A Model of the Molecular Aggregate Processes of Hemoglobin S. Absence of Cristallization

The molecular aggregate formation mechanisms play a major role in the interpretation of the pathophysiology of Sickle Cell disease and in the selection of the therapeutic strategies to follow.  A mechanism and a mathematical model are proposed. The model postu-lates the existence of defecti...

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Autores:
Tipo de recurso:
Fecha de publicación:
2008
Institución:
Universidad Industrial de Santander
Repositorio:
Repositorio UIS
Idioma:
eng
OAI Identifier:
oai:noesis.uis.edu.co:20.500.14071/7037
Acceso en línea:
https://revistas.uis.edu.co/index.php/revistaintegracion/article/view/53
https://noesis.uis.edu.co/handle/20.500.14071/7037
Palabra clave:
Polymerization
Hemoglobin S
Sickle Cell, Modeling
Rights
openAccess
License
Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
id UISANTADR2_7e120ae851b88a3c76c696389460cdb4
oai_identifier_str oai:noesis.uis.edu.co:20.500.14071/7037
network_acronym_str UISANTADR2
network_name_str Repositorio UIS
repository_id_str
spelling Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)http://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)2008-02-292022-03-14T20:23:01Z2022-03-14T20:23:01Zhttps://revistas.uis.edu.co/index.php/revistaintegracion/article/view/53https://noesis.uis.edu.co/handle/20.500.14071/7037The molecular aggregate formation mechanisms play a major role in the interpretation of the pathophysiology of Sickle Cell disease and in the selection of the therapeutic strategies to follow.  A mechanism and a mathematical model are proposed. The model postu-lates the existence of defective microtubules formed by deoxy hemoglobin S and oxy hemoglobin S, and explains the dependence of polymerization on hemoglobin concentration, temperature, and partial oxygen pressure. The analysis focuses on the polymerization of hemoglobin S in the absence of crystallization. The action of other kinds of hemoglobin in the molecular aggregate formation process can be explained.   Los mecanismos de formación molecular agregada desempeña un papel importante en la interpretación de la patofisiología de la anemia de células falciformes (o anemia drepanocítica), y en la selección de las estrategias terapéuticas a seguir.  Aquí se propone un mecanismo y un modelo matemático. el modelo postula la existencia de microtúbulos defectivos formados por deoxihemoglobina S y oxihemoglobina S, y explica la dependencia de la polimerización de la concentración de hemoglobina, la temperatura y la presión parcial de oxígeno. El análisis hace énfasis en la polimerización de hemoglobina S en la ausencia de cristalización. La acción de otras clases de hemoglobinas en la formación molecular agregada puede ser explicada.application/pdfengUniversidad Industrial de Santanderhttps://revistas.uis.edu.co/index.php/revistaintegracion/article/view/53/305Revista integración, temas de matemáticas; Vol. 26 Núm. 1 (2008): Revista Integración, temas de matemáticas; 13-22REVISTA INTEGRACIÓN; v. 26 n. 1 (2008): Revista Integración, temas de matemáticas; 13-222145-84720120-419XPolymerizationHemoglobin SSickle Cell, ModelingA Model of the Molecular Aggregate Processes of Hemoglobin S. Absence of CristallizationA Model of the Molecular Aggregate Processes of Hemoglobin S. Absence of Cristallizationinfo:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Cabal-Mirabal, CarlosRuiz-Chaveco, Iván20.500.14071/7037oai:noesis.uis.edu.co:20.500.14071/70372022-03-16 12:39:53.915metadata.onlyhttps://noesis.uis.edu.coDSpace at UISnoesis@uis.edu.co
dc.title.en-US.fl_str_mv A Model of the Molecular Aggregate Processes of Hemoglobin S. Absence of Cristallization
dc.title.es-ES.fl_str_mv A Model of the Molecular Aggregate Processes of Hemoglobin S. Absence of Cristallization
title A Model of the Molecular Aggregate Processes of Hemoglobin S. Absence of Cristallization
spellingShingle A Model of the Molecular Aggregate Processes of Hemoglobin S. Absence of Cristallization
Polymerization
Hemoglobin S
Sickle Cell, Modeling
title_short A Model of the Molecular Aggregate Processes of Hemoglobin S. Absence of Cristallization
title_full A Model of the Molecular Aggregate Processes of Hemoglobin S. Absence of Cristallization
title_fullStr A Model of the Molecular Aggregate Processes of Hemoglobin S. Absence of Cristallization
title_full_unstemmed A Model of the Molecular Aggregate Processes of Hemoglobin S. Absence of Cristallization
title_sort A Model of the Molecular Aggregate Processes of Hemoglobin S. Absence of Cristallization
dc.subject.en-US.fl_str_mv Polymerization
Hemoglobin S
Sickle Cell, Modeling
topic Polymerization
Hemoglobin S
Sickle Cell, Modeling
description The molecular aggregate formation mechanisms play a major role in the interpretation of the pathophysiology of Sickle Cell disease and in the selection of the therapeutic strategies to follow.  A mechanism and a mathematical model are proposed. The model postu-lates the existence of defective microtubules formed by deoxy hemoglobin S and oxy hemoglobin S, and explains the dependence of polymerization on hemoglobin concentration, temperature, and partial oxygen pressure. The analysis focuses on the polymerization of hemoglobin S in the absence of crystallization. The action of other kinds of hemoglobin in the molecular aggregate formation process can be explained.   
publishDate 2008
dc.date.accessioned.none.fl_str_mv 2022-03-14T20:23:01Z
dc.date.available.none.fl_str_mv 2022-03-14T20:23:01Z
dc.date.none.fl_str_mv 2008-02-29
dc.type.none.fl_str_mv info:eu-repo/semantics/article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.identifier.none.fl_str_mv https://revistas.uis.edu.co/index.php/revistaintegracion/article/view/53
dc.identifier.uri.none.fl_str_mv https://noesis.uis.edu.co/handle/20.500.14071/7037
url https://revistas.uis.edu.co/index.php/revistaintegracion/article/view/53
https://noesis.uis.edu.co/handle/20.500.14071/7037
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://revistas.uis.edu.co/index.php/revistaintegracion/article/view/53/305
dc.rights.license.none.fl_str_mv Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.creativecommons.none.fl_str_mv Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
rights_invalid_str_mv Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.es-ES.fl_str_mv Universidad Industrial de Santander
dc.source.es-ES.fl_str_mv Revista integración, temas de matemáticas; Vol. 26 Núm. 1 (2008): Revista Integración, temas de matemáticas; 13-22
dc.source.pt-BR.fl_str_mv REVISTA INTEGRACIÓN; v. 26 n. 1 (2008): Revista Integración, temas de matemáticas; 13-22
dc.source.none.fl_str_mv 2145-8472
0120-419X
institution Universidad Industrial de Santander
repository.name.fl_str_mv DSpace at UIS
repository.mail.fl_str_mv noesis@uis.edu.co
_version_ 1814095225067405312

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