Introduction of the American/Asian genotype of Dengue-2 virus into Yucatán state, México

ABSTRACT: A dengue (DEN) outbreak occurred in the Yucatan State of Mexico in 2002. Three isolates were obtained from patients presenting with DEN-like symptoms, and examined by partial nucleotide sequencing and phylogenetic analysis. The isolates were identified as DEN-2 viruses of the American-Asian genotype; this is the first report of this genotype in the Yucatan State. The DEN-2 viruses of the American-Asian genotype have been associated with more severe disease outcomes. Thus, its introduction into the Yucatan State presents a serious problem to public health authorities. During this outbreak, DEN virus infection was confirmed in 18% (282 of 1,560) of the patients who presented with DEN-like symptoms. Of these, 87 (31%) patients met the World Health Organization criteria for dengue hemorrhagic fever, including two patients who died. The majority (77%) of the patients experienced secondary infections in this epidemic.

• Autores: Díaz Castrillón, Francisco Javier; Loroño Pino, María A.; Farfán Ale, José A.; Zapata Peraza, Alicia L.; Rosado Paredes, Elsy P.; Flores Flores, Luis F.; García Rejón, Julián E.; Blitvich, Bradley J.; Andrade Narváez, Manuel; Jiménez Ríos, Eusebio; Blair, Carol D.; Olson, Ken E.; Black IV, William; Beaty, Barry J.
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2004
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/32043
• Acceso en línea: https://hdl.handle.net/10495/32043
• Palabra clave: Distribución por Edad; Age Distribution; Anticuerpos Antivirales; Antibodies, Viral; Dengue; Virus del Dengue; Dengue Virus; Brotes de Enfermedades; Disease Outbreaks; Genotipo; Genotype; Dengue Grave; Severe Dengue
• Rights: openAccess
• License: http://creativecommons.org/licenses/by/2.5/co/