Creatine Phosphokinase and Urea as Biochemical Markers of Muscle Injuries in Professional Football Players

ABSTRACT: Background: Although biochemical markers have been used to monitor training loads (TL), it is unknown if they can be used to predict muscle injuries (MI) in professional football (soccer) players (PFP). Objectives: To evaluate the relationship between the incidence of MI, serum concentrati...

Full description

Autores:
Osorio Muñoz, Juan José
Méndez, Edgar
Aguirre Acevedo, Daniel Camilo
Osorio Ciro, Jorge Alberto
Calderón Vélez, Juan Camilo
Gallo Villegas, Jaime Alberto
Tipo de recurso:
Article of investigation
Fecha de publicación:
2018
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/31166
Acceso en línea:
https://hdl.handle.net/10495/31166
Palabra clave:
Creatina Quinasa
Creatine Kinase
Urea
Traumatismos en Atletas
Athletic Injuries
Fútbol
Soccer
Biomarcadores
Biomarkers
Rights
openAccess
License
http://creativecommons.org/licenses/by-nc/2.5/co/
id UDEA2_e66b9ceca7551677438a58884b5ba5e6
oai_identifier_str oai:bibliotecadigital.udea.edu.co:10495/31166
network_acronym_str UDEA2
network_name_str Repositorio UdeA
repository_id_str
dc.title.spa.fl_str_mv Creatine Phosphokinase and Urea as Biochemical Markers of Muscle Injuries in Professional Football Players
title Creatine Phosphokinase and Urea as Biochemical Markers of Muscle Injuries in Professional Football Players
spellingShingle Creatine Phosphokinase and Urea as Biochemical Markers of Muscle Injuries in Professional Football Players
Creatina Quinasa
Creatine Kinase
Urea
Traumatismos en Atletas
Athletic Injuries
Fútbol
Soccer
Biomarcadores
Biomarkers
title_short Creatine Phosphokinase and Urea as Biochemical Markers of Muscle Injuries in Professional Football Players
title_full Creatine Phosphokinase and Urea as Biochemical Markers of Muscle Injuries in Professional Football Players
title_fullStr Creatine Phosphokinase and Urea as Biochemical Markers of Muscle Injuries in Professional Football Players
title_full_unstemmed Creatine Phosphokinase and Urea as Biochemical Markers of Muscle Injuries in Professional Football Players
title_sort Creatine Phosphokinase and Urea as Biochemical Markers of Muscle Injuries in Professional Football Players
dc.creator.fl_str_mv Osorio Muñoz, Juan José
Méndez, Edgar
Aguirre Acevedo, Daniel Camilo
Osorio Ciro, Jorge Alberto
Calderón Vélez, Juan Camilo
Gallo Villegas, Jaime Alberto
dc.contributor.author.none.fl_str_mv Osorio Muñoz, Juan José
Méndez, Edgar
Aguirre Acevedo, Daniel Camilo
Osorio Ciro, Jorge Alberto
Calderón Vélez, Juan Camilo
Gallo Villegas, Jaime Alberto
dc.subject.decs.none.fl_str_mv Creatina Quinasa
Creatine Kinase
Urea
Traumatismos en Atletas
Athletic Injuries
Fútbol
Soccer
Biomarcadores
Biomarkers
topic Creatina Quinasa
Creatine Kinase
Urea
Traumatismos en Atletas
Athletic Injuries
Fútbol
Soccer
Biomarcadores
Biomarkers
description ABSTRACT: Background: Although biochemical markers have been used to monitor training loads (TL), it is unknown if they can be used to predict muscle injuries (MI) in professional football (soccer) players (PFP). Objectives: To evaluate the relationship between the incidence of MI, serum concentration of creatine phosphokinase (CPK) and urea, as well as TL in PFP. Methods: Twenty-three PFP from a Colombian first-division team were enrolled in a retrospective cohort study. CPK, urea, TL and new MI were measured during 19 weeks. CPK and urea serum levels within 4 weeks before a diagnosed MI were compared to those measured preseason. CPK and urea relationship with TL were analyzed using a mixed-effects model. Results: The subjects had an age of 25.3±4.2 years. Nine subjects presented with MI during follow-up, 66.6% of which were localized to hamstrings. Serum CPK and urea profiles were constructed for each player along the season. Injured players had a significant elevation of these markers within 4 weeks before the injury was clinically evident when compared to their own preseason values. Expected individual increases in CPK and urea according to TL during the season were estimated. Conclusions: Since CPK and urea values rose several weeks before the MI became overt, constructing CPK and urea profiles for each player during the whole preseason and season may help identify peaks in their concentration as arly markers of MI. A tight biochemical control of training may become a preventive strategy for MI, but the use of published reference values is discouraged.
publishDate 2018
dc.date.issued.none.fl_str_mv 2018
dc.date.accessioned.none.fl_str_mv 2022-10-09T13:09:04Z
dc.date.available.none.fl_str_mv 2022-10-09T13:09:04Z
dc.type.spa.fl_str_mv info:eu-repo/semantics/article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.hasversion.spa.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.type.redcol.spa.fl_str_mv https://purl.org/redcol/resource_type/ART
dc.type.local.spa.fl_str_mv Artículo de investigación
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status_str publishedVersion
dc.identifier.citation.spa.fl_str_mv J Osorio J, A Méndez E, Aguirre-Acevedo D , Osorio-Ciro J, C Calderón J, et al. Creatine Phosphokinase and Urea as Biochemical Markers of Muscle Injuries in Professional Football Players. Asian J Sports Med. 2018;9(4):e60386. doi: 10.5812/asjsm.60386.
