New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities
ABSTARCT: Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Continuing with our efforts to identify new compounds active against malaria and leishmaniasis, twelve new 1,4-di-N-oxide quinoxaline derivatives were synthesized and evaluated for their in vitro a...
- Autores:
-
Barea, Carlos
Pabón Vidal, Adriana Lucía
Pérez Silanes, Silvia
Galiano, Silvia
González, Germán
Monge, Antonio
Deharo, Eric
Aldana Moraza, Ignacio
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2013
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/7889
- Acceso en línea:
- http://hdl.handle.net/10495/7889
- Palabra clave:
- Antiplasmodial
Leishmanicidal
Quinoxaline
- Rights
- openAccess
- License
- Atribución 2.5
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| dc.title.spa.fl_str_mv |
New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities |
| title |
New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities |
| spellingShingle |
New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities Antiplasmodial Leishmanicidal Quinoxaline |
| title_short |
New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities |
| title_full |
New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities |
| title_fullStr |
New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities |
| title_full_unstemmed |
New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities |
| title_sort |
New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities |
| dc.creator.fl_str_mv |
Barea, Carlos Pabón Vidal, Adriana Lucía Pérez Silanes, Silvia Galiano, Silvia González, Germán Monge, Antonio Deharo, Eric Aldana Moraza, Ignacio |
| dc.contributor.author.none.fl_str_mv |
Barea, Carlos Pabón Vidal, Adriana Lucía Pérez Silanes, Silvia Galiano, Silvia González, Germán Monge, Antonio Deharo, Eric Aldana Moraza, Ignacio |
| dc.subject.none.fl_str_mv |
Antiplasmodial Leishmanicidal Quinoxaline |
| topic |
Antiplasmodial Leishmanicidal Quinoxaline |
| description |
ABSTARCT: Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Continuing with our efforts to identify new compounds active against malaria and leishmaniasis, twelve new 1,4-di-N-oxide quinoxaline derivatives were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against Plasmodium falciparum FCR-3 strain, Leishmania infantum and Leishmania amazonensis. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. The results obtained indicate that a cyclopentyl derivative had the best antiplasmodial activity (2.9 µM), while a cyclohexyl derivative (2.5 µM) showed the best activity against L. amazonensis, and a 3-chloropropyl derivative (0.7 µM) showed the best results against L. infantum. All these compounds also have a Cl substituent in the R7 position |
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2013 |
| dc.date.issued.none.fl_str_mv |
2013 |
| dc.date.accessioned.none.fl_str_mv |
2017-08-09T14:22:30Z |
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2017-08-09T14:22:30Z |
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info:eu-repo/semantics/article |
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Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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Barea, C., Pabón, A., Pérez-Silanes, S., Galiano, S., Gonzalez, G., Monge, A., ... & Aldana, I. (2013). New amide derivatives of quinoxaline 1, 4-di-N-oxide with leishmanicidal and antiplasmodial activities. Molecules, 18(4), 4718-4727. DOI:10.3390/molecules18044718 |
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1420-3049 |
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http://hdl.handle.net/10495/7889 |
| dc.identifier.doi.none.fl_str_mv |
10.3390/molecules18044718 |
| identifier_str_mv |
Barea, C., Pabón, A., Pérez-Silanes, S., Galiano, S., Gonzalez, G., Monge, A., ... & Aldana, I. (2013). New amide derivatives of quinoxaline 1, 4-di-N-oxide with leishmanicidal and antiplasmodial activities. Molecules, 18(4), 4718-4727. DOI:10.3390/molecules18044718 1420-3049 10.3390/molecules18044718 |
| url |
http://hdl.handle.net/10495/7889 |
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eng |
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eng |
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Molecules |
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Atribución 2.5 |
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info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by/2.5/co/ |
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Grupo Malaria |
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Suiza |
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Universidad de Antioquia |
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Barea, CarlosPabón Vidal, Adriana LucíaPérez Silanes, SilviaGaliano, SilviaGonzález, GermánMonge, AntonioDeharo, EricAldana Moraza, Ignacio2017-08-09T14:22:30Z2017-08-09T14:22:30Z2013Barea, C., Pabón, A., Pérez-Silanes, S., Galiano, S., Gonzalez, G., Monge, A., ... & Aldana, I. (2013). New amide derivatives of quinoxaline 1, 4-di-N-oxide with leishmanicidal and antiplasmodial activities. Molecules, 18(4), 4718-4727. DOI:10.3390/molecules180447181420-3049http://hdl.handle.net/10495/788910.3390/molecules18044718ABSTARCT: Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Continuing with our efforts to identify new compounds active against malaria and leishmaniasis, twelve new 1,4-di-N-oxide quinoxaline derivatives were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against Plasmodium falciparum FCR-3 strain, Leishmania infantum and Leishmania amazonensis. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. The results obtained indicate that a cyclopentyl derivative had the best antiplasmodial activity (2.9 µM), while a cyclohexyl derivative (2.5 µM) showed the best activity against L. amazonensis, and a 3-chloropropyl derivative (0.7 µM) showed the best results against L. infantum. All these compounds also have a Cl substituent in the R7 position9application/pdfengBoardGrupo MalariaSuizainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85Atribución 2.5info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by/4.0/AntiplasmodialLeishmanicidalQuinoxalineNew amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activitiesMoleculesMolecules1827184ORIGINALBareaCarlos_2013_NewAmideDerivatives.pdfBareaCarlos_2013_NewAmideDerivatives.pdfArtículo de Revistaapplication/pdf197028http://bibliotecadigital.udea.edu.co/bitstream/10495/7889/1/BareaCarlos_2013_NewAmideDerivatives.pdf03d4c85b6c2d167f09bb57025fc9437dMD51CC-LICENSElicense_urllicense_urltext/plain; charset=utf-849http://bibliotecadigital.udea.edu.co/bitstream/10495/7889/2/license_url4afdbb8c545fd630ea7db775da747b2fMD52license_textlicense_texttext/html; charset=utf-80http://bibliotecadigital.udea.edu.co/bitstream/10495/7889/3/license_textd41d8cd98f00b204e9800998ecf8427eMD53license_rdflicense_rdfapplication/rdf+xml; charset=utf-80http://bibliotecadigital.udea.edu.co/bitstream/10495/7889/4/license_rdfd41d8cd98f00b204e9800998ecf8427eMD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/7889/5/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5510495/7889oai:bibliotecadigital.udea.edu.co:10495/78892021-03-22 19:44:04.984Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |