Huberine, a New Canthin-6-One Alkaloid from the Bark of Picrolemma huberi

ABSTRACT: A new alkaloid, Canthin-6-one, Huberine (1), together with three known compounds including 1-Hydroxy-canthin-6-one (2), Canthin-6-one (3) and stigma sterol (4), were isolated from the stem bark of Picrolemma huberi. The isolation was achieved by chromatographic techniques and the purification was performed on a C18 column using acetonitrile/water (90:10, v/v) with 0.1% formic acid as the mobile phase. The structural elucidation was performed via spectroscopic methods, notably 1D- and 2D-NMR, UV, IR, MS and HRMS. The antiplasmodial activity of the compounds was studied.

• Autores: López Córdoba, Carlos Alberto; Pastrana Restrepo, Manuel Humberto; Ríos Orrego, Alexandra Marcela; Cogollo Pacheco, Álvaro Alfonso; Pabón Vidal, Adriana Lucía
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2018
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/23670
• Acceso en línea: http://hdl.handle.net/10495/23670
• Palabra clave: Simaroubaceae; Canthin-6-one; Picrolemma huberi; Antiplasmodial activity; http://aims.fao.org/aos/agrovoc/c_26241
• Rights: openAccess
• License: http://creativecommons.org/licenses/by/2.5/co/