Inflammatory response in Colombian children with severe protein-energymalnutrition before and after nutritional intervention.

ABSTRACT: Aim: To evaluate the changes in C-reactive protein and pro-inflammatory cytokines in severely malnourished children, before nutritional intervention and at the moment of restoring appetite. Methodology: To assess changes in inflammatory mediators, 20 severely malnourished children under 5 years of age, 10 with kwashiorkor and 10 with marasmus were studied. Hemoglobin, total serum proteins, albumin, ferritin, transferrin, ceruloplasmin, C-reactive protein and pro-inflammatory cytokines (IL-8, IL-1β, IL6, IL-10, TNF-α, and IL-12p70) were determined. Results: Upon hospital admission, the mean values of C-reactive protein in kwashiorkor and marasmus patients (16.3±19.0mg/L and 23.1±27.9 mg/l, respectively) indicated an inflammatory response process with no difference between both groups (p=1.0). Total protein, albumin, transferrin and ceruloplasmin in children with kwashiorkor were significantly lower than in marasmic children (p=0.003, p=0.007, p=0.035, p=0.007, respectively). All cytokines, except IL-12p70, showed significantly higher concentrations in kwashiorkor than in marasmic children. After the stabilization phase, concentrations of C-reactive protein decreased significantly in both groups and albumin increased to normal values, but cytokines remained high. Conclusion: These results show that malnourished children are able to synthesize C-reactive protein in response to an infectious process. Additionally, higher levels of pro-inflammatory cytokines and depletion of albumin in children with kwashiorkor suggest that these inflammatory mediators could be critical biomarkers during clinical phases of kwashiorkor.

• Autores: Velásquez Rodríguez, Claudia María; Navarro Benítez, Carolina; Muñoz Cadavid, César Orlando; González Marín, Ángel Augusto
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2010
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/21394
• Acceso en línea: http://hdl.handle.net/10495/21394; https://colombiamedica.univalle.edu.co/index.php/comedica/article/view/693
• Palabra clave: C-Reactive Protein; Proteína C-Reactiva; malnutrition; Malnutrición; marasmus; Marasmo; kwashiorkor; Kwashiorkor; cytokines; Citoquinas; http://aims.fao.org/aos/agrovoc/c_4543; http://aims.fao.org/aos/agrovoc/c_34049; http://aims.fao.org/aos/agrovoc/c_34303; http://aims.fao.org/aos/agrovoc/c_35078
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc-nd/2.5/co/