Manufacturing and evaluation of Chitosan, PVA and Aloe Vera hydrogels for skin applications

ABSTRACT: The aim of this research was to develop membranes of polyvinyl alcohol (PVA) and chitosan (CH), capable of absorbing an Aloe Vera solution and gradually releasing to accelerate wound healing. The methodology involved varying the membrane’s composition using Chitosan and Polyvinyl Alcohol a...

Full description

Autores:
Escobar Sierra, Diana Marcela
Perea Mesa, Yuli Paola
Tipo de recurso:
Article of investigation
Fecha de publicación:
2017
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/25017
Acceso en línea:
http://hdl.handle.net/10495/25017
Palabra clave:
Hidrogeles
Hydrogels
Alcohol Polivinílico
Polyvinyl Alcohol
Aloe vera
Quitosano
Chitosan
Tracción
Traction
Absorción
Absorption
http://aims.fao.org/aos/agrovoc/c_24725
http://aims.fao.org/aos/agrovoc/c_28288
http://aims.fao.org/aos/agrovoc/c_199305af
http://aims.fao.org/aos/agrovoc/c_27
Rights
openAccess
License
http://creativecommons.org/licenses/by-nc-nd/2.5/co/
id UDEA2_f7a44db7a44d27174d394ba84cc94497
oai_identifier_str oai:bibliotecadigital.udea.edu.co:10495/25017
network_acronym_str UDEA2
network_name_str Repositorio UdeA
repository_id_str
dc.title.spa.fl_str_mv Manufacturing and evaluation of Chitosan, PVA and Aloe Vera hydrogels for skin applications
dc.title.alternative.spa.fl_str_mv Fabricación y evaluación de hidrogeles de Quitosano, PVA y Aloe Vera para aplicaciones cutáneas
title Manufacturing and evaluation of Chitosan, PVA and Aloe Vera hydrogels for skin applications
spellingShingle Manufacturing and evaluation of Chitosan, PVA and Aloe Vera hydrogels for skin applications
Hidrogeles
Hydrogels
Alcohol Polivinílico
Polyvinyl Alcohol
Aloe vera
Quitosano
Chitosan
Tracción
Traction
Absorción
Absorption
http://aims.fao.org/aos/agrovoc/c_24725
http://aims.fao.org/aos/agrovoc/c_28288
http://aims.fao.org/aos/agrovoc/c_199305af
http://aims.fao.org/aos/agrovoc/c_27
title_short Manufacturing and evaluation of Chitosan, PVA and Aloe Vera hydrogels for skin applications
title_full Manufacturing and evaluation of Chitosan, PVA and Aloe Vera hydrogels for skin applications
title_fullStr Manufacturing and evaluation of Chitosan, PVA and Aloe Vera hydrogels for skin applications
title_full_unstemmed Manufacturing and evaluation of Chitosan, PVA and Aloe Vera hydrogels for skin applications
title_sort Manufacturing and evaluation of Chitosan, PVA and Aloe Vera hydrogels for skin applications
dc.creator.fl_str_mv Escobar Sierra, Diana Marcela
Perea Mesa, Yuli Paola
dc.contributor.author.none.fl_str_mv Escobar Sierra, Diana Marcela
Perea Mesa, Yuli Paola
dc.subject.decs.none.fl_str_mv Hidrogeles
Hydrogels
Alcohol Polivinílico
Polyvinyl Alcohol
topic Hidrogeles
Hydrogels
Alcohol Polivinílico
Polyvinyl Alcohol
Aloe vera
Quitosano
Chitosan
Tracción
Traction
Absorción
Absorption
http://aims.fao.org/aos/agrovoc/c_24725
http://aims.fao.org/aos/agrovoc/c_28288
http://aims.fao.org/aos/agrovoc/c_199305af
http://aims.fao.org/aos/agrovoc/c_27
dc.subject.agrovoc.none.fl_str_mv Aloe vera
Quitosano
Chitosan
Tracción
Traction
Absorción
Absorption
dc.subject.agrovocuri.none.fl_str_mv http://aims.fao.org/aos/agrovoc/c_24725
http://aims.fao.org/aos/agrovoc/c_28288
http://aims.fao.org/aos/agrovoc/c_199305af
http://aims.fao.org/aos/agrovoc/c_27
description ABSTRACT: The aim of this research was to develop membranes of polyvinyl alcohol (PVA) and chitosan (CH), capable of absorbing an Aloe Vera solution and gradually releasing to accelerate wound healing. The methodology involved varying the membrane’s composition using Chitosan and Polyvinyl Alcohol at 5 and 10% w/v, and implementing different PVA/CH relations of 30/70, 50/50 and 70/30 (v/v) and embed them in a 2% (v/v) Aloe Vera solution to create hydrogels. Once hydrogels were obtained, they were characterized by Infrared Spectroscopy and Scanning Electronic Microscopy, and evaluated by mechanical and absorption tests as well as bactericide activity assays. The crosslinking degree between PVA/CH allowed obtaining a matrix with high absorption capacity and with gradual release of Aloe Vera, with mechanical properties and dimensional stability even after rehydration. Bactericide assays showed chitosan and Aloe Vera protective activity, which indicates this compound may be suitable for applications that help in wound healing.
publishDate 2017
dc.date.issued.none.fl_str_mv 2017
dc.date.accessioned.none.fl_str_mv 2021-12-13T21:38:37Z
dc.date.available.none.fl_str_mv 2021-12-13T21:38:37Z
dc.type.spa.fl_str_mv info:eu-repo/semantics/article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.hasversion.spa.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.type.local.spa.fl_str_mv Artículo de investigación
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dc.identifier.issn.none.fl_str_mv 0012-7353
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10495/25017
dc.identifier.doi.none.fl_str_mv 10.15446/dyna.v84n203.62742
dc.identifier.eissn.none.fl_str_mv 2346-2183
identifier_str_mv 0012-7353
10.15446/dyna.v84n203.62742
2346-2183
url http://hdl.handle.net/10495/25017
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Dyna
dc.rights.spa.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rights.accessrights.spa.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.creativecommons.spa.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/2.5/co/
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dc.format.extent.spa.fl_str_mv 9
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Universidad Nacional de Colombia, Facultad de Minas, Centro de Publicaciones
dc.publisher.group.spa.fl_str_mv Grupo de Investigación en Biomateriales
dc.publisher.place.spa.fl_str_mv Medellín, Colombia
institution Universidad de Antioquia
bitstream.url.fl_str_mv http://bibliotecadigital.udea.edu.co/bitstream/10495/25017/1/EscobarDiana_2017_ManufacturingEvaluation.pdf
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bitstream.checksumAlgorithm.fl_str_mv MD5
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repository.name.fl_str_mv Repositorio Institucional Universidad de Antioquia
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spelling Escobar Sierra, Diana MarcelaPerea Mesa, Yuli Paola2021-12-13T21:38:37Z2021-12-13T21:38:37Z20170012-7353http://hdl.handle.net/10495/2501710.15446/dyna.v84n203.627422346-2183ABSTRACT: The aim of this research was to develop membranes of polyvinyl alcohol (PVA) and chitosan (CH), capable of absorbing an Aloe Vera solution and gradually releasing to accelerate wound healing. The methodology involved varying the membrane’s composition using Chitosan and Polyvinyl Alcohol at 5 and 10% w/v, and implementing different PVA/CH relations of 30/70, 50/50 and 70/30 (v/v) and embed them in a 2% (v/v) Aloe Vera solution to create hydrogels. Once hydrogels were obtained, they were characterized by Infrared Spectroscopy and Scanning Electronic Microscopy, and evaluated by mechanical and absorption tests as well as bactericide activity assays. The crosslinking degree between PVA/CH allowed obtaining a matrix with high absorption capacity and with gradual release of Aloe Vera, with mechanical properties and dimensional stability even after rehydration. Bactericide assays showed chitosan and Aloe Vera protective activity, which indicates this compound may be suitable for applications that help in wound healing.RESUMEN: El objetivo fue desarrollar membranas de Polivinil Alcohol (PVA) y Quitosano (Qo), capaces de absorber solución de Aloe Vera y luego liberarla gradualmente para acelerar la cicatrización de la herida. La metodología empleada consistió en variar la composición de las membranas usando quitosano y Polivinil Alcohol al 5 y 10% p/v, e implementar diferentes relaciones de PVA/Qo de 30/70, 50/50 y 70/30 (v/v), para posteriormente embeberlas en solución de Aloe Vera al 2% (v/v) y formar hidrogeles. Una vez obtenidos, éstos fueron caracterizados por Espectroscopía de Infrarrojo y Microscopía Electrónica de Barrido, y evaluadas por pruebas mecánicas, pruebas de absorción, y ensayos de actividad bactericida. El grado de entrecruzamiento entre el PVA y el Quitosano permitió obtener una matriz con alta capacidad de absorción y liberación controlada de Aloe Vera, con propiedades mecánicas y estabilidad dimensional aún después de rehidratadas. Las pruebas bactericidas mostraron actividad protectora del quitosano y del Aloe Vera, lo cual hace que este compuesto sea adecuado para aplicaciones que ayudan en la curación de heridas.COL00550499application/pdfengUniversidad Nacional de Colombia, Facultad de Minas, Centro de PublicacionesGrupo de Investigación en BiomaterialesMedellín, Colombiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-nd/4.0/Manufacturing and evaluation of Chitosan, PVA and Aloe Vera hydrogels for skin applicationsFabricación y evaluación de hidrogeles de Quitosano, PVA y Aloe Vera para aplicaciones cutáneasHidrogelesHydrogelsAlcohol PolivinílicoPolyvinyl AlcoholAloe veraQuitosanoChitosanTracciónTractionAbsorciónAbsorptionhttp://aims.fao.org/aos/agrovoc/c_24725http://aims.fao.org/aos/agrovoc/c_28288http://aims.fao.org/aos/agrovoc/c_199305afhttp://aims.fao.org/aos/agrovoc/c_27DynaDyna13414284203ORIGINALEscobarDiana_2017_ManufacturingEvaluation.pdfEscobarDiana_2017_ManufacturingEvaluation.pdfArtículo de investigaciónapplication/pdf1314561http://bibliotecadigital.udea.edu.co/bitstream/10495/25017/1/EscobarDiana_2017_ManufacturingEvaluation.pdfd0190b918b4525340bd2fbfc4d654fedMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/25017/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8823http://bibliotecadigital.udea.edu.co/bitstream/10495/25017/2/license_rdfb88b088d9957e670ce3b3fbe2eedbc13MD5210495/25017oai:bibliotecadigital.udea.edu.co:10495/250172021-12-13 16:54:19.335Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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