What is the Contribution of Executive Dysfunction to the Cognitive Profile of Bipolar Disorder? A WellControlled Direct Comparison Study
ABSTACT: Large scale neuropsychological studies of patients with bipolar disorder have reported verbal memory and executive function deficits that persist during remission. A recent analysis by Thompson et al. (2009) indicated that verbal memory deficits could be entirely explained by the statistica...
- Autores:
-
Lopera Vásquez, Juan Pablo
Bell, Vaughan
López Jaramillo, Carlos Alberto
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2011
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/28184
- Acceso en línea:
- http://hdl.handle.net/10495/28184
- Palabra clave:
- Trastorno Bipolar
Bipolar disorder
Neuropsicología
Neuropsychology
Amnesia
Función Ejecutiva
Executive Function
Executive Control
Memoria
Memory
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-nd/2.5/co/
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What is the Contribution of Executive Dysfunction to the Cognitive Profile of Bipolar Disorder? A WellControlled Direct Comparison Study |
| dc.title.alternative.spa.fl_str_mv |
¿Cuál es la contribución de la disfunción ejecutiva al perfil cognitivo del trastorno bipolar? Un estudio comparativo bien controlado |
| title |
What is the Contribution of Executive Dysfunction to the Cognitive Profile of Bipolar Disorder? A WellControlled Direct Comparison Study |
| spellingShingle |
What is the Contribution of Executive Dysfunction to the Cognitive Profile of Bipolar Disorder? A WellControlled Direct Comparison Study Trastorno Bipolar Bipolar disorder Neuropsicología Neuropsychology Amnesia Función Ejecutiva Executive Function Executive Control Memoria Memory |
| title_short |
What is the Contribution of Executive Dysfunction to the Cognitive Profile of Bipolar Disorder? A WellControlled Direct Comparison Study |
| title_full |
What is the Contribution of Executive Dysfunction to the Cognitive Profile of Bipolar Disorder? A WellControlled Direct Comparison Study |
| title_fullStr |
What is the Contribution of Executive Dysfunction to the Cognitive Profile of Bipolar Disorder? A WellControlled Direct Comparison Study |
| title_full_unstemmed |
What is the Contribution of Executive Dysfunction to the Cognitive Profile of Bipolar Disorder? A WellControlled Direct Comparison Study |
| title_sort |
What is the Contribution of Executive Dysfunction to the Cognitive Profile of Bipolar Disorder? A WellControlled Direct Comparison Study |
| dc.creator.fl_str_mv |
Lopera Vásquez, Juan Pablo Bell, Vaughan López Jaramillo, Carlos Alberto |
| dc.contributor.author.none.fl_str_mv |
Lopera Vásquez, Juan Pablo Bell, Vaughan López Jaramillo, Carlos Alberto |
| dc.subject.decs.none.fl_str_mv |
Trastorno Bipolar Bipolar disorder Neuropsicología Neuropsychology Amnesia Función Ejecutiva Executive Function Executive Control Memoria Memory |
| topic |
Trastorno Bipolar Bipolar disorder Neuropsicología Neuropsychology Amnesia Función Ejecutiva Executive Function Executive Control Memoria Memory |
| description |
ABSTACT: Large scale neuropsychological studies of patients with bipolar disorder have reported verbal memory and executive function deficits that persist during remission. A recent analysis by Thompson et al. (2009) indicated that verbal memory deficits could be entirely explained by the statistical variance attributed to primary executive function deficits. This study tests the hypothesis that verbal memory deficits in bipolar patients are largely the result of executive difficulties by direct comparison of verbal neuropsychological tests primarily differing in their executive load as well as examining potential interactions with medication status. Methods: 33 Bipolar I patients not taking medication, 40 Bipolar I patients taking medication, and 28 healthy controls were compared on measures of IQ, verbal fluency, category fluency, verbal recall, and category prompted recall. Results: After controlling for IQ, performance on tasks that involved additional executive involvement was significantly worse. Medication had a small but reliable effect on cognitive performance. Conclusions: The results provide support to the hypothesis that the most significant source of cognitive impairment in bipolar disorder stems from executive impairment and that verbal memory deficits may arise as a result of this, rather than from primary impairment to core verbal memory mechanisms. |
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2011 |
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2011 |
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2022-05-05T13:52:34Z |
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2022-05-05T13:52:34Z |
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info:eu-repo/semantics/article |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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Artículo de investigación |
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Lopera-Vasquez Juan, Bell Vaughan, López-Jaramillo Carlos. ¿Cuál es la contribución de la disfunción ejecutiva al perfil cognitivo del trastorno bipolar? Un estudio comparativo bien controlado. rev.colomb.psiquiatr. [Internet]. 2011 Oct [cited 2022 Mar 15] ; 40( Suppl 1 ): 64-75. Available from: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0034-74502011000500005&lng=en. |
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0034-7450 |
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http://hdl.handle.net/10495/28184 |
