Estudio anatomopatológico de válvulas aórticas porcinas para la elaboración de bioprótesis cardíacas

ABSTRACT: Research on swine valvular pathology around the world is restricted almost entirely to the mitral valve and there is very little information about the alterations of the aortic valve. Aaortic swine valves are commonly used as bioimplants for humans. For this reason in this study we decided to pursue the following aims: to characterize alterations of the aortic valve in pigs selected for the elaboration of hearth valvular bioprothesis, to discuss the mechanisms involved in the development of these lesions and to analyze the selection criteria to ensure the safety of the implants. Fifty hearts random with evident lesions, and 50 without evident lesions, of the aortic valve were randomly collected. The valves were processed by the histopathologic routine method and stained with Hematoxylin and eosin and blue alciano-PAS. The results were evaluated by descriptive statistic and statistical inference, and Chi-square test using the program SPSS version 1.0 was also run to determine possible associations among the macroscopic and microscopic variables. The microscopic lesions and their frequency for each one of the two groups studied were, respectively, as fallows: vascular dysfunctions 84% and 38%, endocardiosis 80% and 4%, fenestrations 48% only in obviously altered hearts, and valvulitis 42% and 24%. Macro and microscopic lesions are described and correlated and the possible mechanisms involved are discussed. This is the first study dwelling with alterations of aortic swine valves, in Colombia.

• Autores: Aranzazu Taborda, Diego Alfonso; Bustamante Osorno, John; Rodríguez, Berardo de Jesús; Giraldo Mejía, Gloria Eugenia; Riaño Benavides, Carlos Humberto; Garzon Alzate, Anderson Orlando; Aguilar R., Juan Guillermo; Posada Arias, Silvia
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2006
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: spa
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/7370
• Acceso en línea: http://hdl.handle.net/10495/7370
• Palabra clave: Válvulas aórticas; Endocardiosis; Endocarditis; Fenestraciones; Bioprótesis
• Rights: openAccess
• License: Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)