A Model of the Molecular Aggregate Processes of Hemoglobin S. Absence of Cristallization
The molecular aggregate formation mechanisms play a major role in the interpretation of the pathophysiology of Sickle Cell disease and in the selection of the therapeutic strategies to follow. A mechanism and a mathematical model are proposed. The model postu-lates the existence of defecti...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2008
- Institución:
- Universidad Industrial de Santander
- Repositorio:
- Repositorio UIS
- Idioma:
- eng
- OAI Identifier:
- oai:noesis.uis.edu.co:20.500.14071/7037
- Acceso en línea:
- https://revistas.uis.edu.co/index.php/revistaintegracion/article/view/53
https://noesis.uis.edu.co/handle/20.500.14071/7037
- Palabra clave:
- Polymerization
Hemoglobin S
Sickle Cell, Modeling
- Rights
- openAccess
- License
- Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
| Summary: | The molecular aggregate formation mechanisms play a major role in the interpretation of the pathophysiology of Sickle Cell disease and in the selection of the therapeutic strategies to follow. A mechanism and a mathematical model are proposed. The model postu-lates the existence of defective microtubules formed by deoxy hemoglobin S and oxy hemoglobin S, and explains the dependence of polymerization on hemoglobin concentration, temperature, and partial oxygen pressure. The analysis focuses on the polymerization of hemoglobin S in the absence of crystallization. The action of other kinds of hemoglobin in the molecular aggregate formation process can be explained. |
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