In Vitro and In Vivo Cytotoxicities and Antileishmanial Activities of Thymol and Hemisynthetic Derivatives
ABSTRACT: The in vitro and in vivo antileishmanial and cytotoxic activities of thymol and structural derivatives in comparison to those of Glucantime were studied. The results showed here suggest that thymol and hemisynthetic derivatives have promising antileishmanial potential and could be consider...
- Autores:
-
Robledo Restrepo, Sara María
Osorio Durango, Edison Javier
Muñoz Herrera, Diana Lorena
Jaramillo Pérez, Luz Marina
Restrepo Agudelo, Adriana María
Arango Acosta, Gabriel Jaime
Vélez Bernal, Iván Darío
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2005
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/24198
- Acceso en línea:
- http://hdl.handle.net/10495/24198
- Palabra clave:
- Timol
Thymol
Citotoxicidad
Cytotoxicity
http://aims.fao.org/aos/agrovoc/c_34251
- Rights
- openAccess
- License
- http://purl.org/coar/access_right/c_abf2
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| dc.title.spa.fl_str_mv |
In Vitro and In Vivo Cytotoxicities and Antileishmanial Activities of Thymol and Hemisynthetic Derivatives |
| title |
In Vitro and In Vivo Cytotoxicities and Antileishmanial Activities of Thymol and Hemisynthetic Derivatives |
| spellingShingle |
In Vitro and In Vivo Cytotoxicities and Antileishmanial Activities of Thymol and Hemisynthetic Derivatives Timol Thymol Citotoxicidad Cytotoxicity http://aims.fao.org/aos/agrovoc/c_34251 |
| title_short |
In Vitro and In Vivo Cytotoxicities and Antileishmanial Activities of Thymol and Hemisynthetic Derivatives |
| title_full |
In Vitro and In Vivo Cytotoxicities and Antileishmanial Activities of Thymol and Hemisynthetic Derivatives |
| title_fullStr |
In Vitro and In Vivo Cytotoxicities and Antileishmanial Activities of Thymol and Hemisynthetic Derivatives |
| title_full_unstemmed |
In Vitro and In Vivo Cytotoxicities and Antileishmanial Activities of Thymol and Hemisynthetic Derivatives |
| title_sort |
In Vitro and In Vivo Cytotoxicities and Antileishmanial Activities of Thymol and Hemisynthetic Derivatives |
| dc.creator.fl_str_mv |
Robledo Restrepo, Sara María Osorio Durango, Edison Javier Muñoz Herrera, Diana Lorena Jaramillo Pérez, Luz Marina Restrepo Agudelo, Adriana María Arango Acosta, Gabriel Jaime Vélez Bernal, Iván Darío |
| dc.contributor.author.none.fl_str_mv |
Robledo Restrepo, Sara María Osorio Durango, Edison Javier Muñoz Herrera, Diana Lorena Jaramillo Pérez, Luz Marina Restrepo Agudelo, Adriana María Arango Acosta, Gabriel Jaime Vélez Bernal, Iván Darío |
| dc.subject.decs.none.fl_str_mv |
Timol Thymol |
| topic |
Timol Thymol Citotoxicidad Cytotoxicity http://aims.fao.org/aos/agrovoc/c_34251 |
| dc.subject.agrovoc.none.fl_str_mv |
Citotoxicidad Cytotoxicity |
| dc.subject.agrovocuri.none.fl_str_mv |
http://aims.fao.org/aos/agrovoc/c_34251 |
| description |
ABSTRACT: The in vitro and in vivo antileishmanial and cytotoxic activities of thymol and structural derivatives in comparison to those of Glucantime were studied. The results showed here suggest that thymol and hemisynthetic derivatives have promising antileishmanial potential and could be considered as new lead structures in the search for novel antileishmanial drugs. |
| publishDate |
2005 |
| dc.date.issued.none.fl_str_mv |
2005 |
| dc.date.accessioned.none.fl_str_mv |
2021-11-18T00:27:48Z |
| dc.date.available.none.fl_str_mv |
2021-11-18T00:27:48Z |
| dc.type.spa.fl_str_mv |
info:eu-repo/semantics/article |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/publishedVersion |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.redcol.spa.fl_str_mv |
https://purl.org/redcol/resource_type/ART |
| dc.type.local.spa.fl_str_mv |
Artículo de investigación |
| format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
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publishedVersion |
| dc.identifier.citation.spa.fl_str_mv |
Robledo, S., Osorio, E., Muñoz, D., Jaramillo, L. M., Restrepo, A., Arango, G., & Vélez, I. (2005). In vitro and in vivo cytotoxicities and antileishmanial activities of thymol and hemisynthetic derivatives. Antimicrobial agents and chemotherapy, 49(4), 1652–1655. https://doi.org/10.1128/AAC.49.4.1652-1655.2005 |
| dc.identifier.issn.none.fl_str_mv |
0066-4804 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/24198 |
| dc.identifier.doi.none.fl_str_mv |
10.1128/AAC.49.4.1652-1655.2005 |
| dc.identifier.eissn.none.fl_str_mv |
1098-6596 |
| identifier_str_mv |
Robledo, S., Osorio, E., Muñoz, D., Jaramillo, L. M., Restrepo, A., Arango, G., & Vélez, I. (2005). In vitro and in vivo cytotoxicities and antileishmanial activities of thymol and hemisynthetic derivatives. Antimicrobial agents and chemotherapy, 49(4), 1652–1655. https://doi.org/10.1128/AAC.49.4.1652-1655.2005 0066-4804 10.1128/AAC.49.4.1652-1655.2005 1098-6596 |
| url |
http://hdl.handle.net/10495/24198 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Antimicrob. Agents Chemother. |
| dc.rights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.accessrights.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| dc.rights.creativecommons.spa.fl_str_mv |
Derechos reservados - Está prohibida la reproducción parcial o total de esta publicación |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
http://purl.org/coar/access_right/c_abf2 Derechos reservados - Está prohibida la reproducción parcial o total de esta publicación |
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4 |
| dc.format.mimetype.spa.fl_str_mv |
application/pdf |
| dc.publisher.spa.fl_str_mv |
American Society for Microbiology |
| dc.publisher.group.spa.fl_str_mv |
Grupo de Investigación en Sustancias Bioactivas (GISB) Programa de Estudio y Control de Enfermedades Tropicales (PECET) |
| dc.publisher.place.spa.fl_str_mv |
Washington, Estados Unidos |
| institution |
Universidad de Antioquia |
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http://bibliotecadigital.udea.edu.co/bitstream/10495/24198/1/ArangoGabriel_2005_CytotoxicitiesAntileishmanial.pdf http://bibliotecadigital.udea.edu.co/bitstream/10495/24198/2/license.txt |
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MD5 MD5 |
| repository.name.fl_str_mv |
Repositorio Institucional Universidad de Antioquia |
| repository.mail.fl_str_mv |
andres.perez@udea.edu.co |
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1812173108852817920 |
| spelling |
Robledo Restrepo, Sara MaríaOsorio Durango, Edison JavierMuñoz Herrera, Diana LorenaJaramillo Pérez, Luz MarinaRestrepo Agudelo, Adriana MaríaArango Acosta, Gabriel JaimeVélez Bernal, Iván Darío2021-11-18T00:27:48Z2021-11-18T00:27:48Z2005Robledo, S., Osorio, E., Muñoz, D., Jaramillo, L. M., Restrepo, A., Arango, G., & Vélez, I. (2005). In vitro and in vivo cytotoxicities and antileishmanial activities of thymol and hemisynthetic derivatives. Antimicrobial agents and chemotherapy, 49(4), 1652–1655. https://doi.org/10.1128/AAC.49.4.1652-1655.20050066-4804http://hdl.handle.net/10495/2419810.1128/AAC.49.4.1652-1655.20051098-6596ABSTRACT: The in vitro and in vivo antileishmanial and cytotoxic activities of thymol and structural derivatives in comparison to those of Glucantime were studied. The results showed here suggest that thymol and hemisynthetic derivatives have promising antileishmanial potential and could be considered as new lead structures in the search for novel antileishmanial drugs.COL0010359COL00150994application/pdfengAmerican Society for MicrobiologyGrupo de Investigación en Sustancias Bioactivas (GISB)Programa de Estudio y Control de Enfermedades Tropicales (PECET)Washington, Estados Unidosinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Derechos reservados - Está prohibida la reproducción parcial o total de esta publicaciónIn Vitro and In Vivo Cytotoxicities and Antileishmanial Activities of Thymol and Hemisynthetic DerivativesTimolThymolCitotoxicidadCytotoxicityhttp://aims.fao.org/aos/agrovoc/c_34251Antimicrob. Agents Chemother.Antimicrobial Agents and Chemotherapy16521655494ORIGINALArangoGabriel_2005_CytotoxicitiesAntileishmanial.pdfArangoGabriel_2005_CytotoxicitiesAntileishmanial.pdfArtículo de investigaciónapplication/pdf79676http://bibliotecadigital.udea.edu.co/bitstream/10495/24198/1/ArangoGabriel_2005_CytotoxicitiesAntileishmanial.pdf6049104e1ea0002b467b8eb226fb81faMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/24198/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5210495/24198oai:bibliotecadigital.udea.edu.co:10495/241982021-11-17 19:37:56.627Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |