Manufacturing and evaluation of Chitosan, PVA and Aloe Vera hydrogels for skin applications
ABSTRACT: The aim of this research was to develop membranes of polyvinyl alcohol (PVA) and chitosan (CH), capable of absorbing an Aloe Vera solution and gradually releasing to accelerate wound healing. The methodology involved varying the membrane’s composition using Chitosan and Polyvinyl Alcohol a...
- Autores:
-
Escobar Sierra, Diana Marcela
Perea Mesa, Yuli Paola
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2017
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/25017
- Acceso en línea:
- http://hdl.handle.net/10495/25017
- Palabra clave:
- Hidrogeles
Hydrogels
Alcohol Polivinílico
Polyvinyl Alcohol
Aloe vera
Quitosano
Chitosan
Tracción
Traction
Absorción
Absorption
http://aims.fao.org/aos/agrovoc/c_24725
http://aims.fao.org/aos/agrovoc/c_28288
http://aims.fao.org/aos/agrovoc/c_199305af
http://aims.fao.org/aos/agrovoc/c_27
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-nd/2.5/co/
id |
UDEA2_f7a44db7a44d27174d394ba84cc94497 |
---|---|
oai_identifier_str |
oai:bibliotecadigital.udea.edu.co:10495/25017 |
network_acronym_str |
UDEA2 |
network_name_str |
Repositorio UdeA |
repository_id_str |
|
dc.title.spa.fl_str_mv |
Manufacturing and evaluation of Chitosan, PVA and Aloe Vera hydrogels for skin applications |
dc.title.alternative.spa.fl_str_mv |
Fabricación y evaluación de hidrogeles de Quitosano, PVA y Aloe Vera para aplicaciones cutáneas |
title |
Manufacturing and evaluation of Chitosan, PVA and Aloe Vera hydrogels for skin applications |
spellingShingle |
Manufacturing and evaluation of Chitosan, PVA and Aloe Vera hydrogels for skin applications Hidrogeles Hydrogels Alcohol Polivinílico Polyvinyl Alcohol Aloe vera Quitosano Chitosan Tracción Traction Absorción Absorption http://aims.fao.org/aos/agrovoc/c_24725 http://aims.fao.org/aos/agrovoc/c_28288 http://aims.fao.org/aos/agrovoc/c_199305af http://aims.fao.org/aos/agrovoc/c_27 |
title_short |
Manufacturing and evaluation of Chitosan, PVA and Aloe Vera hydrogels for skin applications |
title_full |
Manufacturing and evaluation of Chitosan, PVA and Aloe Vera hydrogels for skin applications |
title_fullStr |
Manufacturing and evaluation of Chitosan, PVA and Aloe Vera hydrogels for skin applications |
title_full_unstemmed |
Manufacturing and evaluation of Chitosan, PVA and Aloe Vera hydrogels for skin applications |
title_sort |
Manufacturing and evaluation of Chitosan, PVA and Aloe Vera hydrogels for skin applications |
dc.creator.fl_str_mv |
Escobar Sierra, Diana Marcela Perea Mesa, Yuli Paola |
dc.contributor.author.none.fl_str_mv |
Escobar Sierra, Diana Marcela Perea Mesa, Yuli Paola |
dc.subject.decs.none.fl_str_mv |
Hidrogeles Hydrogels Alcohol Polivinílico Polyvinyl Alcohol |
topic |
Hidrogeles Hydrogels Alcohol Polivinílico Polyvinyl Alcohol Aloe vera Quitosano Chitosan Tracción Traction Absorción Absorption http://aims.fao.org/aos/agrovoc/c_24725 http://aims.fao.org/aos/agrovoc/c_28288 http://aims.fao.org/aos/agrovoc/c_199305af http://aims.fao.org/aos/agrovoc/c_27 |
dc.subject.agrovoc.none.fl_str_mv |
Aloe vera Quitosano Chitosan Tracción Traction Absorción Absorption |
dc.subject.agrovocuri.none.fl_str_mv |
http://aims.fao.org/aos/agrovoc/c_24725 http://aims.fao.org/aos/agrovoc/c_28288 http://aims.fao.org/aos/agrovoc/c_199305af http://aims.fao.org/aos/agrovoc/c_27 |
description |
ABSTRACT: The aim of this research was to develop membranes of polyvinyl alcohol (PVA) and chitosan (CH), capable of absorbing an Aloe Vera solution and gradually releasing to accelerate wound healing. The methodology involved varying the membrane’s composition using Chitosan and Polyvinyl Alcohol at 5 and 10% w/v, and implementing different PVA/CH relations of 30/70, 50/50 and 70/30 (v/v) and embed them in a 2% (v/v) Aloe Vera solution to create hydrogels. Once hydrogels were obtained, they were characterized by Infrared Spectroscopy and Scanning Electronic Microscopy, and evaluated by mechanical and absorption tests as well as bactericide activity assays. The crosslinking degree between PVA/CH allowed obtaining a matrix with high absorption capacity and with gradual release of Aloe Vera, with mechanical properties and dimensional stability even after rehydration. Bactericide assays showed chitosan and Aloe Vera protective activity, which indicates this compound may be suitable for applications that help in wound healing. |
publishDate |
2017 |
dc.date.issued.none.fl_str_mv |
2017 |
dc.date.accessioned.none.fl_str_mv |
2021-12-13T21:38:37Z |
dc.date.available.none.fl_str_mv |
2021-12-13T21:38:37Z |
dc.type.spa.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.hasversion.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.redcol.spa.fl_str_mv |
https://purl.org/redcol/resource_type/ART |
dc.type.local.spa.fl_str_mv |
Artículo de investigación |
format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
status_str |
publishedVersion |
dc.identifier.issn.none.fl_str_mv |
0012-7353 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/25017 |
dc.identifier.doi.none.fl_str_mv |
10.15446/dyna.v84n203.62742 |
