z2021-09-10T19:22:29Z2021http://hdl.handle.net/20.500.12749/14233instname:Universidad Autónoma de Bucaramanga - UNABreponame:Repositorio Institucional UNABrepourl:https://repository.unab.edu.coIntroducción: el carcinoma diferenciado de tiroides (CDT) es uno de los tipos de cáncer endocrino más comúnmente observados. En general, el pronóstico del CDT es favorable; sin embargo, los pacientes que presentan metástasis a distancia tienen peor pronóstico. La localización a distancia más frecuente de las metástasis del CDT es a nivel pulmonar y la terapia con yodo radiactivo [131I]NaI es las más adecuada para aquellas metástasis pulmonares de CDT ávidas de [131I]NaI pero que no se pueden resecar quirúrgicamente y puede aliviar la afección parcialmente o eliminar la lesión de manera efectiva. Actualmente se ha convertido en la piedra angular del tratamiento de las metástasis pulmonares del CDT y hasta la fecha, algunas investigaciones previas han discutido la eficacia del yodo radioactivo y sus factores influyentes para los pacientes con CDT con metástasis pulmonares. Objetivo: Evaluar la eficacia de la terapia con el [131I]NaI para los pacientes con CDT con metástasis pulmonares, buscando explorar los factores asociados con la remisión imagenológica funcional completa. Materiales y métodos: Se realizó un estudio de cohorte retrospectivo, incluyendo a los pacientes atendidos en un centro de medicina nuclear entre el 1 enero de 2010 al 31 de diciembre de 2019 con diagnóstico de carcinoma diferenciado de tiroides. con metástasis pulmonares, a quienes se les realizó terapia ablativa con yodo radioactivo luego de la tiroidectomía total y posteriormente se analizó la remisión imagenológica completa, mediante los hallazgos del [131I]NaI -RCT posterior a los 24 meses de tratamiento con [131I]NaI. Se tomaron las variables sociodemográficas, histopatológicas, clínicas y quirúrgicas, para establecer los factores asociados con la remisión funcional pulmonar. Resultados: De los 10 años de seguimiento se identificaron 2640 pacientes con CDT el 3,18% presentaron metástasis a nivel pulmonar, y al aplicar los criterios de inclusión - exclusión se reclutaron 54 pacientes (2,05%). En el análisis bivariado, se encontró asociaciones entre la respuesta funcional pulmonar posterior a la terapia con yodo y el tamaño tumoral mayor a 3,5 cm RR 0.56, IC (95% 0.19-1.6) p = 0,28], la presencia de extensión extratiroidea (ETE) [RR 0.53, IC (95% 0.18-1.57) p = 0,24], y tener una dosis acumulada mayor a 370 mCi (13690 MBq) [RR 3.75, IC (95% 1.13-12.34) p = 0.16]. El 42 % de los pacientes presentaron remisión completa posterior a la tercera dosis de [131I] NaI; el tener mas sesiones de terapia con yodo-radioactivo presenta una probabilidad de 4,7 veces más de presentar remisión imagenológica que el realizar menos sesiones de terapia con [131I]NaI [RR 4.7, IC (95% 1.13-12.34) p = 0.03]. Al realizar el análisis multivariado, los factores asociados con la predicción de la eficacia en la terapia con [131I]Na para CDT con metástasis pulmonares fueron la presencia de ETE y la administración de yodo radiactivo en un número de dosis > de 3 veces. Conclusiones: Este estudio indicó que uno de cada cinco pacientes con CDT con metástasis pulmonares pueden obtener una remisión completa después de la terapia con [131I]NaI. La administración de yodo radiactivo en un número de dosis > de 3 veces, es un factor indicativo de buena respuesta.LISTA DE SIGLAS LISTADO DE TABLAS LISTA DE ILUSTRACIONES O FIGURAS LISTA DE ANEXOS RESUMEN ABSTRACT INTRODUCCIÓN JUSTIFICACIÓN MARCO TEÓRICO ESTADO DEL ARTE PREGUNTA DE INVESTIGACIÓN OBJETIVOS METODOLOGÍA PROCEDIMIENTO DISPOSICIONES VIGENTES RESULTADOS DISCUSIÓN CONCLUSIONES FORTALEZAS Y LIMITACIONES FINANCIACIÓN Y CONFLICTOS DE INTERÉS REFERENCIASEspecializaciónIntroduction: differentiated thyroid carcinoma (DTC) is one of the most commonly observed types of endocrine cancer. In general, the prognosis for CDT is favorable; however, patients with distant metastases have a worse prognosis. The most frequent distant localization of CDT metastases is at the pulmonary level and radioactive iodine therapy [131I] NaI is the most appropriate for those pulmonary metastases of CDT avid for [131I] NaI but that cannot be surgically resected and can alleviate the condition partially or remove the injury effectively. It has now become the cornerstone of treatment for CDT lung metastases and to date, some previous research has discussed the efficacy of radioactive iodine and its influencing factors for CDT patients with lung metastases. Objective: To evaluate the efficacy of therapy with [131I] NaI for patients with DTC with pulmonary metastases, seeking to explore the factors associated with complete functional imaging remission Materials and methods: A retrospective cohort study was conducted, including patients treated at a nuclear medicine center