An overview of mice models : a key for understanding subtypes of mania
ABSTRACT: Animal models have been broadly used inthe study of pathophysiology and molecular and neurochemical pathways in neuropsychiatric diseases. Different approaches have used both consanguineous and non-consanguineous mice models to model behavioral patterns associated with the maniac spectrum....
- Autores:
-
Cuartas Arias, Jorge Mauricio
Díaz Zuluaga, Ana María
López Jaramilo, Carlos
- Tipo de recurso:
- Review article
- Fecha de publicación:
- 2016
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/26215
- Acceso en línea:
- http://hdl.handle.net/10495/26215
- Palabra clave:
- Modelos Animales
Models, Animal
Trastorno Bipolar
Bipolar Disorder
Psicosis maniaco-depresiva
Manic-depressive psychoses
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-nd/2.5/co/
| Summary: | ABSTRACT: Animal models have been broadly used inthe study of pathophysiology and molecular and neurochemical pathways in neuropsychiatric diseases. Different approaches have used both consanguineous and non-consanguineous mice models to model behavioral patterns associated with the maniac spectrum. However, the disadvantages of validating clinical and experimental protocols have hindered the replication of these studies. In this article, the advantages and disadvantages of using consanguineous lines and non-consanguineous stocks in mice animal models for the study of mania and its subtypes are discussed. Additionally, new experimental alternatives to advance the pathogenesis and pharmacogenetics of mania using animal models are proposed and analyzed. |
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