Bases genéticas y moleculares de la preeclampsia

La preeclampsia es una enfermedad compleja, exclusiva de la gestación humana y responsables de una alta morbimortalidad perinatal. Ha sido denominada la enfermedad de las múltiples teorÍas, en la cual tanto factores medioambientales como genéticos se han asociado al desarrollo de la misma. para la i...

Full description

Autores:: Serrano Díaz, Norma Cecilia
Páez Leal, María Carolina
Martínez Linares, María Paula
Casas Romero, Juan Pablo
Gil Urbano, Laura
Navarro Mancilla, Álvaro Andrés

Tipo de recurso:: Article of journal

Fecha de publicación:: 2002

Institución:: Universidad Autónoma de Bucaramanga - UNAB

Repositorio:: Repositorio UNAB

Idioma:: spa

id	UNAB2_05c08e35039f54db1d4e89892ced7cc2
oai_identifier_str	oai:repository.unab.edu.co:20.500.12749/10532
network_acronym_str	UNAB2
network_name_str	Repositorio UNAB
repository_id_str
dc.title.none.fl_str_mv	Bases genéticas y moleculares de la preeclampsia
title	Bases genéticas y moleculares de la preeclampsia
spellingShingle	Bases genéticas y moleculares de la preeclampsia Ciencias de la salud Medicina Ciencias médicas Ciencias biomédicas Ciencias de la vida Innovaciones en salud Investigaciones Health Sciences Medicine Medical Sciences Biomedical Sciences Life Sciences Innovations in health Research Genetics Preeclampsia Polymorphisms Linkage studies Association studies Genética humana Biología Ciencias de la vida Genética Preeclampsia Polimorfismos Estudios de ligamiento Estudios de asociación
title_short	Bases genéticas y moleculares de la preeclampsia
title_full	Bases genéticas y moleculares de la preeclampsia
title_fullStr	Bases genéticas y moleculares de la preeclampsia
title_full_unstemmed	Bases genéticas y moleculares de la preeclampsia
title_sort	Bases genéticas y moleculares de la preeclampsia
dc.creator.fl_str_mv	Serrano Díaz, Norma Cecilia Páez Leal, María Carolina Martínez Linares, María Paula Casas Romero, Juan Pablo Gil Urbano, Laura Navarro Mancilla, Álvaro Andrés
dc.contributor.author.spa.fl_str_mv	Serrano Díaz, Norma Cecilia Páez Leal, María Carolina Martínez Linares, María Paula Casas Romero, Juan Pablo Gil Urbano, Laura Navarro Mancilla, Álvaro Andrés
dc.contributor.cvlac.none.fl_str_mv	Serrano Díaz, Norma Cecilia [0000066613] Páez Leal, María Carolina [0000066656] Casas Romero, Juan Pablo [0000018562]
dc.contributor.googlescholar.none.fl_str_mv	Páez Leal, María Carolina [BAPR3-cAAAAJ]
dc.contributor.orcid.none.fl_str_mv	Serrano Díaz, Norma Cecilia [0000-0003-3532-2002] Páez Leal, María Carolina [0000-0002-0310-0125]
dc.contributor.scopus.none.fl_str_mv	Serrano Díaz, Norma Cecilia [7003706613] Páez Leal, María Carolina [12243485600]
dc.contributor.researchgate.none.fl_str_mv	Páez Leal, María Carolina [profile/Maria_Paez-Leal]
dc.contributor.researchgroup.spa.fl_str_mv	Grupo de Estudio Genético de Enfermedades Complejas Grupo de Investigaciones Clínicas
dc.subject.none.fl_str_mv	Ciencias de la salud Medicina Ciencias médicas Ciencias biomédicas Ciencias de la vida Innovaciones en salud Investigaciones
topic	Ciencias de la salud Medicina Ciencias médicas Ciencias biomédicas Ciencias de la vida Innovaciones en salud Investigaciones Health Sciences Medicine Medical Sciences Biomedical Sciences Life Sciences Innovations in health Research Genetics Preeclampsia Polymorphisms Linkage studies Association studies Genética humana Biología Ciencias de la vida Genética Preeclampsia Polimorfismos Estudios de ligamiento Estudios de asociación
dc.subject.keywords.eng.fl_str_mv	Health Sciences Medicine Medical Sciences Biomedical Sciences Life Sciences Innovations in health Research
dc.subject.keywords.none.fl_str_mv	Genetics Preeclampsia Polymorphisms Linkage studies Association studies
dc.subject.lemb.none.fl_str_mv	Genética humana Biología Ciencias de la vida
dc.subject.proposal.none.fl_str_mv	Genética Preeclampsia Polimorfismos Estudios de ligamiento Estudios de asociación
description	La preeclampsia es una enfermedad compleja, exclusiva de la gestación humana y responsables de una alta morbimortalidad perinatal. Ha sido denominada la enfermedad de las múltiples teorÍas, en la cual tanto factores medioambientales como genéticos se han asociado al desarrollo de la misma. para la identificación de los genes candidatos asociados con la PE, se han empleado dos tipos de metodologÍa, los estudios de asociación y los estudios de ligamiento.[Serrano NC, Páes MC, MartÍnez MP, Casas JP, Gil L, Nvarro AA. Bases genéticas y moleculares de la preeclampsia. MedUNAB 2002; 5(15):185-94].Palabras clave: Genética, preeclampsia, polimorfismos, estudios de ligamiento, estudios de asociación, metileneterahidrofolato reductasa, lipoprotein lipasa, óxidonitrico sintasa endotelial, factor V de Leiden, angiotesinógeno, HLA-G, y factor denecrosis tumoral alfa.