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Lopera-Vasquez Juan, Bell Vaughan, López-Jaramillo Carlos. ¿Cuál es la contribución de la disfunción ejecutiva al perfil cognitivo del trastorno bipolar? Un estudio comparativo bien controlado. rev.colomb.psiquiatr. [Internet]. 2011 Oct [cited 2022 Mar 15] ; 40( Suppl 1 ): 64-75. Available from: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0034-74502011000500005&lng=en. 0034-7450 |
| url |
http://hdl.handle.net/10495/28184 |
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eng |
| language |
eng |
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Rev. Colomb. Psiquiatr. |
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Asociación Colombiana de Psiquiatría |
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Grupo de Investigación en Psiquiatría GIPSI |
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Bogotá, Colombia |
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Universidad de Antioquia |
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Lopera Vásquez, Juan PabloBell, VaughanLópez Jaramillo, Carlos Alberto2022-05-05T13:52:34Z2022-05-05T13:52:34Z2011Lopera-Vasquez Juan, Bell Vaughan, López-Jaramillo Carlos. ¿Cuál es la contribución de la disfunción ejecutiva al perfil cognitivo del trastorno bipolar? Un estudio comparativo bien controlado. rev.colomb.psiquiatr. [Internet]. 2011 Oct [cited 2022 Mar 15] ; 40( Suppl 1 ): 64-75. Available from: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0034-74502011000500005&lng=en.0034-7450http://hdl.handle.net/10495/28184ABSTACT: Large scale neuropsychological studies of patients with bipolar disorder have reported verbal memory and executive function deficits that persist during remission. A recent analysis by Thompson et al. (2009) indicated that verbal memory deficits could be entirely explained by the statistical variance attributed to primary executive function deficits. This study tests the hypothesis that verbal memory deficits in bipolar patients are largely the result of executive difficulties by direct comparison of verbal neuropsychological tests primarily differing in their executive load as well as examining potential interactions with medication status. Methods: 33 Bipolar I patients not taking medication, 40 Bipolar I patients taking medication, and 28 healthy controls were compared on measures of IQ, verbal fluency, category fluency, verbal recall, and category prompted recall. Results: After controlling for IQ, performance on tasks that involved additional executive involvement was significantly worse. Medication had a small but reliable effect on cognitive performance. Conclusions: The results provide support to the hypothesis that the most significant source of cognitive impairment in bipolar disorder stems from executive impairment and that verbal memory deficits may arise as a result of this, rather than from primary impairment to core verbal memory mechanisms.RESUMEN: Los estudios neuropsicológicos a gran escala de pacientes con trastorno bipolar han reportado déficits en la memoria verbal y en la función ejecutiva que persisten durante la remisión. Un análisis reciente realizado por Thompson et al. indicó que los déficits en la memoria verbal podían explicarse enteramente por la varianza estadística atribuida a los déficits en la función ejecutiva primaria. Este estudio demuestra la hipótesis de que los déficits en la memoria verbal de pacientes bipolares son mayormente el resultado de las dificultades ejecutivas mediante una comparación directa de pruebas neuropsicológicas verbales, que difieren principalmente en su carga ejecutiva, como también mediante la examinación las interacciones potenciales con el estado de la medicación. Métodos: Se compararon 33 pacientes con trastorno bipolar que no estaban tomando medicamentos con 28 controles saludables respecto a sus medidas de coeficiente intelectual (CI), fluidez verbal, fluidez de categorías, memoria verbal y memoria alentada por categorías. Resultados: Después de realizar controles relacionados con el CI, el desempeño que requería un mayor involucramiento ejecutivo era significativamente peor. Los medicamentos tenían un efecto pequeño pero confiable sobre el desempeño cognitivo. Conclusiones: Los resultados soportan la hipótesis de que la fuente más significativa de trastornos cognitivos en el trastorno bipolar es el trastorno ejecutivo y que pueden surgir déficits en la memoria verbal como resultado de este, y no de un trastorno primario de los mecanismos centrales de la memoria verbalCOL002914712application/pdfengAsociación Colombiana de PsiquiatríaGrupo de Investigación en Psiquiatría GIPSIBogotá, Colombiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-nd/4.0/What is the Contribution of Executive Dysfunction to the Cognitive Profile of Bipolar Disorder? A WellControlled Direct Comparison Study¿Cuál es la contribución de la disfunción ejecutiva al perfil cognitivo del trastorno bipolar? Un estudio comparativo bien controladoTrastorno BipolarBipolar disorderNeuropsicologíaNeuropsychologyAmnesiaFunción EjecutivaExecutive FunctionExecutive ControlMemoriaMemoryRev. Colomb. Psiquiatr.Revista Colombiana de Psiquiatría64s75s40Suplemento 1ORIGINALLoperaJuan_2011_PerfilCognitivoBipolar.pdfLoperaJuan_2011_PerfilCognitivoBipolar.pdfArtículo de investigaciónapplication/pdf270995http://bibliotecadigital.udea.edu.co/bitstream/10495/28184/1/LoperaJuan_2011_PerfilCognitivoBipolar.pdf777a0991b78cd024e1bcb8896e1c3498MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/28184/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8823http://bibliotecadigital.udea.edu.co/bitstream/10495/28184/2/license_rdfb88b088d9957e670ce3b3fbe2eedbc13MD5210495/28184oai:bibliotecadigital.udea.edu.co:10495/281842022-05-05 08:52:34.988Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |