A Model of the Molecular Aggregate Processes of Hemoglobin S. Absence of Cristallization

The molecular aggregate formation mechanisms play a major role in the interpretation of the pathophysiology of Sickle Cell disease and in the selection of the therapeutic strategies to follow.  A mechanism and a mathematical model are proposed. The model postu-lates the existence of defecti...

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Autores:
Tipo de recurso:
Fecha de publicación:
2008
Institución:
Universidad Industrial de Santander
Repositorio:
Repositorio UIS
Idioma:
eng
OAI Identifier:
oai:noesis.uis.edu.co:20.500.14071/7037
Acceso en línea:
https://revistas.uis.edu.co/index.php/revistaintegracion/article/view/53
https://noesis.uis.edu.co/handle/20.500.14071/7037
Palabra clave:
Polymerization
Hemoglobin S
Sickle Cell, Modeling
Rights
openAccess
License
Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
Description
Summary:The molecular aggregate formation mechanisms play a major role in the interpretation of the pathophysiology of Sickle Cell disease and in the selection of the therapeutic strategies to follow.  A mechanism and a mathematical model are proposed. The model postu-lates the existence of defective microtubules formed by deoxy hemoglobin S and oxy hemoglobin S, and explains the dependence of polymerization on hemoglobin concentration, temperature, and partial oxygen pressure. The analysis focuses on the polymerization of hemoglobin S in the absence of crystallization. The action of other kinds of hemoglobin in the molecular aggregate formation process can be explained.