publishDate	2002
dc.date.issued.none.fl_str_mv	2002-12-09
dc.date.accessioned.none.fl_str_mv	2020-10-27T14:22:22Z
dc.date.available.none.fl_str_mv	2020-10-27T14:22:22Z
dc.type.coar.fl_str_mv	http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/article
dc.type.local.spa.fl_str_mv	Artículo
dc.type.coar.none.fl_str_mv	http://purl.org/coar/resource_type/c_6501
dc.type.redcol.none.fl_str_mv	http://purl.org/redcol/resource_type/ART
format	http://purl.org/coar/resource_type/c_6501
dc.identifier.issn.none.fl_str_mv	2382-4603 0123-7047
dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/20.500.12749/10532
dc.identifier.instname.spa.fl_str_mv	instname:Universidad Autónoma de Bucaramanga UNAB
dc.identifier.repourl.none.fl_str_mv	repourl:https://repository.unab.edu.co
dc.identifier.doi.none.fl_str_mv	10.29375/01237047.275
identifier_str_mv	2382-4603 0123-7047 instname:Universidad Autónoma de Bucaramanga UNAB repourl:https://repository.unab.edu.co 10.29375/01237047.275
url	http://hdl.handle.net/20.500.12749/10532
dc.language.iso.spa.fl_str_mv	spa
language	spa
dc.relation.none.fl_str_mv	https://revistas.unab.edu.co/index.php/medunab/article/view/275/258
dc.relation.uri.none.fl_str_mv	https://revistas.unab.edu.co/index.php/medunab/article/view/275
dc.relation.references.none.fl_str_mv	lópez-Jaramillo P, Casas JP, Serrano N. Preeclampsia: fromepidemiological observations to molecular mechanism. Braz JMed Biol Res: 2001;10: 1227-35. Report of the National High Blood Pressure Education ProgramWorking Group on High Blood Pressure in Pregnancy. Am JObstet Gynecol 2000;183 :S1-S22 Gómez P. Ruiz N, Pulido J. Mortalidad materna en el InstitutoMaterno Infantil de Santafé de Bogotá D.C. 1985-1989. RevCol Obst Ginecol 1993;44:39-47 Encuesta Demográfica y de Salud Familiar (ENDES 2000).Disponible en: URL:http://www.minsa.gov.pe/enfermedad/salud-materna.htm Dekker GA, Sibai BM. Etiology and patogenesis of preeclampsia:current concepts. Am J Obstet Gynecol 1998;179:1359-75 Atallah AN, Hofmeyr GJ, Duley L. Calcium supplementationduring pregnancy for preventing hypertensive disorders andrelated problems. Cochrane Library number: CD001059 Dekker G, Sibai B. Primary, secondary and tertiary preventionof pre-eclampsia. Lancet 2001;357:209-15 Roberts JM, Cooper DW. Pathogenesis and genetics of pre-eclampsia. Lancet 2001;357:53-6 Graves JV. Genomic imprinting, development and disease: ispre-eclampsia caused by a maternally imprinted gene? ReprodFertil Dev 1998;10:23-9 Ros HS; Lichtenstein P, Lipworth L, et al. Genetic effects on theliability of developing pre-eclampsia and gestacionalhypertension. Am J Med Genet 2000;91:256-60 Risch NJ. Searching for genetic determinants in the newmillennium. Naturez 2000;405(15):847-56 Moses E, Lade J, Guo G, et al. A genome scan in families fromAustralia and New Zealand confirms the presence of a maternalsusceptibility locus for Pre-eclampsia, on chromosome 2. Am.J. Hum. Genet. 2000;67:1581-5 Arngrímsson R, Sigurardóttir S, Frigge ML, et al. A genome-widescan reveals a maternal susceptibility locus for pre-eclampsia onchromosome 2p13. Hum Mol Genet 1999;8:1799-1805 Harrison GA, Humphrey KE, Jones N, et al. Aa genomewidelinkage study of preeclampsia/eclampsia reveals evidence fora candidate regios on 4q. Am J Hum Genet 1997;60:1158-67 Guo GL, Lade JA, Wilton AN, et al. Genetic susceptibility to pre-eclampsia and chromosome 7q36. Hum Genet 1999;105:641-7. Hirschhorn JN, Lohmueller K, Byrne E, Hirschhorn K. Acomprehensive review of genetic association studies. Genet Med2002:4(2):45-61 Cardon LR, Bell J. Association study designs for complexdiseases. Nature Reviews Genetics 2001;2:91-99 Pritchard JK, Rosenberg NA. Use of unlinked genetic markersto detect population stratification in association studies. Am JHum Genet 1999;65:220-8 Devlin B, Roeder K. Genomic control for association studies.Biometrics 1999;55:997-1004 Reich DE, Goldtein DB. Detecting association in case-controlstudy while correcting for population stratification. GenetEpidemiol 2001;20:4-16 Refsum H, Veland PM, Nygard O. Homocysteine andcardiovascular disease. Annu Rev Med 1998;49:31-62 Goddijn-Wessel TAW, Wouters M, Molen van der EF.Hyperhomocysteinemeia risk factor for placental abruption orinfarction. Eur Obstet Gynecol Reprod Biol 1996;66:23-9 Wouters MGAJ, Boers GHJ, Blom HJ et al.Hyperhomocysteinemia a risk factor in women with unexplainedrecurrent early pregnancy loss. Fertil Steril 1993;60:820-5 Jara-Prado A, Santa María A. Homocisteina: un nuevo factorde riesgo para enfermedades vasculares. Arch Neurocien2002;7(1):43-50 Rajkovic A, Catalano PM, Malinow MR. Elevated homcysteinelevels with Preeclampsia. Obstet Gynecol 1997;90:168-71 Rajkovic A, Mahomed K, Malinow MR et al. Plasmahomocysteine concentrations in eclamptic and preeclampticAfrican women postpartum. Obstet Gynecol 1999;94:355-60 Frosst P, Blom HJ, Milos R et al. A candidate genetic risk factorfor vascular disease: a common mutation in methylen-etetrahydrofolate reductase. Nat Genet 1995;10:111-3 van der Put NM, Grabreels F, Stevens EM. A second commonmutation in the methylenetetrahydrofolate reductase gene: unadditional risk factor for neural tube defects? Am J Hum Gener1998;62:1044-51 Powers RW, Evans RW, Majors AK et al. Plasma homocysteineconcentrations is increased in preeclamptic and is associatedwith evidence of endothelial activation. Am J Obstet Gynecol1999;179:1605-11 Sohda S, Arinami T, Hamada H et al. Methylenetetrahydrofolatereductase polymorphisms and preeclampsia. J Med Genet1997;34:526-36 Grandone E, Margaglione M, Colarzzo D et al. Factor vV Leiden,C677T methylenetetrahydrofolate reductase polymorphisms andgenetic susceptibility to preeclampsia. Thromb Haemost1997;77:1052-4 Nagy B, Toth T, Rigo J et al. Detection of factor V leiden mutationin sever preeclampsia. Hungarian women. Clin Genet1998;53:478-81 Kaisser T, Brennecke SP, Moses EK. Methylenetetrahydrofolatereductase polymorphisms are not a risk factor for Preeclampsia– Eclampsia in Australian women. Gynecol Obstet Invest2000;50:100-2 Lachmeijer Am, Arngrímsson R, Bastiaans EJ et al. Mutationsin the gene for methylenetetrahydrofolate reductase, hocysteinelevels, and vitamin status in women with a history ofpreeclampsia. Am J Obstet Gynecol 2001;184:394-402 Powers RW, Minich LA, Lykins DL et al. Methylen-etetrahydrofolatereductase polymorphisms, float and susceptibility to preeclampsia.J Soc Gynecol Invest 1999;6:74-9 Chikos AB, Moodley J, Pegoraro RJ et al. 5,10 methylen-etetrahydrofolate polymorphisms in black South African womenwith preeclampsia. Br Obstet Gynaecol 1999;106:1219-20 Zousterzeel PLM, Visser W, Blom H et al. Methylen-etetrahydrofolate reductase polymorphisms in preeclampsia andHELLP syndrome. Hypertension Preg 2000;19(3):299-307 Bertina R, Koelman B, Koster T et al. Mutation in bloodcoagulation factor V associated with resistance to activatedprotein C. Nature 1994;369:64-7 Dahlback B. Inherited resistance to activated protein C, a majorcause of venous thrombosis is due to amutation in the factor Vgene. Haemostasis 1994;24:139-51 Bonnar J. Venous thromboembolism and pregnancy. Clin ObstetGynecol 1981;30:455-73 Dizon-Townson D, Nelson L, Easton K et al. The factor V Leidenmutation may predispose women to severe preeclampsia. AmJ Obstet Gynecol 1996;175:902-5 D’Elia AV, Driul L, Giacomello R, et al. Frequency of factor V,prothrombin and methylenetetrahydrofolate reductase genevariants in preeclampsia. Gynecol Obstet Invest 2002;53(2):84-7 Watanabe H, Hamada H, Yamada N, et al. Association analysisof nine missense polymorphisms in the coagulation factor V genewith severe preeclampsia in pregnant Japanese women. J HumGenet 2002;47(3):131-5 Currie L, Peek M, McNiven M, Prosser I, Mansour J, RidgwayJ. Is there an increased maternal-infant prevalence of Factor VLeiden in association with severe pre-eclampsia?BJOG 2002 Feb;109(2):191-6 van Pampus MG, Wolf H, Koopman MM, van den Ende A, BullerHR, Reitsma PH. Prothrombin 20210 G: a mutation and FactorV Leiden mutation in women with a history of severepreeclampsia and (H)ELLP syndrome. Hypertens Pregnancy2001;20(3):291-8 Livingston JC, Barton JR, Park V, Haddad B, Phillips O, SibaiBM. Maternal and fetal inherited thrombophilias are not relatedto the development of severe preeclampsia. Am J ObstetGynecol 2001 Jul;185(1):153-7 Kim YJ, Williamson RA, Murray JC, et al. Genetic susceptibilityto preeclampsia: roles of cytosineto-thymine substitution atnucleotide 677 of the gene for methylenetetrahydrofolatereductase, 68-base pair insertion at nucleotide 844 of the genefor cystathionine beta-synthase, and factor V Leiden mutation.Am J Obstet Gynecol 2001 May;184(6):1211-7 Rigo J Jr, Nagy B, Fintor L, et al. Maternal and neonatal outcomeof preeclamptic pregnancies: the potential roles of factor VLeiden mutation and 5,10 methylenetetrahydrofolate reductase.Hypertens Pregnancy 2000;19(2):163-72 Kobashi G, Yamada H, Asano T, et al. The factor V Leiden mutationis not a common cause of pregnancy-induced hypertension inJapan. Semin Thromb Hemost 1999;25(5):487-9 De Groot CJ, Bloemenkamp KW, Duvekot EJ, et al.Preeclampsia and genetic risk factors for thrombosis: a case-control study. Am J Obstet Gynecol 1999 Oct;181(4):975-80 O’Shaughnessy KM, Fu B, Ferraro F, Lewis I, Downing S, MorrisNH. Factor V Leiden and thermolabile methylenetetrahydrofolatereductase gene variants in an East Anglian preeclampsia cohort.Hypertension 1999 Jun;33(6):1338-41 Nagy B, Toth T, Rigo J Jr, Karadi I, Romics L, Papp Z. Detectionof factor V Leiden mutation in severe pre-eclamptic Hungarianwomen. Clin Genet 1998 Jun;53(6):478-81 Grandone E, Margaglione M, Colaizzo D, et al. Factor V Leiden,C > T MTHFR polymorphism and genetic susceptibility topreeclampsia. Thromb Haemost 1997 Jun;77(6):1052-4 Dizon-Townson DS, Nelson LM, Easton K, Ward K. The factor VLeiden mutation may predispose women to severe preeclampsia.Am J Obstet Gynecol 1996 Oct;175(4 Pt 1):902-5 Campbell D. Circulating and tissue angiotensin systems. J ClinInvest 1987;79:1-6. Powell J, Clozel J-P, Muller R et al. Inhibitors of angotensin-converting enzyme prevent myointimal proliferation aftervascular injury. Science 1989;245:186-8 Ward K, Hata A, Jeunemaitre X et al. A molecular variant ofangiotensinogen associated with preeclampsia. Nature Genetics1993:4;59-61 Kobashi G. A case – control study of pregnancy – inducehypertension with a genetic predisposition: Asociation of amolecular variant of AGT in the Japanese women. Hok Ig Zasshi1995;70:649-57 Kobashi G, Shido K, Hata A et al. Multivariate analysis of geneticand acquired factors; T235 variant of the angiotensinogen geneis a potent independent risk factor for preeclampsia. SeminThromb Hemost 2001;27(2):143-7 Suzuki Y, Tanemura M, Murakami I et al. Is angiotensinogengene polymorphism associated with hipertensión in pregnancy?Hypertens Pregnancy 1999;18:261-71 Guo G, Wilton AN, Fu Y et al. Angiotensinogen gene variationin apopulation cas-control study of preeclampsia/eclampsia inAustralians and Chinese. Electrophoresis 1997;18:1646-9 Morgan L, Baker P, Pipkin FB et al. Pre-eclampsia and theangiotensinogen gene. BIOG 1995;102:489-90 Inoue F, Nakajima T, Williams C et al. A nucleotide substitutionin the promoter of human AGT is associated with essentialhypertension and effects basal transcriptions. J Clin Invest1997;99:1786-97 Morgan T, Craven C, Nelson L. Angiotensinogen T235expression is elevated in decidual spiral arteries. J Clin Invest1997;100:1406-15 Morgan T, Ward K. New Insights into the genetics ofpreeclampsia. Seminars in Perinatology 1999;23(1):14-23 Williams RR, Hunt SC, Hopkins PN et al. Tabulations andexpectations regarding the genetics human