High expression of antiviral proteins in mucosa from individuals exhibiting resistance to human immunodeficiency virus
ABSTARCT: Several soluble factors have been reported to have the capacity of inhibiting HIV replication at different steps of the virus life cycle, without eliminating infected cells and through enhancement of specific cellular mechanisms. Yet, it is unclear if these antiviral factors play a role in...
- Autores:
-
Taborda Vanegas, Natalia Andrea
González Diaz, Sandra Milena
Feria Garzón, Manuel Gerónimo
Arcia Anaya, Eliuth David
Aguilar Jiménez, Wbeimar
Zapata Builes, Wildeman
Ruge, María Teresa
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2015
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/11564
- Acceso en línea:
- http://hdl.handle.net/10495/11564
- Palabra clave:
- Amidohidrolasa
Cohort Studies
Elafina
HIV Infections
Immunology
ARN Mensajero
Adenovirus humanos
Virus Replication
- Rights
- openAccess
- License
- Atribución 2.5
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| dc.title.spa.fl_str_mv |
High expression of antiviral proteins in mucosa from individuals exhibiting resistance to human immunodeficiency virus |
| title |
High expression of antiviral proteins in mucosa from individuals exhibiting resistance to human immunodeficiency virus |
| spellingShingle |
High expression of antiviral proteins in mucosa from individuals exhibiting resistance to human immunodeficiency virus Amidohidrolasa Cohort Studies Elafina HIV Infections Immunology ARN Mensajero Adenovirus humanos Virus Replication |
| title_short |
High expression of antiviral proteins in mucosa from individuals exhibiting resistance to human immunodeficiency virus |
| title_full |
High expression of antiviral proteins in mucosa from individuals exhibiting resistance to human immunodeficiency virus |
| title_fullStr |
High expression of antiviral proteins in mucosa from individuals exhibiting resistance to human immunodeficiency virus |
| title_full_unstemmed |
High expression of antiviral proteins in mucosa from individuals exhibiting resistance to human immunodeficiency virus |
| title_sort |
High expression of antiviral proteins in mucosa from individuals exhibiting resistance to human immunodeficiency virus |
| dc.creator.fl_str_mv |
Taborda Vanegas, Natalia Andrea González Diaz, Sandra Milena Feria Garzón, Manuel Gerónimo Arcia Anaya, Eliuth David Aguilar Jiménez, Wbeimar Zapata Builes, Wildeman Ruge, María Teresa |
| dc.contributor.author.none.fl_str_mv |
Taborda Vanegas, Natalia Andrea González Diaz, Sandra Milena Feria Garzón, Manuel Gerónimo Arcia Anaya, Eliuth David Aguilar Jiménez, Wbeimar Zapata Builes, Wildeman Ruge, María Teresa |
| dc.subject.none.fl_str_mv |
Amidohidrolasa Cohort Studies Elafina HIV Infections Immunology ARN Mensajero Adenovirus humanos Virus Replication |
| topic |
Amidohidrolasa Cohort Studies Elafina HIV Infections Immunology ARN Mensajero Adenovirus humanos Virus Replication |
| description |
ABSTARCT: Several soluble factors have been reported to have the capacity of inhibiting HIV replication at different steps of the virus life cycle, without eliminating infected cells and through enhancement of specific cellular mechanisms. Yet, it is unclear if these antiviral factors play a role in the protection from HIV infection or in the control of viral replication. Here we evaluated two cohorts: i) one of 58 HIV-exposed seronegative individuals (HESNs) who were compared with 59 healthy controls (HCs), and ii) another of 13 HIV-controllers who were compared with 20 HIV-progressors. Peripheral blood, oral and genital mucosa and gut-associated lymphoid tissue (GALT) samples were obtained to analyze the mRNA expression of ELAFIN, APOBEC3G, SAMHD1, TRIM5α, RNase 7 and SerpinA1 using real-time PCR. RESULTS: HESNs exhibited higher expression of all antiviral factors in peripheral blood mononuclear cells (PBMCs), oral or genital mucosa when compared with HCs. Furthermore, HIV-controllers exhibited higher levels of SerpinA1 in GALT. CONCLUSIONS: These findings suggest that the activity of these factors is compartmentalized and that these proteins have a predominant role depending on the tissue to avoid the infection, reduce the viral load and modulate the susceptibility to HIV infection. |
| publishDate |
2015 |
| dc.date.issued.none.fl_str_mv |
2015 |
| dc.date.accessioned.none.fl_str_mv |
2019-07-25T21:54:03Z |
| dc.date.available.none.fl_str_mv |
2019-07-25T21:54:03Z |
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info:eu-repo/semantics/article |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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https://purl.org/redcol/resource_type/ART |
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Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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publishedVersion |
| dc.identifier.citation.spa.fl_str_mv |
