Categorizaion of the Main Descriptors of Different Ampicillin Crystal Habits

ABSTRACT: With the purpose of enabling the analysis by digital methods of particles of multisource pharmaceutical raw materials, this study analyzed different crystal habits of ampicillin particles, by grouping the external shapes obtained from 3 different solvents (acetonitrile, ethanol, and methan...

Full description

Autores:
Flórez Acosta, Óscar Albeiro
Tobón Zapata, Gloria Elena
Valencia Vásquez, Jaime
Tipo de recurso:
Article of investigation
Fecha de publicación:
2010
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/25226
Acceso en línea:
http://hdl.handle.net/10495/25226
Palabra clave:
Análisis Multivariante
Multivariate Analysis
Ampicilina
Ampicillin
Análisis de Fourier
Fourier Analysis
Rights
openAccess
License
http://creativecommons.org/licenses/by-nc-sa/2.5/co/
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repository_id_str
dc.title.spa.fl_str_mv Categorizaion of the Main Descriptors of Different Ampicillin Crystal Habits
title Categorizaion of the Main Descriptors of Different Ampicillin Crystal Habits
spellingShingle Categorizaion of the Main Descriptors of Different Ampicillin Crystal Habits
Análisis Multivariante
Multivariate Analysis
Ampicilina
Ampicillin
Análisis de Fourier
Fourier Analysis
title_short Categorizaion of the Main Descriptors of Different Ampicillin Crystal Habits
title_full Categorizaion of the Main Descriptors of Different Ampicillin Crystal Habits
title_fullStr Categorizaion of the Main Descriptors of Different Ampicillin Crystal Habits
title_full_unstemmed Categorizaion of the Main Descriptors of Different Ampicillin Crystal Habits
title_sort Categorizaion of the Main Descriptors of Different Ampicillin Crystal Habits
dc.creator.fl_str_mv Flórez Acosta, Óscar Albeiro
Tobón Zapata, Gloria Elena
Valencia Vásquez, Jaime
dc.contributor.author.none.fl_str_mv Flórez Acosta, Óscar Albeiro
Tobón Zapata, Gloria Elena
Valencia Vásquez, Jaime
dc.subject.decs.none.fl_str_mv Análisis Multivariante
Multivariate Analysis
Ampicilina
Ampicillin
Análisis de Fourier
Fourier Analysis
topic Análisis Multivariante
Multivariate Analysis
Ampicilina
Ampicillin
Análisis de Fourier
Fourier Analysis
description ABSTRACT: With the purpose of enabling the analysis by digital methods of particles of multisource pharmaceutical raw materials, this study analyzed different crystal habits of ampicillin particles, by grouping the external shapes obtained from 3 different solvents (acetonitrile, ethanol, and methanol), thereby reducing the number of descriptors necessary to adequately represent each shape. For this purpose, a selection of morphological descriptors was used including: circularity, roughness, roundness, compactness, aspect ratio, effective diameter, solidity, convexity, fractal dimension, and 10 Complex Fourier descriptors. These measures cover highly diverse morphological properties and define the crystal habit of a particle. Principal Component Analysis (PCA) and the Cluster Analysis (CA) were the grouping techniques used, which demonstrated the possibility of using between 2 and 4 descriptors instead of the 18 proposed initially.
publishDate 2010
dc.date.issued.none.fl_str_mv 2010
dc.date.accessioned.none.fl_str_mv 2022-01-12T16:45:01Z
dc.date.available.none.fl_str_mv 2022-01-12T16:45:01Z
dc.type.spa.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.spa.fl_str_mv Flórez-Acosta O, Tobón-Zapata G, Valencia-Velasquez J. Categorization of the main descriptors of different ampicillin crystal habits . Braz. J. Pharm. Sci. [Internet]. 2010Dec.1 [cited 2022Jan.12];46(4):679-85. Available from: https://www.revistas.usp.br/bjps/article/view/10824
dc.identifier.issn.none.fl_str_mv 1984-8250