hypertension. KidneyInt 1994;45:s57-s64 Kastelein JIP, Groenemeyer BE, Hallman DM et al. The Asn9variant of lipoprotein lipase is associated with the – 93G promotormutation and an increased risk of coronary artery disease Walsh S. Lipid peroxidation in pregnancy. Hypertens Preg1994;13:1-25 Kim YJ, Williamson KC, Smith JL et al. Lipoprotein lipase genemutations and the genetic susceptibility of preeclampsia.Hypertension 2001;38:992-6 VanWijk MJ, Kublickiene K, Boer K et al. Vascular function inpreeclampsia. Cardiovascular Research 2000;47:38-48 Meekins JW, Pijnenborg R, Anssens M et al. A study of placentalbed spiral arteries and trophoblast invasion in normal and sever pre-eclamptic pregnancies. Br J Obstet Gyanecol 1994;101:669-74 Humphrey KE, Harrison GA, Cooper DW et al. HLA-G deletionpolymorphisms and preeclampsia/eclampsia. Br J ObstetGynaecol 1995;102(9):707-10 Bermingham J, Jenkins D, Mc Carthy T et al. Genetic analysisof insulin-like growth factor II and HLA-G in preeclampsia.Biochem Soc Trans 2000:28(2):215-9 O’Brien M, McCarthy T, Jenkins D et al. Altered HLA-Gtranscription in pre-eclampsia is associated with allele specificinheritance: possible role of the HLA-G gene in susceptibility tothe disease. Cell Mol Life Sci 2001 58(12-13):1943-9 Hara N, Fujii T, Yamashita T, Kozuma S et al. Altered expressionof human leukocyte antigen G (HLA-G) on extravilloustrophoblasts in preeclampsia: immunohistological demonstration Goldman-Wohl DS, Ariel I, Greenfield C et al. Lack of human leuko-cyte antigen-G expression in extravillous trophoblast is associatedwith pre-eclampsia. Mol Hum Reprod 2000 Jan;6(1):88-95 erranova PF, Huntor VJ, Roby KF. Tumor necrosis factor-alpha infemale reproductive tract. Proc Soc Exp Biol Med 1995;209:325-42 Hun JS, Chen HL, Miller L et al. Tumor necrosis factor: pivotalcomponents of pregnancy? Biol Reprod 1996;4554-62 Wheler T, Evans PW, Anthony FW et al. Relationship betweenmaternal serum vascular endothelia growth factor concentrationsin early pregnancy and fetal and placental growth. Hum Reprod1999;14:1619-23 Nevils B, Conrad K, Increased circulating levels of TNF-a inpreeclampsia: Aposible role for cytokines in the pathogenesisof the disease. J Gynecol Invest 1995;2:311 Conrad KP, Benyo DE. Placental cytokines and the pathogenesisof preeclampsia. Am J Reprod Immunol 1997;.37:240-9 Li K, Wang L, Tong X. Study on tumor necrosis factor andpathogenesis of pregnancy induced hypertension. ZhonghuaFu Chan Ke Za Zhi 1999;34(6):339-41. Medline Dekker GA, Sibai BM. Etiology and pathogenensis ofpreeclampsia:Current concepts. Am J Obstet Gynecol1998;179:1359-75 Williams MA, Farrand A, Mittendorf R et al. Maternal secondtrimester serum tumor necrosis factor-alpha-soluble receptorp55 (sTNFp55) and subsequent risk of preeclampsia. Am JEpidemiol 1999 Feb 15;149(4):323-9 Rinehart BK, Terrone DA, Lagoo-Deenadayalan S et al.Expression of the placental cytokines tumor necrosis factoralpha, interleukin 1beta, and interleukin 10 is increased inpreeclampsia. Am J Obstet Gynecol 1999;181(4):915-20 Dizon-Townson DS, Major H, Ward K. A promoter mutation inthe tumor necrosis factor alpha gene is not associated withpreeclampsia. Reprod Immunol 1998 Apr;38(1):55-61 Livingston JC, Park V, Barton JR,Lack of association of severepreeclampsia with maternal and fetal mutant alleles for tumor necrosisfactor alpha and lymphotoxin alpha genes and plasma tumor necrosisfactor alpha levels. Am J Obstet Gynecol 2001;184(6):1273-7 Lachmeijer AM, Crusius JB, Pals G et al. Polymorphisms in thetumor necrosis factor and lymphotoxin-alpha gene region andpreeclampsia. Obstet Gynecol 2001;98(4):612-9 Heiskanen J, Romppanen EL, Hiltunen M. Polymorphism in thetumor necrosis factor-alpha gene in women with preeclampsia.J Assist Reprod Genet 2002;19(5):220-3 Palmer RM, Ferrige AG, Mocada S. Nitric oxide release accountsfor the biological activity of endothelium-derived relaxing factor.Nature1987;327:524-26 Sladek SM, Magness RR, Conrad KP. Nitric oxide andpregnancy. Am J Physiol 1997;272:441-463 Davidge ST, Stranko CP, Roberts JM. Urine but not plasma nitricoxide metabolites are decreased in women with preeclampsia.Am J Obstet Gynecol 1996;174:1008-1013 Nobunaga T, Tokugawa Y, Hashimoto K, et al. Plasma nitricoxide levels in pregnant patients with preeclampsia and essentialhypertension. Gynecol Obstet Invest 1996;41:189-193 Di Ioro R, Marinoni E, Emiliani S, et al. Nitric oxide inpreeclampsia: lack of evidence for decreases production. Eur JObstet Gynecol Reprod Biol 1998;76:65-70 Morris NH, Eaton BM, Dekker G. Nitric oxide, the endotheliumpregnancy and pre-eclampsia. Br J Obstet Gynecol 1996;103:4-15 Hingorani AD, Liang CF, Fatibene J, et al. A common variant ofthe endothelial nitric oxide synthase (Glu298Asp) is a major riskfactor for coronary artery disease in the UK. Circulation1999;100:1515-20 Yoshimura M. A missense Glu298Asp variant in the endothelialnitric oxide synthase gene is associated with coronary spasmin the Japanese. Hum Genet 1998;103:65-69 Yoshimura M et al. Genetic risk factor for coronary artery spasm:significance of endothelial nitric oxide synthase gene T786Cand missense Glu298Asp variants. J Invest Med 2000;48:367-74. Miyamoto Y, Saito Y, Kajiyama N, et al. Endothelial nitric oxidesynthase gene is positively associated with essentialhypertension. Hypertension 1998;32:3-8 Shoji M et al. Positive association of endothelial nitric oxidesynthase gene polymorphism with hypertension in northernJapan. Life Sci 2000;66:2557-62 Shimasaki Y, et al. Association of the missense Glu298Aspvariant of the nitric oxide synthase gene with myocardialinfarction. J Am Coll Cardiol 1999;31:1506-10 Teasuro M, Thompson WC, Rogliani P et al. Intracellularprocessing of endothelial nitric oxide synthase isoformsassociated with differences in severity of cardiopulmonarydiseases: cleavage of proteins with aspartate vs. glutamate atposition 298. Proc Natl Acad Sci USA 2000 97;2832-35 Savvidou MD, Vallance PJ, Nicolaides KH et al. Endothelialnitric oxide synthase gene polymorphism and maternal vascularadaptation to pregnancy. Hypertension 2001 Dec 1;38(6):1289-93 Kobashi G, Yamada H, Ohta K et al. Endothelial nitric oxidesynthase gene (NOS3) variant and hypertension in pregnancy.Am J Med Genet 2001 Oct 15;103(3):241-4 Bashford MT, Hefler LA, Vertrees TW et al. Angiotensinogenand endothelial nitric oxide synthase gene polymorphismsamong Hispanic patients with preeclampsia. Am J ObstetGynecol 2001 Jun;184(7):1345-50; discussion 1350-1
dc.rights.coar.fl_str_mv	http://purl.org/coar/access_right/c_abf2
dc.rights.uri.none.fl_str_mv	http://creativecommons.org/licenses/by-nc-nd/2.5/co/
rights_invalid_str_mv	http://creativecommons.org/licenses/by-nc-nd/2.5/co/ http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.spa.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Universidad Autónoma de Bucaramanga UNAB
dc.publisher.faculty.none.fl_str_mv	Facultad Ciencias de la Salud
dc.publisher.program.none.fl_str_mv	Pregrado Medicina
publisher.none.fl_str_mv	Universidad Autónoma de Bucaramanga UNAB
dc.source.none.fl_str_mv	MedUNAB; Vol. 5 Núm. 15 (2002): Preeclampsia, Escorpionismo, Disfunción eréctil, Psicofarmacología; 185-194
institution	Universidad Autónoma de Bucaramanga - UNAB
bitstream.url.fl_str_mv	https://repository.unab.edu.co/bitstream/20.500.12749/10532/1/2002_Bases_gen%c3%a9ticas_y_moleculares_de_la_preeclampsia.pdf https://repository.unab.edu.co/bitstream/20.500.12749/10532/2/2002_Bases_gen%c3%a9ticas_y_moleculares_de_la_preeclampsia.pdf.jpg
bitstream.checksum.fl_str_mv	8f4f71bad9d6569d418ca3c75b26ebdc a8203cd552148ac0f3dd77f895d133ae
bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5
repository.name.fl_str_mv	Repositorio Institucional \| Universidad Autónoma de Bucaramanga - UNAB
repository.mail.fl_str_mv	repositorio@unab.edu.co
_version_	1808410535316684800
spelling	Serrano Díaz, Norma Ceciliac2a02112-8d21-4fee-b12f-06ce5fcc6fd4Páez Leal, María Carolina4c30d3de-095b-4497-b14c-f1501234ab69Martínez Linares, María Paulaeb41016a-e4cb-4d65-adaa-3fcd9727bb16Casas Romero, Juan Pabloaf55f6fc-e060-47ec-9862-837a091bdb7aGil Urbano, Laurabdc79cef-3a00-442a-a845-1491a678d884Navarro Mancilla, Álvaro Andrésb77c309c-0a5d-4f44-a7bf-7f0646298860Serrano Díaz, Norma Cecilia [0000066613]Páez Leal, María Carolina [0000066656]Casas Romero, Juan Pablo [0000018562]Páez Leal, María Carolina [BAPR3-cAAAAJ]Serrano Díaz, Norma Cecilia [0000-0003-3532-2002]Páez Leal, María Carolina [0000-0002-0310-0125]Serrano Díaz, Norma Cecilia [7003706613]Páez Leal, María Carolina [12243485600]Páez Leal, María Carolina [profile/Maria_Paez-Leal]Grupo de Estudio Genético de Enfermedades ComplejasGrupo de Investigaciones Clínicas2020-10-27T14:22:22Z2020-10-27T14:22:22Z2002-12-092382-46030123-7047http://hdl.handle.net/20.500.12749/10532instname:Universidad Autónoma de Bucaramanga UNABrepourl:https://repository.unab.edu.co10.29375/01237047.275La preeclampsia es una enfermedad compleja, exclusiva de la gestación humana y responsables de una alta morbimortalidad perinatal. Ha sido denominada la enfermedad de las múltiples teorÍas, en la cual tanto factores medioambientales como genéticos se han asociado al desarrollo de la misma. para la identificación de los genes candidatos asociados con la PE, se han empleado dos tipos de metodologÍa, los estudios de asociación y los estudios de ligamiento.[Serrano NC, Páes MC, MartÍnez MP, Casas JP, Gil L, Nvarro AA. Bases genéticas y moleculares de la preeclampsia. MedUNAB 2002; 5(15):185-94].Palabras clave: Genética, preeclampsia, polimorfismos, estudios de ligamiento, estudios de asociación, metileneterahidrofolato reductasa, lipoprotein lipasa, óxidonitrico sintasa endotelial, factor V de Leiden, angiotesinógeno, HLA-G, y factor denecrosis tumoral alfa.Preeclampsia is a complex disease, exclusive of human pregnancy and responsible for high perinatal morbidity and mortality. It has been called the disease of multiple theories, in which both environmental and genetic factors have been associated with its development. For the identification of candidate genes associated with PE, two types of methodology have been used, association studies and linkage studies. This article explains the rationale for both studies and reviews the main candidate genes within the pathophysiology of the disease, including those that code for the enzymes methylene tetrahydrofolate reductase, lipoprotein lipase and endothelial nitric oxide synthase; factor V Leiden, angiotensinogen, HLA-G, and necrotumor factor alphaapplication/pdfspaUniversidad Autónoma de Bucaramanga UNABFacultad Ciencias de la SaludPregrado Medicinahttps://revistas.unab.edu.co/index.php/medunab/article/view/275/258https://revistas.unab.edu.co/index.php/medunab/article/view/275lópez-Jaramillo P, Casas JP, Serrano N. Preeclampsia: fromepidemiological observations to molecular mechanism. Braz JMed Biol Res: 2001;10: 1227-35.Report of the National High Blood Pressure Education ProgramWorking Group on High Blood Pressure in Pregnancy. Am JObstet Gynecol 2000;183 :S1-S22Gómez P. Ruiz N, Pulido J. Mortalidad materna en el InstitutoMaterno Infantil de Santafé de Bogotá D.C. 1985-1989. RevCol Obst Ginecol 1993;44:39-47Encuesta Demográfica y de Salud Familiar (ENDES 2000).Disponible en: URL:http://www.minsa.gov.pe/enfermedad/salud-materna.htmDekker GA, Sibai BM. Etiology and patogenesis of preeclampsia:current concepts. Am J Obstet Gynecol 1998;179:1359-75Atallah AN, Hofmeyr GJ, Duley L. Calcium supplementationduring pregnancy for preventing hypertensive disorders andrelated problems. Cochrane Library number: CD001059Dekker G, Sibai B. Primary, secondary and tertiary preventionof pre-eclampsia. Lancet 2001;357:209-15Roberts JM, Cooper DW. Pathogenesis and genetics of pre-eclampsia. Lancet 2001;357:53-6Graves JV. Genomic imprinting, development and disease: ispre-eclampsia caused by a maternally imprinted gene? ReprodFertil Dev 1998;10:23-9Ros HS; Lichtenstein P, Lipworth L, et al. Genetic effects on theliability of developing pre-eclampsia and gestacionalhypertension. Am J Med Genet 2000;91:256-60Risch NJ. Searching for genetic determinants in the newmillennium. Naturez 2000;405(15):847-56Moses E, Lade J, Guo G, et al. A genome scan in families fromAustralia and New Zealand confirms the presence of a maternalsusceptibility locus for Pre-eclampsia, on chromosome 2. Am.J. Hum. Genet. 2000;67:1581-5Arngrímsson R, Sigurardóttir S, Frigge ML, et al. A genome-widescan reveals a maternal susceptibility locus for pre-eclampsia onchromosome 2p13. Hum Mol Genet 1999;8:1799-1805Harrison GA, Humphrey KE, Jones N, et al. Aa genomewidelinkage study of preeclampsia/eclampsia reveals evidence fora candidate regios on 4q. Am J Hum Genet 1997;60:1158-67Guo GL, Lade JA, Wilton AN, et al. Genetic susceptibility to pre-eclampsia and chromosome 7q36. Hum Genet 1999;105:641-7.Hirschhorn JN, Lohmueller K, Byrne E, Hirschhorn K. Acomprehensive review of genetic association studies. Genet Med2002:4(2):45-61Cardon LR, Bell J. Association study designs for complexdiseases. Nature Reviews Genetics 2001;2:91-99Pritchard JK, Rosenberg NA. Use of unlinked genetic markersto detect population stratification in association studies. Am JHum Genet 1999;65:220-8Devlin B, Roeder K. Genomic control for association studies.Biometrics 1999;55:997-1004Reich DE, Goldtein DB. Detecting association in case-controlstudy while correcting for population stratification. GenetEpidemiol 2001;20:4-16Refsum H, Veland PM, Nygard O. Homocysteine andcardiovascular disease. Annu Rev Med 1998;49:31-62Goddijn-Wessel TAW, Wouters M, Molen van der EF.Hyperhomocysteinemeia risk factor for placental abruption orinfarction. Eur Obstet Gynecol Reprod Biol 1996;66:23-9Wouters MGAJ, Boers GHJ, Blom HJ et al.Hyperhomocysteinemia a risk factor in women with unexplainedrecurrent early pregnancy loss. Fertil Steril 1993;60:820-5Jara-Prado A, Santa María A. Homocisteina: un nuevo factorde riesgo para enfermedades vasculares. Arch Neurocien2002;7(1):43-50Rajkovic A, Catalano PM, Malinow MR. Elevated homcysteinelevels with Preeclampsia. Obstet Gynecol 1997;90:168-71Rajkovic A, Mahomed K, Malinow MR et al. Plasmahomocysteine concentrations in eclamptic and preeclampticAfrican women postpartum. Obstet Gynecol 1999;94:355-60Frosst P, Blom HJ, Milos R et al. A candidate genetic risk factorfor vascular disease: a common mutation in methylen-etetrahydrofolate reductase. Nat Genet 1995;10:111-3van der Put NM, Grabreels F, Stevens EM. A second commonmutation in the methylenetetrahydrofolate reductase gene: unadditional risk factor for neural tube defects? Am J Hum Gener1998;62:1044-51Powers RW, Evans RW, Majors AK et al. Plasma homocysteineconcentrations is increased in preeclamptic and is associatedwith evidence of endothelial activation. Am J Obstet Gynecol1999;179:1605-11Sohda S, Arinami T, Hamada H et al. Methylenetetrahydrofolatereductase polymorphisms and preeclampsia. J Med Genet1997;34:526-36Grandone E, Margaglione M, Colarzzo D et al. Factor vV Leiden,C677T methylenetetrahydrofolate reductase polymorphisms andgenetic susceptibility to preeclampsia. Thromb Haemost1997;77:1052-4Nagy B, Toth T, Rigo J et al. Detection of factor V leiden mutationin sever preeclampsia. Hungarian women. Clin Genet1998;53:478-81Kaisser T, Brennecke SP, Moses EK. Methylenetetrahydrofolatereductase polymorphisms are not a risk factor for Preeclampsia– Eclampsia in Australian women. Gynecol Obstet Invest2000;50:100-2Lachmeijer Am, Arngrímsson R, Bastiaans EJ et al. Mutationsin the gene for methylenetetrahydrofolate reductase, hocysteinelevels, and vitamin status in women with a history ofpreeclampsia. Am J Obstet Gynecol 2001;184:394-402Powers RW, Minich LA, Lykins DL et al. Methylen-etetrahydrofolatereductase polymorphisms, float and susceptibility to preeclampsia.J Soc Gynecol Invest 1999;6:74-9Chikos AB, Moodley J, Pegoraro RJ et al. 5,10 methylen-etetrahydrofolate polymorphisms in black South African womenwith preeclampsia. Br Obstet Gynaecol 1999;106:1219-20Zousterzeel PLM, Visser W, Blom H et al. Methylen-etetrahydrofolate reductase polymorphisms in preeclampsia andHELLP syndrome. Hypertension Preg 2000;19(3):299-307Bertina R, Koelman B, Koster T et al. Mutation in bloodcoagulation factor V associated with resistance to activatedprotein C. Nature 1994;369:64-7Dahlback B. Inherited resistance to activated protein C, a majorcause of venous thrombosis is due to amutation in the factor Vgene. Haemostasis 1994;24:139-51Bonnar J. Venous thromboembolism and pregnancy. Clin ObstetGynecol 1981;30:455-73Dizon-Townson D, Nelson L, Easton K et al. The factor V Leidenmutation may predispose women to severe preeclampsia. AmJ Obstet Gynecol 1996;175:902-5D’Elia AV, Driul L, Giacomello R, et al. Frequency of factor V,prothrombin and methylenetetrahydrofolate reductase genevariants in preeclampsia. Gynecol Obstet Invest 2002;53(2):84-7Watanabe H, Hamada H, Yamada N, et al. Association analysisof nine missense polymorphisms in the coagulation factor V genewith severe preeclampsia in pregnant Japanese women. J HumGenet 2002;47(3):131-5Currie L, Peek M, McNiven M, Prosser I, Mansour J, RidgwayJ. Is there an increased maternal-infant prevalence of Factor VLeiden in association with severe pre-eclampsia?BJOG 2002 Feb;109(2):191-6van Pampus MG, Wolf H, Koopman MM, van den Ende A, BullerHR, Reitsma PH. Prothrombin 20210 G: a mutation and FactorV Leiden mutation in women with a history of severepreeclampsia and (H)ELLP syndrome. Hypertens Pregnancy2001;20(3):291-8Livingston