Gonzalez SM, Taborda NA, Feria MG, Arcia D, Aguilar-Jiménez W, Zapata W, Rugeles MT. High Expression of Antiviral Proteins in Mucosa from Individuals Exhibiting Resistance to Human Immunodeficiency Virus. PLoS One. 2015 Jun 19;10(6):e0131139 |
| dc.identifier.issn.none.fl_str_mv |
1932-6203 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/11564 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0131139 |
| identifier_str_mv |
Gonzalez SM, Taborda NA, Feria MG, Arcia D, Aguilar-Jiménez W, Zapata W, Rugeles MT. High Expression of Antiviral Proteins in Mucosa from Individuals Exhibiting Resistance to Human Immunodeficiency Virus. PLoS One. 2015 Jun 19;10(6):e0131139 1932-6203 10.1371/journal.pone.0131139 |
| url |
http://hdl.handle.net/10495/11564 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
PLoS One |
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Atribución 2.5 |
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info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by/2.5/co/ |
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Atribución 2.5 http://creativecommons.org/licenses/by/2.5/co/ http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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12 |
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application/pdf |
| dc.publisher.group.spa.fl_str_mv |
Inmunovirología |
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Estados Unidos |
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Universidad de Antioquia |
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andres.perez@udea.edu.co |
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Taborda Vanegas, Natalia AndreaGonzález Diaz, Sandra MilenaFeria Garzón, Manuel GerónimoArcia Anaya, Eliuth DavidAguilar Jiménez, WbeimarZapata Builes, WildemanRuge, María Teresa2019-07-25T21:54:03Z2019-07-25T21:54:03Z2015Gonzalez SM, Taborda NA, Feria MG, Arcia D, Aguilar-Jiménez W, Zapata W, Rugeles MT. High Expression of Antiviral Proteins in Mucosa from Individuals Exhibiting Resistance to Human Immunodeficiency Virus. PLoS One. 2015 Jun 19;10(6):e01311391932-6203http://hdl.handle.net/10495/1156410.1371/journal.pone.0131139ABSTARCT: Several soluble factors have been reported to have the capacity of inhibiting HIV replication at different steps of the virus life cycle, without eliminating infected cells and through enhancement of specific cellular mechanisms. Yet, it is unclear if these antiviral factors play a role in the protection from HIV infection or in the control of viral replication. Here we evaluated two cohorts: i) one of 58 HIV-exposed seronegative individuals (HESNs) who were compared with 59 healthy controls (HCs), and ii) another of 13 HIV-controllers who were compared with 20 HIV-progressors. Peripheral blood, oral and genital mucosa and gut-associated lymphoid tissue (GALT) samples were obtained to analyze the mRNA expression of ELAFIN, APOBEC3G, SAMHD1, TRIM5α, RNase 7 and SerpinA1 using real-time PCR. RESULTS: HESNs exhibited higher expression of all antiviral factors in peripheral blood mononuclear cells (PBMCs), oral or genital mucosa when compared with HCs. Furthermore, HIV-controllers exhibited higher levels of SerpinA1 in GALT. CONCLUSIONS: These findings suggest that the activity of these factors is compartmentalized and that these proteins have a predominant role depending on the tissue to avoid the infection, reduce the viral load and modulate the susceptibility to HIV infection.12application/pdfenginfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85Atribución 2.5info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by/4.0/AmidohidrolasaCohort StudiesElafinaHIV InfectionsImmunologyARN MensajeroAdenovirus humanosVirus ReplicationHigh expression of antiviral proteins in mucosa from individuals exhibiting resistance to human immunodeficiency virusInmunovirologíaEstados UnidosPLoS OnePLoS One113106ORIGINALGonzalezSandraMilena_2015_AntiviralProteinsMucosa.pdfGonzalezSandraMilena_2015_AntiviralProteinsMucosa.pdfGonzalezSandraMilena_2015_AntiviralProteinsMucosaapplication/pdf1592390http://bibliotecadigital.udea.edu.co/bitstream/10495/11564/1/GonzalezSandraMilena_2015_AntiviralProteinsMucosa.pdfd1e37cb2865d691e46d07566fb7fc67dMD51CC-LICENSElicense_urllicense_urltext/plain; charset=utf-849http://bibliotecadigital.udea.edu.co/bitstream/10495/11564/2/license_url4afdbb8c545fd630ea7db775da747b2fMD52license_textlicense_texttext/html; charset=utf-80http://bibliotecadigital.udea.edu.co/bitstream/10495/11564/3/license_textd41d8cd98f00b204e9800998ecf8427eMD53license_rdflicense_rdfapplication/rdf+xml; charset=utf-80http://bibliotecadigital.udea.edu.co/bitstream/10495/11564/4/license_rdfd41d8cd98f00b204e9800998ecf8427eMD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/11564/5/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5510495/11564oai:bibliotecadigital.udea.edu.co:10495/115642021-03-24 21:08:57.881Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.coTk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo= |