dc.identifier.issn.none.fl_str_mv 2008-000X
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10495/31166
dc.identifier.doi.none.fl_str_mv 10.5812/asjsm.60386
dc.identifier.eissn.none.fl_str_mv 2008-7209
identifier_str_mv J Osorio J, A Méndez E, Aguirre-Acevedo D , Osorio-Ciro J, C Calderón J, et al. Creatine Phosphokinase and Urea as Biochemical Markers of Muscle Injuries in Professional Football Players. Asian J Sports Med. 2018;9(4):e60386. doi: 10.5812/asjsm.60386.
2008-000X
10.5812/asjsm.60386
2008-7209
url https://hdl.handle.net/10495/31166
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Asian J. Sports Med.
dc.rights.spa.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by-nc/2.5/co/
dc.rights.accessrights.spa.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.creativecommons.spa.fl_str_mv https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/2.5/co/
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
dc.format.extent.spa.fl_str_mv 10
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Tehran University of Medical Sciences Press
dc.publisher.group.spa.fl_str_mv Grupo Académico de Epidemiología Clínica
Grupo de Investigación en Fisiología y Bioquímica - Physis
Grupo de Investigación en Medicina Aplicada a la Actividad Física y el Deporte (GRINMADE)
dc.publisher.place.spa.fl_str_mv Teherán, Irán
institution Universidad de Antioquia
bitstream.url.fl_str_mv https://bibliotecadigital.udea.edu.co/bitstream/10495/31166/1/OsorioJuan_2018_CreatinePhosphokinaseUrea.pdf
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MD5
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repository.name.fl_str_mv Repositorio Institucional Universidad de Antioquia
repository.mail.fl_str_mv andres.perez@udea.edu.co
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spelling Osorio Muñoz, Juan JoséMéndez, EdgarAguirre Acevedo, Daniel CamiloOsorio Ciro, Jorge AlbertoCalderón Vélez, Juan CamiloGallo Villegas, Jaime Alberto2022-10-09T13:09:04Z2022-10-09T13:09:04Z2018J Osorio J, A Méndez E, Aguirre-Acevedo D , Osorio-Ciro J, C Calderón J, et al. Creatine Phosphokinase and Urea as Biochemical Markers of Muscle Injuries in Professional Football Players. Asian J Sports Med. 2018;9(4):e60386. doi: 10.5812/asjsm.60386.2008-000Xhttps://hdl.handle.net/10495/3116610.5812/asjsm.603862008-7209ABSTRACT: Background: Although biochemical markers have been used to monitor training loads (TL), it is unknown if they can be used to predict muscle injuries (MI) in professional football (soccer) players (PFP). Objectives: To evaluate the relationship between the incidence of MI, serum concentration of creatine phosphokinase (CPK) and urea, as well as TL in PFP. Methods: Twenty-three PFP from a Colombian first-division team were enrolled in a retrospective cohort study. CPK, urea, TL and new MI were measured during 19 weeks. CPK and urea serum levels within 4 weeks before a diagnosed MI were compared to those measured preseason. CPK and urea relationship with TL were analyzed using a mixed-effects model. Results: The subjects had an age of 25.3±4.2 years. Nine subjects presented with MI during follow-up, 66.6% of which were localized to hamstrings. Serum CPK and urea profiles were constructed for each player along the season. Injured players had a significant elevation of these markers within 4 weeks before the injury was clinically evident when compared to their own preseason values. Expected individual increases in CPK and urea according to TL during the season were estimated. Conclusions: Since CPK and urea values rose several weeks before the MI became overt, constructing CPK and urea profiles for each player during the whole preseason and season may help identify peaks in their concentration as arly markers of MI. A tight biochemical control of training may become a preventive strategy for MI, but the use of published reference values is discouraged.COL0007328COL0070223COL000712110application/pdfengTehran University of Medical Sciences PressGrupo Académico de Epidemiología ClínicaGrupo de Investigación en Fisiología y Bioquímica - PhysisGrupo de Investigación en Medicina Aplicada a la Actividad Física y el Deporte (GRINMADE)Teherán, Iráninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc/4.0/Creatine Phosphokinase and Urea as Biochemical Markers of Muscle Injuries in Professional Football PlayersCreatina QuinasaCreatine KinaseUreaTraumatismos en AtletasAthletic InjuriesFútbolSoccerBiomarcadoresBiomarkersAsian J. Sports Med.Asian Journal of Sports Medicine1109ORIGINALOsorioJuan_2018_CreatinePhosphokinaseUrea.pdfOsorioJuan_2018_CreatinePhosphokinaseUrea.pdfArtículo de investigaciónapplication/pdf391747https://bibliotecadigital.udea.edu.co/bitstream/10495/31166/1/OsorioJuan_2018_CreatinePhosphokinaseUrea.pdf8072ada640d606debb0f16fb85373681MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8933https://bibliotecadigital.udea.edu.co/bitstream/10495/31166/2/license_rdfc0c92b0ffc8b7d22d9cf56754a416a76MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstream/10495/31166/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5310495/31166oai:bibliotecadigital.udea.edu.co:10495/311662022-10-09 08:09:05.188Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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