JC, Barton JR, Park V, Haddad B, Phillips O, SibaiBM. Maternal and fetal inherited thrombophilias are not relatedto the development of severe preeclampsia. Am J ObstetGynecol 2001 Jul;185(1):153-7Kim YJ, Williamson RA, Murray JC, et al. Genetic susceptibilityto preeclampsia: roles of cytosineto-thymine substitution atnucleotide 677 of the gene for methylenetetrahydrofolatereductase, 68-base pair insertion at nucleotide 844 of the genefor cystathionine beta-synthase, and factor V Leiden mutation.Am J Obstet Gynecol 2001 May;184(6):1211-7Rigo J Jr, Nagy B, Fintor L, et al. Maternal and neonatal outcomeof preeclamptic pregnancies: the potential roles of factor VLeiden mutation and 5,10 methylenetetrahydrofolate reductase.Hypertens Pregnancy 2000;19(2):163-72Kobashi G, Yamada H, Asano T, et al. The factor V Leiden mutationis not a common cause of pregnancy-induced hypertension inJapan. Semin Thromb Hemost 1999;25(5):487-9De Groot CJ, Bloemenkamp KW, Duvekot EJ, et al.Preeclampsia and genetic risk factors for thrombosis: a case-control study. Am J Obstet Gynecol 1999 Oct;181(4):975-80O’Shaughnessy KM, Fu B, Ferraro F, Lewis I, Downing S, MorrisNH. Factor V Leiden and thermolabile methylenetetrahydrofolatereductase gene variants in an East Anglian preeclampsia cohort.Hypertension 1999 Jun;33(6):1338-41Nagy B, Toth T, Rigo J Jr, Karadi I, Romics L, Papp Z. Detectionof factor V Leiden mutation in severe pre-eclamptic Hungarianwomen. Clin Genet 1998 Jun;53(6):478-81Grandone E, Margaglione M, Colaizzo D, et al. Factor V Leiden,C > T MTHFR polymorphism and genetic susceptibility topreeclampsia. Thromb Haemost 1997 Jun;77(6):1052-4Dizon-Townson DS, Nelson LM, Easton K, Ward K. The factor VLeiden mutation may predispose women to severe preeclampsia.Am J Obstet Gynecol 1996 Oct;175(4 Pt 1):902-5Campbell D. Circulating and tissue angiotensin systems. J ClinInvest 1987;79:1-6.Powell J, Clozel J-P, Muller R et al. Inhibitors of angotensin-converting enzyme prevent myointimal proliferation aftervascular injury. Science 1989;245:186-8Ward K, Hata A, Jeunemaitre X et al. A molecular variant ofangiotensinogen associated with preeclampsia. Nature Genetics1993:4;59-61Kobashi G. A case – control study of pregnancy – inducehypertension with a genetic predisposition: Asociation of amolecular variant of AGT in the Japanese women. Hok Ig Zasshi1995;70:649-57Kobashi G, Shido K, Hata A et al. Multivariate analysis of geneticand acquired factors; T235 variant of the angiotensinogen geneis a potent independent risk factor for preeclampsia. SeminThromb Hemost 2001;27(2):143-7Suzuki Y, Tanemura M, Murakami I et al. Is angiotensinogengene polymorphism associated with hipertensión in pregnancy?Hypertens Pregnancy 1999;18:261-71Guo G, Wilton AN, Fu Y et al. Angiotensinogen gene variationin apopulation cas-control study of preeclampsia/eclampsia inAustralians and Chinese. Electrophoresis 1997;18:1646-9Morgan L, Baker P, Pipkin FB et al. Pre-eclampsia and theangiotensinogen gene. BIOG 1995;102:489-90Inoue F, Nakajima T, Williams C et al. A nucleotide substitutionin the promoter of human AGT is associated with essentialhypertension and effects basal transcriptions. J Clin Invest1997;99:1786-97Morgan T, Craven C, Nelson L. Angiotensinogen T235expression is elevated in decidual spiral arteries. J Clin Invest1997;100:1406-15Morgan T, Ward K. New Insights into the genetics ofpreeclampsia. Seminars in Perinatology 1999;23(1):14-23Williams RR, Hunt SC, Hopkins PN et al. Tabulations andexpectations regarding the genetics human hypertension. KidneyInt 1994;45:s57-s64Kastelein JIP, Groenemeyer BE, Hallman DM et al. The Asn9variant of lipoprotein lipase is associated with the – 93G promotormutation and an increased risk of coronary artery diseaseWalsh S. Lipid peroxidation in pregnancy. Hypertens Preg1994;13:1-25Kim YJ, Williamson KC, Smith JL et al. Lipoprotein lipase genemutations and the genetic susceptibility of preeclampsia.Hypertension 2001;38:992-6VanWijk MJ, Kublickiene K, Boer K et al. Vascular function inpreeclampsia. Cardiovascular Research 2000;47:38-48Meekins JW, Pijnenborg R, Anssens M et al. A study of placentalbed spiral arteries and trophoblast invasion in normal and sever pre-eclamptic pregnancies. Br J Obstet Gyanecol 1994;101:669-74Humphrey KE, Harrison GA, Cooper DW et al. HLA-G deletionpolymorphisms and preeclampsia/eclampsia. Br J ObstetGynaecol 1995;102(9):707-10Bermingham J, Jenkins D, Mc Carthy T et al. Genetic analysisof insulin-like growth factor II and HLA-G in preeclampsia.Biochem Soc Trans 2000:28(2):215-9O’Brien M, McCarthy T, Jenkins D et al. Altered HLA-Gtranscription in pre-eclampsia is associated with allele specificinheritance: possible role of the HLA-G gene in susceptibility tothe disease. Cell Mol Life Sci 2001 58(12-13):1943-9Hara N, Fujii T, Yamashita T, Kozuma S et al. Altered expressionof human leukocyte antigen G (HLA-G) on extravilloustrophoblasts in preeclampsia: immunohistological demonstrationGoldman-Wohl DS, Ariel I, Greenfield C et al. Lack of human leuko-cyte antigen-G expression in extravillous trophoblast is associatedwith pre-eclampsia. Mol Hum Reprod 2000 Jan;6(1):88-95erranova PF, Huntor VJ, Roby KF. Tumor necrosis factor-alpha infemale reproductive tract. Proc Soc Exp Biol Med 1995;209:325-42Hun JS, Chen HL, Miller L et al. Tumor necrosis factor: pivotalcomponents of pregnancy? Biol Reprod 1996;4554-62Wheler T, Evans PW, Anthony FW et al. Relationship betweenmaternal serum vascular endothelia growth factor concentrationsin early pregnancy and fetal and placental growth. Hum Reprod1999;14:1619-23Nevils B, Conrad K, Increased circulating levels of TNF-a inpreeclampsia: Aposible role for cytokines in the pathogenesisof the disease. J Gynecol Invest 1995;2:311Conrad KP, Benyo DE. Placental cytokines and the pathogenesisof preeclampsia. Am