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10495/25226
dc.identifier.doi.none.fl_str_mv 10.1590/S1984-82502010000400009
dc.identifier.eissn.none.fl_str_mv 2175-9790
identifier_str_mv Flórez-Acosta O, Tobón-Zapata G, Valencia-Velasquez J. Categorization of the main descriptors of different ampicillin crystal habits . Braz. J. Pharm. Sci. [Internet]. 2010Dec.1 [cited 2022Jan.12];46(4):679-85. Available from: https://www.revistas.usp.br/bjps/article/view/10824
1984-8250
10.1590/S1984-82502010000400009
2175-9790
url http://hdl.handle.net/10495/25226
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Braz. J. Pharm. Sci.
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dc.publisher.spa.fl_str_mv Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
dc.publisher.group.spa.fl_str_mv Diseño y Formulación de Medicamentos Cosméticos y Afines
Grupo de Manejo Eficiente de la Energía (GIMEL)
dc.publisher.place.spa.fl_str_mv Sao Paulo, Brasil
institution Universidad de Antioquia
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spelling Flórez Acosta, Óscar AlbeiroTobón Zapata, Gloria ElenaValencia Vásquez, Jaime2022-01-12T16:45:01Z2022-01-12T16:45:01Z2010Flórez-Acosta O, Tobón-Zapata G, Valencia-Velasquez J. Categorization of the main descriptors of different ampicillin crystal habits . Braz. J. Pharm. Sci. [Internet]. 2010Dec.1 [cited 2022Jan.12];46(4):679-85. Available from: https://www.revistas.usp.br/bjps/article/view/108241984-8250http://hdl.handle.net/10495/2522610.1590/S1984-825020100004000092175-9790ABSTRACT: With the purpose of enabling the analysis by digital methods of particles of multisource pharmaceutical raw materials, this study analyzed different crystal habits of ampicillin particles, by grouping the external shapes obtained from 3 different solvents (acetonitrile, ethanol, and methanol), thereby reducing the number of descriptors necessary to adequately represent each shape. For this purpose, a selection of morphological descriptors was used including: circularity, roughness, roundness, compactness, aspect ratio, effective diameter, solidity, convexity, fractal dimension, and 10 Complex Fourier descriptors. These measures cover highly diverse morphological properties and define the crystal habit of a particle. Principal Component Analysis (PCA) and the Cluster Analysis (CA) were the grouping techniques used, which demonstrated the possibility of using between 2 and 4 descriptors instead of the 18 proposed initially.COL0003623COL00104777application/pdfengUniversidade de São Paulo, Faculdade de Ciências FarmacêuticasDiseño y Formulación de Medicamentos Cosméticos y AfinesGrupo de Manejo Eficiente de la Energía (GIMEL)Sao Paulo, Brasilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-sa/4.0/Categorizaion of the Main Descriptors of Different Ampicillin Crystal HabitsAnálisis MultivarianteMultivariate AnalysisAmpicilinaAmpicillinAnálisis de FourierFourier AnalysisBraz. J. Pharm. Sci.Brazilian Journal of Pharmaceutical Sciences679685464ORIGINALFlórezÓscar_2010_CategorizationMainDescriptors.pdfFlórezÓscar_2010_CategorizationMainDescriptors.pdfArtículo de investigaciónapplication/pdf638010http://bibliotecadigital.udea.edu.co/bitstream/10495/25226/1/Fl%c3%b3rez%c3%93scar_2010_CategorizationMainDescriptors.pdf9b4f194ff5f9296f1aec053717022e72MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81051http://bibliotecadigital.udea.edu.co/bitstream/10495/25226/2/license_rdfe2060682c9c70d4d30c83c51448f4eedMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/25226/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5310495/25226oai:bibliotecadigital.udea.edu.co:10495/252262022-01-12 11:45:01.957Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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