between January 1, 2010 and December 31, 2019 with a diagnosis of differentiated thyroid carcinoma with pulmonary metastases, who underwent he performed ablative therapy with radioactive iodine after total thyroidectomy, and complete imaging remission was subsequently analyzed, using the [131I] NaI -RCT findings after 24 months of treatment with [131I] NaI. Sociodemographic, histopathological, clinical and surgical variables were taken to establish the factors associated with functional pulmonary remission. Results: Of the 10 years of follow-up, 2,640 patients with DTC were identified, 3.18% presented metastases at the lung level, and when applying the inclusion-exclusion criteria, 54 patients (2.05%) were recruited. In the bivariate analysis, associations were found between the pulmonary functional response after iodine therapy and tumor size greater than 3.5 cm RR 0.56, CI (95% 0.19-1.6) p = 0.28], the presence of extrathyroid extension (TEE) [RR 0.53, CI (95% 0.18-1.57) p = 0.24], and having a cumulative dose greater than 370 mCi (13690 MBq) [RR 3.75, CI (95% 1.13-12.34) p = 0.16]. 42% of the patients had complete remission after the third dose of [131I] NaI; having more sessions of therapy with radioactive iodine is 4.7 times more likely to present imaging remission than having fewer sessions of therapy with [131I] NaI [RR 4.7, CI (95% 1.13-12.34) p = 0.03 ]. When performing multivariate analysis, the factors associated with the prediction of efficacy in [131I] Na therapy for CDT with lung metastases were the presence of TEE and the administration of radioactive iodine in a number of doses> 3 times. Conclusions: This study indicated that one in five CDT patients with lung metastases can achieve complete remission after [131I] NaI therapy. The administration of radioactive iodine in a number of doses> 3 times is an indicative factor of a good response.Modalidad Presencialapplication/pdfspahttp://creativecommons.org/licenses/by-nc-nd/2.5/co/Abierto (Texto Completo)info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial-SinDerivadas 2.5 ColombiaFactores asociados a remisión imagenológica funcional completa en pacientes con carcinoma diferenciado de tiroides tratados con yodo radiactivo para manejo de metástasis pulmonaresFactors associated with complete functional imaging remission in patients with differentiated thyroid carcinoma treated with radioactive iodine for the management of lung metastasesEspecialista en Medicina NuclearUniversidad Autónoma de Bucaramanga UNABFacultad Ciencias de la SaludEspecialización en Medicina Nuclearinfo:eu-repo/semantics/masterThesisTesishttp://purl.org/redcol/resource_type/TMMedical sciencesHealth sciencesNuclear medicineRadiationPhysiological effectThyroid cancerLung metastasisRadioactive iodine therapyWhole body scanEndocrine glandsThyroid diseasesCarcinomasCiencias médicasMedicina nuclearRadiaciónEfectos fisiológicosGlándulas endocrinasEnfermedades de las tiroidesCarcinomasCiencias de la saludCáncer de tiroidesMetástasis pulmonarTerapia yodo radioactivoRastreo corporal total1. 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J Formos Med Assoc. 2016 Aug;115(8):665-71.ORIGINAL2021_Tesis_Liliana_Patricia_Torres.pdf2021_Tesis_Liliana_Patricia_Torres.pdfTesisapplication/pdf1773705https://repository.unab.edu.co/bitstream/20.500.12749/14233/1/2021_Tesis_Liliana_Patricia_Torres.pdf3b2282b0ca8f63e604aa5b0ff908d996MD51open access2021_Licencia_Liliana_Patricia_Torres.pdf2021_Licencia_Liliana_Patricia_Torres.pdfLicenciaapplication/pdf100691https://repository.unab.edu.co/bitstream/20.500.12749/14233/2/2021_Licencia_Liliana_Patricia_Torres.pdfc5688f2125fdb04a89bceca69fa2367fMD52metadata only accessLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repository.unab.edu.co/bitstream/20.500.12749/14233/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD53open accessTHUMBNAIL2021_Tesis_Liliana_Patricia_Torres.pdf.jpg2021_Tesis_Liliana_Patricia_Torres.pdf.jpgIM Thumbnailimage/jpeg6231https://repository.unab.edu.co/bitstream/20.500.12749/14233/4/2021_Tesis_Liliana_Patricia_Torres.pdf.jpg850e7f21791bcbcac7b6982c006979a7MD54open access2021_Licencia_Liliana_Patricia_Torres.pdf.jpg2021_Licencia_Liliana_Patricia_Torres.pdf.jpgIM Thumbnailimage/jpeg9961https://repository.unab.edu.co/bitstream/20.500.12749/14233/5/2021_Licencia_Liliana_Patricia_Torres.pdf.jpgca8ea159b6fb428e6abe6528620fde30MD55metadata only access20.500.12749/14233oai:repository.unab.edu.co:20.500.12749/142332024-01-18 11:20:52.254open accessRepositorio Institucional \| Universidad Autónoma de Bucaramanga - UNABrepositorio@unab.edu.coTk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=

Factores asociados a remisión imagenológica funcional completa en pacientes con carcinoma diferenciado de tiroides tratados con yodo radiactivo para manejo de metástasis pulmonares

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