Categorizaion of the Main Descriptors of Different Ampicillin Crystal Habits
ABSTRACT: With the purpose of enabling the analysis by digital methods of particles of multisource pharmaceutical raw materials, this study analyzed different crystal habits of ampicillin particles, by grouping the external shapes obtained from 3 different solvents (acetonitrile, ethanol, and methan...
- Autores:
-
Flórez Acosta, Óscar Albeiro
Tobón Zapata, Gloria Elena
Valencia Vásquez, Jaime
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2010
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/25226
- Acceso en línea:
- http://hdl.handle.net/10495/25226
- Palabra clave:
- Análisis Multivariante
Multivariate Analysis
Ampicilina
Ampicillin
Análisis de Fourier
Fourier Analysis
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-sa/2.5/co/
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dc.title.spa.fl_str_mv |
Categorizaion of the Main Descriptors of Different Ampicillin Crystal Habits |
title |
Categorizaion of the Main Descriptors of Different Ampicillin Crystal Habits |
spellingShingle |
Categorizaion of the Main Descriptors of Different Ampicillin Crystal Habits Análisis Multivariante Multivariate Analysis Ampicilina Ampicillin Análisis de Fourier Fourier Analysis |
title_short |
Categorizaion of the Main Descriptors of Different Ampicillin Crystal Habits |
title_full |
Categorizaion of the Main Descriptors of Different Ampicillin Crystal Habits |
title_fullStr |
Categorizaion of the Main Descriptors of Different Ampicillin Crystal Habits |
title_full_unstemmed |
Categorizaion of the Main Descriptors of Different Ampicillin Crystal Habits |
title_sort |
Categorizaion of the Main Descriptors of Different Ampicillin Crystal Habits |
dc.creator.fl_str_mv |
Flórez Acosta, Óscar Albeiro Tobón Zapata, Gloria Elena Valencia Vásquez, Jaime |
dc.contributor.author.none.fl_str_mv |
Flórez Acosta, Óscar Albeiro Tobón Zapata, Gloria Elena Valencia Vásquez, Jaime |
dc.subject.decs.none.fl_str_mv |
Análisis Multivariante Multivariate Analysis Ampicilina Ampicillin Análisis de Fourier Fourier Analysis |
topic |
Análisis Multivariante Multivariate Analysis Ampicilina Ampicillin Análisis de Fourier Fourier Analysis |
description |
ABSTRACT: With the purpose of enabling the analysis by digital methods of particles of multisource pharmaceutical raw materials, this study analyzed different crystal habits of ampicillin particles, by grouping the external shapes obtained from 3 different solvents (acetonitrile, ethanol, and methanol), thereby reducing the number of descriptors necessary to adequately represent each shape. For this purpose, a selection of morphological descriptors was used including: circularity, roughness, roundness, compactness, aspect ratio, effective diameter, solidity, convexity, fractal dimension, and 10 Complex Fourier descriptors. These measures cover highly diverse morphological properties and define the crystal habit of a particle. Principal Component Analysis (PCA) and the Cluster Analysis (CA) were the grouping techniques used, which demonstrated the possibility of using between 2 and 4 descriptors instead of the 18 proposed initially. |
publishDate |
2010 |
dc.date.issued.none.fl_str_mv |
2010 |
dc.date.accessioned.none.fl_str_mv |
2022-01-12T16:45:01Z |
dc.date.available.none.fl_str_mv |
2022-01-12T16:45:01Z |
dc.type.spa.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.hasversion.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.redcol.spa.fl_str_mv |
https://purl.org/redcol/resource_type/ART |
dc.type.local.spa.fl_str_mv |
Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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publishedVersion |
dc.identifier.citation.spa.fl_str_mv |
Flórez-Acosta O, Tobón-Zapata G, Valencia-Velasquez J. Categorization of the main descriptors of different ampicillin crystal habits . Braz. J. Pharm. Sci. [Internet]. 2010Dec.1 [cited 2022Jan.12];46(4):679-85. Available from: https://www.revistas.usp.br/bjps/article/view/10824 |
dc.identifier.issn.none.fl_str_mv |
1984-8250 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/25226 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S1984-82502010000400009 |
dc.identifier.eissn.none.fl_str_mv |
2175-9790 |
identifier_str_mv |
Flórez-Acosta O, Tobón-Zapata G, Valencia-Velasquez J. Categorization of the main descriptors of different ampicillin crystal habits . Braz. J. Pharm. Sci. [Internet]. 2010Dec.1 [cited 2022Jan.12];46(4):679-85. Available from: https://www.revistas.usp.br/bjps/article/view/10824 1984-8250 10.1590/S1984-82502010000400009 2175-9790 |
url |
http://hdl.handle.net/10495/25226 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Braz. J. Pharm. Sci. |
dc.rights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc-sa/2.5/co/ |
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http://purl.org/coar/access_right/c_abf2 |
dc.rights.creativecommons.spa.fl_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-sa/2.5/co/ http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-sa/4.0/ |
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7 |
dc.format.mimetype.spa.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas |
dc.publisher.group.spa.fl_str_mv |
Diseño y Formulación de Medicamentos Cosméticos y Afines Grupo de Manejo Eficiente de la Energía (GIMEL) |
dc.publisher.place.spa.fl_str_mv |
Sao Paulo, Brasil |
institution |
Universidad de Antioquia |
bitstream.url.fl_str_mv |
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Repositorio Institucional Universidad de Antioquia |
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1812173199496970240 |
spelling |
Flórez Acosta, Óscar AlbeiroTobón Zapata, Gloria ElenaValencia Vásquez, Jaime2022-01-12T16:45:01Z2022-01-12T16:45:01Z2010Flórez-Acosta O, Tobón-Zapata G, Valencia-Velasquez J. Categorization of the main descriptors of different ampicillin crystal habits . Braz. J. Pharm. Sci. [Internet]. 2010Dec.1 [cited 2022Jan.12];46(4):679-85. Available from: https://www.revistas.usp.br/bjps/article/view/108241984-8250http://hdl.handle.net/10495/2522610.1590/S1984-825020100004000092175-9790ABSTRACT: With the purpose of enabling the analysis by digital methods of particles of multisource pharmaceutical raw materials, this study analyzed different crystal habits of ampicillin particles, by grouping the external shapes obtained from 3 different solvents (acetonitrile, ethanol, and methanol), thereby reducing the number of descriptors necessary to adequately represent each shape. For this purpose, a selection of morphological descriptors was used including: circularity, roughness, roundness, compactness, aspect ratio, effective diameter, solidity, convexity, fractal dimension, and 10 Complex Fourier descriptors. These measures cover highly diverse morphological properties and define the crystal habit of a particle. Principal Component Analysis (PCA) and the Cluster Analysis (CA) were the grouping techniques used, which demonstrated the possibility of using between 2 and 4 descriptors instead of the 18 proposed initially.COL0003623COL00104777application/pdfengUniversidade de São Paulo, Faculdade de Ciências FarmacêuticasDiseño y Formulación de Medicamentos Cosméticos y AfinesGrupo de Manejo Eficiente de la Energía (GIMEL)Sao Paulo, Brasilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-sa/4.0/Categorizaion of the Main Descriptors of Different Ampicillin Crystal HabitsAnálisis MultivarianteMultivariate AnalysisAmpicilinaAmpicillinAnálisis de FourierFourier AnalysisBraz. J. Pharm. Sci.Brazilian Journal of Pharmaceutical Sciences679685464ORIGINALFlórezÓscar_2010_CategorizationMainDescriptors.pdfFlórezÓscar_2010_CategorizationMainDescriptors.pdfArtículo de investigaciónapplication/pdf638010http://bibliotecadigital.udea.edu.co/bitstream/10495/25226/1/Fl%c3%b3rez%c3%93scar_2010_CategorizationMainDescriptors.pdf9b4f194ff5f9296f1aec053717022e72MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81051http://bibliotecadigital.udea.edu.co/bitstream/10495/25226/2/license_rdfe2060682c9c70d4d30c83c51448f4eedMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/25226/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5310495/25226oai:bibliotecadigital.udea.edu.co:10495/252262022-01-12 11:45:01.957Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |