Regulación de la expresión y liberación de la hormona liberadora de gonadotropinas (GnRH): Los glucocorticoides como inhibidores de la reproducción. Revisión

ABSTRACT: Gonadotropin releasing hormone (GnRH) plays a key role in regulation of the reproductive competence in vertebrates. This decapeptide produced by a few cells in the anterior and medial hypothalamus is released in a pulsatile manner onto the pituitary, where it induces the secretion of gonadotropins: follicle stimulating hormone (FSH) and luteinizing hormone (LH). Stress negatively affects reproductive competence in animals. However, the level of this inhibition and its molecular mechanisms are not completely understood. Recent evidence that glucocorticoids inhibit GnRH gene expression suggest that it could be one of the forms by which high glucocorticoid concentrations affect reproduction. This review presents the current knowledge about GnRH and its molecular structure, the ontogenesis and distribution of the cells that produce this hormone, new tools that facilitate the study of gene expression, synthesis and release of GnRH. The mechanisms of action of glucocorticoids are discussed as well as their negative regulation on the expression and release of GnRH and consequently on reproduction.

• Autores: Rodríguez Osorio, Nélida
• Tipo de recurso: Review article
• Fecha de publicación: 2000
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: spa
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/7256
• Acceso en línea: http://hdl.handle.net/10495/7256
• Palabra clave: Estrés en animales; Reproducción animal; Gonadotropinas; Glucocorticoides; Gonadorelina
• Rights: openAccess
• License: Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)