J Reprod Immunol 1997;.37:240-9Li K, Wang L, Tong X. Study on tumor necrosis factor andpathogenesis of pregnancy induced hypertension. ZhonghuaFu Chan Ke Za Zhi 1999;34(6):339-41. MedlineDekker GA, Sibai BM. Etiology and pathogenensis ofpreeclampsia:Current concepts. Am J Obstet Gynecol1998;179:1359-75Williams MA, Farrand A, Mittendorf R et al. Maternal secondtrimester serum tumor necrosis factor-alpha-soluble receptorp55 (sTNFp55) and subsequent risk of preeclampsia. Am JEpidemiol 1999 Feb 15;149(4):323-9Rinehart BK, Terrone DA, Lagoo-Deenadayalan S et al.Expression of the placental cytokines tumor necrosis factoralpha, interleukin 1beta, and interleukin 10 is increased inpreeclampsia. Am J Obstet Gynecol 1999;181(4):915-20Dizon-Townson DS, Major H, Ward K. A promoter mutation inthe tumor necrosis factor alpha gene is not associated withpreeclampsia. Reprod Immunol 1998 Apr;38(1):55-61Livingston JC, Park V, Barton JR,Lack of association of severepreeclampsia with maternal and fetal mutant alleles for tumor necrosisfactor alpha and lymphotoxin alpha genes and plasma tumor necrosisfactor alpha levels. Am J Obstet Gynecol 2001;184(6):1273-7Lachmeijer AM, Crusius JB, Pals G et al. Polymorphisms in thetumor necrosis factor and lymphotoxin-alpha gene region andpreeclampsia. Obstet Gynecol 2001;98(4):612-9Heiskanen J, Romppanen EL, Hiltunen M. Polymorphism in thetumor necrosis factor-alpha gene in women with preeclampsia.J Assist Reprod Genet 2002;19(5):220-3Palmer RM, Ferrige AG, Mocada S. Nitric oxide release accountsfor the biological activity of endothelium-derived relaxing factor.Nature1987;327:524-26Sladek SM, Magness RR, Conrad KP. Nitric oxide andpregnancy. Am J Physiol 1997;272:441-463Davidge ST, Stranko CP, Roberts JM. Urine but not plasma nitricoxide metabolites are decreased in women with preeclampsia.Am J Obstet Gynecol 1996;174:1008-1013Nobunaga T, Tokugawa Y, Hashimoto K, et al. Plasma nitricoxide levels in pregnant patients with preeclampsia and essentialhypertension. Gynecol Obstet Invest 1996;41:189-193Di Ioro R, Marinoni E, Emiliani S, et al. Nitric oxide inpreeclampsia: lack of evidence for decreases production. Eur JObstet Gynecol Reprod Biol 1998;76:65-70Morris NH, Eaton BM, Dekker G. Nitric oxide, the endotheliumpregnancy and pre-eclampsia. Br J Obstet Gynecol 1996;103:4-15Hingorani AD, Liang CF, Fatibene J, et al. A common variant ofthe endothelial nitric oxide synthase (Glu298Asp) is a major riskfactor for coronary artery disease in the UK. Circulation1999;100:1515-20Yoshimura M. A missense Glu298Asp variant in the endothelialnitric oxide synthase gene is associated with coronary spasmin the Japanese. Hum Genet 1998;103:65-69Yoshimura M et al. Genetic risk factor for coronary artery spasm:significance of endothelial nitric oxide synthase gene T786Cand missense Glu298Asp variants. J Invest Med 2000;48:367-74.Miyamoto Y, Saito Y, Kajiyama N, et al. Endothelial nitric oxidesynthase gene is positively associated with essentialhypertension. Hypertension 1998;32:3-8Shoji M et al. Positive association of endothelial nitric oxidesynthase gene polymorphism with hypertension in northernJapan. Life Sci 2000;66:2557-62Shimasaki Y, et al. Association of the missense Glu298Aspvariant of the nitric oxide synthase gene with myocardialinfarction. J Am Coll Cardiol 1999;31:1506-10Teasuro M, Thompson WC, Rogliani P et al. Intracellularprocessing of endothelial nitric oxide synthase isoformsassociated with differences in severity of cardiopulmonarydiseases: cleavage of proteins with aspartate vs. glutamate atposition 298. Proc Natl Acad Sci USA 2000 97;2832-35Savvidou MD, Vallance PJ, Nicolaides KH et al. Endothelialnitric oxide synthase gene polymorphism and maternal vascularadaptation to pregnancy. Hypertension 2001 Dec 1;38(6):1289-93Kobashi G, Yamada H, Ohta K et al. Endothelial nitric oxidesynthase gene (NOS3) variant and hypertension in pregnancy.Am J Med Genet 2001 Oct 15;103(3):241-4Bashford MT, Hefler LA, Vertrees TW et al. Angiotensinogenand endothelial nitric oxide synthase gene polymorphismsamong Hispanic patients with preeclampsia. Am J ObstetGynecol 2001 Jun;184(7):1345-50; discussion 1350-1http://creativecommons.org/licenses/by-nc-nd/2.5/co/http://purl.org/coar/access_right/c_abf2MedUNAB; Vol. 5 Núm. 15 (2002): Preeclampsia, Escorpionismo, Disfunción eréctil, Psicofarmacología; 185-194Ciencias de la saludMedicinaCiencias médicasCiencias biomédicasCiencias de la vidaInnovaciones en saludInvestigacionesHealth SciencesMedicineMedical SciencesBiomedical SciencesLife SciencesInnovations in healthResearchGeneticsPreeclampsiaPolymorphismsLinkage studiesAssociation studiesGenética humanaBiologíaCiencias de la vidaGenéticaPreeclampsiaPolimorfismosEstudios de ligamientoEstudios de asociaciónBases genéticas y moleculares de la preeclampsiainfo:eu-repo/semantics/articleArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/redcol/resource_type/ARTORIGINAL2002_Bases_genéticas_y_moleculares_de_la_preeclampsia.pdf2002_Bases_genéticas_y_moleculares_de_la_preeclampsia.pdfArticuloapplication/pdf373062https://repository.unab.edu.co/bitstream/20.500.12749/10532/1/2002_Bases_gen%c3%a9ticas_y_moleculares_de_la_preeclampsia.pdf8f4f71bad9d6569d418ca3c75b26ebdcMD51open accessTHUMBNAIL2002_Bases_genéticas_y_moleculares_de_la_preeclampsia.pdf.jpg2002_Bases_genéticas_y_moleculares_de_la_preeclampsia.pdf.jpgIM Thumbnailimage/jpeg9821https://repository.unab.edu.co/bitstream/20.500.12749/10532/2/2002_Bases_gen%c3%a9ticas_y_moleculares_de_la_preeclampsia.pdf.jpga8203cd552148ac0f3dd77f895d133aeMD52open access20.500.12749/10532oai:repository.unab.edu.co:20.500.12749/105322024-01-19 14:39:20.281open accessRepositorio Institucional \| Universidad Autónoma de Bucaramanga - UNABrepositorio@unab.edu.co

Bases genéticas y moleculares de la preeclampsia

Publicaciones similares