dc.identifier.eissn.none.fl_str_mv |
2346-2183 |
identifier_str_mv |
0012-7353 10.15446/dyna.v84n203.62742 2346-2183 |
url |
http://hdl.handle.net/10495/25017 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Dyna |
dc.rights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/2.5/co/ |
dc.rights.accessrights.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.creativecommons.spa.fl_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-nd/2.5/co/ http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.format.extent.spa.fl_str_mv |
9 |
dc.format.mimetype.spa.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Universidad Nacional de Colombia, Facultad de Minas, Centro de Publicaciones |
dc.publisher.group.spa.fl_str_mv |
Grupo de Investigación en Biomateriales |
dc.publisher.place.spa.fl_str_mv |
Medellín, Colombia |
institution |
Universidad de Antioquia |
bitstream.url.fl_str_mv |
http://bibliotecadigital.udea.edu.co/bitstream/10495/25017/1/EscobarDiana_2017_ManufacturingEvaluation.pdf http://bibliotecadigital.udea.edu.co/bitstream/10495/25017/3/license.txt http://bibliotecadigital.udea.edu.co/bitstream/10495/25017/2/license_rdf |
bitstream.checksum.fl_str_mv |
d0190b918b4525340bd2fbfc4d654fed 8a4605be74aa9ea9d79846c1fba20a33 b88b088d9957e670ce3b3fbe2eedbc13 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositorio Institucional Universidad de Antioquia |
repository.mail.fl_str_mv |
andres.perez@udea.edu.co |
_version_ |
1812173191871725568 |
spelling |
Escobar Sierra, Diana MarcelaPerea Mesa, Yuli Paola2021-12-13T21:38:37Z2021-12-13T21:38:37Z20170012-7353http://hdl.handle.net/10495/2501710.15446/dyna.v84n203.627422346-2183ABSTRACT: The aim of this research was to develop membranes of polyvinyl alcohol (PVA) and chitosan (CH), capable of absorbing an Aloe Vera solution and gradually releasing to accelerate wound healing. The methodology involved varying the membrane’s composition using Chitosan and Polyvinyl Alcohol at 5 and 10% w/v, and implementing different PVA/CH relations of 30/70, 50/50 and 70/30 (v/v) and embed them in a 2% (v/v) Aloe Vera solution to create hydrogels. Once hydrogels were obtained, they were characterized by Infrared Spectroscopy and Scanning Electronic Microscopy, and evaluated by mechanical and absorption tests as well as bactericide activity assays. The crosslinking degree between PVA/CH allowed obtaining a matrix with high absorption capacity and with gradual release of Aloe Vera, with mechanical properties and dimensional stability even after rehydration. Bactericide assays showed chitosan and Aloe Vera protective activity, which indicates this compound may be suitable for applications that help in wound healing.RESUMEN: El objetivo fue desarrollar membranas de Polivinil Alcohol (PVA) y Quitosano (Qo), capaces de absorber solución de Aloe Vera y luego liberarla gradualmente para acelerar la cicatrización de la herida. La metodología empleada consistió en variar la composición de las membranas usando quitosano y Polivinil Alcohol al 5 y 10% p/v, e implementar diferentes relaciones de PVA/Qo de 30/70, 50/50 y 70/30 (v/v), para posteriormente embeberlas en solución de Aloe Vera al 2% (v/v) y formar hidrogeles. Una vez obtenidos, éstos fueron caracterizados por Espectroscopía de Infrarrojo y Microscopía Electrónica de Barrido, y evaluadas por pruebas mecánicas, pruebas de absorción, y ensayos de actividad bactericida. El grado de entrecruzamiento entre el PVA y el Quitosano permitió obtener una matriz con alta capacidad de absorción y liberación controlada de Aloe Vera, con propiedades mecánicas y estabilidad dimensional aún después de rehidratadas. Las pruebas bactericidas mostraron actividad protectora del quitosano y del Aloe Vera, lo cual hace que este compuesto sea adecuado para aplicaciones que ayudan en la curación de heridas.COL00550499application/pdfengUniversidad Nacional de Colombia, Facultad de Minas, Centro de PublicacionesGrupo de Investigación en BiomaterialesMedellín, Colombiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-nd/4.0/Manufacturing and evaluation of Chitosan, PVA and Aloe Vera hydrogels for skin applicationsFabricación y evaluación de hidrogeles de Quitosano, PVA y Aloe Vera para aplicaciones cutáneasHidrogelesHydrogelsAlcohol PolivinílicoPolyvinyl AlcoholAloe veraQuitosanoChitosanTracciónTractionAbsorciónAbsorptionhttp://aims.fao.org/aos/agrovoc/c_24725http://aims.fao.org/aos/agrovoc/c_28288http://aims.fao.org/aos/agrovoc/c_199305afhttp://aims.fao.org/aos/agrovoc/c_27DynaDyna13414284203ORIGINALEscobarDiana_2017_ManufacturingEvaluation.pdfEscobarDiana_2017_ManufacturingEvaluation.pdfArtículo de investigaciónapplication/pdf1314561http://bibliotecadigital.udea.edu.co/bitstream/10495/25017/1/EscobarDiana_2017_ManufacturingEvaluation.pdfd0190b918b4525340bd2fbfc4d654fedMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/25017/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8823http://bibliotecadigital.udea.edu.co/bitstream/10495/25017/2/license_rdfb88b088d9957e670ce3b3fbe2eedbc13MD5210495/25017oai:bibliotecadigital.udea.edu.co:10495/250172021-12-13 16:54:19.335Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |