Complex segregation analysis of nonsyndromic Cleft Lip/Palate in Antioquia, Colombia

ABSTRACT: The present study was undertaken to examine the pattern of inheritance of Ceft Lip/Palate (CLP) in pedigrees ascertained from Antioquia, Colombia. Ninety-five extended and multigenerational pedigrees, constituted by 201 nuclear components and 1.136 records were analyzed. Ten hypothetical models were contrasted using likelihood ratio tests. The hypotheses of no familial transmission, multifactorial component compared against that of the existence of a major gene only, the existence of a recessive major gene, that of non major component in the mixed model and that of the non transmission of major effect (t1 = 12 = (3) were rejected. In contrast. hypotheses postulating a major locus (dominant, codominant) and that of no polygenic component in the mixed model could not be rejected. Iteration of the parameter 12 was the most parsimonious. Thus far, the most parsimonious model is that of a major gene (dominant-codominant) without multifactorial effects but, taking into account, that the (2 iteration in the major gene model with unrestricted d. result in a significantly improving of the model likelihood, oligogenic interactions can not be underrated.

• Autores: Moreno Uribe, Lina María; Lidral, Andrew; Fonseca González, Idalyd; Arcos Burgos, Oscar Mauricio
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2001
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/20918
• Acceso en línea: http://hdl.handle.net/10495/20918; https://revistas.udea.edu.co/index.php/actbio/article/view/329618
• Palabra clave: Cleft Palate; Fisura del Paladar; Genética; Genetics; Anomalías de la Boca; Mouth Abnormalities; Labio; Lip; Grupos Étnicos; Ethnic Groups; Genética Humana; Human Genetics; Antioquia (Colombia); Malformaciones
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc-sa/2.5/co/